Precisely defining transcription unit boundaries across eukaryotic genomes is fundamental to understanding individual gene function and regulation. The multifaceted process of RNA 3' end formation es…

Precisely defining transcription unit boundaries across eukaryotic genomes is fundamental to understanding individual gene function and regulation. The multifaceted process of RNA 3' end formation es…

Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

In this episode, Dr. Jurgi Camblong travels to the University of Oxford to meet Professor Nicholas Proudfoot, one of the true pioneers of molecular biology.

Author summary Genes are turned on or off through complex processes involving many proteins that interact with DNA wrapped histones and modify their structure. These changes, known as epigenetic modif...

Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restrictor acts over a downstream “restriction zone.” For transcription to proceed, CDK7/9 oppose Integrator, while U1 snRNP counteracts both Integrator and Restrictor.

Estell and Łazowski et al. show that Integrator and Restrictor form distinct pathways for early attenuation of RNA polymerase II: Integrator acts at the promoter-proximal pause site, whereas Restricto...

This fellowship is for non-UK scientists who are at an early stage of their research career and wish to conduct research in the UK.

Best local food destinations in the world according to audience ratings for local restaurants, iconic dishes, and ingredients from the respective regions.