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Kris Willis

@kawillis.bsky.social
303 followers 117 following 879 posts

Systems biologist, data scientist, policy wonk, runner. Former NIH-funded investigator, former NIH program official. Founder, Woodley Park Institute. Writing about understanding and accelerating scientific progress at theprogressbarwpi.org

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Reposted by Kris Willis
elizabethginexi.bsky.social @elizabethginexi.bsky.social · 2h
NIH’s move toward multiyear funding is a major reason for the drop in grant numbers: The agency now commits several years of funding at once to fewer awards, rather than paying for projects one year at a time. www.the-scientist.com/federal-rese...
the-scientist.com
NIH Grant Awards Fall to a Six-Year Low in FY2026 | The Scientist
A public dataset from Grant Witness shows NIH has issued about 11 percent fewer grant awards this fiscal year than its five-year average pace.
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Kris Willis @kawillis.bsky.social · 30/09/2026
The drive to help patients is the fundamental source of the culture of urgency that permeates so much of biomedical research. Delays cost literal lives. 🧪 #SupportBreakthroughs #SupportScience
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Eos @eos.org · 29/09/2026
NASA has ignored recommended funding levels for planetary research & analysis for 15 years, according to a new investigative report by Mark Sykes (@coop.planetary-research.org). And for FY2025, it hasn’t even spent 50% of what it budgeted for R&A. 🧪🪐🔭 eos.org/research-and...
eos.org
NASA has Underspent on Research and Analysis for 15 Years - Eos
Spending for NASA’s research and analysis programs has remained relatively flat for 15 years, ignoring recommendations from community-led decadal surveys and directives by Congress.
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Carl T. Bergstrom @carlbergstrom.com · 27/09/2026
Ignore for a moment the question about whether Anthropic trains on user sessions. I am I right in reading this as saying that Anthropic's "never-before-discovered" reverse transcriptase was *patented* three years ago?
Dr. Mestre first encountered the enzymes in jumbo phages in 2022 while searching for new reverse transcriptases. He worked briefly as a consultant for ReNegade Therapeutics, which filed a patent in 2023 on a number of reverse transcriptases, including the ones Dr. Mestre found. He is listed as a co-inventor on the patent filing.
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Greg Priest @gregpriest.bsky.social · 25/09/2026
Thomas Hunt Morgan was born OTD in 1866. If you're ever feeling that your work is uending and unedifying, remember that he once said this: "Two years work wasted, I have been breeding those flies for all that time and I've got nothing out of it." 🌱🐋🧪 #HistSTM
Photograph of Morgan's Fly Room at Columbia University, around 1920. American Philosophical Society.
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Kris Willis @kawillis.bsky.social · 24/09/2026
👀🧪
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Reposted by Kris Willis
AP Stylebook @apstylebook.com · 23/09/2026
Artificial intelligence systems do not think, feel, want or understand. Avoid language that gives them human characteristics.
apnews.com
https://apnews.com/article/openai-safety-ai-framework-089e75b95bc935af092da7b79d92706d
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Harmit Singh Malik @harmitmalik.bsky.social · 24/09/2026
Some random thoughts: Good science doesn't always need disruptors. Often, it needs load-bearing walls. You can't pivot away from a failed multi-year experiment or "iterate" your way out of a mentee's PhD. Science needs stable foundations, not churn. Don't break the people building on top of it.
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Kris Willis @kawillis.bsky.social · 22/09/2026
Really important, considering the discussions about using “golden ticket” mechanisms to distribute grant funds. This is why we need to study what works, and make decisions based on data not vibes.
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Stuart Buck @stuartbuck.bsky.social · 22/09/2026
Just published this guest column about a huge White House vs. NIH battle that no one has yet publicly noticed: newsletter.goodscienceproject.org/p/policy-imp...
newsletter.goodscienceproject.org
Policy Impoundment
How OMB is using Regulatory Review to Slow NIH Policymaking
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American Association for the Advancement of Science @aaas.org · 21/09/2026
Read the statement from AAAS CEO Sudip Parikh on reports about seizing political control of NIH research: www.aaas.org/news/statement-reports…
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 18/09/2026
“the rest of society cannot be in the position of constantly pleading with A.I. executives to act altruistically. A key role of government is to protect society’s best interests from private interests.”
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Federation of American Scientists @scientistsorg.bsky.social · 18/09/2026
If you believe this – like we do – then we welcome you to share with us your ideas. We know a thing or two about turning evidence-based, scientifically-backed ideas into tangible public policy. We did it in 1946. We can do it again. Scientists, the world needs you yet again.
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Federation of American Scientists @scientistsorg.bsky.social · 18/09/2026
This is why we exist. The McMahon Act. The Clean Air Act/s. When our president revealed the CIA was spying on people by opening their mail in the 70s. Now artificial intelligence. We believe scientists have a duty to prevent the fruits of their labor for being used for malice.
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kate k @kathrwn.bsky.social · 18/09/2026
shoutout to the new york times editorial board for conveniently failing to mention that "public campaign by scientists" was lead by an organization that still exists today and is actually working on policy solutions to AI as an existential risk 🤪 anyway 👇
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Cole Donovan @colesci.bsky.social · 17/09/2026
