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Butt Lab - Oxford

@interneuron.bsky.social
948 followers 260 following 19 posts

How the mammalian brain comes online with a focus on local GABAergic interneurons | electrophysiology & imaging | in vitro & in vivo approaches 🧠🧪

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Helen Barron @helencbarron.bsky.social · 28/07/2026
***New preprint from the lab*** showing “Generative replay across hippocampal-neocortical circuits”. In sleep we show spiking sequences in V1 (sensory neocortex!) that represent information that has not been directly experienced www.biorxiv.org/content/10.6... @bndu.ox.ac.uk @ndcnoxford.bsky.social
biorxiv.org
Generative replay across hippocampal-neocortical circuits
To make flexible decisions, the brain needs to make inferences between events that were not directly experienced together. In sharp-wave ripple (SWR) events, during periods of rest and sleep, spiking ...
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Butt Lab - Oxford @interneuron.bsky.social · 25/11/2025
Hi all, we're on the look out for a postdoctoral researcher with links to Denmark who would interested in applying for a Novo Nordisk Fellowship to join a collaborative endeavour between Oxford and Copenhagen (novonordiskfonden.dk/en/grant/pos...).
novonordiskfonden.dk
Postdoctoral Fellowships at University of Oxford - 2026 - Novo Nordisk Fonden
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Armin Lak @laklab.bsky.social · 16/10/2025
Out today at Neuron, our experiments show that frontal cortical representation of economic variables is jointly determined by spatial organization and downstream connectivity of neurons, revealing a structured, multi-scale code for economic variables. www.cell.com/neuron/fullt...
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Franck Polleux @franckp.bsky.social · 21/09/2025
Excited to highlight a new paper from my graduate student Sergio Bernal Garcia who, together withLuke Hammond, developed RESPAN, a new deep-learning pipeline automating the segmentation of neuronal morphology and dendritic spines from fluorescent microscopy images: www.cell.com/cell-reports...
cell.com
A deep learning pipeline for accurate and automated restoration, segmentation, and quantification of dendritic spines
Garcia et al. present RESPAN, a pipeline that enables automated dendritic spine analysis through seamless integration of deep learning image restoration and segmentation capabilities with comprehensiv...
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Butt Lab - Oxford @interneuron.bsky.social · 18/09/2025
A rather 'unique' paper from our lab is online in @cp-cellreports.bsky.social now. Unique in the sense that I don't think anyone else will be rushing to optotag cortical interneurons in the early postnatal brain... because it is nigh on impossible! www.sciencedirect.com/science/arti...
sciencedirect.com
GABAergic circuits reflect different requirements for sensory integration in postnatal mouse neocortex
Information transfer in mammalian cerebral cortex is dependent on GABAergic interneuron circuits that are widely assumed to be uniform across the neoc…
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Mark Blumberg @marksblumberg.bsky.social · 14/07/2025
Two faculty positions in my department this year. Please spread the word! And don't hesitate to reach out if you want to learn more.
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Butt Lab - Oxford @interneuron.bsky.social · 06/06/2025
Our study on the impact of altered serotonin (5-HT) signalling on the developing sensory cortex is now live at Nature Comms. We use longitudinal in vivo imaging of 5-HT and neural activity to show that this neuromodulator is buffered in early life to promote bottom-up instruction of sensory areas.
Image of a coronal section through postnatal mouse somatosensory cortex (S1BF with transient expression of the serotonin transporter in thalamic afferents shown in red.
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Grubb Lab @grubblabneuro.bsky.social · 09/01/2025
Save the date! We're organising a workshop on Data Sharing on the 10th of February at Guy's Campus (KCL)! All you need to know to make your datasets open to the public + engaging in open science practices. More details to come soon — stay tuned!
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OxfordDPAG @oxforddpag.bsky.social · 07/01/2025
Congratulations to Gabriel! @interneuron.bsky.social
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OxfordDPAG @oxforddpag.bsky.social · 08/01/2025
Well done Ivan! @interneuron.bsky.social
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Laura Andreae @landreae.bsky.social · 06/01/2025
This sounds interesting... definitely one to check out.
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David @dav1dcg.bsky.social · 15/12/2024
Fast-spike interneurons in visual cortical layer 5: Heterogeneous response properties are related to thalamocortical connectivity Some L5 INT with strong input from LGN and visual responses more similar to L4 INT than those receiving little direct LGN input. www.jneurosci.org/content/earl...
jneurosci.org
Fast-spike interneurons in visual cortical layer 5: Heterogeneous response properties are related to thalamocortical connectivity
Layer 4 of rabbit V1 contains fast-spiking GABAergic interneurons (suspected inhibitory interneurons, SINs) that receive potent synaptic input from the LGN and generate fast, local feed-forward inhibi...
