iiinova — where your digital self keeps evolving

Reposted by Sean Ryder

Michael D. Green, PhD @michaeldgreen.phd · 28/05/2026

President of MIT not mincing words today in @statnews.com www.statnews.com/2026/05/27/s...

So let me say it as clearly as I can: Without basic scientific research, supported by the kind of farsighted public investment that allows large-scale, undirected, curiosity-driven inquiry, the scientific pipeline will run dry.
In daily life, people may not feel the effects right away, or even in 10 years. But we will feel it. And when someone we love needs therapies that could have emerged but didn't or when other countries now
investing in science can launch new science-based industries or run their societies on vast resources of fusion energy or reap the benefits of quantum computing power or advanced medical breakthroughs, America will wish it sustained its leadership in scientific research here and now.
Sally Kornbluth is the president of MIT.

Sean Ryder @seanryderphd.bsky.social · 26/03/2026

My lab released a new preprint today. The work is the culmination of a long term project led by Peren Coskun, Ph.D., who investigated the biological role of the C. elegans glp-1 3'UTR in its endogenous context. Please join me in congratulating Peren! www.biorxiv.org/content/10.6...

An image of C. elegans hermphrodite gonad, with DAPI stain in cyan and PH-3 immunofluorescence in red.

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Sean Ryder @seanryderphd.bsky.social · 03/03/2026

Please register at this link: forms.office.com/Pages/Respon...

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Sean Ryder @seanryderphd.bsky.social · 03/03/2026

The RNA Society and the Alliance for mRNA Medicines (AMM) are collaborating on communication and advocacy training for members. Please fill out this form if you would like to attend on March 6, 2:00-3:00pm ET. forms.office.com/Pages/Respon...

forms.office.com

Microsoft Forms

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Reposted by Sean Ryder

UMass Chan Medical School @umasschan.bsky.social · 26/12/2025

Sean Ryder, PhD, spoke with Worcester Magazine about RNA therapeutics and how they may treat a wide variety of health conditions in the future and the quest to separate facts from misconception: direc.to/oinD #RNA @seanryderphd.bsky.social @rti-umasschan.bsky.social @worcestermagazine.bsky.social

direc.to

Professor Sean Ryder: It's time to rock that ribonucleic acid

Can you rock the RNA? Professor Sean Ryder of UMass Chan Medical School's got a book for you.

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Sean Ryder @seanryderphd.bsky.social · 30/10/2025

I am grateful to share that the latest research paper from the lab is now published in RNA. This work was a wonderful collaboration with Francesca Massi’s lab. Please join me in congratulating co-first authors Asli Ertekin and Sharon Noronha. rnajournal.cshlp.org/content/31/1...

rnajournal.cshlp.org

A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

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Sean Ryder @seanryderphd.bsky.social · 26/10/2025

I gave a public educational seminar on the history of vaccines yesterday sponsored by @gain-indivisible.bsky.social. I encourage all scientists to give public educational seminars a shot. You’ll learn something and you will be surprised (in a good way) by the people you meet.

A professor stands at a podium in a Universalist Church, speaking to audience members in the pews.

The cover of a book titled Everyday RNA: The future of RNA medicine. The cover is pink with a single stranded nucleic acid cartoon.

The professor signing a copy of his book at a podium in a church.

A projected image on a TV screen of the title slide that reads "GAIN presents "From Cows to COVID (And Beyond): A brief history of vaccines" by Sean P. Ryder, Ph.D.

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Sean Ryder @seanryderphd.bsky.social · 19/10/2025

My son (the wizard), myself, and @repmcgovern.bsky.social at the #Worcester #NoKings rally put on by @gain-indivisible.bsky.social. It was a glorious day to fight the power with my people. Representative McGovern is my guy, 100%. He shows up and he tells it like it is.

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Reposted by Sean Ryder

Development @dev-journal.bsky.social · 30/09/2025

MEX-3’s untranslated region helps worms beat the heat This Research Highlight showcases the work from Sean Ryder (@seanryderphd.bsky.social) and colleagues: journals.biologists.com/dev/article/...

Figure 5: Germ layer patterning defects in the mex-3 Δ3′UTR mutant. (A) mex-3 RNAi results in dead embryos with a large expansion of muscle lineage cells (mesoderm, yellow). Control animals develop normally, with all three germ layers present and appropriately patterned. Cytoplasmic (C) green represents GFP::MEX-3 protein, nuclear (N) green indicates endoderm, nuclear (N) yellow indicates mesoderm and nuclear (N) red indicates ectoderm. (B) At elevated temperature, the mex-3 Δ3′UTR mutants form all three germ layers, but patterning appears defective with a moderate expansion of muscle lineage cells (yellow). (C) Fraction of embryos that appear normal versus abnormal binned as in Fig. 4. The genotype and the temperature of growth are shown. CTL is a control for the germ layer background (strain OD1854). All sample sizes and statistical test outcomes are listed in Table S3. Scale bars: 10 μm.

