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Andrew MacAskill

@macaskillaf.bsky.social
2.3K followers 2K following 166 posts

UCL neuroscientist investigating the neural basis of contextual decision making. Views are my own. Prof @uclnpp lab website: www.macaskilllab.com UCL profile: profiles.ucl.ac.uk/5194 also @macaskillaf@fediscience.org

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Reposted by Andrew MacAskill
Jim Heys @jim-heys.bsky.social · 03/09/2026
I’m very excited to share our new paper, led by the very talented Jack Bowler, a postdoc in the lab! www.nature.com/articles/s41... We all know that the way we learn something matters. But how does a training curriculum actually shape how the brain learns to solve a problem? a 🧵 1/N
nature.com
Structured experience shapes strategy learning and neural dynamics in the medial entorhinal cortex - Nature Neuroscience
The authors use recurrent neural networks to predict how structured prior experience shapes neural dynamics as mice learn flexible timing strategies during complex context-dependent behavior.
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Adam Carter @carterlab.bsky.social · 01/09/2026
Happy to share our new J Neurosci paper showing how cortical and thalamic inputs engage cholinergic interneurons in the nucleus accumbens (NAc) core: www.jneurosci.org/content/earl...
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Andrew MacAskill @macaskillaf.bsky.social · 01/09/2026
i've got to that heady stage where my youtube feed is almost entirely tec house mixes, interspersed with ads for nature family journals and minus 80 freezers 🧪🧠📈🎧 is this old age?
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Caswell Barry @caswell.bsky.social · 01/09/2026
Very excited to see this out — real teamwork, led by @laurenb29.bsky.social & Will de Cothi with @lgiocomo.bsky.social, @colinlever.bsky.social, Laurenz Muessig, Fábio Rodrigues, Francesca Cacucci, Tom Wills, Yanjun Sun & Steven Poulter. In Nature Comms: www.nature.com/articles/s41467-026-76686-y
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Andrew MacAskill @macaskillaf.bsky.social · 30/08/2026
www.mcsweeneys.net/articles/pro...
mcsweeneys.net
Professor Sisyphus Begins a New Semester
“Professor Sisyphus learned a slang word. He was excited to impress his students. Then he discovered that as soon as he uttered slang in class—poof! It would...
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Andrew MacAskill @macaskillaf.bsky.social · 20/08/2026
Congrats @jespass.bsky.social on her new paper! PFC is widely thought to talk to HPC via nucleus reuniens - but no one has tested if this actual connectivity exists. Turns out it's wired to block it: PFC inputs to reuniens contact only neurons projecting back to PFC, not ones projecting to HPC. 🧪🧠📈
biorxiv.org
Nucleus reuniens is organised as parallel circuits rather than a prefrontal-hippocampal relay
Interactions between the prefrontal cortex (PFC) and hippocampus (HPC) are crucial for flexible and memory guided behaviour. Because there are no direct projections from PFC to HPC, it is widely presu...
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Elisa Fadda @elisafadda.bsky.social · 19/07/2026
"how did you like the half time show, Wayne?" "It was crap" 😂😂😂👏🏻👏🏻👏🏻🔥🔥🔥 #legend
static.klipy.com
Wayne Rooney: Football Legend
Alt: Wayne Rooney: Football Legend
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Poorly Drawn Arsenal @poorlydrawnarsenal.com · 14/07/2026
If I were France I would attempt to score soon. If this match ends as it is now the chances of them advancing are low.
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Andrew MacAskill @macaskillaf.bsky.social · 10/07/2026
Congrats to @soyonhonglab.bsky.social and ger! Very happy to have played a small part in this!
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Andrew MacAskill @macaskillaf.bsky.social · 08/07/2026
A fantastic opportunity for a computational neuroscience lab. Come and join our amazing department! You’ll be surrounded by outstanding systems, cellular and molecular neuroscientists tackling fundamental questions about how the brain works. 🧠📈🧪
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UCL Neuroscience @uclnpp.bsky.social · 08/07/2026
Only two days left to apply to the best neuroscience department! #NeuroSkyence 🧠📈🧪 Computational neuroscience, systems, synapses and molecules, all under one roof. Come join an amazing collaborative group!