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Butt Lab - Oxford @interneuron.bsky.social · 14/12/2024
We did this. Beautiful work from the 🦋less Gabriel Ocana-Santero & team. More to follow soon but state-dependent neuromodulation is coming to developmental neuroscience in a big way 🧠🧪
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Luke Sjulson @lukesjulson.bsky.social · 13/12/2024
Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube! Please like and repost to help us get the word out! www.youtube.com/playlist?lis... Lecture 1: Signals and data acquisition Focusing on hardware, digital/analog I/O, synchronization 🧵
youtube.com
Neuroscience methods - YouTube
Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...
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Ana Dorrego Rivas @adorrego.bsky.social · 07/12/2024
A toolbox for ablating excitatory and inhibitory synapses elifesciences.org/reviewed-pre...
elifesciences.org
A toolbox for ablating excitatory and inhibitory synapses
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Butt Lab - Oxford @interneuron.bsky.social · 05/12/2024
Our 2nd new Doctor in as many days! Many congratulations to Gabi on the successful defence of his thesis (in vivo 5-HT in neurodevelopment; preprint out soon!). Huge thanks to the 🦋less, elite examining team of Oscar Marin & Colin Akerman, also co-PI Trevor Sharp and Serotonin & Beyond @ec.europa.eu
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Armin Lak @laklab.bsky.social · 04/12/2024
NEW DOCTOR from the lab, Antara Majumdar🥳 🍾 thanks to @kerrywalker.bsky.social @jpassecker.bsky.social for examination & 2nd supervisor @interneuron.bsky.social. Here is Antara's preprint, came out right around the US election and X being deserted: www.biorxiv.org/content/10.1...
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Jimmy Dooley @jimmycdooley.bsky.social · 27/11/2024
Looking for an escape over the holiday? @meikeesther.bsky.social and I published a ViewPoint looking at the intersection of Developmental and Systems Neuroscience titled “More Than a Small Brain: The Importance of Studying Neural Function during Development” www.jneurosci.org/content/44/4...
jneurosci.org
More Than a Small Brain: The Importance of Studying Neural Function during Development
The nervous system contains complex circuits comprising thousands of cell types and trillions of connections. Here, we discuss how the field of “developmental systems neuroscience” combines the molecu...
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Miguel Maravall @mmaravall.bsky.social · 27/11/2024
A huge pleasure to repost this announcement - over 40 students have graduated from our fantastic @sussexneuro.bsky.social PhD programme, and each year brings new perspectives and opportunities for both the new joiners and ourselves as their hosts. Do consider applying!
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Brain, Body, and Self Lab @brainself.bsky.social · 26/11/2024
We are recruiting a PhD student at the Brain, Body, and Self Lab, Department of Neuroscience, Karolinska Institutet. Learn more and apply here: kidoktorand.varbi.com/en/what:job/...
kidoktorand.varbi.com
Doctoral (PhD) student position in Cognitive Neuroscience
Do you want to contribute to top quality medical research? To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individu
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Carmen Sandi @carmensandi10.bsky.social · 26/11/2024
Neuroscientists! A key message from the ALBA Network Please help us spread the word and share this with your network!!! Nominate (self-n allowed) a mid-career neuroscientist (5+ years post-PhD) for the ALBA-Roche Research Prize for Excellence in Neuroscience! 🔎http://loom.ly/_EvQvm4 🗓️20 January 2025
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Onur Dagliyan @onurdagliyan.bsky.social · 23/11/2024
go.bsky.app/43wgshX
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rodriguez-carleton-labs @carleton-lab.bsky.social · 22/11/2024
Dive into our latest findings on this powerful structure here: “The claustrum is critical for maintaining working memory” biorxiv.org/cgi/content/...
biorxiv.org
The claustrum is critical for maintaining working memory information
Working memory (WM) enables the mammalian brain to temporarily store and manipulate information, supporting cognitive tasks and communication processes. Rather than depending on a single specialized a...
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Prof Sarah-Jayne Blakemore @sjblakemore.bsky.social · 21/11/2024
**We are recruiting** Seeking a postdoc to work on a Wellcome-funded cohort study focusing on social-cognitive processing in typically developing children and adolescents (aged 8-18 years) and children and adolescents with 22q11.1 deletion syndrome. www.jobs.cam.ac.uk/job/49291/
jobs.cam.ac.uk
Research Assistant/Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Assistant/Research Associate (Fixed Term) in the Department of Psychology at the University of Cambridge.
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Gonçalo Castelo-Branco @gocastelobranco.bsky.social · 21/11/2024
Fantastic work by @peruhlen.bsky.social and @kanashigeaki.bsky.social, with a beautiful cover in Science that tells it all! www.science.org/doi/10.1126/...