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Reposted by Sean Ryder

Development @dev-journal.bsky.social · 30/09/2025

To learn more about this work and the people behind it, we spoke to first author Hannah Brown and corresponding author Sean Ryder @seanryderphd.bsky.social, Professor and Vice Chair for Outreach, Biochemistry and Molecular Biotechnology @umasschan.bsky.social journals.biologists.com/dev/article/...

Sean Ryder and research group, including first author Hannah Brown. Picture shows seven people with their hands up and/or doing jazz hands in a hallway.

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Sean Ryder @seanryderphd.bsky.social · 26/09/2025

Help protect our hard-working federal employees at the NIH

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Sean Ryder @seanryderphd.bsky.social · 19/09/2025

Copies of "Everyday RNA" are arriving in the US. I ordered 30 copies—they arrived at my house yesterday. If you haven't pre-ordered a copy, your best bet is to order directly from World Scientific Press . The online retailers won't get them until later. www.worldscientific.com/worldscibook...

worldscientific.com

Everyday RNA

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Sean Ryder @seanryderphd.bsky.social · 10/09/2025

Amazon Rankings: #1 New Release in Biotechnology (#3 overall) #2 New Release in Medical Research (#25 overall) #3 New Release in Genetics (#10 overall) I have been assured by the publisher that it will be available in the first week of October. Thank you all for pre-ordering! everydayrna.com

everydayrna.com

Everyday RNA

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Sean Ryder @seanryderphd.bsky.social · 04/09/2025

In 2013, my father lost his life to multiple myeloma. Now, a variety of new treatment options are extending myeloma patient lives for years if not decades. It's been amazing to watch. Support the the NIH, fight back against RFK, and protect academic research. www.fastcompany.com/91388585/

fastcompany.com

Why a rare blood cancer has become a testing ground for cancer drug innovation

A model of innovation

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Reposted by Sean Ryder

Sam Wang @samwang.bsky.social · 29/08/2025

There’s a book from political scientists Macedo and Lee that claims the COVID-19 pandemic was not as much of a threat to public health as was supposed, calling into question the role of expertise. Here, an excellent corrective to that erroneous position: joshuasweitz.substack.com/p/revisionis...

joshuasweitz.substack.com

Revisionism in the Wake of Covid

A dialogue confronting the premise of revisionist efforts to diminish the pandemic's severity and dismantle public health institutions.

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Sean Ryder @seanryderphd.bsky.social · 26/08/2025

Newsweek is reporting the RFK plans an outright ban on mRNA vaccines in the United States within a few months. That's a huge mistake. Please, speak out against those who would derail the most promising technology to curb virus spread since Charles Maitland and cow pox.

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Sean Ryder @seanryderphd.bsky.social · 14/08/2025

I did a thing. I wrote a textbook about #RNA. I wrote it so that those without formal science training could understand what RNA is and how it is used in medicine. It releases in the US and Europe on September 8th. www.worldscientific.com/worldscibook...

A book cover with a strand of RNA on a pink background, with the title, authors name, and publisher.

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Reposted by Sean Ryder

Aaron and the Hoskins Lab at UW Madison @uwmadisonrna.bsky.social · 18/07/2025

Very timely review for those of you who have been following all of the recent developments in this area... also @cp-trendsbiochem.bsky.social why can't we share via bsky directly from the article???

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Reposted by Sean Ryder

Brad Lander @bradlander.bsky.social · 17/06/2025

Hi, it’s Meg again. Brad is still in ICE custody. We are grateful to the many friends, supporters, and allies who have gathered in Federal Plaza. Together we are standing up for those with no voice.

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Brad Lander @bradlander.bsky.social · 17/06/2025

Hi, this is Meg Barnette, Brad's wife. While escorting a defendant out of immigration court at 26 Federal Plaza, Brad was taken by masked agents and detained by ICE. This is still developing, and our team is monitoring the situation closely.

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Sean Ryder @seanryderphd.bsky.social · 15/06/2025

Grateful to share a microphone and a stage with one of the very best Congresspersons in the nation, @repmcgovern.bsky.social! This was at the #Worcester #NoKings rally. 2000+ energized attendees at the rally behind city hall. #GAIN

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Reposted by Sean Ryder

Greater Assabet Indivisible Network (GAIN) @gain-indivisible.bsky.social · 13/06/2025

Tomorrow we stand together. We stand for democracy. We stand for basic human decency. We stand so that our great Republic will not fall. We need you. We need ALL of you. Stand with us. Together we are Indivisible. Together we will have liberty and justice for all www.facebook.com/share/1AE97P...

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MeidasTouch @meidastouch.com · 12/06/2025

Longer video of the forcible removal, detainment, and arrest of Sen. Alex Padilla by the Trump regime during a DHS press conference. Footage provided by Sen. Padilla's team.

