Reposted by Franklin NobregaWolfgang Hess @cyanolab.bsky.social · 19hBakteriopolis, now in Freiburg. A cool, interactive exhibition about the tiny ones. Mo-Fri 10:00 to 16:00, other times can be arranged. 0116
Reposted by Franklin NobregaLuis E. Valentin-Alvarado @luisvalentin.bsky.social · 09/10/2026Excited to share our work on bacterial immune signaling! Our preprint reveals how RNA-guided Cas13 cleaves host tRNAs to generate small-molecule messengers that activate 2TMβ, linking RNA recognition to membrane damage and phage defense. 1/11 26531
Reposted by Franklin NobregaYoann Santin @ysantin.bsky.social · 07/10/2026Dear colleagues, I am delighted to announce that the team’s website is now live santinlab.weebly.com 🥳🥳 I would also like to take this opportunity to let you know that, I am recruiting a junior postdoc to start on 1 January 2027. For further information, please feel free to contact me.santinlab.weebly.comSantin LabHome page of the Santin Lab website. 1167
Reposted by Franklin NobregaElisa Fadda @elisafadda.bsky.social · 09/10/2026This ⬇️ is 🔥 #glycotime 🔥! Super congrats Meg and @joel-allen.bsky.social 🧪 022
Reposted by Franklin NobregaTung Le @tunglejic.bsky.social · 08/10/2026🚨PhD opportunity alert!!! Come work with us on this new cool NERC DTP PhD project Investigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments. Retweet = nice. Thank you!!! aries-dtp.ac.uk/studentships...aries-dtp.ac.ukInvestigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments? | AriesProfessor Tung Le, John Innes Centre – contact me Professor Jonathan Todd, Quadram Institute & UEA Dr Ngat Tran, John Innes Centre Horizontal gene transfer (HGT) is a major driver of bacterial… 04140
Reposted by Franklin NobregaGeorge O'Toole (he/him/his) @geiselbiofilm.bsky.social · 07/10/2026Pls share:The Department of Microbiology at the University of Georgia invites applications for a tenure track Associate or Full professor position in Medical Mycology, beginning August 1, 2027. www.ugajobsearch.com/postings/508...ugajobsearch.comAssociate Professor or Professor of Microbiology in Medical MycologyThe Department of Microbiology at the University of Georgia invites applications for a nine-month, tenure-track position in Medical Mycology at the rank of Associate or Full Professor, with an anticip... 11037
Reposted by Franklin NobregaXavier Charpentier @labxc.bsky.social · 07/10/2026Very happy that this work found a good home at @pnas.org Thanks to the reviewers for their constructive comments. www.pnas.org/doi/10.1073/...pnas.orgTwo D-loop resolution systems enable natural genetic transformation in bacteria | PNASNatural transformation is a widespread mechanism driving genetic exchanges in bacteria. It proceeds from the capture of extracellular DNA released ... 03320
Reposted by Franklin NobregabioRxiv Microbiology @biorxiv-microbiol.bsky.social · 06/10/2026Uncovering novel phage defense systems through genomic island analysis in Streptococcus thermophilus www.biorxiv.org/content/10.64898/20… 0126
Reposted by Franklin NobregaSternberg Lab @sternberglab.bsky.social · 05/10/20261/2 Here we report the activity of Arc, a 50-aa DNA-binding protein encoded within IS605-family transposons. www.biorxiv.org/content/10.6...biorxiv.orgArc represses gene expression in IS605-family transposonsBacterial insertion sequences (IS) are compact transposable elements that encode proteins required for their mobility and maintenance, yet many also encode accessory proteins with poorly understood fu... 13812
Reposted by Franklin NobregaHoong Chuin Lim @handle.invalid · 02/10/2026www.biorxiv.org/content/10.6... New preprint from my lab revealing molecular conflicts between host replication and antiviral defense. RecBCD prevents this conflict by clearing immunogenic DNA ends produced during normal replication termination. #MicroSky #PhageSkybiorxiv.orgRecBCD Prevents Bacterial Autoimmunity by Clearing Self-DNA Ends Produced During Replication TerminationViral-induced DNA damage triggers both eukaryotic and prokaryotic innate immunity. Here, we report that self-DNA ends generated routinely during normal termination of bacterial replication suffice to ... 12414
