This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation.

The Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins (CCeMMP) is holding their 2nd Annual ‘Bench to Art’ Exhibition to showcase the artistic flair of structural bio...

A GPCR and a moonlighting transcription factor together drive metastasis in breast cancer.

Structure of the TSC:WIPI3 lysosomal recruitment complex

In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporte...

In a recent issue of Nature, Bayly-Jones et al. report the cryo-EM structures of a lysosomal cholesterol sensor, LYCHOS, also known as GPR155, which reveals a unique fusion of a plant auxin-transporte...