iiinova — where your digital self keeps evolving

ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 09/07/2026

When a chemist becomes barista, we end up this sort of setup in cafe. Been observed in Dr Dax at Florey institute

ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 20/04/2026

We are pleased to invite you to an upcoming webinar, sponsored by Leica, featuring cutting‑edge advances in spatial proteomics. Megakaryocyte Proteome in Myeloproliferative Neoplasms Speaker: Dr. Indu Raman @wehi-research.bsky.social Register: bio-protocol.org/webinar/deta...

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ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 24/06/2025

I'm excited to share that I’ve joined Leica Microsystems as Territory Manager for Life Science Research (LSR) and Industry. I’m truly grateful to the Leica team for trusting in my abilities, and I would also like to thank my past mentors who have played a key role in my professional growth.

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3i @the.3i.social · 27/03/2025

Here is a paper detailing the method from the research groups of close collaborator Dr. Valentina Emiliani and 3i customer Dr. François St-Pierre: www.nature.com/articles/s41...

nature.com

Scanless two-photon voltage imaging - Nature Communications

Detection of membrane potential changes using voltage indicators typically requires fast imaging rates and highly sensitive imaging methods. Here, the authors introduce scanless two-photon imaging, an...

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3i @the.3i.social · 27/03/2025

Want to do scanless 2-photon voltage imaging with JEDI-2P (or similar) voltage indicators? Phasor scanless computer-generated holography enables #2P #voltageimaging paradigms alongside a Photometrics Kinetix22 camera. Learn more: www.teledynevisionsolutions.com/learn/learni...

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Reto Fiolka @retof.bsky.social · 02/04/2025

Our manuscript on accelerating the acquisition rate in oblique plane microscopy (OPM) is online now: opg.optica.org/boe/fulltext... Our work addresses the issue that an OPM PSF is tilted, and as such it leaves a lot of "empty space" in Fourier space (FFT of experimental data on the right)... 1/n

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MichelleDigman @digmanlab.bsky.social · 05/04/2025

Open-Rank Faculty Cluster Hire in Depression Research Exciting opportunity at UCI in the department of Biomedical Engineering! We're seeking an innovative Assistant or Tenured Associate Professor to pioneer novel approaches in phenotyping and treatment of depression. recruit.ap.uci.edu/JPF09510

recruit.ap.uci.edu

Open-Rank Faculty Cluster Hire in Depression Research

University of California, Irvine is hiring. Apply now!

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3i @the.3i.social · 26/03/2025

Visit us the next 2 days @NeuroforumNWG #NWG2025 and learn how our #spinningdisk, #lightsheet, and #multiphoton microscopes can accelerate your research! Ask our team about demoing AxL CTLS in our local office in Göttingen!

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Special Ed @edwardlachica3.bsky.social · 23/03/2025

This is a mouse eye. The white stuff? That's #sclera. It's digitally "blocking" visualization of the# vasculature in the #retina (this is a #lightsheet 🔬btw). The sclera is chemically cleared, otherwise, the lightsheet wouldn't be able to interrogate the vasculature. Need your help, nerds

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Ben Hogan @benjhogan.bsky.social · 21/03/2025

Run a lab at an international cancer research centre in Melbourne, Australia! Applications open until May 9th…. 👇👇👇

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3i @the.3i.social · 23/03/2025

If you are attending #ABRF2025, stop by our booth and chat with our team about microscopes, AI-driven analysis, and how to boost instrument productivity and utilization. We've got koozies at the ready for the cocktail reception this evening! #lightsheet #spinningdisk #multiphoton #microscopy

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Special Ed @edwardlachica3.bsky.social · 14/03/2025

Hey nerds. Lamina Cribosa from the pig retina imaged with a lightsheet #microscope 🔬from @the.3i.social . I've been told this is impossible to see with a 2P or an OCT. Takes a stupid amount of time to image with a 1P. This was imaged in 35mins @1x1x2um vox. Happy #FluorescenceFriday.