Reposted by Franklin NobregaNature Reviews Microbiology @natrevmicro.nature.com · 02/10/2026New online! How bacterial immune systems sense phage infectiondlvr.itHow bacterial immune systems sense phage infectionNature Reviews Microbiology, Published online: 02 October 2026; doi:10.1038/s41579-026-01376-xBacteria deploy diverse immune systems to counter phage infection, yet how these systems sense invasion remains incompletely understood. This Review categorizes phage-derived triggers and outlines emerging principles that govern immune recognition of phage infection. 04319
Reposted by Franklin NobregaEirik Lågeide @eiriklag.bsky.social · 01/10/2026Very excited to share the first preprint from my PhD with the community! This is also the first paper from the Plant Immunogenomics group with @galofir.bsky.social, so stay tuned for more! www.biorxiv.org/content/10.6... 1/n 🧵biorxiv.orgNO VEIN is an ancestral immunity protein involved in plant-virus interactionThe conservation of immune systems from prokaryotes to eukaryotes can guide discovery of immunity genes across the tree of life. Most studies to date have focused on metazoan systems, while the extent... 29955
Reposted by Franklin NobregaAndrew Santiago-Frangos @asantiagofrangos.bsky.social · 01/10/2026Our lab's first preprint! The antiphage protein Tiamat is an ATPase and DNase with homologs across the tree of life. What started as undergrad Shirley Yuan's summer project grew into a paper and a collaboration with @jpkbravo.bsky.social's group. Link: www.biorxiv.org/content/10.6... 14924
Reposted by Franklin NobregaKranzusch Lab @kranzuschlab.bsky.social · 01/10/2026Our story with @hobbslabutah.bsky.social discovering CBASS sensing of phage proteases out now in @science.org New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo www.science.org/doi/10.1126/...science.orgPhage proteases activate CBASS antiphage immunityCyclic oligonucleotide–based antiphage signaling systems (CBASS) are bacterial immune pathways evolutionarily related to cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) in humans. ... 08838
Reposted by Franklin NobregaBernard Kim @bernardkim.bsky.social · 15/09/2026Princeton EEB is running a very broad faculty search at the Assistant Professor level. Please consider applying to join us! This is a wonderful, collaborative, cohesive department with diverse interests and amazing colleagues. apply.interfolio.com/193474apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 098104
Reposted by Franklin NobregaHauke Hillen @haukehillen.bsky.social · 30/09/2026We are looking for a new team member! Interested in structural biology, gene expression and organelles? Then apply now to our open PhD position: umg.recruiting-portal.com/r/z11okjqp6v...umg.recruiting-portal.comInstitut für Zellbiochemie -- PhD (f/m/d)PhD (f/m/d) 12426
Reposted by Franklin NobregaUwe Ohler @uweohler.bsky.social · 30/09/2026Our #genome still holds many mysteries… Want to help figuring out what is actually translated into proteins and how it is regulated? Our research network #ORFeus is looking for motivated #PhD students to join projects across Europe. Deadline is soon (Oct 22), have a look! www.orfeus-dn.eu/apply/orfeus-dn.euApply to ORFeus — 15 fully funded PhD positions15 fully funded PhD positions across Europe, starting 2027. Applications open 1 October and close 22 October 2026. Rank up to three projects. 088
Reposted by Franklin NobregaPleuni Pennings @pleunipennings.bsky.social · 29/09/2026I am hiring a postdoc! Are you interested to work on population genetics/ drug resistance/ data? Want to work in Montpellier, France? Fastq files don't scare you? PhD required, start date hopefully Nov 1! (end date Sep 30 2028) Please share! abetterscientist.wordpress.com/2026/09/29/p...abetterscientist.wordpress.comPostdoc position on drug resistance evolution in Montpellier, FranceI have some exciting news (again!). I got money from the region (Occitanie) to hire a postdoc (and later an engineer / technician) to work on drug resistance evolution in malaria (P. faciparum) and… 179105
