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Franklin Nobrega

@fnobrega.bsky.social
932 followers 395 following 55 posts

Phage Biology, Bacterial defense systems, CRISPR-Cas, Microbial communities, Mucus interactions www.fnobregalab.org www.klebphacol.org www.phage-collection.org

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Reposted by Franklin Nobrega
Wolfgang Hess @cyanolab.bsky.social · 19h
Bakteriopolis, now in Freiburg. A cool, interactive exhibition about the tiny ones. Mo-Fri 10:00 to 16:00, other times can be arranged.
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Reposted by Franklin Nobrega
Luis E. Valentin-Alvarado @luisvalentin.bsky.social · 09/10/2026
Excited to share our work on bacterial immune signaling! Our preprint reveals how RNA-guided Cas13 cleaves host tRNAs to generate small-molecule messengers that activate 2TMβ, linking RNA recognition to membrane damage and phage defense. 1/11
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Yoann Santin @ysantin.bsky.social · 07/10/2026
Dear colleagues, I am delighted to announce that the team’s website is now live santinlab.weebly.com 🥳🥳 I would also like to take this opportunity to let you know that, I am recruiting a junior postdoc to start on 1 January 2027. For further information, please feel free to contact me.
santinlab.weebly.com
Santin Lab
Home page of the Santin Lab website.
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Elisa Fadda @elisafadda.bsky.social · 09/10/2026
This ⬇️ is 🔥 #glycotime 🔥! Super congrats Meg and @joel-allen.bsky.social 🧪
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Reposted by Franklin Nobrega
Tung Le @tunglejic.bsky.social · 08/10/2026
🚨PhD opportunity alert!!! Come work with us on this new cool NERC DTP PhD project Investigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments. Retweet = nice. Thank you!!! aries-dtp.ac.uk/studentships...
aries-dtp.ac.uk
Investigate How Bacterial Hosts Control Domesticated Viral Machines to Drive Horizontal Gene Transfer in Marine Environments? | Aries
Professor Tung Le, John Innes Centre – contact me Professor Jonathan Todd, Quadram Institute & UEA Dr Ngat Tran, John Innes Centre Horizontal gene transfer (HGT) is a major driver of bacterial…
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 07/10/2026
Pls share:The Department of Microbiology at the University of Georgia invites applications for a tenure track Associate or Full professor position in Medical Mycology, beginning August 1, 2027. www.ugajobsearch.com/postings/508...
ugajobsearch.com
Associate Professor or Professor of Microbiology in Medical Mycology
The Department of Microbiology at the University of Georgia invites applications for a nine-month, tenure-track position in Medical Mycology at the rank of Associate or Full Professor, with an anticip...
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Xavier Charpentier @labxc.bsky.social · 07/10/2026
Very happy that this work found a good home at @pnas.org Thanks to the reviewers for their constructive comments. www.pnas.org/doi/10.1073/...
pnas.org
Two D-loop resolution systems enable natural genetic transformation in bacteria | PNAS
Natural transformation is a widespread mechanism driving genetic exchanges in bacteria. It proceeds from the capture of extracellular DNA released ...
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Reposted by Franklin Nobrega
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 06/10/2026
Uncovering novel phage defense systems through genomic island analysis in Streptococcus thermophilus www.biorxiv.org/content/10.64898/20…
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Sternberg Lab @sternberglab.bsky.social · 05/10/2026
1/2 Here we report the activity of Arc, a 50-aa DNA-binding protein encoded within IS605-family transposons. www.biorxiv.org/content/10.6...
biorxiv.org
Arc represses gene expression in IS605-family transposons
Bacterial insertion sequences (IS) are compact transposable elements that encode proteins required for their mobility and maintenance, yet many also encode accessory proteins with poorly understood fu...
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Hoong Chuin Lim @handle.invalid · 02/10/2026
www.biorxiv.org/content/10.6... New preprint from my lab revealing molecular conflicts between host replication and antiviral defense. RecBCD prevents this conflict by clearing immunogenic DNA ends produced during normal replication termination. #MicroSky #PhageSky
biorxiv.org
RecBCD Prevents Bacterial Autoimmunity by Clearing Self-DNA Ends Produced During Replication Termination
Viral-induced DNA damage triggers both eukaryotic and prokaryotic innate immunity. Here, we report that self-DNA ends generated routinely during normal termination of bacterial replication suffice to ...
