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Psychiatric Genomics Consortium (PGC)

@pgcgenetics.bsky.social
662 followers 213 following 655 posts

With 1700+ international scientists & 900,000 participants, the PGC is the largest biological investigation in the history of psychiatry 🧬

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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 10/09/2026
On September 10, we mark #WorldSuicidePreventionDay. It's time to remember those affected by suicide, to raise awareness, and to focus efforts on directing treatment to those who need it most.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 19/08/2026
✨Publication alert!✨The Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) has, for the first time, identified genetic factors associated with binge eating and compared them to the genetic factors linked to anorexia nervosa. doi.org/10.1038/s442...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 09/06/2026
📢 New publication in @nathumbehav.nature.com from the PGC Anxiety Working Group: the largest GWAS of generalised anxiety symptoms to date, analysing ~700k across 14 cohorts. We found 74 genome-wide significant loci, 39 novel for anxiety.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 26/05/2026
1/ We conclude this Twitter takeover spotlighting an upcoming symposium at #WCPG2026 “Advancing Psychiatric Genomics through Large-Scale African Cohorts” 🌍🧬 The session will highlight how African cohorts are reshaping psychiatric genetics globally @ispg.bsky.social
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 26/05/2026
1/ 🧠🌍 Spotlight on the African Bioinformatics Institute (ABI)! ABI is helping drive data-driven biomedical research across Africa by building computational infrastructure, empowering African scientists, and ensuring genomic discoveries better represent African populations.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 25/05/2026
New preprint alert 📢: A Giant Leap for Childhood Brain Research in Africa! 🌍👶 NeuroDev is one of the largest clinical & genetic studies of neurodevelopmental disorders (NDDs) conducted in Africa 👏🏼 www.medrxiv.org/content/10.6...
medrxiv.org
NeuroDev: etiology and experience of neurodevelopmental disorders in Kenya and South Africa
The NeuroDev study, conducted in Kenya and South Africa, is a large-scale clinical, genetic, and epidemiologic characterization of neurodevelopmental disorders (NDDs) on the African continent. NeuroDe...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 25/05/2026
Final #PipelinePeek [Unpublished data]: For a long time, the "DNA risk scores" (PRS) used to predict mental health conditions were based mostly on people of European descent. But our genes are diverse! see poster 👇
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 23/05/2026
#PipelinePeek [Unpublished data]: Beyond the Virus: How HIV and Life Experiences "Rewrite" Your Biology 🧬🌍 Other exciting research from @pgc-africa.bsky.social Early-career scientists uncovers a fascinating connection between our physical health and our mental history! posters👇
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 21/05/2026
#PipelinePeek [Unpublished data]: Unlocking the Secrets of a Healthy Start! 👶✨@pgc-africa.bsky.social Early Career Scientists from @suhealthsci.bsky.social Lauren Martin and Colleagues investigate how a mother’s health and a baby’s environment shape a child's growing brain. 🧠👇
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 20/05/2026
Take a look at the “Behind-the-Scenes Journey” from the Editorial on Challenges and Strategic Insights of the DepGenAfrica study as provided by @pgc-africa.bsky.social Comm’s rep Dr. Jared .G. Maina and Colleagues 🛠️🚀 www.cambridge.org/core/journal...
cambridge.org
Psychiatric genetics research in Africa: challenges, opportunities and strategic insights from the Depression Genetics in Africa (DepGenAfrica) study | The British Journal of Psychiatry | Cambridge Co...
Psychiatric genetics research in Africa: challenges, opportunities and strategic insights from the Depression Genetics in Africa (DepGenAfrica) study
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 19/05/2026
Today, we would highlight the Master plan from the DepGenAfrica Study Protocol by one of PGC Africa's @pgc-africa.bsky.social co-chairs Dr. Adeniran Okewole and colleagues 📝🌍 wellcomeopenresearch.org/articles/10-...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 18/05/2026
Hello from the PGC Africa working group 👋 Today, we begin our takeover to share with you exciting happenings from the working group and its members🎉This takeover is proudly brought to you by @pgc-africa.bsky.social Africa Comms and Outreach team. Stay tuned!