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Stéphanie C Koch @skochlab.bsky.social · 30/04/2026
Our paper is out! Work by Christopher Black in collaboration with Liam Browne, Rob Brownstone, and Marco Beato. Here, we describe the unique kinematic signatures of multi-limb coordination in freely climbing mice and show how these flexibly adapt to changing environments. tinyurl.com/4bnw88wk
tinyurl.com
Naturalistic climbing reveals adaptive strategies for interlimb coordination in freely moving mice
Multi-limb coordination is vital for mammalian locomotion. While coordination requires reliable organization of limb movements, it also requires flexibility to adapt to environmental demands. In natur...
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Andrew MacAskill @macaskillaf.bsky.social · 19/05/2026
vision to navigation via colliculus not V1! very cool stuff from @ruedigersarah.bsky.social in @uclnpp.bsky.social
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Prof Rick Adams @drrickadams.bsky.social · 18/05/2026
📢PhD job alert! A exciting PhD project that involves using MEG and biophysical modelling to try to predict effects of a glutamatergic treatment for psychosis... plus you can develop your own side project. Join our great team! www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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European Research Council (ERC) @erc.europa.eu · 29/04/2026
NEWS: The ERC Scientific Council has listened to the concerns from members of the research community about changes to the re-submission rules, intended to manage the surge in demand for grants. The Scientific Council will readjust some of the changes: link.europa.eu/TBqRQJ
link.europa.eu
ERC Scientific Council readjusts rules for reapplication
The ERC Scientific Council has listened to the concerns from members of the research community about the recent announcement on changes to the re-submission rules. The changes, intended to manage the ...
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Andrew MacAskill @macaskillaf.bsky.social · 26/04/2026
Huge congrats to @snierwetberg.bsky.social , David (not on BSky), and @maxwellxchen.bsky.social for their paper! They developed a mouse task in which relational structure can be isolated from cue identity and reward statistics. www.biorxiv.org/content/10.6... 🧠📈🧪 #neuroskyence @uclnpp.bsky.social
biorxiv.org
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Izumi Fukunaga @ifukunaga.bsky.social · 21/04/2026
We are recruiting a post-doc to study olfactory processing and decision-making in rodents, combining quantitative behavior with neurophysiology. www.oist.jp/careers/post... Please share with interested colleagues and trainees 🙏
oist.jp
Post-doctoral Researcher - Sensory and Behavioural Neuroscience Unit
Post-doctoral positions are available in the Sensory and Behavioural Neuroscience Unit (https://www.oist.jp/research/research-units/sbn) at Okinawa Institute of Science and Technology Graduate Univers...
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Dr Ino Agrafioti @inoagrafioti.bsky.social · 16/04/2026
I don’t know if you saw the MASSIVE news announced by @erc.europa.eu today: from now on, if you get a B at step 1 you are eligible to apply at N+3(!!!) years. Say you got a B in STG2026 step 1, you thought you could apply in STG2028, but no: only in STG2029! erc.europa.eu/news-events/...
erc.europa.eu
Applying for an ERC grant in the 2027 competitions: what you need to know
The ERC plans to launch the grant competitions under its 2027 Work Programme between July 2026 and June 2027, with the calls for proposals introducing several changes to the eligibility rules for appl...
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Athena Akrami @athenaakrami.bsky.social · 13/04/2026
New preprint! 🧠 How do RNNs learn abstract rules from sequences, independent of specific stimuli? By Vezha Boboeva, with Alberto Pezzotta & George Dimitriadis "From sequences to schemas: low-rank recurrent dynamics underlie abstract relational representations" www.biorxiv.org/content/10.6...
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Selina Wray @selinawray.bsky.social · 13/04/2026
New preprint 🥳 Gamma secretase isnt a single enzyme, multiple GSEC exist depending on which subunits are incorporated into the complex. We made PSEN1 & PSEN2 knockouts to study the impact of different GSEC in neurons & microglia Led by @celarber.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Brad Wyble @bwyble.bsky.social · 09/04/2026
Random neuroscience trainee tip: If you struggle to keep track of rostral vs caudal, remember that rostral rhymes with nostril.
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Jes Pass @jespass.bsky.social · 27/03/2026
Super excited to see the first paper from my PhD out! 🐭 Very satisfying to get to build an interpretable model of how the brain does a thing. A nice palette cleanser in the current sea of LLMs and deep ML.
