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James Ware

@jamesware.bsky.social
769 followers 98 following 14 posts

Clinician Scientist. Cardiovascular genetics, genomics in healthcare, inherited cardiac conditions, open science, patient participation. He/him. profiles.imperial.ac.uk/j.ware

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James Ware @jamesware.bsky.social · 17/09/2026
Scholarship and short-talk deadlines are approaching (30 Sept) for @keystoneSymposia.bsky.social Genetic Medicines to Treat Cardiovascular Disease, this January in Keystone. A great line up of speakers. See key dates: keysym.us/KSCardioGeneMed27 #KSCardioGeneMed27
keysym.us
Genetic Medicines to Treat Cardiovascular Disease | Keystone Symposia
Join us at the Keystone Symposia on Genetic Medicines to Treat Cardiovascular Disease, January 2027, in Keystone, with field leaders!
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James Ware @jamesware.bsky.social · 21/11/2025
Excellent post-doc opportunities for collaborative scientists at the LMS...
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 20/11/2025
📣 We’re hiring 6 new Team Science postdocs! Our Team Science approach brings together interdisciplinary researchers to tackle questions no single field can solve alone. Find out more and download our brochure below
lms.mrc.ac.uk
MRC Postdoctoral Research Scientists x 6 - MRC Laboratory of Medical Sciences
Team Science Project
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The Heart Hive @thehearthive.bsky.social · 24/07/2025
Last week we went to the Cardiomyopathy UK Midlands HCP Study Day to share what we’re doing with specialists from across the UK. Thank you to everyone who has been helping us to open up research to more people, and to all the Heart Hivers who have given up their time to take part in research ❤
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Mallory Freeberg @malloryfreeberg.bsky.social · 23/07/2025
🧬 New @emblebi.bsky.social service beta launched: Perturbation Catalogue 🔎 Browse genetic perturbation datasets 🧠 Train models 🧬 Interpret variant function 🧭 Explore gene dependencies Search, test APIs, suggest datasets, send feedback! 🔗 www.ebi.ac.uk/perturbation... Funded by @opentargets.org
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 09/07/2025
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue. A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
lms.mrc.ac.uk
Study reveals the hidden benefits of weight loss on fat tissue
Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...
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Magdalena Skipper @magdalenaskipper.bsky.social · 08/05/2025
Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research. #academicSky 🧪 www.nature.com/articles/d41...
nature.com
Renewal of NIH grants linked to more innovative results, study finds
Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.
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Jodie Ingles @jodieingles27.bsky.social · 17/04/2025
Our paper now published! 🙌🏻🧬🫀 @alexbutters25.bsky.social @k-jt.bsky.social @njhenden.bsky.social @dgmacarthur.bsky.social @kathrynmcgurk.bsky.social @jamesware.bsky.social @sharday-penn.bsky.social @rdbagnall.bsky.social @garvaninstitute.bsky.social @escardio.bsky.social doi.org/10.1093/eurh...
doi.org
A rare splice-site variant in TNNT2: the need for ancestral diversity in genomic reference data sets
Inherited cardiomyopathies, including hypertrophic (HCM), dilated (DCM), and restrictive (RCM) cardiomyopathies affect ∼1 in 200–500 in the population. Gen
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 28/04/2025
There's still time to apply for an Emerging Innovators Fellowship for scientists of Black heritage! If you’re ready to take the next step in your career and make an impact in the world of biomedical research, we encourage you to apply. Applications close 11 May 2025. Find out more 👇
lms.mrc.ac.uk
Emerging Innovators Fellowship - MRC Laboratory of Medical Sciences
The Emerging Innovators Fellowship is a new 3-year fully-funded postdoctoral fellowship for scientists from Black Heritage Backgrounds.