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 13/05/2026
🧬 New paper on ADHD epigenetics. Instead of analyzing “bulk blood”, this study performed cell type-specific methylome-wide association studies (MWAS) for childhood ADHD symptoms - revealing signals hidden in traditional analyses.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 09/05/2026
What biology is involved in ADHD? This study points strongly to brain biology. #ADHD #genetics #psychiatry #mentalhealth
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 08/05/2026
Genetic findings are not only about diagnosis. They can also help us understand differences in developmental and life trajectories. #ADHD #genetics #psychiatry #mentalhealth
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 07/05/2026
ADHD is not a single genetic story. The new study reinforces that ADHD risk can come from different sources of genetic variation. #ADHD #genetics #psychiatry #mentalhealth
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 07/05/2026
Three genes stood out in the study: MAP1A ANO8 ANK2 Rare damaging variants in these genes were associated with substantially increased ADHD risk. #ADHD #genetics #psychiatry #mentalhealth
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 05/05/2026
ADHD is highly genetic, but we still do not fully understand all the genetic factors involved. A new large-scale study helps fill an important part of that gap. #ADHD #genetics #psychiatry #mentalhealth www.nature.com/articles/s41...
nature.com
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology - Nature
An analysis of rare genetic variants identifies three genes—MAP1A, ANO8 and ANK2—that have a role in attention deficit hyperactivity disorder (ADHD) and investigates the potential underlying biologica...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 28/04/2026
New autism GWAS incoming! At #INSAR2026, @jakobgrove.bsky.social presented the latest updates on the yet-to-be-released autism GWAS. Curious about the findings? Find them below ⬇️
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 28/04/2026
#INSAR2026 's Saturday could be described as ‘genetics day’, as it started with an impressive keynote by the even more impressive @angelicaronald.bsky.social
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 27/04/2026
🧬Autism is influenced by a combination of common variants with small effects, and rare variants with large effects (see below for a great plot, from tinyurl.com/TomaTrends)
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 27/04/2026
Looking back at an amazing #INSAR2026 conference full of genetics. INSAR 2026 started with a masterclass in fundamentals, including an amazing and accessible talk by @stephansanders.bsky.social providing an overview of what genetics research is, and how we can (and can not) use it.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 23/04/2026
The autism sex ratio may be closer than we thought. A new study using Swedish birth register data shows the diagnostic ratio is decreasing over time, and age at diagnosis matters. Women are diagnosed later, and by age 20, nearly as many women as men are diagnosed.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 21/04/2026
Age at diagnosis is gaining attention in autism research. AaD is heritable, with genetic factors influencing whether someone is diagnosed earlier or later. The genetic correlation is only moderate, suggesting differing genetic profiles. Commentary: doi.org/10.1038/d415... #autism #genetics
doi.org
Early- and late-diagnosed autism are genetically distinct
Analyses of symptoms and genomic data indicate that autism that manifests in early childhood is distinct from autism that is diagnosed later in development.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 20/04/2026
Over the next two weeks, we’ll be posting about autism! From April 22–25, we’ll share live updates from the INSAR annual meeting, the largest global conference on autism research, featuring the latest in autism genetics. Follow x.com/autisminsar #autism #genetics #INSAR
x.com
International Society for Autism Research, INSAR (@AutismINSAR) / X
International Society for Autism Research, INSAR (@AutismINSAR) / X
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 29/03/2026
🧵 New preprint from the PGC Anxiety Working Group: the largest GWAS of generalised anxiety symptoms to date, analysing 700k across 14 cohorts. 📄 Skelton et al found 74 genome-wide significant loci, 39 novel for anxiety doi.org/10.1101/2025...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 27/03/2026
🧵 Mitchell et al. report the first genome-wide significant loci for panic attacks (16 loci; 61,746 cases) & panic disorder (7 loci; 29,775 cases), combining data from 5 international cohorts. 📄Preprint on medRxiv doi.org/10.1101/2025...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 26/03/2026
🧬 Are the genetics of anxiety different in females and males? In a new preprint, Hu et al. report the first sex-specific GWAS meta-analysis of anxiety disorders, combining UK Biobank and All of Us: 85,000 female cases & 36,720 male cases 📄 doi.org/10.1101/2025...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 25/03/2026
🧬 DNA methylation is an epigenetic modification that can influence gene expression. What role does it play in generalised anxiety disorder? Gupta et al. conducted one of the largest epigenome-wide association studies of GAD in 45.5k from the Million Veteran Program 📄 doi.org/10.1101/2025...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 24/03/2026
🔬Does inflammation play a role in anxiety? Mac Giollabhui et al. triangulated observational, Mendelian randomization (MR) & genetic risk score analyses of inflammatory markers in ~55k from the Lifelines cohort 📄 doi.org/10.1038/s413...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 21/03/2026
🧬How genetically similar are fear & GAD? A new preprint by ter Kuile et al. addresses this via their GWAS of fear-based disorders as a group (panic, agoraphobia, specific phobia, social anxiety) & a separate GWAS of GAD.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 18/03/2026
🧵 A new review in Molecular Psychiatry by Ohi et al. takes a look at the clinical and genetic features of five anxiety disorders through the lens of anxiety, fear, & avoidance doi.org/10.1038/s413...
