Three PhD students who attended the Joint FEBS/EMBO Lecture Course on 'Membranes and their lipids and proteins in organelle biogenesis' in Spetses Island, Greece, share their experiences of the scienc...

Speakers invités: Giovanni D’Angelo (EPFL, Lausanne, Suisse) Christophe Leterrier (INP, Marseille, France) Miriam Stoeber (University of Geneva, Genève, Suisse)

Utrecht University

Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal damage.

Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynam...

Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...

Nature Communications - The author presents an overview of the complex challenge of protein export from the Endoplasmic Reticulum, and discusses how cells may deploy novel pathways utilizing...

In recent years, several European countries, including France, have reduced their investment in scientific research, with biomedical research taking a significant hit. The primary casualty is basic re...

Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N...

Flotillin 1 and 2 scaffold sphingolipid-rich membrane microdomains involved in endocytosis and  endolysosome maturation through the generation of sphingosine 1-phosphate (S1P) by sphingosine kinase 2...

Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

Le Club Exocytose-Endocytose est une association à but non lucratif, sans financement ni cotisation. Il rassemble près de 340 chercheurs, enseignants ou étudiants travaillant dans des domaines variés ...

The biosynthetic secretory pathway is comprised of multiple steps, modifications and interactions that form a highly precise pathway of protein trafficking and secretion, that is essential for eukaryo...

The unfolded protein response can switch from a pro-survival to a maladaptive, pro-apoptotic mode. D

The endoplasmic reticulum (ER) is shaped by abundant, membrane curvature-generating proteins that in