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Andy Moore @aaandmoore.bsky.social · 10/03/2025

Poor little vimentin stick man 😱 A couple of months later than expected, but I'm finally gearing up to share *FilaBuster* - our approach for light-mediated IF disassembly. Stay tuned!

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Sam Connell @samuelconnell.3i.social · 04/03/2025

What a fantastic use of spinning disc confocal microscopy! Shoutout to the crew in long time @the.3i.social customer Kinneret Keren's Lab at Technion with first author @yonitmms.bsky.social. With co-senior author @markopopovicsk.bsky.social at Max-Planck Institute for Physics of Complex Systems.🔥🔬👍

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Cesar Valades-Cruz @cessvala.bsky.social · 28/02/2025

Happy to share DeepCristae😀, a CNN for mitochondria restoration, now in @commsbio.bsky.social y.social rdcu.be/ebrAQ S.Papereux, @ludovicleconte.bsky.social, @zhixingchen2.bsky.social, J.Salamero, C.Kervrann, A.Badoual @the.3i.social @institutcurie.bsky.social #inria @france-bioimaging.bsky.social

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Cesar Valades-Cruz @cessvala.bsky.social · 22/02/2025

Happy to contribute to the analysis of β1integrin endocytosis using @the.3i.social LLSM, now in @naturecellbiology.bsky.social rdcu.be/eaLM9 L. Leconte @christianwunder.bsky.social @aforrester.bsky.social @ewanmacdonald.bsky.social @institutcurie.bsky.social #inria @france-bioimaging.bsky.social

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ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 22/02/2025

I knew the storm was approaching, but I didn’t miss the moment when the calm ocean embraced the wild clouds.

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Sam Connell @samuelconnell.3i.social · 19/02/2025

Love seeing some amazing Lattice LightSheet movies resurface a decade later to remind us what can be done with this crazy gentle microscopy technique! Thanks Pablo for bumping this amazing one @pjsaez.bsky.social! www.intelligent-imaging.com/lattice

intelligent-imaging.com

Lattice LightSheet - 3i

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Special Ed @edwardlachica3.bsky.social · 18/02/2025

Spinal cord from E15.5 mouse embryo captured with a #lightsheet microscope 🔬from @the.3i.social . The growth cones at the ends of these axons are spectacular.🧪

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Special Ed @edwardlachica3.bsky.social · 10/02/2025

Hey nerds, happy #microscopyMonday from your friends @the.3i.social working the Tissue Clearing Workshop at Harvard. Day 1’s 3-channel embryo captured with our #lightsheet #microscope🧪🔬

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3i @the.3i.social · 11/02/2025

Happy #microscopyMonday indeed! Thanks to #TCW2025 @harvardmed.bsky.social MicRon "Day 1’s 3-channel embryo captured with our #lightsheet #microscope🧪🔬" 🧪 micron.hms.harvard.edu/tissue-clear... 🔬 intelligent-imaging.com/AxL #aslm #lightsheet #microscopy

intelligent-imaging.com

AxL Cleared Tissue LightSheet - 3i

AxL CTLS is a lightsheet microscope for imaging cleared tissue in 3D. AxL CTLS is an easy to use lightsheet system for cleared specimen imaging for labs and imaging facilities.

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ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 09/02/2025

The Kusama art exhibition at NGV was exotic, impressive, and truly unique. Experiencing the Infinity Mirror Room was particularly fascinating. it was remarkable to see the seamless fusion of art and science, where optical principles were creatively and wisely integrated into the artwork.

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Special Ed @edwardlachica3.bsky.social · 08/02/2025

@the.3i.social is ready to roll with its #lightsheet #microscope at @paulamonterollopis.bsky.social Tissue Clearing workshop #TCW2025 See you Monday!

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3i @the.3i.social · 08/02/2025

And what it really looks like in #SlideBook!

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3i @the.3i.social · 08/02/2025

Oh, just playing around with the #AllenBrainAtlas in #SlideBook for #FluorescenceFriday... 🔬 www.intelligent-imaging.com/AxL 🧠 brain-map.org 🖥️ www.intelligent-imaging.com/SlideBook

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Reto Fiolka @retof.bsky.social · 05/02/2025

Fantastic opportunity. Great place to do research! And Lausanne is a beautiful place.