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Nature Reviews Microbiology @natrevmicro.nature.com · 02/10/2026
New online! How bacterial immune systems sense phage infection
dlvr.it
How bacterial immune systems sense phage infection
Nature Reviews Microbiology, Published online: 02 October 2026; doi:10.1038/s41579-026-01376-xBacteria deploy diverse immune systems to counter phage infection, yet how these systems sense invasion remains incompletely understood. This Review categorizes phage-derived triggers and outlines emerging principles that govern immune recognition of phage infection.
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Eirik Lågeide @eiriklag.bsky.social · 01/10/2026
Very excited to share the first preprint from my PhD with the community! This is also the first paper from the Plant Immunogenomics group with @galofir.bsky.social, so stay tuned for more! www.biorxiv.org/content/10.6... 1/n 🧵
biorxiv.org
NO VEIN is an ancestral immunity protein involved in plant-virus interaction
The conservation of immune systems from prokaryotes to eukaryotes can guide discovery of immunity genes across the tree of life. Most studies to date have focused on metazoan systems, while the extent...
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Andrew Santiago-Frangos @asantiagofrangos.bsky.social · 01/10/2026
Our lab's first preprint! The antiphage protein Tiamat is an ATPase and DNase with homologs across the tree of life. What started as undergrad Shirley Yuan's summer project grew into a paper and a collaboration with @jpkbravo.bsky.social's group. Link: www.biorxiv.org/content/10.6...
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Kranzusch Lab @kranzuschlab.bsky.social · 01/10/2026
Our story with @hobbslabutah.bsky.social discovering CBASS sensing of phage proteases out now in @science.org New data include CBASS recognition of diverse proteases beyond T4, and verifying CD-NTase activation loop cleavage as the trigger for defense in vivo www.science.org/doi/10.1126/...
science.org
Phage proteases activate CBASS antiphage immunity
Cyclic oligonucleotide–based antiphage signaling systems (CBASS) are bacterial immune pathways evolutionarily related to cGAS-STING (cyclic GMP-AMP synthase–stimulator of interferon genes) in humans. ...
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Bernard Kim @bernardkim.bsky.social · 15/09/2026
Princeton EEB is running a very broad faculty search at the Assistant Professor level. Please consider applying to join us! This is a wonderful, collaborative, cohesive department with diverse interests and amazing colleagues. apply.interfolio.com/193474
apply.interfolio.com
Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio
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Hauke Hillen @haukehillen.bsky.social · 30/09/2026
We are looking for a new team member! Interested in structural biology, gene expression and organelles? Then apply now to our open PhD position: umg.recruiting-portal.com/r/z11okjqp6v...
umg.recruiting-portal.com
Institut für Zellbiochemie -- PhD (f/m/d)
PhD (f/m/d)
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Uwe Ohler @uweohler.bsky.social · 30/09/2026
Our #genome still holds many mysteries… Want to help figuring out what is actually translated into proteins and how it is regulated? Our research network #ORFeus is looking for motivated #PhD students to join projects across Europe. Deadline is soon (Oct 22), have a look! www.orfeus-dn.eu/apply/
orfeus-dn.eu
Apply to ORFeus — 15 fully funded PhD positions
15 fully funded PhD positions across Europe, starting 2027. Applications open 1 October and close 22 October 2026. Rank up to three projects.
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Pleuni Pennings @pleunipennings.bsky.social · 29/09/2026
I am hiring a postdoc! Are you interested to work on population genetics/ drug resistance/ data? Want to work in Montpellier, France? Fastq files don't scare you? PhD required, start date hopefully Nov 1! (end date Sep 30 2028) Please share! abetterscientist.wordpress.com/2026/09/29/p...
abetterscientist.wordpress.com
Postdoc position on drug resistance evolution in Montpellier, France
I have some exciting news (again!). I got money from the region (Occitanie) to hire a postdoc (and later an engineer / technician) to work on drug resistance evolution in malaria (P. faciparum) and…
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Jesse Shapiro @bjesseshapiro.bsky.social · 29/09/2026
Our latest, spearheaded by the truly indefatigable @emderrick.bsky.social in which we search for selective sweeps in nature and genetic targets of selection within a species in the context of a diverse background community @isme-microbes.bsky.social doi.org/10.1093/isme... 🧵 1/n
doi.org
Validate User
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Sternberg Lab @sternberglab.bsky.social · 28/09/2026
1/13 — New pre-print from the Sternberg Lab in collaboration with Leifu Chang's Lab! TnpB nucleases have repeatedly given rise to TldRs, nuclease-dead RNA-guided transcription factors. Here we define the biological role of one TldR clade in its native host. Story: www.biorxiv.org/content/10.6...