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Reposted by Sean Ryder

DudePool @dudepoolrising.bsky.social · 28/05/2025

No kings, masters, overlords or any of that bullshit. Time to take the country back.

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Sean Ryder @seanryderphd.bsky.social · 29/05/2025

Anybody else just completely over all of this? Like, for real? I wear this out of the house most places I go so turds know to leave me alone. What up, palanteeeer.

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Sean Ryder @seanryderphd.bsky.social · 20/05/2025

Chalk talks are always so much fun.

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Sean Ryder @seanryderphd.bsky.social · 18/05/2025

Research = New Discoveries = Hope Trump = Huge Cuts to #Science = No Research No Research = No Hope Trump = No Hope

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Sean Ryder @seanryderphd.bsky.social · 18/05/2025

Every American scientist needs to get real loud, real fast. Talk to the locals in your community. Work with patient advocacy groups relevant to your research. Explain what is happening in plain English. Go to the protests. Write op/eds. Speak at town halls. Don't be hogtied by fear. Do SOMETHING.

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Sean Ryder @seanryderphd.bsky.social · 18/05/2025

This made me giggle. Found out Reddit.

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Reposted by Sean Ryder

Harvard T.H. Chan School of Public Health @hsph.harvard.edu · 16/05/2025

With nearly all of Harvard Chan School’s direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work: hsph.me/whygive

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Sean Ryder @seanryderphd.bsky.social · 10/05/2025

On Thursday, ICE agents detained this Brazilian woman pulling her away her from her emotional 16 year old daughter and an infant. Then, four Worcester PD arrested the daughter too, for disorderly conduct. The WPD has recently been investigated by DOJ for excessive force and other abuses of power.

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Sean Ryder @seanryderphd.bsky.social · 08/05/2025

While legislators in several states debate whether or not mRNA should be classified as a "weapon of mass destruction", the latest clinical trial data from Moderna on a combined flu / covid shot shows excellent results. jamanetwork.com/journals/jam...

jamanetwork.com

Immunogenicity and Safety of Influenza and COVID-19 Multicomponent Vaccine

This study examines the immunogenicity and safety of an investigational mRNA-based vaccine against seasonal influenza and SARS-CoV-2 in adults 50 years and older.

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Sean Ryder @seanryderphd.bsky.social · 05/05/2025

This is my experience www.msn.com/en-us/news/u...

msn.com

MSN

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Sean Ryder @seanryderphd.bsky.social · 03/05/2025

I strongly believe this is the plan for the NIH, and has been the plan all along, and I need for scientists to get super vocal about it or we are all cooked. donmoynihan.substack.com/p/the-nih-bu...

donmoynihan.substack.com

The NIH budget is on a fast track to disaster

An NIH insider explains what Republicans are likely to do next, and what we can do

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Sean Ryder @seanryderphd.bsky.social · 03/05/2025

Something positive Saturday. My son got an award at his high school that comes with a 40K /year scholarship to RPI 😮. His friend Annabelle also got an award too, from a different school.

Two high school kids posing for the camera

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Sean Ryder @seanryderphd.bsky.social · 02/05/2025

As anticipated, the White House has officially requested an $18 billion cut to the FY2026 #NIH budget (among lots of other cuts). The full guidance from the White House to the appropriations committee is linked. NIH is on page 12. #braindrain #sciencexit www.whitehouse.gov/wp-content/u...

whitehouse.gov

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Dr. Lucky Tran @luckytran.com · 30/04/2025

A new study by economists estimates that a 25% cut in science funding would result in a GDP decline similar in magnitude to the 2008 recession. They also estimate that a 75% cut to government science would trigger a larger GDP decline than in any recession since the Great Depression.

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Jamie Gangel @jamiegangel.bsky.social · 30/04/2025

“Trump budget draft ends Narcan program and other addiction measures. A $56 million grant to train emergency responders and supply them with the overdose reversal spray, plus other programs that address addiction, could be eliminated.” www.nytimes.com/live/2025/04...

nytimes.com

Trump budget draft ends Narcan program and other addiction measures.

A $56 million grant to train emergency responders and supply them with the overdose reversal spray, plus other programs that address addiction, could be eliminated.

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Sean Ryder @seanryderphd.bsky.social · 28/04/2025

The John Oliver segment on the #NIH was great! The whole episode is hilarious, but the NIH stuff starts at 8:08 youtu.be/8H34jcpEsFs

youtu.be

RFK Jr. & HHS: Last Week Tonight with John Oliver (HBO)

YouTube video by LastWeekTonight

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Reposted by Sean Ryder

Carl T. Bergstrom @carlbergstrom.com · 26/04/2025

They are taking away our vaccines. Jay Bhattacharya is talking about eliminating mRNA vaccines. Meanwhile, RFK Jr. has managed to ratfuck the Novavax approval process.

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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 27/04/2025

Can confirm: 60 Minutes will be worth watching tonight about #NIH.

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