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ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 04/02/2025

Incredible keynote talk by Li-An Chu at #APMC13, highlighting axially swept lightsheet microscopy for ultra-fast volumetric imaging. A wonderful tribute to the memory of Spencer Shorte.

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ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 01/02/2025

I’ll be attending APMC13 in Brisbane next week and would love to catch up with fellow optical microscopists to discuss cutting-edge imaging solutions. Come visit us at Booth 24 to chat about the latest advancements in live-cell, intravital, lightsheet and super-res microscopy

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Special Ed @edwardlachica3.bsky.social · 30/01/2025

@erturklab.bsky.social derya sargin from ucalgary says hello

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3i @the.3i.social · 30/01/2025

Great work from the @aliceyting.bsky.social lab (and collaborators) with their Marianas SDC and SlideBook! 🔬www.intelligent-imaging.com/marianas 🖥️ www.intelligent-imaging.com/slidebook

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Sam Connell @samuelconnell.3i.social · 30/01/2025

OK, this is wild. Another bonkers development from the Ting Lab at Stanford. Long time @the.3i.social customer @aliceyting.bsky.social et al have created a unique tool for the neuroscience community: Light-Activated TeNT that potently inhibits synaptic transmission when and where you want it. 🔬🔥🧠

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Jose Maldonado, PhD @josemald.bsky.social · 28/01/2025

Just a gorgeous #Purkinje neuron all by itself in the cerebellum. Only with #lightsheet #microscopy on a whole #cleared sample could you ever hope to catch a lone reporter expressing cell in it’s entirety. #science 🧪

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Kara McKinley @karalmckinley.bsky.social · 29/01/2025

I have a wonderful scientist in my lab who is looking to move to Europe. Is anyone looking for a staff scientist? She has a PhD. She is particularly in her element doing field work. Great skills with rodents and very open to non-rodent positions as well. Please send leads, please amplify!

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Daniel von Wangenheim @dvonwangenheim.bsky.social · 24/11/2024

I am lucky! - Spectacular cardioid ♥️ sample from Lavinia Ceci Ginistrelli at IMBA, Vienna @imbavienna.bsky.social - Isotropic resolution using AxL Cleared Tissue LightSheet 🔬@the.3i.social - Breathtaking visualization in syGlass VR 😎 @michael-syglass.bsky.social

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Sam Connell @samuelconnell.3i.social · 29/01/2025

Very cool chemistry with multifunctional fluorescent ligands and cutting-edge microscopy y'all! Great to see the referenced cameo from @so-lets-kilab70.bsky.social collaborating with @rhodamine110.bsky.social et al rocking one of the @the.3i.social Lattice LightSheets @stjuderesearch.bsky.social.

Figure 6. Comparison of (S)-JQ1-JF646-HaloTag ligand (19HTL) and (S)-JQ1-JF635-HaloTag ligand
(20HTL) for BRD4 translocation. (A) Schematic illustrating the manipulation of BRD4 localization. (B)
Chemical structure of (S)-JQ1-JF-HaloTag ligands 19HTL and 20HTL. (C) Spectral and chemical properties
of 19HTL and 20HTL, and their HaloTag conjugates. All measurements were taken in 10 mM HEPES, pH 7.3.
λabs/λem are in nm, and ε are in M−1cm−1
. KL–Z measurements were performed in 1:1 (v/v) dioxane–water.
(D) Absorbance of 19HTL and 20HTL in the absence or presence (+HT) of excess HaloTag protein. (E)
Correlation between logD7.4 versus logKL–Z. (F–H) Extracted fluorescence from time course lattice light
sheet microscopy in Neuro2A cells (n > 10 nuclei) expressing coilin–HaloTag and sfGFP–BRD4 upon
incubation with 19HTL or 20HTL. Scale bar: 5 μm. (I) Cumulative rhodamine and BRD4 fluorescence within
HaloTag domains (mean ± SEM).

