iiinova — where your digital self keeps evolving

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Brandy A Freitas @brandy-syglass.bsky.social · 17/09/2026

A special #3DThursday: cleared human embryos showing the developing cerebral vasculature in 3D. 🔬 @miltenyibiotec.bsky.social Blaze #LSFM + iDISCO+ 🥼 Shotar et al. 📝 Journal of Anatomy (2026) 🏛️ Institut de la Vision, Paris 🎬 #syGlass v2.2.1+ @alainchedotal.bsky.social @sorbonne-universite.fr

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Michael Morehead @michael-syglass.bsky.social · 16/07/2026

Our first big push into hardware! Shipping software is relatively easy -- manufacturing delays and shipping physical hardware has a lot of logistics, but I'm really happy with our first move into supplying the world with cutting-edge visualization tools.

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Brandy A Freitas @brandy-syglass.bsky.social · 11/06/2026

Mouse spine data #3DThursday from our partners at 3i! 🎉 Specimen from Pantelis Tsoulfas, imaged at #LSFM26 on 3i’s AxL light sheet. Axial sweeping helps preserve whole-spine context while improving optical sectioning across a thick cleared specimen. #syGlass @the.3i.social @univmiami.bsky.social

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Michael Morehead @michael-syglass.bsky.social · 13/04/2026

I am beaming with pride! Congratulations to Brandy and the entire syGlass team!

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Brandy A Freitas @brandy-syglass.bsky.social · 09/04/2026

#UMAP in VR for #3DThursday! In this zebrafish embryogenesis dataset, RNA-seq + ATAC-seq across 94k+ cells reveal changing regulatory programs over time. 🥼 Yang-Joon Kim, Loic Royer @loicaroyer.bsky.social , Matthias Haury 📝 www.biorxiv.org/content/10.1... 🏛️ Biohub @biohub.org 🎬 #syGlass v2.6.0

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Brandy A Freitas @brandy-syglass.bsky.social · 26/03/2026

Fun #3DThursday update: #syGlass now supports the #Sony Spatial Reality Display! 🎉📺 Glasses-free 3D—no headset needed. Just walk up, look, and see depth instantly. A powerful new way to share scientific data with researchers, students, and the public. #3DVisualization #SciComm #EdTech

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Brandy A Freitas @brandy-syglass.bsky.social · 19/03/2026

☘️ A special #3DThursday for St Patrick's: Beer foam evolving in 4D in a microCT! 🍻 This is a Belgian Duvel (sorry not Irish...) from @tescan.bsky.social + Wesley De Boever Who’s off to #FOM2026 in Stockholm? I'll be there next week! www.focusonmicroscopy.org #Microscopy #MicroCT #Imaging #syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 12/03/2026

Streaming OME-Zarr data directly into syGlass for #3DThursday🌍🔬 With #syGlass v2.6.0, datasets can stream from disk, S3, or HTTPS with no massive downloads required. Huge thanks to the community building open imaging standards: @openmicroscopy.org #OMEZarr #Microscopy #OpenScience #Bioimaging

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Brandy A Freitas @brandy-syglass.bsky.social · 05/03/2026

The fruit fly of plant science for #3DThursday! 🌱 #ModelOrganism 🔬: #microCT, Zeiss @zeiss-microscopy.bsky.social Versa 520 XRM (contrast-enhanced with OsO₄) 🌱: Arabidopsis thaliana 🥼: Keith Duncan @cygnusplantxray.bsky.social 🏛️: Danforth Center @danforthcenter.bsky.social 🎬: syGlass.io #syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 26/02/2026

New in syGlass for #3DThursday: a VR surface brush for editing meshes🖌️Here, I’m isolating a component from a @lumafield.bsky.social #microCT scan of a VR headset, painting partitions directly onto the surface and exporting clean .OBJs: v2.6.0 #VR #3DVisualization #syGlass #ScientificVisualization

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LifeCanvas Technologies @lifecanvastech.bsky.social · 12/02/2026

We had a great time sharing 3D data from our pipeline at the Massachusetts Life Sciences Center's Convening of the Cores! Thanks to Sony and syGlass for making our data pop on the Spatial Reality Display. MA researchers, check out LifeCanvas tools at cores near you: bit.ly/3O8SgO0

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Brandy A Freitas @brandy-syglass.bsky.social · 12/02/2026

