The Brantley Lab is seeking a Research Technician who is passionate about basic science and being a reliable, collaborative member of an academic research team. Research in the Brantley Lab uses quant...

Spermatogonial stem cells (SSCs) maintain male fertility, but how their clonal dynamics change with age remains poorly understood. Here, we use in vivo CRISPR barcoding in zebrafish to label SSCs and ...

In Drosophila, cell fate switching in adult intestinal stem cells is determined through an epigenetic mechanism in which these cells count divisions, switching from producing enterocytes to producing ...

In Metazoa, transposon expression is suppressed by the piRNA pathway, and disruption of this pathway leads to rampant transposon expression. However, it remains unclear whether increased transposon ex...

Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.

How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...

Using quantitative live imaging, Brantley et al. reveal that cells decode dynamic BMP signaling during dorsal patterning of the Drosophila embryo by integrating activity over time. These results advan...

A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.

Wednesday, April 22nd at 10 am ET (Eastern, US/Canada) Hosted by: European Molecular Biology Laboratory (EMBL) and Istituto Italiano di Tecnologia - RNA Technologies Flagship (IIT) Zoom Registration:...

Accurate estimates of allele frequencies aid in genetic discovery, including rare disease diagnosis, common disease investigations, and population genetics. Here, we present the Genome Aggregation Dat...

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

Precisely defining transcription unit boundaries across eukaryotic genomes is fundamental to understanding individual gene function and regulation. The multifaceted process of RNA 3' end formation es…

Featuring: "HEXIM1 Directs a Cell Type-Specific Transcriptional Program" Laurie Steiner, MD (U Rochester) & "Mechanistic insights into complete transgene insertion by R2 retrotransposon proteins" ...