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Brendan Manning

@bdmanning.bsky.social
840 followers 144 following 30 posts

Scientist working on signaling and metabolism in cancer, metabolic diseases, aging, and physiology. AKT-TSC-mTOR🧪

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Reposted by Brendan Manning
Fusion Conferences @fusionconf.bsky.social · 24/06/2026
📢SAVE THE DATE! 2nd Redox Biology in Health & Disease Conference 📅Date: 25 - 28 May 2027 🌏Location: Durrës, Albania Sign up for updates to find out more information on the conference: bit.ly/4eF65xf #FusionCancerResearch #FusionMetabolism #FusionHumanDisease #RedoxBio
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Brendan Manning @bdmanning.bsky.social · 20/04/2026
Congrats to Jess Ubellacker! Brilliant PI in Molecular Metabilism @met-hsph.bsky.social at Harvard TH Chan School of Public Health. @hsph.harvard. edu www.aacr.org/about-the-aa...
aacr.org
AACR Announces Recipients of AACR Trailblazer Cancer Research Grants
SAN DIEGO – The American Association for Cancer Research (AACR) today announced the recipients of the AACR Trailblazer Cancer Research Grants during the Opening Ceremony of the AACR Annual Meeting 202...
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DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · 17/04/2026
This kind of stable, sustained support can transform a career: @hhmi-science.bsky.social's #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 yrs, plus salary & benefits. Postdoc? This year's competition has a program for you too. Applications open 11/3! bit.ly/4vhC0LA
bit.ly
Early Career Faculty Program | Freeman Hrabowski Scholars | HHMI
The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...
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cniostopcancer.bsky.social @cniostopcancer.bsky.social · 23/03/2026
✍️ Registration open: bit.ly/45jaORu Sponsored by @caixaresearch.bsky.social @fendtlab.bsky.social @arkaitzcarracedo.bsky.social @bdmanning.bsky.social
bit.ly
CNIO CaixaResearch Frontiers Meeting: Metabolism and Cancer: Insights from Obesity and Beyond #CFM_MetCanc
Fecha límite de inscripción 05/05/2026 Fecha límite de envío de resumen 27/04/2026 precio 200 € Students, CNIO staff and CNIO Alumni; 400 € Post-docs and Academia; 600 € Industry
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Prague Metabolism and Signaling Symposium @praguemetab.bsky.social · 27/02/2026
Excited about the 2026 Prague Metabolism & Signaling Symposium in Prague, Czechia, bringing together leading scientists to explore cutting-edge research in metabolism, signaling, aging, cancer, immune responses & more! 🧬🔬 📅 June 24–27, 2026 More details at 👉 praguemetabolismsymposium.com
praguemetabolismsymposium.com
Prague Metabolism Symposium 2026 – Prague Metabolism Symposium 2026
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Rich Possemato @richpossemato.bsky.social · 09/01/2026
Join us for the 2026 NYAS Cancer Metabolism conference on March 24th at NYU Langone! The poster deadline is rapidly approaching. Speakers include @airdlab.bsky.social @bensahralab.bsky.social Javier Garcia-Bermudez, Marcus Goncalves, @naama-kanarek.bsky.social @bdmanning.bsky.social Erika Pearce,
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Brendan Manning @bdmanning.bsky.social · 05/01/2026
Clear evidence from Josh Shin in our lab that mTORC1 signaling and autophagy reciprocally influence the length of primary cilia. Question remains how do changes in length affect cilia signaling and function in the largely quiescent cells comprising our brains and bodies. www.cell.com/iscience/ful...
cell.com
Growth factor-independent mTORC1 signaling promotes primary cilia length via suppression of autophagy
Molecular physiology; Cell biology
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Brendan Manning @bdmanning.bsky.social · 29/07/2025
Just two of thousands of such stories. substack.com/home/post/p-...
substack.com
I Was Just About To When My Grant Was Cut.
We ask researchers to send us their stories of what they were working on when their research grant was cut. Today, we share the stories of Tashara and Brendan.
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Ardem Patapoutian @ardemp.bskyverified.social · 18/07/2025
I still can’t believe that all NIH grants to my colleagues at Harvard and Harvard Medical School have been nullified. And that, as a nation, we’re somehow okay with this illegal, arbitrary, and petty act. Just think of the consequences: scientists, students, and patients will all suffer.