❤️ A cleared guinea pig heart for #3DThursday! Clearing a heart is HARD — dense muscle, deep antibody labeling, big volume. But to understand coronary networks, you need the whole organ. 🔬: Miltenyi Ultramiscroscope 🥼: Pam Rios Coronado, @pamrc.bsky.social 🏛️: Red-Horse lab @stanford.edu 🎬: #syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 29/01/2026

Running TotalSegmentator inside #syGlass for #3DThursday! 🔬 Automated segmentation needs strong clinical data for training and benchmarking, plus models that generalize. Mayo Clinic Low Dose CT Grand Challenge + #TotalSegmentator by Jakob Wasserthal are great examples. #MedicalImaging #3DImaging

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Brandy A Freitas @brandy-syglass.bsky.social · 22/01/2026

The Allen Mouse Brain Atlas is a cornerstone of #neuroscience: a standardized, high-resolution map of brain anatomy built to keep experiments comparable across labs. 🧠 Here’s a 3D walk through its anatomical meshes in #syGlass! @alleninstitute.org #3DThursday #DataViz #VR

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Brandy A Freitas @brandy-syglass.bsky.social · 15/01/2026

For #3DThursday, a skeleton shrimp imaged on a Flamingo light sheet microscope — a modular, traveling #LSFM built to bring the microscope to the biology.🔬🦩Fast 3D imaging, low phototoxicity. 🥼: Carsten Wolff @carsten-wolff.bsky.social 📝: huiskenlab.com/flamingo/ 🏛️: @morgridgeinstitute.bsky.social

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Brandy A Freitas @brandy-syglass.bsky.social · 08/01/2026

🪰 For #3DThursday, this #microCT scan of an adult #Drosphila (Schoborg et al.) captures the entire fly intact. Using #VR, we can teach anatomy by labeling the 3D fly from a 2D diagram. Spatial context changes everything. #SciComm 🔬: Bruker SkyScan 1172 🏛️: UWyoming 🎬: #syGlass, v2.5.0

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Brandy A Freitas @brandy-syglass.bsky.social · 01/01/2026

2025 took us around the world 🌍 From Zurich to Beijing, London, Paris, Montreal, all over the Americas, we explored scientific datasets in VR with the researchers who created them -- and pushed #syGlass to new limits for 3D analysis. On to 2026. 🔬✨ #3DThursday #Microscopy #ScientificImaging

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Brandy A Freitas @brandy-syglass.bsky.social · 23/12/2025

Nice feature from NVIDIA on #syGlass at the MBL! Exciting to see AI, RTX GPUs, and VR coming together to explore massive 3D brain datasets, with high school students contributing to ongoing, cutting-edge neuroscience research. @mblscience.bsky.social blogs.nvidia.com/blog/mbl-hum...

blogs.nvidia.com

Marine Biological Laboratory Explores Human Memory With AI and Virtual Reality

The lab in Massachusetts is studying molecular mechanisms of human memory function powered by NVIDIA RTX GPUs, HP Z Workstations and virtual-reality technology.

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Brandy A Freitas @brandy-syglass.bsky.social · 11/12/2025

#syGlass v2.5.0 is out! 🎉 New depth-aware colormaps, expanded file formats (NRRD/MRC/TCF/OME-Zarr v3), better #VR segmentation tools, and upgraded narration workflows — all focused on making #3Ddata easier to explore and share. Blog: www.syglass.io/blog/syglass... #Microscopy #Imaging #3DThursday

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Brandy A Freitas @brandy-syglass.bsky.social · 04/12/2025

Guest lectured at UNH–Manchester’s Techniques in Microscopy this week, and the students are already thinking like researchers. Early exposure to real #Microscopy and #ImageAnalysis tools makes all the difference. 🔬: Zeiss LSM 510 🥼: Students + Prof Mark Scimone 🎬: syGlass.io #3DThursday #syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 27/11/2025

One year of #3DThursday! Revisiting our first specimen, a Pekin duck: thanks to this community we learned she was Beaker, a rescued duck from Utah who later contributed to science. 🔬: #CTScan, Scarlet Imaging's BriteVu 🥼: Scott Echols 🎬: syGlass.io 🦆📸: credit TIFOtter #Anatomy #syGlass #SciComm

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Michael Morehead @michael-syglass.bsky.social · 17/11/2025

Stoked to be back in San Diego for #sfn25 with syGlass and the rest of the team. This week, we're showing off our new AI based axon tracer and the new Sony Spatial Display. Come visit us at booth 813!