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 17/03/2026
Day 2 of the PGC ANX takeover! Our case-control GWAS meta-analysis of anxiety disorders in 122,341 cases was published earlier this year in Nature Genetics (doi.org/10.1038/s415...). If you missed it, catch up here 👇🧵
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 16/03/2026
Hello from the PGC Anxiety Working Group 👋. Get ready for #anxiety #genomics updates as we take over the PGC social media!
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 13/03/2026
On the last day of the PGC #Bipolar work group take over, we want to focus on the people living with bipolar disorder every day. The Bipolar Commission and charity Bipolar UK, has spent five years gathering evidence on the state of bipolar care in the UK. Here's what they found:
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 12/03/2026
There is high symptom and genetic overlap across psychiatric conditions. @andrewgrotzinger.bsky.social et al. (2025) explored this using our #GWAS data of over 1 mil cases across 14 conditions. They assessed the genetic architecture and the functional roles of genes across these conditions.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 11/03/2026
1/5 Merola et al. (2026) and Richards et al. (2022) used genomic structural equation modelling (gSEM) to identify latent genetic constructs and explore how they map onto observed traits.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 10/03/2026
1/3 Today we are focusing on Merola et al. who identified a mania specific genetic factor (unique from depression and psychosis) and explored its relationships with bipolar, MDD and schizophrenia.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 10/03/2026
There is high heterogeneity in the presentation of bipolar disorder which could be explained by differences in genetic risk for specific symptoms or related mental health conditions. Over the next three days, we will be discussing research aiming to understand this better ✨
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 09/03/2026
We hoped you enjoyed our International Women’s day posts! To continue on the conversation, we would like to highlight some of the important work happening to understand bipolar disorder in women better.
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 08/03/2026
And that's a wrap folks! Thanks for joining us in celebrating International Women's Day, 2026 and highlighting some of our fabulous #FemsinSTEM🌷 Remember, promoting and supporting women is more than just a day 🫶🏽
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 08/03/2026
And last, but definitely not least, we want to highlight Perline Aline Delle Demange (University of Oslo)🥳!
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 08/03/2026
Check out these two 💫amazing #WomenInSTEM💫, Hyejung Won (Univeristy of North Carolina) and Ofure Okoh (Max Planck Institute)
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 08/03/2026
And we are continuing our #InternationalWomenDay2026👩🏾‍🔬! ✨Meet Jessica Yang (Cardiff University) and Ziada Ayorech (University of Oslo)✨
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 08/03/2026
The next two awesome scientists we are highlighting are the✨awesome✨Maria Koromina (Mount Sinai), and Sandra Sanchez-Roige (UCSD)
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 07/03/2026
Next, meet Robyn Wootton (University of Bristol) and Rosa Cheesman (University of Oslo) 👏🏽👏🏽
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 06/03/2026
Our first highlights are Jiayi Xu (Yale) and Niamh Mullins (Mount Sinai) 🥳
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 06/03/2026
In celebration of #InternationalWomensDay this Sunday, 8th of March, we wanted to highlight some of our early and mid-career #WomenInSTEM here at the PGC🎉! Stay tuned to find out what some of these✨awesome✨ scientists are doing and what being a woman in STEM means to them!
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 06/03/2026
Last year researchers used our data to publish a paper in Nature Neuroscience mapping genetic variants identified from our previous #bipolar #GWAS to genes and exploring their likely functional effects
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Psychiatric Genomics Consortium (PGC) @pgcgenetics.bsky.social · 05/03/2026
Last year the PGC BD group published an updated GWAS of #bipolar disorder to date in Nature — and the findings are a major leap forward.
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