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Alex Butters @alexbutters25.bsky.social · 24/02/2025
🚨 New paper alert! 🚨 Using SHaRe registry data, we explored how clinical & genetic risk factors influence heart failure, arrhythmias, and mortality in men & women with HCM. This study, from my PhD, emphasises the need for sex-specific approaches to improve care. 📖 Read more: bit.ly/41vlF9r
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Sean @seanlzheng.bsky.social · 18/02/2025
🚨Our double header on genetics of hypertrophic #cardiomyopathy out today in @naturegenet.bsky.social 🧬 📍GWAS www.nature.com/articles/s41... 📍polygenic scores www.nature.com/articles/s41... A consortia effort by @jamesware.bsky.social Hugh Watkins @conniebezzina.bsky.social Rafik Tadros & Anuj Goel
nature.com
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Jodie Ingles @jodieingles27.bsky.social · 18/02/2025
Q: How many genes should be tested for patients with hypertrophic cardiomyopathy? A: 29 Excited to share our latest: Re-Appraisal of HCM genes by our ClinGen Hereditary CVD Gene Curation Expert Panel out today in @jaccjournals.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Genes Associated With Hypertrophic Cardiomyopathy: A Reappraisal by the ClinGen Hereditary Cardiovascular Disease Gene Curation Expert Panel
Hypertrophic cardiomyopathy (HCM) is an inherited cardiac condition affecting ∼1 in 500 and exhibits marked genetic heterogeneity. Previously publishe…
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Jodie Ingles @jodieingles27.bsky.social · 18/02/2025
TWO STAR co-first authors did most of the heavy lifting on this: Sophie Hespe and Amber Waddell 🌟 🌟 And huge high five to our biocurators and experts @jamesware.bsky.social @roddywalsh.bsky.social @chloereuter.bsky.social @andrewlandstrom.bsky.social @anwarchahal.bsky.social +++
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Kathryn McGurk @kathrynmcgurk.bsky.social · 22/11/2024
We’re really excited to focus on understanding takotsubo cardiomyopathy. Have your say and take part in research to help us find the causes, risks, and treatments 💪🫀🧬 @thebhf.bsky.social
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Andrea Ganna @andganna.bsky.social · 07/02/2025
The long awaited European guidelines for the use of Polygenic score for primary prevention of cardiovascular diseases are out! It took > 10 years from the first results proposing its use as additional screening factor among patients with intermediate CVD risk academic.oup.com/eurheartj/ad...
academic.oup.com
Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease: A clinical consensus statement of the ESC Council on Cardiovascular Genomics, the ESC Cardiovascular...
Abstract. Genome-wide association studies have revealed hundreds of genetic variants associated with cardiovascular diseases (CVD). Polygenic risk scores (
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British Heart Foundation @thebhf.bsky.social · 07/02/2025
Most cardiac arrests happen at home, and knowing CPR could save the life of someone you love. All you need is your phone and a cushion to learn CPR in just 15 minutes, for free with RevivR. Be ready for when it matters most. ❤️ Find out more about RevivR here: bit.ly/3E7D0fg:
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The Heart Hive @thehearthive.bsky.social · 05/02/2025
February is #HeartMonth! Want to get involved in heart research but not sure how? The Heart Hive is an online portal where you can sign up to take part in research studies. Go to thehearthive.org to find out more and register today. #NationalHeartMonth #HeartResearch #ParticipateInResearch
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Kathryn McGurk @kathrynmcgurk.bsky.social · 06/02/2025
Fantastic to work with Emma, a patient-scientist with DCM, on this review informed by her perspective, please check it out! www.cambridge.org/core/journal...
cambridge.org
Dilated cardiomyopathy in the young: a patient-scientist informed review of unmet needs | Cardiology in the Young | Cambridge Core
Dilated cardiomyopathy in the young: a patient-scientist informed review of unmet needs
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Mark Lindsay @markelindsay.bsky.social · 09/01/2025
🚨🚨🚨 In collaboration with @pnatarajanmd.bsky.social we are excited to launch gVasc, a new biobank focused on the genetics of spontaneous coronary artery dissection (SCAD)! with a participant-facing enrollment portal, 👉 gvascstudy.org 👈
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deciphergenomics.bsky.social @deciphergenomics.bsky.social · 08/01/2025
The prevalence for cardiomyopathies is also now displayed for genes associated with cardiac disorders @jamesware.bsky.social @kathrynmcgurk.bsky.social
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deciphergenomics.bsky.social @deciphergenomics.bsky.social · 08/01/2025
Cardiac case/control cohort data, which demonstrates the confidence of cardiac gene-phenotype relationships associated with specific variant classes, has been updated; more variant classes e.g. canonical splice site variants @jamesware.bsky.social @kathrynmcgurk.bsky.social
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deciphergenomics.bsky.social @deciphergenomics.bsky.social · 08/01/2025
Estimated population penetrance for variants associated with cardiomyopathies are now displayed alongside cardiac allele frequencies. This information is useful when considering secondary findings @jamesware.bsky.social @kathrynmcgurk.bsky.social
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deciphergenomics.bsky.social @deciphergenomics.bsky.social · 08/01/2025
DECIPHER version 11.29 has been released. See the new features at www.deciphergenomics.org #variantinterpretation
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 06/01/2025
We’re hiring for Programme Leader Track positions! This is an outstanding opportunity to advance your career in a discovery science institute of world-leading excellence. Application deadline is 13 January 2025. lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
Programme Leader Track - MRC Laboratory of Medical Sciences
Programme Leader Track appointments are an open-ended contract, which comprises a six-year advanced career development scheme after which you will be considered for promotion to Programme Leader.
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James Ware @jamesware.bsky.social · 08/01/2025
Are you a computational biologist, looking for a role in a diverse and collaborative team, and eager to help us understand genetic heart muscle diseases? Come and join us. Closing date 12th January...