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Brendan Manning @bdmanning.bsky.social · 09/07/2025
Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 30/06/2025
Much appreciated support from biotech execs and investors 🙏 www.statnews.com/2025/06/27/b...
statnews.com
Proposed cuts could have ‘catastrophic effect,’ 110 biomedical, health sciences industry leaders tell Congress
Proposed cuts will have “a catastrophic effect on the advancement of biomedical and biotechnology capabilities in the United States,” more than 100 leaders of biomedical/health sciences companies tell...
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Brendan Manning @bdmanning.bsky.social · 05/06/2025
Congrats to Yann Cormerais and the entire lab for this publication on a new mouse model that disconnects the primary signal from PI3K to mTORC1, involving Akt-mediated phosphorylation of TSC2, which I discovered as a postdoc in Lew Cantley's lab 23 years ago. authors.elsevier.com/a/1lDFh5Sx5g...
authors.elsevier.com
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Brendan Manning @bdmanning.bsky.social · 04/06/2025
Congrats to @harperlabhms.bsky.social and colleagues in @harvardcellbio.bsky.social for this tour de force dissection of endosomes
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Nature @nature.com · 04/06/2025
Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes go.nature.com/3Z6mJ1X
go.nature.com
EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature
A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.
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Harvard Molecular Metabolism @met-hsph.bsky.social · 28/05/2025
From @hsph.harvard.edu Hotamışlıgil Lab, @renata-goncalves.bsky.social identifies an important mechanism that leads to liver dysfunction in obesity—defective coenzyme Q metabolism. This finding paves the way for more targeted diabetes & metabolic disease treatments. Read more: hsph.me/mitoT2D
hsph.harvard.edu
Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes | Harvard T.H. Chan School of Public Health
A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic disorders in individuals with obesity, according to a new study led by Harvard C...
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Harvard Molecular Metabolism @met-hsph.bsky.social · 30/05/2025
For 25 years, Dr. Manning & his lab have advanced TSC research, uncovering how the mTOR pathway shapes cell growth—and unlocking insights across cancer, diabetes & more. Research that until recently was supported by taxpayers through the NIH. #TSC #science #ResearchMatters
tscalliance.org
Brendan Manning: Unraveling the cell’s inner workings
For Brendan Manning, PhD, today’s advances in basic science are the stepping stones to the next breakthrough in treating tuberous sclerosis complex (TSC). Manning has spent the last 25 years researchi...
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Ed Yong is offline @edyong209.bsky.social · 30/05/2025
I urge everyone to read Unbreaking’s new page on everything the govt is doing to destroy & diminish medical research funding. It’s the best thing I’ve read on this topic: @lizneeley.bsky.social & co have such done an incredible job. unbreaking.org/issues/medic...
unbreaking.org
Medical Research Funding — Unbreaking
How the administration is breaking the government, and what that means for all of us.
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Joe Allen @joeallenjoe.bsky.social · 25/05/2025
28 of the most important drugs approved by the Food and Drug Administration (FDA) between 1985 and 2009. They found that 80 percent stemmed directly from basic discoveries made in the lab, often by scientists trying to understand a biological process or disease bit.ly/4jLCfbC
bit.ly
Tracing the Path from Basic Research to Transformative Therapies
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Brendan Manning @bdmanning.bsky.social · 23/05/2025
Why?
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Brendan Manning @bdmanning.bsky.social · 21/05/2025
I thank the taxpayers of the United States for supporting this research designed to better understand and treat the uncontrolled growth of cancer cells over the past 10 years.
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Brendan Manning @bdmanning.bsky.social · 21/05/2025
Indeed, our Outstanding Investigator Award from the National Cancer Institute, which funded all research personnel and activities in my modest-sized lab of 5 has been unceremoniously terminated.
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Harvard T.H. Chan School of Public Health @hsph.harvard.edu · 16/05/2025
With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive
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Ubellacker Lab @ubellackerlab.bsky.social · 18/04/2025
A reminder that for next month’s BCDI in place of our regular discussion, we encourage you to attend the Cutter Distinguished Lecture @met-hsph.bsky.social by the great Scott Dixon! See you there: Monday May 12, 2025, Kresge Building at HSPH, G1 auditorium, 12:00-1:00pm
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Rich Possemato @richpossemato.bsky.social · 18/04/2025
From Nobel prize winning cancer researcher Bill Kaelin Killing the Science Golden Goose - The American Journal of Medicine www.amjmed.com/article/S000...
amjmed.com
Killing the Science Golden Goose
In the 1970’s I was probably one of the last American high school students who was told that if you wanted to go to medical school, you should learn to speak German. This was because in the late 19th ...