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Michael Morehead @michael-syglass.bsky.social · 14/11/2025

Exciting News! 😎 syGlass is proud to announce our new collaboration with Sony, featuring their revolutionary glasses-free 3D Spatial Reality Display. Experience the future of visualization at the 2025 Society for Neuroscience conference. Stop by our booth #813 to see it in action! #sfn25 #sfn2025

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Brandy A Freitas @brandy-syglass.bsky.social · 13/11/2025

For #3DThursday we’re introducing Dynamic Depth color mapping! It encodes distance with smooth depth-aware gradients so layered structures pop without losing context. 🔬 #MicroCT of a P1 mouse 🥼 Hsu Lab, Baylor, @cwloganhsu.bsky.social 🎬 syGlass.io #Microscopy #SciComm #3DVisualization #syGlass

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Michael Morehead @michael-syglass.bsky.social · 06/11/2025

Expansion with Magnify for #3DThursday this week! This mouse brain tissue was imaged using Magnify Biosciences, Inc. expansion microscopy — a simple, low-cost way to achieve nanoscale resolution with a standard confocal.

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Michael Morehead @michael-syglass.bsky.social · 31/10/2025

it was great to present syGlass, Inc at CACIE, part of the largest international educational conference in China, with Kenan Sener, Ed.D. Very grateful for CAEIE for hosting me for this week in Beijing. ❤️ lnkd.in/g8KQMa8x

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Michael Morehead @michael-syglass.bsky.social · 30/10/2025

Taking over #3DThursday while Brandy Freitas @brandy-syglass.bsky.social is out of office for some adventures! 🦇: Rousettus aegyptiacus stained in 10% Lugol’s iodine for 3 months 🔬: PerkinElmer Quantum GX microCT 🥼: @acsharp.bsky.social 🏛️: University of Liverpool’s Centre for Preclinical Imaging

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Michael Morehead @michael-syglass.bsky.social · 29/10/2025

Absolutely amazing to hike the Great Wall of China. Truly an engineering marvel and an amazing historic achievement.

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Michael Morehead @michael-syglass.bsky.social · 25/10/2025

It's great to visit my good friend Alain Chédotal for an extra special lecture of tissue clearing and light sheet microscopy -- at Faculté de Médecine Lyon Est, Université Claude Bernard Lyon 1 + Hospices Civils de Lyon - HCL @hospicescivilslyon.bsky.social

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Michael Morehead @michael-syglass.bsky.social · 23/10/2025

The #mesoSPIM symposium really opened my eyes to the power of open source hardware. I've highlighted some of the surprising outcomes in a new blog post: How Open Source Microscopy is Solving the Funding Crisis: Insights from the mesoSPIM 10-Year Symposium www.syglass.io/blog/how-ope...

syglass.io

How Open Source Microscopy is Solving the Funding Crisis — syGlass

Insights from the mesoSPIM 10-year symposium, as reported by Michael Morehead, the CEO of syGlass.

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Michael Morehead @michael-syglass.bsky.social · 23/10/2025

I have really neglected Bluesky. I'm going to try to add my backlog of adventures here now. To start, #mesoSPIM symposium in Zurich! Amazing conference, amazing people, amazing talks!

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Brandy A Freitas @brandy-syglass.bsky.social · 25/09/2025

👀 #3DThursday: Cross your eyes to see this super res pollen dataset in 3D! Good old fashioned stereo pairs in #syGlass bringing science to life. 🌿✨ 🔬: Zeiss LSM 980 with Airyscan 2 🥼: Nat Prunet, @nat-prunet.bsky.social 🏛️: UNC Biological Microscopy Core: tarheels.live/biologymicro... 🎬: syGlass.io

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Jean-François Cudennec @limpetnerd.eurosky.social · 08/09/2025

Just woke up from a social media pause and the first thing I see is an incredible footage of a sperm whale casually cruising with a giant squid in its mouth ?? 🦑 🌊 🌿

Vertical photo of a sperm whale with a giant squid in its mouth. The tentacles and body of the squid can be seen emerging between the teeth.

Ventral view of the same scene : a sperm whale with a giant squid in its mouth. The tentacles and body of the squid can be seen emerging between the teeth.