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Wiebke Arlt @wiebkearlt.bsky.social · 24/12/2024
Check out our @mrc-lms.bsky.social Programme Leader Track opportunities - open for Submission of applications until 13/01/2025, interviews for shortlisted candidates in March lms.mrc.ac.uk/wp-content/u... #scisky #medsky
lms.mrc.ac.uk
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 17/12/2024
We’re delighted to share our recruitment brochure for our current Programme Leader Track vacancies at the MRC Laboratory of Medical Sciences. You can download the brochure on our vacancy web page 👇 lms.mrc.ac.uk/work/vacanci...
lms.mrc.ac.uk
Programme Leader Track - MRC Laboratory of Medical Sciences
Programme Leader Track appointments are an open-ended contract, which comprises a six-year advanced career development scheme after which you will be considered for promotion to Programme Leader.
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James Ware @jamesware.bsky.social · 10/12/2024
Fantastic opportunity of funded research position for clinician scientists in training (predoctoral fellowships). Come and see why the LMS is a fun and rewarding place to do science...
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 04/12/2024
The deadline to apply for our PhD studentships is fast approaching! If you’d like to study a PhD at the LMS make sure to get your applications in by the 6th of December! If our world class science isn't convincing enough, then hear what our students have to say lms.mrc.ac.uk/work-and-stu...
Image of a PhD student next to a quote by him - “I immediately felt at home at the LMS thanks to my highly supportive research group and friendly research environment. The state-of-the-art building with its wonderful facilities makes it a true joy for me to come to work every day and contribute to the growing body of science in the field of human infertility”
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MRC Laboratory of Medical Sciences @mrc-lms.bsky.social · 03/12/2024
#ParentalLeave is an important part of the journey towards #GenderEquity at the workplace, which is why the LMS supports those on parental leave through our #RovingResearchers www.nature.com/articles/d41...
nature.com
Could roving researchers help address the challenge of taking parental leave?
Institutions are taking notice of a handful of programmes designed to address the issues scientists face when choosing to take a long-term absence.
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Declan O’Regan @drdeclanoregan.bsky.social · 29/11/2024
The @mrc-lms.bsky.social kicks off at the wonderful Royal Institution with talk on #teamscience by @wiebkearlt.bsky.social.
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James Ware @jamesware.bsky.social · 22/11/2024
It turns out much needed huge international efforts on dilated cardiomyopathy are like buses: 🚌🚌 ... nature.com/articles/s41... nature.com/articles/s41... ... bsky.app/profile/conn... bsky.app/profile/sean... ... Look forward to plans to bring all this together...
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James Ware @jamesware.bsky.social · 21/11/2024
It's nice to be able to kick off on bsky with this story from Sean & Albert - a partnership with Tom Lumbers and the Hermes consortium to tackle the genetics of DCM.
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James Ware @jamesware.bsky.social · 21/11/2024
Hi. Noob skeeting/tweeting/posting here for first time. Finally transitioning to bsky for all the reasons… I lead a research group in London, UK, focused on cardiovascular genetics, and genome medicine more broadly. I look forward to connecting...
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Alex Hoischen @ahoischen.bsky.social · 18/11/2024
The preliminary #eshg25 program is online. Stellar line-up of invited speakers - full breadth of our amazing field. Grateful to a wonderful SPC @eshg that made this possible. See you all in Milan next year! 2025.eshg.org/programme-at...
2025.eshg.org
Programme at a Glance
Pre-conference courses Thursday, May 22, 2025 & Friday, May 23, 2025 - TBA Conference programme Saturday, May 24, 2025 08:30 - 10:00 Educational Sessions E01 E01 Single cell genomics and diseases W...
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Nicky Whiffin @nickywhiffin.bsky.social · 15/11/2024
I couldn't spot a starter pack for rare disease / clinical genomics, so I started one: go.bsky.app/SUWZ9Hw Very much a work in progress, and biased by who I have already found here, so please suggest people to add! Self-nominations encouraged. #ClinicalInformatics #genomics #bioinformatics 🖥️🧬
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Andrew Landstrom @andrewlandstrom.bsky.social · 18/11/2024
A landmark gene therapy study! Out today with NEJM AAV mediated gene replacement of LAMP2 in boys with Danon disease Phase 1 trial demonstrates a reasonable safety profile www.nejm.org/doi/pdf/10.1... This is a big deal #cardiosky #medsky #genetherapy #Dana at #AHA24 @ahascience.bsky.social
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Kathryn McGurk @kathrynmcgurk.bsky.social · 20/11/2024
Exciting first bluesky post! We estimated trabecular complexity in 50,000 UK Biobank participants to identify influencing genetic, clinical, and lifestyle factors. Trabeculation progresses with cardiac diseases and changes can occur early in pathogenesis.
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James Ware @jamesware.bsky.social · 14/11/2024
Thank you - a handy starter tool...
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