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Andrea Baccarelli @deanbaccarelli.bsky.social · 15/04/2025
Our partnership with the federal government has powered discoveries and solutions that have saved tens of millions of lives around the world. 🌎 The funding has enabled breakthrough research on deadly diseases from cancer to Alzheimer’s to stroke to HIV. 🦠 hsph.harvard.edu/news/trump-a...
hsph.harvard.edu
Trump administration freezes $2.2 billion in grants to Harvard | Harvard T.H. Chan School of Public Health
The Trump administration announced late Monday that it was moving to freeze $2.2 billion in grants and $60 million in contracts to Harvard University. The federal freeze came hours after Harvard rejec...
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Dibble Lab @dibblelab.bsky.social · 15/04/2025
Check out the new homepage for Harvard!! Love it !! www.harvard.edu
harvard.edu
Harvard University
Harvard University is devoted to excellence in teaching, learning, and research, and to developing leaders who make a difference globally.
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Andrea Baccarelli @deanbaccarelli.bsky.social · 21/03/2025
With support from federal funding, @hsph.harvard.edu faculty have conducted groundbreaking research that has led directly to treatments, policies, and programs that have saved lives by the millions, in the US and around the world. Here are just three examples: hsph.harvard.edu/news/federal...
hsph.harvard.edu
Federal funding drives groundbreaking research at Harvard Chan School | Harvard T.H. Chan School of Public Health
Harvard Chan faculty conduct groundbreaking research that has led directly to lifesaving vaccines, treatments, policies, and programs.
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Brendan Manning @bdmanning.bsky.social · 17/02/2025
Tough day on the slopes trying to keep up with these guys. But beats watching the news.
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Brendan Manning @bdmanning.bsky.social · 08/02/2025
There it is! The end of academic science in the US. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
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Brendan Manning @bdmanning.bsky.social · 15/01/2025
Last day to apply to the hub of metabolism research at Harvard.
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Brendan Manning @bdmanning.bsky.social · 08/01/2025
One week left to apply for a faculty position with us! We have a new website that still needs some love, but learn more about the department here: hsph.harvard.edu/department/m...
hsph.harvard.edu
Department of Molecular Metabolism | Harvard T.H. Chan School of Public Health
The Department of Molecular Metabolism researches the complex interplay between genetics, environment, and metabolic processes at the molecular level to understand how deviations can lead to widesprea...
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Brendan Manning @bdmanning.bsky.social · 08/01/2025
Congrats to this incredible group!
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Brendan Manning @bdmanning.bsky.social · 29/12/2024
Thanks NYG. Too bad we need 51 new players to make this team competitive again. hhttps://www.boston.com/sports/new-england-patriots/2024/12/29/new-england-patriots-nfl-draft-no-1-pick-first-giants-titans/
boston.com
Patriots now in control of No. 1 pick in 2025 NFL Draft
After losing Saturday to the Chargers and seeing the Giants beat the Colts, the Patriots now hold the No. 1 pick in the 2025 NFL Draft.
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Brendan Manning @bdmanning.bsky.social · 23/12/2024
But…..ok, ok, I’m convinced. Elegant and definitive. www.science.org/doi/10.1126/...
science.org
Metformin targets mitochondrial complex I to lower blood glucose levels
Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.
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Ben-Sahra Lab @bensahralab.bsky.social · 25/11/2024
Happy to share this News & Views piece @natureportfolio.bsky.social on Prof. Parada's work, which reveals the antitumoral effects of the small molecule Gliocidin through inhibition of guanine nucleotide metabolism in glioblastoma! Congrats to the authors! www.nature.com/articles/d41...
nature.com
Brain-penetrating molecule might offer a route to treat glioblastoma tumours
Molecule targeting brain tumours disrupts nucleotide production.
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Brendan Manning @bdmanning.bsky.social · 23/11/2024
Awesome structure! Question remains - what happens next? www.biorxiv.org/content/10.1...
biorxiv.org
Structural basis for growth factor and nutrient signal integration on the lysosomal membrane by mTORC1
Mechanistic target of rapamycin complex 1 (mTORC1), which consists of mTOR, Raptor, and mLST8, receives signaling inputs from growth factor signals and nutrients. These signals are mediated by the Rhe...
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Brendan Manning @bdmanning.bsky.social · 21/11/2024
Join us in Boston! The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health has just opened a Jr. Faculty search. Apply by January 15, 2025 at academicpositions.harvard.edu/postings/14371
academicpositions.harvard.edu
Assistant Professor, Department of Molecular Metabolism
The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health invites applications for the level of assistant professor. The shared interest of MET faculty is to explor...
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