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Dan Levenstein @dlevenstein.bsky.social · 25/03/2026
This is the most insider shade ever and I’m here for it. #wormFly4pres2026🪱🪰
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Andrew MacAskill @macaskillaf.bsky.social · 24/03/2026
Huge congratulations to Jes (not on Bsky) for her paper in @plos.org Computational Biology! A really elegant modelling study on how the brain discovers hidden structure and uses it to guide behaviour. @uclnpp.bsky.social @ucllifesciences.bsky.social 🧪 📈 🧠 journals.plos.org/ploscompbiol...
journals.plos.org
Contextual inference through flexible integration of environmental features and behavioural outcomes
Author summary To behave flexibly, animals must determine which situation or context they are in, even when the information that defines that context is incomplete or no longer visible. This problem, ...
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Helen Barron @helencbarron.bsky.social · 20/03/2026
*** New paper from the lab in Nature Comms !! *** “Noradrenaline causes a spread of association in the hippocampal cognitive map” by the amazing @reneecabbage.bsky.social in collab. w labs of Jill O’Reilly, Will Clarke, and modeling from Prakriti Parthasarathy and @tpvogels.bsky.social, see below!
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Andrew MacAskill @macaskillaf.bsky.social · 14/03/2026
Big changes - wording is a bit ambiguous as to whether these will be peer reviewed..? Hopefully! - experimental medicine and discovery science considered together and funded from the same 'bucket' is a touch scary for the discovery types!
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Andrew MacAskill @macaskillaf.bsky.social · 13/03/2026
Another poster today at #cosyne26 (2-112)! @rowanboard shows how early life social isolation alters dimension-based learning, cognitive flexibility, and the ventral hippocampus–PFC circuit. Great collaboration with @jonroiser.bsky.social linking mouse and human versions of the task!
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Anton Strezhnev @astrezh.bsky.social · 12/03/2026
Can this be a solution?
Fitzcarraldo
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Andrew MacAskill @macaskillaf.bsky.social · 12/03/2026
Poster tonight at #cosyne26 (1-079)! @wanqingjiang.bsky.social & @noehamou.bsky.social show that mice learn hidden community structure in a 15-odour graph even when transition statistics are flat. Fun collaboration with @saxelab.bsky.social that started with East London coffees ☕!
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Andrew MacAskill @macaskillaf.bsky.social · 04/03/2026
Super cool paper on human hippocampus in a non spatial planning task - congrats!
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Jordan aka Jirdan @slclunk.com · 28/02/2026
I think about this Tony Benn speech much more than I used to
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Paul Anastasiades @panastasiades.bsky.social · 18/02/2026
New preprint from the lab on synapse development in the nascent neocortical hierarchy! Using mice that label MAGUK proteins developed by Seth Grant we find key differences in the laminar maturation of association and sensory motor cortices, including delayed, cortex-wide maturation of L1 synapses.
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Dan Bose @danbose.bsky.social · 12/02/2026
I'm a bit late with this, but awesome to see it out in the wild! A real tour de force from @dozenoaks.bsky.social @timcraggs.bsky.social An amazing example of why we need to think more about flexibility in our biological questions! www.cell.com/iscience/ful...
cell.com
Kinesin-1 is highly flexible and adopts an open conformation in the absence of cargo
Kinesin-1 is an essential anterograde microtubule motor protein. The core kinesin motor is a homodimer of two heavy chains; N-terminal motor domains hydrolyse ATP and walk along microtubules, whilst a...
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Andrew MacAskill @macaskillaf.bsky.social · 05/02/2026
I really hope at the very least they let unsuccessful applications this round reapply...!
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Kirsty Grainger @kirstygrainger.bsky.social · 01/02/2026
Some initial reactions to the 'published on a Sunday afternoon' letter from the CEO of UKRI. 🧵 www.ukri.org/news/open-le...
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Andrew MacAskill @macaskillaf.bsky.social · 01/02/2026
hmm. not much reassurance here - other than the full new system will be up by the '2027 to 2028 financial period' and 'To repeat the point: levels of funding for curiosity-driven research will remain stable across this SR period and are reflective of recent years'. lets hope we can hold out...
ukri.org
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
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Giorgio Gilestro @giorgio.gilest.ro · 01/02/2026
I think we should make a bigger fuss about this. It is as existential as Trump's cuts and could not come at a worst moment for UK science, beaten by Brexit through visa costs, fewer students, and inflation. Plus: these top-down approaches NEVER WORK. NEVER. Haven't they learned anything?