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James Lloyd 🧬 @jamespblloyd.bsky.social · 25/09/2026
I’m delighted to share our new pre-print: Make it so: Rapid and affordable plasmid sequencing on ONT platforms with PICARD-seq www.biorxiv.org/content/10.6... I wanted to use a MinION to sequence my large repetitive plasmids in-house. Luckily @jwdebler.bsky.social was willing to help. 1/14
biorxiv.org
Make it so: Rapid and affordable plasmid sequencing on ONT platforms with PICARD-seq
Plasmid construction underpins molecular biology and synthetic biology, yet validation is often limited to the inserted fragment rather than the whole plasmid, and around a third of laboratory-made pl...
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The Ferrari Lab @theferrarilab.bsky.social · 27/09/2026
TT Assistant Professor position in Ecology and Evolution of Infectious Disease at University of Florida
explore.jobs.ufl.edu
University of Florida - Details - Assistant Professor of Biology
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Kathrin Tomasek @ktomasek.bsky.social · 26/09/2026
New in PLOS Pathogens 🎉 How does OM-89 (Uro-Vaxom) protect against recurrent UTIs? 🦠 Our paper: it activates lysosomes in bladder epithelial cells, pushing intracellular E. coli into acidic, protease-active compartments and improving antibiotic killing. 🧵 10.1371/journal.ppat.1014448 #UTISky #UPEC
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Ulrich Hammes @uhammes.bsky.social · 24/09/2026
We’re looking for a new colleague in Würzburg! 🌱 W3 Professorship in Plant Metabolism 💊 Chair of Pharmaceutical Biology 🧪 Head of the Metabolomics Core Unit jobs.zeit.de/jobs/univers... Please spread the word! Questions? Feel free to contact me. www.biologie.uni-wuerzburg.de/en/about-the...
biologie.uni-wuerzburg.de
W3_Pflanzenmetabolismus - FACULTY OF BIOLOGY
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Kate Baker @ksbakes.bsky.social · 25/09/2026
We have an open Assistant/Associate Professor position in Pathogen Biology at the Department of Genetics - come and join us! 🦠 🧫 🧬https://www.cam.ac.uk/jobs/assistantassociate-professor-in-pathogen-genetics-pc51175
cam.ac.uk
Assistant/Associate Professor in Pathogen Genetics
Applications are invited for an Assistant or Associate Professorship in Pathogen Genetics to be held in the Department of Genetics. We are searching for a talented individual with a track record of fu...
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Malcolm White @mfwhite2.bsky.social · 25/09/2026
New from the @multidefence.bsky.social consortium: a deep dive into MANTIS defence. Thanks to @ukri.org for funding. www.biorxiv.org/content/10.6...
biorxiv.org
Dual ATPase-activated DNA hemimethylation and cleavage by the MANTIS defence system
Bacterial defence systems are diverse and form major barriers to horizontal gene transfer and bacteriophage (phage) infection. Though restriction-modification systems were the first such defences disc...
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Reposted by Franklin Nobrega
Vasilii Mikirtumov @vasiliimikirtumov.bsky.social · 24/09/2026
thrilled to share that my main phd project is finally out in @natcomms.nature.com we present high-resolution structures of RyR1 in native membranes across multiple functional states by both cryo-ET/StA #TeamTomo and SPA! paper: www.nature.com/articles/s41... and a thread below⬇️⬇️⬇️
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Erin Hotchkiss @fluvialbenthos.bsky.social · 24/09/2026
We (Biological Sciences at Virginia Tech) are #hiring TWO tenure-track Molecular Microbiology professors! Review of applications starts 1 Nov. I'm happy to answer questions about the department, VT, life in Blacksburg, etc.! More info / to apply: jobs.apply.vt.edu/jobs/assista... 🧪👩‍🔬🦠 #academicjobs
jobs.apply.vt.edu
Assistant/Associate Professor - Blacksburg, Virginia, United States
Job Description The Department of Biological Sciences in the College of Science at Virginia Tech seeks applicants for two (2) tenure-track research and teaching positions at the Assistant/Associate ...