Reposted by Franklin NobregaJesse Shapiro @bjesseshapiro.bsky.social · 29/09/2026Our latest, spearheaded by the truly indefatigable @emderrick.bsky.social in which we search for selective sweeps in nature and genetic targets of selection within a species in the context of a diverse background community @isme-microbes.bsky.social doi.org/10.1093/isme... 🧵 1/ndoi.orgValidate User 44023
Reposted by Franklin NobregaSternberg Lab @sternberglab.bsky.social · 28/09/20261/13 — New pre-print from the Sternberg Lab in collaboration with Leifu Chang's Lab! TnpB nucleases have repeatedly given rise to TldRs, nuclease-dead RNA-guided transcription factors. Here we define the biological role of one TldR clade in its native host. Story: www.biorxiv.org/content/10.6... 15122
Reposted by Franklin NobregaJames Lloyd 🧬 @jamespblloyd.bsky.social · 25/09/2026I’m delighted to share our new pre-print: Make it so: Rapid and affordable plasmid sequencing on ONT platforms with PICARD-seq www.biorxiv.org/content/10.6... I wanted to use a MinION to sequence my large repetitive plasmids in-house. Luckily @jwdebler.bsky.social was willing to help. 1/14biorxiv.orgMake it so: Rapid and affordable plasmid sequencing on ONT platforms with PICARD-seqPlasmid construction underpins molecular biology and synthetic biology, yet validation is often limited to the inserted fragment rather than the whole plasmid, and around a third of laboratory-made pl... 13514
Reposted by Franklin NobregaThe Ferrari Lab @theferrarilab.bsky.social · 27/09/2026TT Assistant Professor position in Ecology and Evolution of Infectious Disease at University of Floridaexplore.jobs.ufl.eduUniversity of Florida - Details - Assistant Professor of Biology 11435
Reposted by Franklin NobregaKathrin Tomasek @ktomasek.bsky.social · 26/09/2026New in PLOS Pathogens 🎉 How does OM-89 (Uro-Vaxom) protect against recurrent UTIs? 🦠 Our paper: it activates lysosomes in bladder epithelial cells, pushing intracellular E. coli into acidic, protease-active compartments and improving antibiotic killing. 🧵 10.1371/journal.ppat.1014448 #UTISky #UPEC 343
Reposted by Franklin NobregaUlrich Hammes @uhammes.bsky.social · 24/09/2026We’re looking for a new colleague in Würzburg! 🌱 W3 Professorship in Plant Metabolism 💊 Chair of Pharmaceutical Biology 🧪 Head of the Metabolomics Core Unit jobs.zeit.de/jobs/univers... Please spread the word! Questions? Feel free to contact me. www.biologie.uni-wuerzburg.de/en/about-the...biologie.uni-wuerzburg.deW3_Pflanzenmetabolismus - FACULTY OF BIOLOGY 03349
Reposted by Franklin NobregaKate Baker @ksbakes.bsky.social · 25/09/2026We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175cam.ac.ukAssistant/Associate Professor in Pathogen GeneticsApplications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu... 03970
Reposted by Franklin NobregaMalcolm White @mfwhite2.bsky.social · 25/09/2026New from the @multidefence.bsky.social consortium: a deep dive into MANTIS defence. Thanks to @ukri.org for funding. www.biorxiv.org/content/10.6...biorxiv.orgDual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence systemBacterial defence systems are diverse and form major barriers to horizontal gene transfer and bacteriophage (phage) infection. Though restriction-modification systems were the first such defences disc... 02614
Reposted by Franklin NobregaVasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026thrilled to share that my main phd project is finally out in @natcomms.nature.com we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA! paper: www.nature.com/articles/s41... and a thread below⬇️⬇️⬇️ 45820
Reposted by Franklin NobregaErin Hotchkiss @fluvialbenthos.bsky.social · 24/09/2026We (Biological Sciences at Virginia Tech) are #hiring TWO tenure-track Molecular Microbiology professors! Review of applications starts 1 Nov. I'm happy to answer questions about the department, VT, life in Blacksburg, etc.! More info / to apply: jobs.apply.vt.edu/jobs/assista... 🧪👩🔬🦠 #academicjobsjobs.apply.vt.eduAssistant/Associate Professor - Blacksburg, Virginia, United StatesJob Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ... 03348