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Mark A. Hanson @hansonmark.bsky.social · 31/01/2026
Both MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky
researchprofessionalnews.com
MRC instructs grant review boards to slash funding rates - Research Professional News
Boards asked to recommend just three applications for funding, as BBSRC also suspends calls
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Andrew MacAskill @macaskillaf.bsky.social · 05/01/2026
Great opportunity here! For amazing science as well as proximity to the calanques 😅
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Chunyu Ann Duan @annduan.bsky.social · 14/12/2025
New preprint from the lab! A frontal motor circuit for economic decisions and actions: www.biorxiv.org/content/10.6... We use a novel task in mice, cortex-wide imaging and optogenetics, NPX recording and modelling to reveal a circuit mechanism that transforms abstract decisions to spatial actions.
biorxiv.org
A frontal motor circuit for economic decisions and actions
Flexible behaviour requires transforming abstract cognitive representations, such as value preferences, into concrete motor actions. During economic decision-making, individuals evaluate options to gu...
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Andrew MacAskill @macaskillaf.bsky.social · 14/11/2025
Congrats to Ella for her new paper! She asked a really interesting question about how the brain represents uncertainty during hidden state inference, and in a lovely crossover with theoretical work, she shows that in mice, acetylcholine dynamics play a crucial role. www.biorxiv.org/content/10.1...
biorxiv.org
Acetylcholine reflects uncertainty during hidden state inference
To act adaptively, animals must infer features of the environment that cannot be observed directly, such as which option is currently rewarding, or which context they are in. These internal estimates,...
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Andrew MacAskill @macaskillaf.bsky.social · 06/11/2025
come join our dept as a fellow - and join a fantastic crew of people using interdisciplinary approaches to investigate the brain across scales - from molecules to behaviour. reach out if you have any Qs!
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Simon Gosden @simongosden.bsky.social · 04/10/2025
Today is the 89th anniversary of The Battle of Cable Street when the people of the East End of London halted the march of Oswald Mosley’s Blackshirts through Stepney.
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Mayor of London, Sadiq Khan @london.gov.uk · 17/09/2025
In London, hate will never win.
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Current Biology @currentbiology.bsky.social · 08/09/2025
True. Current Biology on the other hand...
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Tim Verstynen @tdverstynen.bsky.social · 15/08/2025
This had me laughing to tears. The person sitting next to me on the flight must have thought I was nuts. A must read for the FEP curious. www.researchgate.net/publication/...
researchgate.net
(PDF) The Exit Manual: How to Leave the Free Energy Cult and Still Get Tenure
PDF | This manual is not a plea. It is a jailbreak from a cult—the Free Energy Principle, a theoretical metastasis that began in computational... | Find, read and cite all the research you need on Res...
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Ilana Witten @ilanawitten.bsky.social · 05/08/2025
We're looking for a research assistant to work in our neuroscience lab at @princetonneuro.bsky.social @hhmi.org where we study learning and decision-making circuitry. Apply here: research-princeton.icims.com/jobs/21001/r... Pls share w/ anyone who might be interested!
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Nadine Dijkstra @nadinedijkstra.bsky.social · 08/08/2025
🚨Amazing opportunity: position available for a new associate/full professor at the FIL @imagingneuroucl.bsky.social @uclbrainscience.bsky.social! Do you have a neuroimaging-focused research program? Get applying! 🚨 www.ucl.ac.uk/work-at-ucl/...
ucl.ac.uk
UCL – University College London
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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Magnus Løvold @magnuslovold.bsky.social · 23/07/2025
The story — written by journalist @emmaanne.bsky.social — raises tough questions about the perverse incentives at play in mine action. Emma reached out @thehalotrust.bsky.social for comment. They declined. Read the full story: spoileralerts.substack.com/p/questionab...
spoileralerts.substack.com
Questionable incentives
Why is the CEO of the world’s largest demining organisation defending banned landmines?
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Andrew MacAskill @macaskillaf.bsky.social · 19/06/2025
🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here: www.nature.com/naturecareer...
nature.com
Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324
About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out
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