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Nick Loman @pathogenomenick.bsky.social · 22/09/2026
Folks - if you're interested in how machine learning/AI can be used for microbial genomics, microbiome and metagenomics studies - please join us for a workshop in Birmingham on Thursday 8th October organised with CLIMB & NVIDIA. www.climb.ac.uk/blog/2026/09...
climb.ac.uk
Call for Applications: GPU-Accelerated Computing for Microbiome and Metagenomic Research · CLIMB
CLIMB is a cloud computing infrastructure for microbial bioinformatics — notebook servers, shared storage and reproducible workflows for genomics, metagenomics and pathogen surveillance researchers ac...
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Ben de Bivort @debivort.bsky.social · 22/09/2026
Hello friends, the Harvard Life Science departments have banded together to hire a new colleague working at the intersection of Life Sciences and AI. Could be primarily an experimentalist, or could be primarily a compute/theorist. academicpositions.harvard.edu/postings/16773
academicpositions.harvard.edu
Tenure-Track Professor in Life Science and AI
The Life Sciences Departments in Harvard Faculty of Arts and Sciences seek to recruit a tenure-track professor whose research is at the interface of AI and life sciences, from methodological developme...
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Will Matlock @wtmatlock.bsky.social · 22/09/2026
Want to explore host-plasmid and plasmid-plasmid distributions in your dataset? Or any tree with a set of binary traits? I’ve made a CLI for our model here: github.com/wtmatlock/pl...
github.com
GitHub - wtmatlock/plasmid-model-cli
Contribute to wtmatlock/plasmid-model-cli development by creating an account on GitHub.
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Daria Van Tyne @dariavantyne.bsky.social · 22/09/2026
My lab at Pitt is looking for a Laboratory Technician to help our research and phage therapy efforts. Please share and apply! cfopitt.taleo.net/careersectio...
cfopitt.taleo.net
Laboratory Technician
Click the link provided to see the complete job description.
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Simon Bayly @simonbayly.bsky.social · 21/09/2026
ALT text “pink protein slides towards and then aggressively hugs smaller teal protein”
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Malcolm White @mfwhite2.bsky.social · 21/09/2026
New preprint from PhD student Yu Sun. TSR1 is a TIR effector specialised for CRISPR defence. It is an obligate dimer activated by cA3 and degrades its own activator using a ring nuclease domain. Perhaps the first confirmed dimeric TIR effector? www.biorxiv.org/content/10.6...
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Jorge Moura de Sousa @jmouradesousa.bsky.social · 20/09/2026
Happy to see our work on the evolution of antiviral repertoires in P4-like satellites and their P2-like helper phages (check out the 🧵 👇) out in @narjournal.bsky.social 🔗 doi.org/10.1093/nar/... #phagesky #MicroSky #evosky
doi.org
Shuttling, swapping, and mixing: the rapid modular evolution of antiviral repertoires in temperate phages and their satellites
Abstract. Interactions between bacteria, bacteriophages, and their satellites are shaped by a myriad of defence and counter-defence mechanisms. Here, we id
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Vivek Mutalik @vivekmutalik.bsky.social · 19/09/2026
Some of the smallest 😎 viruses on Earth are all around us. Three or four genes 😍 each, in nearly every environment. We keep finding thousands by sequencing, yet don't know who they infect, can't easily isolate them, or even how the few we have infect a cell. Our new preprint takes this on 🧵👇
Schematics of how single strand RNA and DNA phages infect bacteria with F-pilus
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Akos Nyerges @akosnyerges.bsky.social · 19/09/2026
Proud and excited to share our first preprint 🚀 in which we • create a high-fitness firewalled organism, • that stably colonizes the mouse gut for >100 days, • resists all tested phages in the gut, • and blocks horizontal gene transfer. + A new method: Chimera genomes to tailor existing synthetic
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Noah Whiteman @nkwhiteman.bsky.social · 18/09/2026
Reminder that the deadline for the tenure track position in my division in MCB is one month away (October 19), as you’ll see it is a wide open search in terms of area within and across fields of genetics, genomics, evolution, and development. Please circulate.
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Anthony Vecchiarelli @cellforganized.bsky.social · 19/09/2026
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 19/09/2026
BFVD v3 contains 5.8M viral protein structures, 16× more than v2; 75% high quality, filling a major gap in AFDB coverage. It fully covers 72.6% of reference proteomes and spans 72.7% of ICTV species. Great work by @eunbelivable.bsky.social et al. 📄 www.biorxiv.org/content/10.6... 🌐 bfvd.foldseek.com
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Kranzusch Lab @kranzuschlab.bsky.social · 17/09/2026
New enzymes that create natural phosphorothioate modifications in RNA share homology with proteins in bacterial DndABCDE anti-phage defense! www.cell.com/cell/abstrac...