Reposted by Franklin NobregaNick Loman @pathogenomenick.bsky.social · 22/09/2026Folks - if you're interested in how machine learning/AI can be used for microbial genomics, microbiome and metagenomics studies - please join us for a workshop in Birmingham on Thursday 8th October organised with CLIMB & NVIDIA. www.climb.ac.uk/blog/2026/09...climb.ac.ukCall for Applications: GPU-Accelerated Computing for Microbiome and Metagenomic Research · CLIMBCLIMB is a cloud computing infrastructure for microbial bioinformatics — notebook servers, shared storage and reproducible workflows for genomics, metagenomics and pathogen surveillance researchers ac... 31920
Reposted by Franklin NobregaBen de Bivort @debivort.bsky.social · 22/09/2026Hello friends, the Harvard Life Science departments have banded together to hire a new colleague working at the intersection of Life Sciences and AI. Could be primarily an experimentalist, or could be primarily a compute/theorist. academicpositions.harvard.edu/postings/16773academicpositions.harvard.eduTenure-Track Professor in Life Science and AIThe Life Sciences Departments in Harvard Faculty of Arts and Sciences seek to recruit a tenure-track professor whose research is at the interface of AI and life sciences, from methodological developme... 34254
Reposted by Franklin NobregaWill Matlock @wtmatlock.bsky.social · 22/09/2026Want to explore host-plasmid and plasmid-plasmid distributions in your dataset? Or any tree with a set of binary traits? I’ve made a CLI for our model here: github.com/wtmatlock/pl...github.comGitHub - wtmatlock/plasmid-model-cliContribute to wtmatlock/plasmid-model-cli development by creating an account on GitHub. 0155
Reposted by Franklin NobregaDaria Van Tyne @dariavantyne.bsky.social · 22/09/2026My lab at Pitt is looking for a Laboratory Technician to help our research and phage therapy efforts. Please share and apply! cfopitt.taleo.net/careersectio...cfopitt.taleo.netLaboratory TechnicianClick the link provided to see the complete job description. 0824
Reposted by Franklin NobregaSimon Bayly @simonbayly.bsky.social · 21/09/2026ALT text “pink protein slides towards and then aggressively hugs smaller teal protein” 4155
Reposted by Franklin NobregaMalcolm White @mfwhite2.bsky.social · 21/09/2026New preprint from PhD student Yu Sun. TSR1 is a TIR effector specialised for CRISPR defence. It is an obligate dimer activated by cA3 and degrades its own activator using a ring nuclease domain. Perhaps the first confirmed dimeric TIR effector? www.biorxiv.org/content/10.6... 03421
Reposted by Franklin NobregaJorge Moura de Sousa @jmouradesousa.bsky.social · 20/09/2026Happy to see our work on the evolution of antiviral repertoires in P4-like satellites and their P2-like helper phages (check out the 🧵 👇) out in @narjournal.bsky.social 🔗 doi.org/10.1093/nar/... #phagesky #MicroSky #evoskydoi.orgShuttling, swapping, and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellitesAbstract. Interactions between bacteria, bacteriophages, and their satellites are shaped by a myriad of defence and counter-defence mechanisms. Here, we id 25940
Reposted by Franklin NobregaVivek Mutalik @vivekmutalik.bsky.social · 19/09/2026Some of the smallest 😎 viruses on Earth are all around us. Three or four genes 😍 each, in nearly every environment. We keep finding thousands by sequencing, yet don't know who they infect, can't easily isolate them, or even how the few we have infect a cell. Our new preprint takes this on 🧵👇 513557
Reposted by Franklin NobregaAkos Nyerges @akosnyerges.bsky.social · 19/09/2026Proud and excited to share our first preprint 🚀 in which we • create a high-fitness firewalled organism, • that stably colonizes the mouse gut for >100 days, • resists all tested phages in the gut, • and blocks horizontal gene transfer. + A new method: Chimera genomes to tailor existing synthetic 33315