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ℍ𝕒𝕞𝕚𝕕 𝕊⌬𝕝𝕖𝕚𝕞𝕒𝕟𝕚𝕟𝕖𝕛𝕒𝕕 🔬🐨 @hamidsolly.bsky.social · 29/01/2025

祝我的中国同事和朋友们新年快乐，祝你们新的一年幸福安康! 🎉🎉🎊🎊🎇🐍🐍

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Ethan Scott's Lab @ethanscottlab.bsky.social · 22/01/2025

JOIN US! We're seeking a new PhD student in beautiful Melbourne🇦🇺. Join our diverse, supportive team of optical physicists, neuroscientists, and mathematicians as we study how #zebrafish brains perceive the world. Deadline: February 12th. Details👇. Please repost.

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Christophe Le Clainche @actin-paris-saclay.bsky.social · 27/01/2025

The Institute for Integrative Biology of the Cell (I2BC) is recruiting group leaders in cell biology. Don't miss the opportunity to start your team in the vibrant environment of Paris-Saclay University. Application deadline: Feb 28, 2025 www.i2bc.paris-saclay.fr @i2bcparissaclay.bsky.social

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Rubén Marín-Juez @rmarinjuez.bsky.social · 24/01/2025

🚨We are hiring!🚨 We have postdoctoral positions available! If you're passionate about studying cardiac regeneration and development, join our team in vibrant and beautiful Montreal! Please help spread the word 🫶 For more details see here research.chusj.org/RECHERCHE/fi...

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Special Ed @edwardlachica3.bsky.social · 24/01/2025

@the.3i.social I've been modeling #PSFs for #lightsheet #microscopy using the brainstem as a model for deconvolution. Start w/the root of CNVI, hi-way of cortico-spinals. Cross over to view the dendrite-less neurons in facial motor nucleus just caudal to the abducens n. Happy #FluorescenceFriday.

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Paul Frankland @franklandlab.bsky.social · 23/01/2025

Just giving this a boost for those who may not have seen it yet... we have a PI position (molecular and cellular basis of cognition) at The Hospital for Sick Children (Toronto). The position comes with an appointment at Assist/Assoc Prof level at U of T. Share widely! can-acn.org/scientist-se...

can-acn.org

Scientist/Senior Scientist – Research Institute, Hospital for Sick Children, University of Toronto – Canadian Association for Neuroscience

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Christophe 🔬 Leterrier @christlet.bsky.social · 23/01/2025

Actin and clathrin-coated pits are reassuringly found along the plasma membrane on the 3D-SIM stacks #realtimemicroscopy

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Valerie Tornini @valetornini.bsky.social · 09/12/2024

We are openly recruiting at all levels at the Tornini Lab at the University of California, Los Angeles (UCLA)! Please share with your networks. For more information, please check the info below, visit www.torninilab.org, or email me directly at vtornini at ucla dot edu. Thank you in advance!

Open recruitment for the Tornini Lab
Department of Integrative Biology and Physiology & Institute for Society and Genetics
Hispanic Serving Institution Infrastructure Initiative
University of California, Los Angeles (UCLA)
www.torninilab.org
We are a new developmental, cell, and molecular biology lab interested in understanding the
genetics of vertebrate neurodevelopment.
We use genome engineering, single-cell technologies, behavioral analyses, pharmacological
profiling, confocal imaging, genomics, and computational biology using the vertebrate
zebrafish (Danio rerio) system and other models (like sea lamprey) for evolutionary studies.
Our work is driven by curiosity, independence and teamwork, fun, a sense of urgency, and a
desire to understand how networks of genes regulate brain and organismal development. This
work can help us better understand basic mechanisms of what happens in human
developmental disorders or diseases and can inform novel therapeutic strategies.
We are recruiting across all levels.
Our lab works in multiple complementary areas (please see below).
We’re looking to match motivated people with what motivates them in a supportive and
engaging environment.
We are recruiting staff research scientists (1-2 years after undergrad+), graduate students (open
rotation positions), postdocs, and other positions as relevant.
While multiple of our projects are already funded, we strongly support candidates to identify
and apply for your own fellowships/grants with the full mentorship and resources of the lab.
Like our research? Think you might be a good fit?
Consider joining us!
For more information, please visit our website, the next page, or contact Val at: vtornini at ucla
dot edu
UCLA is an equal opportunity employer.