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Benoit Pons @benoitjpons.bsky.social · 17/09/2026
🦠 Phage–Host Interactions — Cellular Scale with Franklin Nobrega @fnobrega.bsky.social from the University of Southampton 🇬🇧 🌱 Ecology & Evolution — Population Scale with Anna Dragoš @annadragos.bsky.social from the University of Ljubljana 🇸🇮
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Julian Parkhill @julianparkhill.bsky.social · 16/09/2026
This will be an amazing opportunity for the right person. The Department of Veterinary Medicine in Cambridge is recruiting for an established chair who will also be our Head of Department. Your research can be in any area of veterinary science. Please circulate. www.cam.ac.uk/jobs/profess...
cam.ac.uk
Professorship of Veterinary Science
The Board of Electors to the Professorship of Veterinary Science invite applications for this Professorship from persons whose work is connected with veterinary science (ideally in research aligned wi...
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Malcolm White @mfwhite2.bsky.social · 16/09/2026
Our paper on type II Panoptes is now published at PLOS Biology with new data on phage escapers - quite a step up in microbiology for our lab, led by Sabine Gruschow. Thanks to @erc.europa.eu for funding dx.plos.org/10.1371/jour...
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Lingchen He 何灵尘 @lingchenhe.bsky.social · 16/09/2026
What a beautiful work! Must read for understanding how plasmids emerge 🌿🌿🌿
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Will Ratcliff @wcratcliff.bsky.social · 15/09/2026
1/17 Submissions are now open for the 2027 Microbial Population Biology GRC! We expect this meeting to be extraordinarily oversubscribed. If you want to come, time is of the essence--apply ASAP! June 27–July 2 • Andover, NH www.grc.org/microbial-po...
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Adam Siepielski @adamsiepielski.bsky.social · 15/09/2026
The Department of Biological Sciences at the University of Arkansas is hiring a TT Assistant Professor Position in Ecology. We have a wonderful group of colleagues. Join us! Apply here: tinyurl.com/yxk5marb
Photograph of the University of Arkansas in Fall.
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Sjors Scheres @sjorsscheres.bsky.social · 15/09/2026
Michel Goedert and myself are looking for two postdocs to work on #cryoEM and #masspec of #alphasynuclein filaments from neurodegenerative disease. Come join our bubbly and friendly team at the @mrclmb.ac.uk in lovely Cambridge, UK. www.nature.com/naturecareer...
nature.com
Postdoctoral Scientist | Neurobiology | Dr Michel Goedert | LMB 2842 - Cambridgeshire job with MRC Laboratory of Molecular Biology | 12864505
Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK To work in the group of Dr M...
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Claus Wilke @clauswilke.com · 15/09/2026
The Department of Integrative Biology at UT Austin has two open positions for assistant professors, one in evolutionary biology and one in mechanistic processes. Please share. Apply here: apply.interfolio.com/193270
Two Assistant Professor Positions in Evolutionary Biology and Mechanistic Processes

Description
The Department of Integrative Biology at The University of Texas at Austin seeks to fill two faculty positions in the areas of Evolutionary Biology and Mechanistic Processes, broadly defined. We are looking for candidates who are advancing (1) evolutionary biology or (2) the mechanistic understanding of organismal processes. These positions will be filled at the level of Assistant Professor.


Qualifications
Candidates should be using innovative approaches in evolutionary biology and/or the mechanistic understanding of whole-organism processes. Mechanistic processes include, but are not limited to, behavior, biomechanics, cognition, physiology, and development. The phylogenetic scope of the Evolutionary Biology position may include eukaryotes, prokaryotes, viruses, and the scale may include individual molecules to entire ecosystems and beyond. Candidates for either position may employ experimental, theoretical, or computational frameworks, or a combination thereof. Special consideration will be given to applicants with demonstrated potential for integrating across our target disciplines. 

We seek applicants with a strong record of high-quality research, publications, potential for extramural funding, and a commitment to excellence in teaching and mentorship. A PhD or equivalent is required at the time of appointment, and postdoctoral research experience is strongly recommended.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 13/09/2026
Fold Spacer lets you fly through protein structures (Weekend project #2). It’s my first game: I originally set out to build a racer with structures as the tracks, but was a little too crazy. So it became this instead. You can upload your own structures. 🌐 martin-steinegger.github.io/Fold-Spacer/
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