Reposted by Franklin NobregaNoah Whiteman @nkwhiteman.bsky.social · 18/09/2026Reminder that the deadline for the tenure track position in my division in MCB is one month away (October 19), as you’ll see it is a wide open search in terms of area within and across fields of genetics, genomics, evolution, and development. Please circulate. 02624
Reposted by Franklin NobregaAnthony Vecchiarelli @cellforganized.bsky.social · 19/09/2026Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early! 26738
Reposted by Franklin NobregaMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 19/09/2026BFVD v3 contains 5.8M viral protein structures, 16× more than v2; 75% high quality, filling a major gap in AFDB coverage. It fully covers 72.6% of reference proteomes and spans 72.7% of ICTV species. Great work by @eunbelivable.bsky.social et al. 📄 www.biorxiv.org/content/10.6... 🌐 bfvd.foldseek.com 18431
Reposted by Franklin NobregaKranzusch Lab @kranzuschlab.bsky.social · 17/09/2026New enzymes that create natural phosphorothioate modifications in RNA share homology with proteins in bacterial DndABCDE anti-phage defense! www.cell.com/cell/abstrac... 14319
Reposted by Franklin NobregaBenoit Pons @benoitjpons.bsky.social · 17/09/2026🦠 Phage–Host Interactions — Cellular Scale with Franklin Nobrega @fnobrega.bsky.social from the University of Southampton 🇬🇧 🌱 Ecology & Evolution — Population Scale with Anna Dragoš @annadragos.bsky.social from the University of Ljubljana 🇸🇮 111
Reposted by Franklin NobregaJulian Parkhill @julianparkhill.bsky.social · 16/09/2026This will be an amazing opportunity for the right person. The Department of Veterinary Medicine in Cambridge is recruiting for an established chair who will also be our Head of Department. Your research can be in any area of veterinary science. Please circulate. www.cam.ac.uk/jobs/profess...cam.ac.ukProfessorship of Veterinary ScienceThe Board of Electors to the Professorship of Veterinary Science invite applications for this Professorship from persons whose work is connected with veterinary science (ideally in research aligned wi... 11023
Reposted by Franklin NobregaMalcolm White @mfwhite2.bsky.social · 16/09/2026Our paper on type II Panoptes is now published at PLOS Biology with new data on phage escapers - quite a step up in microbiology for our lab, led by Sabine Gruschow. Thanks to @erc.europa.eu for funding dx.plos.org/10.1371/jour... 14628
Reposted by Franklin NobregaLingchen He 何灵尘 @lingchenhe.bsky.social · 16/09/2026What a beautiful work! Must read for understanding how plasmids emerge 🌿🌿🌿 011
Reposted by Franklin NobregaWill Ratcliff @wcratcliff.bsky.social · 15/09/20261/17 Submissions are now open for the 2027 Microbial Population Biology GRC! We expect this meeting to be extraordinarily oversubscribed. If you want to come, time is of the essence--apply ASAP! June 27–July 2 • Andover, NH www.grc.org/microbial-po... 310571
Reposted by Franklin NobregaAdam Siepielski @adamsiepielski.bsky.social · 15/09/2026The Department of Biological Sciences at the University of Arkansas is hiring a TT Assistant Professor Position in Ecology. We have a wonderful group of colleagues. Join us! Apply here: tinyurl.com/yxk5marb 14032
Reposted by Franklin NobregaSjors Scheres @sjorsscheres.bsky.social · 15/09/2026Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...nature.comPostdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M... 01728
Reposted by Franklin NobregaClaus Wilke @clauswilke.com · 15/09/2026The Department of Integrative Biology at UT Austin has two open positions for assistant professors, one in evolutionary biology and one in mechanistic processes. Please share. Apply here: apply.interfolio.com/193270 05583
Reposted by Franklin NobregaMartin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 13/09/2026Fold Spacer lets you fly through protein structures (Weekend project #2). It’s my first game: I originally set out to build a racer with structures as the tracks, but was a little too crazy. So it became this instead. You can upload your own structures. 🌐 martin-steinegger.github.io/Fold-Spacer/ 215759