Recent changes in Genentech’s scientific organization, occurring as the company makes artificial intelligence (AI) increasingly central to its research strategy, highlight a broader question facing bi...

Microtubules are key components of the eukaryotic cytoskeleton involved in vital functions in virtually every cell. Among the emerging molecular mechanisms to adapt microtubules to their diverse funct...

The ciliary transition zone (TZ) regulates ciliary proteome composition, yet its molecular architecture, protein content, and contribution to motile ciliopathies remain poorly defined. We applied in situ cryo-electron tomography and subtomogram averaging ...

Microtubules are essential components of the cytoskeleton, yet important links between their molecular properties and organismal functions remain unresolved. In this Roadmap, Janke et al. discuss key ...

Polarized epithelial cells assemble a primary cilium by an unknown mechanism. After cytokinesis, the central part of the intercellular bridge, which is ref

Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,

Cheng, Fan, and colleagues develop CenSegNet, a generalist AI framework for large-scale mapping of centrosome phenotypes, uncovering distinct patterns associated with breast tumour heterogeneity, dise...

The Helsen lab at the University of Geneva explores how centromeres and chromosomes evolve, diversify, and function across eukaryotes. Discover our latest publications, research team, and open positio...

The recent launch of qed’s “top 1%” preprint ranking has sparked controversy, with concerns about its arbitrary nature, potential harm to authors, and low-quality inclusions. Whil…

A spatially resolved map of the human proteome across a variety of healthy tissues and cancers provides wide-ranging insights in developmental biology and oncology, and could aid the identification of...

How physically magnifying objects using a key ingredient in diapers has opened an unprecedented view of the microbial world.