CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

📣 📣 📣 Job alert!!! Join us at Karolinska Institutet We are looking for a postdoc to the Carlström lab curious to dissect metabolic and epigenetic interplay using iPSCs and animal models coupled with...

Researchers at Karolinska Institutet have created the first detailed map showing how genetic activity is controlled in individual cells of the adult human brain and spinal cord. The study, published i...

In a new study from Karolinska Institutet, published in Nature Neuroscience, researchers have identified the neurogenic progenitor that give rise to dopaminergic neurons, the primary neurons affected ...

Zhu et al. find that aging causes region-specific myelin damage in the spinal cord, which is counteracted by enhanced TGFβ signaling in microglia, revealing a protective mechanism for healthy aging.

Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...

Engineered deletions are a powerful probe for studying genome architecture, function, and regulation. Yet, the lack of effective methods to create them in large numbers and at multi-kilobase scale has...

A new study from Karolinska Institutet, published in Nature Neuroscience, explores how oligodendrocytes, the cells that produce myelin in the brain and spinal cord, respond during the development of m...

Single-cell ATAC/RNA multiomic profiling was used to investigate how oligodendrocyte lineage cells respond across multiple disease stages within a mouse MS model, revealing early activation of immune ...

Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

Researchers at Karolinska Institutet and Yale University have created a multidimensional, molecular map of how the mouse brain develops after birth and how it reacts to inflammation. The study, which ...

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The continued development of high-dimensional CRISPR screen readouts, such as single-cell RNA sequencing and high-content imaging, necessitates compact libraries to enable functional interrogation at ...

Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

Cecilia Uddén har hamnat i fokus för debatten om journalistik och opartiskhet.

Statsepidemiologen Magnus Gisslén berättar i debattartikel att han tappat sitt förtroende för Folkhälsomyndigheten

In der Klinik für Alterspsychiatrie und Kognitive Störungen des Universitätsklinikums Bonn ist zum nächstmöglichen Zeitpunkt folgende Stelle in Teilzeit (19,25 Std. / Woche) zu besetzen. Die Stelle is...

Kennedys pengastopp till mRNA-forskning i USA riskerar att hindra medicinska framsteg. Dessutom ger han antivaxxare ännu fler skäl att misstro myndigheter.