Alejandra Tomas @tomaslab-imperial.bsky.social · 04/02/2026I am delighted to report that our latest paper has now been published in Science Advances: www.science.org/doi/10.1126/... In this study, we generated and characterised a humanised GLP‑1R mouse model carrying the gain‑of‑function A316T variant using CRISPR/Cas9 knock‑in technology. 164
Alejandra Tomas @tomaslab-imperial.bsky.social · 16/01/2026Our review on GLP-1R signal compartmentalization is now out in JCI, where we discuss current evidence for the existence of GLP-1R–cAMP–PKA signalosomes at different subcellular locations and the complexity of the GLP-1R spatiotemporal signaling architecture: www.jci.org/articles/vie...jci.org JCI - Signaling architecture of the glucagon-like peptide-1 receptor 042
Alejandra Tomas @tomaslab-imperial.bsky.social · 31/08/2025I’m delighted to share that I have been promoted to Professor of Cell Biology at Imperial College London. I am deeply grateful to those who have supported me along the way, through the many ups and downs that led to this point. 3101
Alejandra Tomas @tomaslab-imperial.bsky.social · 20/08/2025And a new paper from our group now published in DOM on a novel dual GLP-1R/GIPR agonist with improved action in vivo doi.org/10.1111/dom.... 050
Alejandra Tomas @tomaslab-imperial.bsky.social · 20/08/2025Our newest study looking at the impact of missense GIPR variants in BMI versus glycemia, receptor stability, and pancreatic islet function. www.medrxiv.org/content/10.1... A collaboration of Imperial College with Eli Lilly and University of Cambridge.medrxiv.orgGlycaemic and bodyweight effects of GIPR coding variation reflect differences in both surface expression and intrinsic functional impairmentThe glucose-dependent insulinotropic polypeptide receptor (GIPR) is the target of several approved and investigational drugs for type 2 diabetes and obesity. Missense coding variation in GIPR could co... 060
Alejandra Tomas @tomaslab-imperial.bsky.social · 09/03/2025Still time to apply to this Lectureship position in our Section. Deadline 25th March. 032
Alejandra Tomas @tomaslab-imperial.bsky.social · 08/03/2025Congratulations to Liliane ElEid who successfully passed her PhD viva yesterday! Here are some pictures of the post-viva celebrations. Many thanks to Prof David Hodson @daveyboyhod.bsky.social and Dr Bryn Owen for assessing her thesis and to David for his visit and Seminar. 040
Alejandra Tomas @tomaslab-imperial.bsky.social · 15/02/2025Our newly revised manuscript on ER-mitochondria membrane contact site-localised GLP-1R signalling hub now out in bioRxiv: www.biorxiv.org/content/10.1...biorxiv.orgGLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and functionGlucagon-like peptide-1 receptor (GLP-1R) agonists (GLP-1RAs) ameliorate mitochondrial health by increasing mitochondrial turnover in metabolically relevant tissues. Mitochondrial adaptation under met... 060
Alejandra Tomas @tomaslab-imperial.bsky.social · 15/02/2025Are you interested in developing a research programme in cell biology of diabetes? Do you work in pancreatic islets and/or other metabolically relevant cells? We have a Lectureship post opening in our Section @imperialcollegeldn.bsky.social Apply by 25th March: www.imperial.ac.uk/jobs/search-...imperial.ac.ukDescriptionPlease note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment... 0811
Alejandra Tomas @tomaslab-imperial.bsky.social · 17/01/2025Our newest preprint about a new GLP-1R/GIPR dual agonist: www.biorxiv.org/content/10.1...biorxiv.orgBinding Kinetics, Bias, Receptor Internalization and Effects on Insulin Secretion in vitro and in vivo of a Novel GLP-1R/GIPR Dual Agonist, HISHS-2001The use of incretin analogues has emerged in recent years as an effective approach to achieve both enhanced insulin secretion and weight loss in type 2 diabetes (T2D) patients. Agonists which bind and... 091
Alejandra Tomas @tomaslab-imperial.bsky.social · 06/01/2025Last few days to apply for a postdoc position in my lab 001
Alejandra Tomas @tomaslab-imperial.bsky.social · 22/12/2024Our collaboration with the talented Sarah Rouse now out in bioRxiv: "Human class B1 GPCR modulation by plasma membrane lipids" www.biorxiv.org/content/10.1...biorxiv.org 041
Alejandra Tomas @tomaslab-imperial.bsky.social · 20/12/2024Still time to apply to this position! Application open until 15th Jan 2025. 000
Alejandra Tomas @tomaslab-imperial.bsky.social · 18/12/2024Our attempt to tag endogenous GIPR in vivo with a Halo-tag www.biorxiv.org/content/10.1...biorxiv.orgThe physiological impact of an N-terminal Halo-tag on GIPR function in miceAims: G protein-coupled receptors (GPCRs) modified with self-labelling enzymatic tags (e.g. Halo, SNAP, CLIP) have enabled the in vitro study of receptor expression and trafficking. We developed a Gip... 0103
Alejandra Tomas @tomaslab-imperial.bsky.social · 13/12/2024PhD Studentship available in the lab of Dr Paras Anand at Imperial, in collaboration with me: www.findaphd.com/phds/project...findaphd.comDeciphering the metabolic regulation of inflammasome activation at Imperial College London on FindAPhD.comPhD Project - Deciphering the metabolic regulation of inflammasome activation at Imperial College London, listed on FindAPhD.com 000
Alejandra Tomas @tomaslab-imperial.bsky.social · 08/12/2024A postdoctoral position is available in my lab to study the subcellular organisation of signalling of the glucagon receptor family. For more information and to apply please click here: www.imperial.ac.uk/jobs/search-... 053