Biochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati...

COMMD proteins assemble into a heterodecameric ring in the Commander complex, which plays a role in endosomal membrane trafficking and signalling in eukaryotes. Here, Liu et al. identify COMMD-like pr...

Nature Reviews Immunology, Published online: 08 April 2026; doi:10.1038/s41577-026-01290-6This Review discusses how cytokine multimerization affects the engagement of cytokines with their receptors and their biological activity. The authors explain the relevance of cytokine multimerization in disease settings and the implications for cytokine-targeting therapies.

Nature Metabolism, Published online: 18 March 2026; doi:10.1038/s42255-026-01484-1The accumulation of phosphoinositides at the lysosomal surface is shown to enhance RagGTPase–mTORC1 activity, which affects skeletal muscle cell differentiation. Inhibition of this signalling pathway improves muscle physiology in a mouse myopathy model.

Nature Structural & Molecular Biology - This study shows how the bacterial retron Eco2 defends against viruses. Phage nucleases trigger activation of Eco2, which cuts RNAs, shuts down protein...

This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-i...

I’ve struggled my whole life to discern the difference between being right vs. effective. Over the past decade, the U.S. has been on a slow burn to fascism. The best description I’ve seen of America’s...

Institute for Molecular Bioscience Full-time (100%), permanent position Base salary will be in the range $117,958.12 - $132,247.57+ 17% Superannuation (HEW Level 8) Based at our St Lucia Campus About ...

Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...

The Retromer coat is conserved in all eukaryotes and is crucial for the correct intracellular sorting of many transmembrane receptors and lysosomal hydrolases. Retromer is an effector of the late endosomal small GTPase RAB7 and is also implicated in its inactivation required for proper endosomal maturation. Here, we explore the role of controlled GTP hydrolysis by the RAB7 ortholog Ypt7 in the formation of Retromer-coated membrane carriers in yeast. Proximity labelling and genetic ablation identify the GTPase Activating Protein (GAP) Gyp6 as a critical regulator of Ypt7 activity in the context or Retromer. Structural studies show that Retromer recruits Gyp6 through its Vps29 subunit, which recognises a specific PL motif and a secondary binding site in the C-terminal domain of Gyp6. This interaction does not occur with other yeast GAPs. Ablation of the Gyp6-Retromer interface or the catalytic activity of Gyp6 leads to the accumulation of tubular structures on endo-lysosomal compartments and to increased association of Ypt7 with Retromer and its cargo Vps10. These results support a model in which Gyp6 controls the switch from Ypt7-dependent Retromer coat assembly and cargo collection to the departure of the carrier through membrane fission and uncoating. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, APP2016410 Swiss National Science Foundation, https://ror.org/00yjd3n13, 31003A_179306, 310030_204713, 10.006.083

Nature Metabolism, Published online: 12 January 2026; doi:10.1038/s42255-025-01442-3In this Review, Smith et al. summarize the most recent findings on AMPK and emphasize its role as a nutrient sensor and in regulating metabolic homeostasis, as well as how AMPK dysregulation contributes to various diseases.

This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-i...

This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation.

Reducing dietary levels of protein or specific essential amino acids (EAAs) promotes favorable metabolic reprogramming, including improved glucose tolerance, increased insulin sensitivity and reduced ...

ABC toxins are bacterial insecticides with biotechnological potential. Here, Low et al. have deciphered soluble and membrane-inserted structures of YenTc that highlight structural and mechanistic dive...

A GPCR and a moonlighting transcription factor together drive metastasis in breast cancer.

The world’s most valuable company is building an Australia-first supercomputer that will initially tackle cancer research.

Intracellular pathogens hijack host gene expression to subvert cellular processes. Here, the authors show that Legionella pneumophila’s PieF effector inhibits the human CCR4-NOT deadenylation machiner...