Hepatic stellate cells (HSCs) are the key cellular drivers of liver fibrosis. During liver injury and chronic inflammation HSCs adopt an activated phenotype and secrete fibrotic extracellular matrix (...

ALT: Carol Beer: Computer Says No (Little Britain)

Summary: The placenta is the only mammalian organ that harbors a cancer-like genome while remaining functional and healthy. This Review highlights its high mutational load, structural variants, aneupl...

Autophagy has a highly complex and context-dependent role in cancer, challenging the development of autophagy-modulating strategies. This Review discusses the potential of targeting autophagy to count...

Microtubules are key components of the eukaryotic cytoskeleton involved in vital functions in virtually every cell. Among the emerging molecular mechanisms to adapt microtubules to their diverse funct...

Here the authors show that αV-class integrins distinguish the RGD motif of vitronectin from other ligands and, within seconds, deploy β-subunit-specific, load-dependent programs in which αVβ3 and αVβ5...

Proteins that distinguish quiescent cells from other non-proliferative states and actively regulate their return to proliferation remain poorly understood. Here, we combined quantitative proteomics wi...

Prostate cancer (PCa) progression is accompanied by profound alterations in cell-extracellular matrix (ECM) adhesion, nuclear architecture and mechanical adaptability, yet the molecular mechanisms lin...

Summary: Integrin function is dynamically shaped by post-translational modifications that regulate folding, trafficking and signalling, highlighting combinatorial control of cell–matrix adhesion in pr...

UKRI is updating its grant assessment approach to speed up grant decisions, respond to generative AI and ensure we continue backing the best talent and ideas.

John Burn-Murdoch hears about the unheard revolution changing the world of healthcare.

In this Review, Grimm et al. describe the range of non-invasive diagnostic imaging approaches to monitor the various hallmarks of cancer and how their implementation is shaping clinical practice.

Scientists share help and advice on how they got their research discussions flowing.

Humans are around 70% water. But where is it all? And what's it doing inside us?

Our 'Cell Science at a Glance' articles are short primers that act as an introduction to an area of cell biology. Perfect if you're new to a field, or want to find out the latest on a particular topic...

Here, Sun et al. demonstrate that loss of the transcription factor STAT5A reduces α-actinin-1 expression, leading to collapse of the actin cytoskeleton. Th

Key Points. A four–residue IPRR insertion enhances kindlin-3 membrane recruitment and promotes β2 integrin activationFERMT3 alternative splicing dynamicall

Most original articles published in the medical literature report the results of multiple statistical tests. In a few simple cases, there is agreement on whether to adjust for the number of performed...

A biology journal that paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.

Nature Reviews Gastroenterology & Hepatology, Published online: 29 June 2026; doi:10.1038/s41575-026-01223-7Liver fibrosis drives chronic liver disease and liver cancer. This Review dissects how actin cytoskeleton dynamics and related pathways govern hepatic stellate activation and fibrogenesis with implications for targeted therapy.

Google Scholar provides a simple way to broadly search for scholarly literature. Search across a wide variety of disciplines and sources: articles, theses, books, abstracts and court opinions.

Extracellular fibrillin-1 is present in many tissues, including adipose tissue. Mutations in fibrillin-1 cause Marfan syndrome, paradoxically presenti…

Mani, Tardif, Rossier et al. show that mechanical stress triggers caveolin-1 release from caveolae, enabling its diffusion in the plasma membrane and interaction with signalling effectors to regulate ...

A spatially resolved map of the human proteome across a variety of healthy tissues and cancers provides wide-ranging insights in developmental biology and oncology, and could aid the identification of...

A new study finds that hundreds of lives have been saved since school-age girls were offered the HPV jab in 2008.

Every year, thousands of cancer patients treated at The Christie NHS Foundation Trust, Manchester University NHS Foundation Trust and Northern Care Alliance NHS Foundation Trust choose to donate tissue samples to the Manchester Cancer Research Centre Biobank.

Cancer-associated thrombosis (CAT) is the second leading cause of death in cancer patients, with venous thromboembolism affecting 20–30% of cases. While conventional models emphasize biochemical media...

Background Integrin alpha 6 (ITGA6) has been implicated in tumorigenesis and progression, but its roles across cancer types and its functional significance in uveal melanoma (UVM) remain incompletely ...