A mechanistic understanding of how regulatory T cell plasticity is controlled remains lacking. A study shows that TIF1γ modulates this plasticity by restraining β-catenin signaling.

A mechanistic understanding of how regulatory T cell plasticity is controlled remains lacking. A study shows that TIF1γ modulates this plasticity by restraining β-catenin signaling.

This study identifies TIF1γ as a critical regulator of regulatory T cell stability during inflammation. By restraining β-catenin–TCF7 signaling, TIF1γ preserves Foxp3 expression, prevents inflammatory...

Analysis of the somatic and transcriptomic profile of 123 acral melanoma samples from Mexican patients helps understand tumour origins and prognosis, and highlights the importance of including samples...

KrasLSL−G12D/+; p53fl/fl (KP) mice have been described previously55. KP mice were crossed with Rosa26LSL−tdTomato mice to generate KP; LSL-tdTomato mice. Wild-type C57BL/6 J, Trpv1-cre, Rosa26LSL−DTR (LSL-DTR), Vglut2-cre, Baf53b-cre, Pparγfl/fl and CD11c-cre mice were purchased from The Jackson Laboratory. Trpv1-cre and...

Nature - Ontogeny and transcriptional regulation of Thetis cells

A tiny population of cells that are passed across the placenta between mother and baby challenge basic tenets of human immunology.

This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...

Huang et al. study the heterogeneity of regulatory T (Treg) cells in a genetic model of colorectal cancer (CRC) and find that interleukin (IL)-10− Treg cells promote tumor progression, whereas IL-10+ ...

Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.

Skin microbiota can be engineered into topical vaccines

Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have won the Nobel Prize in medicine for their discoveries about peripheral immune tolerance.

Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible defects of ‘‘helpless’’ memory CD8+ T cells (Immunity 2025)

Help Wanted: CD4⁺ T Cells as Architects and Rescuers of CD8⁺ T Cell Responses Verena Van Der Heide, (Icahn School of Medicine at Mount Sinai ) Prolonged but finite antigen presentation promotes reversible...

Prenatal stress triggers molecular dysregulations in fetal neuroimmune circuits, leading to altered mast cell and sensory neuron function, which predisposes offspring to develop eczema in response to ...