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Here the authors show that CD4+ effector T cells prevent or reverse CD8+ T cell dysfunction by licensing Kupffer cells to trigger IL-27 production, defining a liver-specific immune circuit and a poten...

Interleukin-27 (IL-27), a member of the IL-12 cytokine family, was long viewed primarily as a regulator of CD4+ T cell immunity. Subsequent studies re…

This essay uses immunology to illuminate human relationships. Moving beyond self/non-self toward danger-based models, it draws parallels between cytokine communication and language, tolerance and forgiveness, microbiota diversity and coexistence. Recognizing these metaphors reveals pathways toward healthier connections within individuals, communities, and societies.

Valentina Venzin, (IRCCS San Raffaele Scientific Institute-Pasteur Institute) CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming

Intrahepatic immune responses are often insufficient to control hepatitis virus infections. A recent study by Venzin and colleagues demonstrates a detailed mechanism by which an intrahepatic tricellular network and the cytokine IL-27 can augment virus-specific immunity.

Tertiary lymphoid structures (TLSs) arise in non-lymphoid tissues in response to persistent antigen stimulation and chronic inflammation. Spanning organs from lung and liver to meninges, skin, and be...

Mini placentas can be grown in the lab to study pregnancy and complications like preeclampsia. Using 3D printing technology, we have bioprinted the first placental organoids and studied the impact of their environment on cell behaviour.

Podcast Episode · The Immunology Podcast · 08/21/2025 · 25m

The transfer of microbiota and pathogens from wild mice to genetically tractable laboratory mice has been shown to enhance modeling of human immune responses in preclinical studies. However, the long-term stability of the transferred complex microbiota and the induced immune phenotype in a standard laboratory mouse colony are not known. Oh et al. demonstrate that microbiota from wild mice maintain their composition and biodiversity over multiple years in a laboratory mouse colony, with increased myeloid cell numbers and immune cell function across organs. This phenotype can be transferred to adult lab mice, creating a sharable resource for preclinical research.

Dr. Johnathan Canton is an Assistant Professor at the University of Calgary, where his lab uses advanced microscopy techniques to study dendritic cells, macrophages, and innate immunity. He talks abou...

Effector CD4⁺ T cells restore antiviral CD8⁺ T cell function in the liver by licensing Kupffer cells via CD40–CD40L interactions. This triggers IL-27 production and reprograms the hepatic immune envir...

RNA-targeting therapies hold promise for contributing to HBV cure regimens, but challenges remain before that promise can be realized.

The U.S. government has sought to restrict immigration under the “America First” doctrine. These policies severely harm American science by stripping it of talent and eliminating a major driver of its...

Shruti Naik, an immunologist and a strong advocate for diversity in science, has joined forces with Aaron Mertz, who leads programmes that help to explain, connect and maximize the benefits of science...

“Rigorous science demands” it, authors write in landmark commentary