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Brandy A Freitas @brandy-syglass.bsky.social · 11/09/2025

🦐 High-res microCT of #Parhyale hawaiensis for #3DThursday! A powerful crustacean model for studying limb development, regeneration, and evo-devo. 🥼: Nipam Patel & Andrew Gillis, 2017 🏛️: University of Cambridge @cam.ac.uk 🎬: syGlass.io #Parhyale #MicroCT #DevBio #EvoDevo #ModelOrganisms #syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 04/09/2025

Pollen diversity #3DThursday!🌼🌾 Thanks to Nat Prunet's careful microscopy, we see ridges, spikes & pores that reveal how plants spread & survive. 🔬: @zeiss-microscopy.bsky.social LSM 980, Airyscan 2 🥼: @nat-prunet.bsky.social 🏛️: UNC Biological Microscopy Core 🎬: syGlass.io v2.4.0 #syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 28/08/2025

Chicken balancing for #3DThursday!🐔 These utricle hair cells sense gravity & straight-line motion. We segmented them with #CellposeSAM in #syGlass. 🥼: Stefan Heller Group 🏛️: Stanford @stanfordmedicine.bsky.social 🎬: syGlass.io v2.4.0, out now! #Neuroanatomy #Microscopy #3DVisualization #SciComm

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Michael Morehead @michael-syglass.bsky.social · 11/08/2025

Another great conference at M&M (Microscopy and Microanalysis) means another annual interview with the fantastic Eric Jay Miller! Check out the short interview here: www.youtube.com/watch?v=herZ...

youtube.com

SyGlass VR Data Explorer @ M&M 2025 || Instructinate

YouTube video by Instructinate

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Brandy A Freitas @brandy-syglass.bsky.social · 31/07/2025

Automated Segmentation by Cellpose-SAM using syGlass for #3DThursday! This took about 30 minutes to run on one of the gaming laptops. Crazy. 🔬: Synchrotron #MicroCT 🥼: Keith Cheng, MD, PhD, @pennstateuniv.bsky.social 📝: #CellposeSAM www.biorxiv.org/content/10.1... 🥽: syGlass.io v2.4.0 -- out soon!

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Michael Morehead @michael-syglass.bsky.social · 24/07/2025

If you're attending 🎉 Microscopy & Microanalysis 2025! 🎉 definitely say hello at booth 1228 and try out the latest workflows in syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 10/07/2025

A #microscopy mystery for #3DThursday!🌾 What is this? 🔍 Things that I know: it is a #plant, it was imaged on a Lumafield #microCT, and the color is a LUT (look up table) that I applied in #syGlass and has nothing to do with the organism (microCT comes in as grayscale). Help! #SciComm

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Michael Morehead @michael-syglass.bsky.social · 03/07/2025

The Confetti Cannon was the work of one of our UC Berkeley @ucberkeleyofficial.bsky.social summer interns!

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Brandy A Freitas @brandy-syglass.bsky.social · 03/07/2025

Happy 4th for #3DThursday! 🎉 Do I occasionally forget and then remember ecstatically that we have a confetti cannon in the syGlass room? Yes, yes, I do ... #syGlass #VRScience #Microscopy #SciComm

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Brandy A Freitas @brandy-syglass.bsky.social · 26/06/2025

Finally plants for #3DThursday!🌽 A maize root tip, imaged using #microCT, from the Topp Roots Lab. 🔬: @zeiss-microscopy.bsky.social Versa 520 XRM 🥼: Keith Duncan @cygnusplantxray.bsky.social 🏛️: Danforth Center @danforthcenter.bsky.social 📝: academic.oup.com/plphys/artic... 🎬: syGlass.io #syGlass

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Michael Morehead @michael-syglass.bsky.social · 23/06/2025

I am incredibly honored to represent the NCSSS at the China-US STEM and AI Education Seminar. Fantastic to share our work at syGlass on the forefront of immersive science, education, and #AI. I look forward to working with our Chinese allies in connecting students and scientists around the world.

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Brandy A Freitas @brandy-syglass.bsky.social · 19/06/2025

Get your 3D glasses out for #3DThursday! And click the link below to see syGlass on the really big screen at the @mit.edu MIT Museum last week. (guys it's my first syGlass blog ...) 📝: www.syglass.io/blog/a-night... 🥼: Kory Evans @sternarchella.bsky.social , Rice University 🎥: syGlass.io #syGlass

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Brandy A Freitas @brandy-syglass.bsky.social · 12/06/2025

LIVE sea urchin larvae for #3DThursday! Catch me at the MIT Museum tonight at AfterDark and see it in person. 🔬: @brukercorporation.bsky.social TruLive3D 🥼: Amro Hamdoun @hamdounlab.bsky.social ‬, Tzer Han Tan's @tzerhan29.bsky.social group at UCSD 🌌: Painted Sea Urchin 🎥: syGlass.io #syGlass

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