Novel micropeptides in vertebrate neurodevelopment
Using zebrafish models, we
ask: what are these proteins; what are their functions in neurodevelopment; what are other
“ignored” or “dark proteome” genes we are missing; and what can they reveal about human
neurodevelopmental disorders or diseases?
Chromatin regulators in vertebrate development and behavior
A growing group of evolutionarily conserved chromatin regulators have been identified as
genes linked with neurodevelopmental disorders, such as autism. In many cases, patients may
struggle with co-occurring conditions that impact daily life in childhood and adulthood,
including seizures, sleeplessness or sleep disruptions, and autoimmune disruptions. How do
these genes work to establish and maintain neural cell types during development, and in turn
shape circuits during early critical periods, including interactions with the environment, to
establish organismal physiological processes?

Non-neuronal regulation during development and aging
Non-neuronal cell types, including oligodendrocytes and microglia, have emerged as key
players in shaping neurodevelopment and into adulthood. How are the cellular, molecular, and
physiological dynamics of these cell types in developing and aging brains affected in mutant
genetic models linked to neurodevelopmental disorders? Can we target these cells to
modulate neural dysregulation and resulting behaviors in these mutant models?

Evolution of vertebrate brain cell states
We seek to understand the principles of how novel genes co-evolve with the emergence of
neural cell types found only in vertebrates.
We use cross-species genomics and functional approaches with the jawless vertebrate model,
sea lamprey, to elucidate the roles of vertebrate-specific genes on the gene regulatory
networks.
Bioethics, neuroethics, and genetics
We seek to integrate evidence-based methods throughout our projects to investigate and address bioethical considerations in this research domain.

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3i @the.3i.social · 22/01/2025

Happy to support Advanced Imaging Methods #AIM2025! Stop by our table and chat with the team about our exciting innovations for #multiphoton and #lightsheet imaging (and more). Or catch our vendor talk at 6:05PM PT (in 30 minutes)!

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Imaging & Optics Facility @ISTA @istaustria-iof.bsky.social · 16/01/2025

The Image & Optics Facility @ Institute of Science and Technology Austria is expanding it’s image analysis services and has a vacant position for a service oriented *Image Analysis Specialist* with a strong interest for data infrastructure organization🔬🧑‍💻📈 - sharing is much appreciated!

ista.ac.at

Job details

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Sam Connell @samuelconnell.3i.social · 18/01/2025

🧪🔬🔥🎓👩‍🏫🏫🧠🧬🥼👩‍🔬🧫⚛️⚗️🥽

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Sam Connell @samuelconnell.3i.social · 14/01/2025

Congrats to the whole community in the @erturklab.bsky.social including first author @jie-luo-lab.bsky.social starting his new Lab at Purdue just last week! Nice work y'all! Amazing contribution to this growing body of work using LightSheet microscopy for whole mouse imaging. 🧪🧵🔬

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Sam Connell @samuelconnell.3i.social · 15/01/2025

Congratulations to lead author @elisafrankel.bsky.social in @pkurshan.bsky.social Lab at Einstein and the whole crew of collaborators! Great to see a fantastic @the.3i.social CSU rig generating great data for y'all. What a cool model system for studying synaptogenesis and pre-synaptic assembly. 🔬🔥 🪱

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Michael Morehead @michael-syglass.bsky.social · 14/01/2025

Congratulations to the @erturklab.bsky.social lab for another big paper on nanoparticles, with some nice manual ground-truth segmentation created in syGlass. Some pretty nice movies in supplemental materials, too! (Video speed set to 2X to accommodate Bluesky's 1 min limit)

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