iiinova — where your digital self keeps evolving

Reposted by Ewan MacDonald

Journal of Cell Biology @jcb.org · 01/06/2026

Heterogeneity of late #endosome/#lysosomes shown by multiplexed DNA-PAINT imaging. Quantitative pipeline developed by Charles Bond, Melike Lakadamyali @melikel.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...

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Ewan MacDonald @ewanmacdonald.bsky.social · 02/06/2026

New research from the Lamaze team 🎉 mechanical stress triggers caveolae disassembly, releasing caveolin-1 scaffolds that diffuse across the plasma membrane to remotely inhibit key signalling enzymes. www.nature.com/articles/s41... @natcellbio.nature.com #CellBiology, #CellBio, #microscopy

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Reposted by Ewan MacDonald

Stella Hurtley @smhsci.bsky.social · 15/05/2026

My choice last week in @science.org Deltaviruses spread through a viral Trojan Horse 10.1016/j.cell.2026.01.037

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Reposted by Ewan MacDonald

CNRS @cnrs.fr · 27/04/2026

As a historic world record has just been broken at the London marathon 🏃‍♂️, CNRS researchers explain why runners often experience a sharp drop in performance, called the "30-km wall", at the 30th kilometre, and how to counter this phenomenon.

news.cnrs.fr

Breaking the wall

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Reposted by Ewan MacDonald

CRBM-Montpellier @crbm-montpellier.bsky.social · 18/06/2025

📢 Seminar – Thurs, June 26, 11am @cnrsoccitanieest.bsky.social 🧪 Dr. Itay Budin (UC San Diego) will talk about how small lipid changes shape membranes & help marine life adapt to pressure/temp — with insights into climate resilience 🌊❄️🔥 📰 2023 Science paper: pubmed.ncbi.nlm.nih.gov/38935710/

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Reposted by Ewan MacDonald

Ivaska Lab @ivaskalab.bsky.social · 26/05/2025

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

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Ewan MacDonald @ewanmacdonald.bsky.social · 15/05/2025

🚨 New review out! We explore how extracellular acidification shapes key processes like endocytosis, neurotransmission & immune responses — and highlight tools to study it. 📖 Read more [doi.org/10.1016/j.ceb.2025.102531] w/ amazing collaborators 🙌 #CellBiology #Endocytosis #GPCR

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Reposted by Ewan MacDonald

Stella Hurtley @smhsci.bsky.social · 11/04/2025

My choice this week in @science.org www.nature.com/articles/s41... @ewanmacdonald.bsky.social

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Reposted by Ewan MacDonald

The Freeman Lab @spencerfreeman.bsky.social · 27/02/2025

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

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Reposted by Ewan MacDonald

Fran Bottanelli @franbottanelli.bsky.social · 24/02/2025

Do not miss the #membrane seminars this THU! As usual zoom link and info here felixcampelo.wixsite.com/membranetraf... or via the mailing list lists.icfo.es/mailman/list... @felixmendu.bsky.social @ishier.bsky.social

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Reposted by Ewan MacDonald

Eunus S. Ali, Ph.D. @eunusali.bsky.social · 24/02/2025

JCI - Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases www.jci.org/articles/vie...

jci.org

JCI - Purifying and profiling lysosomes to expand understanding of lysosomal dysfunction–associated diseases

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Reposted by Ewan MacDonald

Christian Wunder @ Curie Institute @christianwunder.bsky.social · 22/02/2025

Growth factors trigger receptor desialylation at the plasma membrane, galectin binding and subsequent endocytosis. => A proton pump driven glycoswitch @naturecellbiology.bsky.social : rdcu.be/eaLM9 #glycotime, @institutcurie.bsky.social, @cnrs.fr, @inserm.fr, #NIH, #CellBiol, #Cancer

"Growth factor-triggered de-sialylation
controls glycolipid-lectin-driven endocytosis"
An excellent collaboration between the US, India, Denmark, UK, Netherlands and France.

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Ewan MacDonald @ewanmacdonald.bsky.social · 22/02/2025

Thrilled to share our latest publication! We describe a novel acid-dependent mechanism regulating clathrin-independent endocytosis. This study was a fantastic collaborative effort with the labs of Ludger Johannes, Roberto Weigert, and Satyajit Mayor. nature.com/articles/s4155….

nature.com

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Reposted by Ewan MacDonald

Luciano A. Masullo @lumasullo.bsky.social · 10/02/2025

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬 The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy www.biorxiv.org/content/10.1...

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