Reposted by Cas Blaauw
Are weak TF motifs important? Weilert et al use deep learning to systematically map low-affinity pioneer binding sites in mESCs and show that they cooperate with strong pioneer motifs to drive chromatin opening. Paper: www.cell.com/cell-genomic... Preview w/ Grace Bower: www.cell.com/cell-genomic...
cell.com
Deep learning uncovers hidden power of low-affinity motifs
Low-affinity transcription factor binding sites are functionally important but difficult
to map and mechanistically poorly understood. In this issue of Cell Genomics, Weilert
et al. leverage sequence-...