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Butt Lab - Oxford @interneuron.bsky.social · 21/11/2024
This made for an interesting read over breakfast: science publishing and behaviour all crammed into 1 article. ‘Mad egghead’ who built a mouse utopia www.theguardian.com/science/2024...
theguardian.com
The ‘mad egghead’ who built a mouse utopia
The long read: John Calhoun designed an apartment complex for mice, to examine the effects of overcrowding. It was hailed as a groundbreaking study of social breakdown, but is largely forgotten. So wh...
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Matthew L. Kraushar @matthewkraushar.bsky.social · 20/11/2024
@tonyzador.bsky.social on development: "it turns out to be pretty interesting!" shout out to Tony for highlighting what i believe will be an important partnership towards mutual progress developmental neuro 🤝 NeuroAI the future is NeuroDev 🔥 open.spotify.com/episode/3rZ5...
open.spotify.com
BI 198 Tony Zador: Neuroscience Principles to Improve AI
Brain Inspired · Episode
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Anna Molofsky Lab @annamolofskylab.bsky.social · 17/11/2024
ok- sci bsky - trying this out. our latest paper with @arimolofskylab.bsky.social shows that "allergic" immune cells (ILC2s) have a healthy function in developing brain: formation of inhibitory synapses - key tuners of brain activity www.science.org/stoken/autho...
science.org
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
The innate immune system shapes brain development and is implicated in neurodevelopmental diseases. It is critical to define the relevant immune cells and signals and their impact on brain circuits. I...
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Tim Behrens @behrenstimb.bsky.social · 16/11/2024
Deadline Monday…
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Sergiu P. Pasca @sergiuppasca.bsky.social · 16/11/2024
go.bsky.app/SxcKi5z
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adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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Blake Richards @tyrellturing.bsky.social · 13/11/2024
This paper from Claudia Clopath's lab is very exciting for me. I've been musing for a while now that the challenge of approximating gradient descent is probably made way easier in the brain by feedback signals for control. Here they show it!!! openreview.net/forum?id=xav... 🧠📈 #NeuroAI 🧪
openreview.net
Feedback control guides credit assignment in recurrent neural networks
How do brain circuits learn to generate behaviour? While significant strides have been made in understanding learning in artificial neural networks, applying this knowledge to biological networks...
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Peter Kok @peterkok.bsky.social · 12/11/2024
Fascinating study on V1 responses to predicted-but-occluded images, as measured with optical imaging in mice. Impressive consistency across species! Led by @kseignet.bsky.social. #neuroskyence
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Nazim Kourdougli @nkourdougli.bsky.social · 10/11/2024
For all the Developmental Neuroscientists ... So excited to see our review out in NatRevNeursoci @natureportfolio.bsky.social (w/ Michelle Wu, lead by C. Portera-Cailliau) "Network state transitions during cortical development" www.nature.com/articles/s41...
nature.com
Network state transitions during cortical development - Nature Reviews Neuroscience
At early developmental stages, spontaneous activity in the mammalian cortex is characterized by the occurrence of highly synchronous network events. Portera-Cailliau and colleagues describe these acti...
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Kirsten Adam @kirsten-adam.bsky.social · 04/09/2024
I'm excited to share that Rice is hiring TWO new faculty members in Cognitive Neuroscience (1 Assistant level, 1 Associate/Full)! Asst ad: apply.interfolio.com/153086 Assoc/full ad: apply.interfolio.com/153384 Please share, and reach out if you have questions!
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PessoaBrain @pessoabrain.bsky.social · 19/11/2023
If you want to check the book's content, check it out in the open access version! direct.mit.edu/books/oa-mon...
direct.mit.edu
The Entangled Brain: How Perception, Cognition, and Emotion Are Woven Together
A new vision of the brain as a fully integrated, networked organ.Popular neuroscience accounts often focus on specific mind-brain aspects like addiction, cognit
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Butt Lab - Oxford @interneuron.bsky.social · 13/11/2023
The lab is SFN with 2 posters, Tues afternoon: (1) Gabriel Ocana-Santero presenting our 5-HT imaging story, showing a state-dependent role for this neuromodulator in circuit development. (2) Ivan Lazarte presenting our IN optotagging story across S1 & V1, revealing different circuits in these areas.
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manes @michaelanes.bsky.social · 17/10/2023
Inhibition - it's what makes us us.
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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · 10/10/2023
Transthalamic input to higher-order cortex selectively conveys state information www.biorxiv.org/content/10.1101/202…
biorxiv.org
Transthalamic input to higher-order cortex selectively conveys state information https://www.biorxiv.org/content/10.1101/2023.10.08.561424v1
Communication among different neocortical areas is largely thought to be mediated by long-range syna
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Ed Yong is offline @edyong209.bsky.social · 10/10/2023
This is a cool result, and follows on from similar evidence for whale strandings that I wrote about in the Before Times. www.theatlantic.com/science/arch...
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