If the awards are low value, then need to consider how many awards are needed to actually run a lab successfully. When agencies demand more accountability from grantees, they themselves should also be more accountable for the actual workload that they’re creating and how that’s used.
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Cole Donovan @colesci.bsky.social · 17/09/2026
This is really key. The amount of time spent applying for funding and the stress of meeting application deadlines is absolutely part of the overall burden. Pair that with low success rates, number of proposals needed to be submitted to get funded, and you have a closer estimate of actual burden.
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Kris Willis @kawillis.bsky.social · 17/09/2026
As a former program official, I know it takes time for the community to become aware of a funding opportunity, no matter how hard you work to advertise it. 4 weeks between publication and application due date means only a subset of potential applicants are likely to respond.
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Alisa Bokulich @alisabokulich.bsky.social · 17/09/2026
Now also a paid part-time *graduate student* internship @ Harvard Smithsonian Center for Astrophysics working on American Women's History Museum project to make scientific work of 19th-& early 20th-century women more findable & accessible Deadline: October 5, 2026 #HPS www.indeed.com/viewjob?jk=a...
indeed.com
Graduate Student Research Intern | History of Women in Science - Cambridge, MA 02138 - Indeed.com
Apply for the Graduate Student Research Intern | History of Women in Science job in Cambridge, MA! Learn more about the job description, salary, and job details to see if you qualify on Indeed today.
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Kristian G. Andersen @kgandersen.bsky.social · 16/09/2026
"Pennsylvania’s Measles Outbreak Is Enormous". Indeed it is. Given 4 _reported_ deaths from measles and given a 0.1% - 0.3% CFR, the true number of cases - currently reported at 731 - is likely a couple/few thousand. That is big - and 100% vaccine preventable. www.theatlantic.com/health/2026/...
theatlantic.com
Pennsylvania’s Measles Outbreak Is Enormous
The two latest deaths suggest that the true number of infections is much larger than reported.
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STAT @statnews.com · 15/09/2026
A fourth measles death is reported in Pennsylvania — via @apnews.com www.statnews.com/2026/09/15/f...
statnews.com
A fourth measles death is reported in Pennsylvania
Pennsylvania officials have reported a fourth measles-associated death within the past month, the latest in an unvaccinated 18-year-old.
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 15/09/2026
Pls share: Princeton has an open rank faculty search in the areas of cancer biology, cancer prevention, and cancer-relevant computational science, including connections between cancer and immunology or metabolism. apply.interfolio.com/191852
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Joe Bak-Coleman @jbakcoleman.bsky.social · 15/09/2026
I was pretty chuffed about science when the doctors at NYU figured out why my face had gone numb and I had lost the ability to speak and swallow. They turned to the scientific literature, which guided them through keeping me from dying from a rare disorder and regaining the ability to speak and eat.
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Mark Peifer (He, him) @peiferlabunc.bsky.social · 14/09/2026
These pictures of REAL chromatin in vivo will both blow your mind and blow out of the water those textbook diagrams of "higher order nucleosome structures"
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Kris Willis @kawillis.bsky.social · 13/09/2026
Of interest: a great explainer on what the national debt means for our ability to fund science, plus a valuable discussion of the concerning choices CDC has made regarding the reporting of recent measles deaths in Pennsylvania
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Alfonso Martinez Arias @amartinezarias.bsky.social · 12/09/2026
make this mutant, changed that residue, tried this technique, run that test….not to mention statistical analysis of gene expression data. We ignore real questions about the biology because, increasingly, we are forgetting about them.
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Needhi Bhalla 💅🏽 @needhibhalla.bsky.social · 11/09/2026
"The issues [we face] now are similar to issues that other scientific and creative professions are facing, and indicate issues that all of humanity might face: how to make sure that, as AI changes the way work is done, we do not lose sight of what that work was meant to achieve in the first place"
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Kris Willis @kawillis.bsky.social · 11/09/2026
Completely agree. Programs developed by #NIH and #NSF must be demonstrably responsive to both public need and scientific opportunity, not political agendas. 🧪
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Kris Willis @kawillis.bsky.social · 11/09/2026
Can someone in the #physics world please enlighten me as to how the “Weyl” in Weyl semimetals is pronounced? Is it “Wail” or “Well” or something less intuitive?
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Cole Donovan @colesci.bsky.social · 11/09/2026
Kris nails it
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Kris Willis @kawillis.bsky.social · 10/09/2026
Visiting friends @aip.bsky.social today!
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Reposted by Kris Willis
Mel Andrews @bayesianboy.bsky.social · 09/09/2026
Possibly a significant addendum to the LLM advancements on Navier-Stokes. The problem is not restricted to the model’s potential reproduction of training data, either. A team at OpenAI was prompting their models with the mathematicians’ unpublished work without their knowledge.
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Reposted by Kris Willis
Nature @nature.com · 08/09/2026
Nancy Grace Roman - honoured by the newest telescope in space - spearheaded a pioneering programme as NASA’s first chief astronomer, says Robert W. Smith go.nature.com/4A1qQgu
go.nature.com
‘Mother of Hubble’: how Nancy Grace Roman ushered in a new era of astronomy
The scientist honoured by the newest telescope in space spearheaded a pioneering programme as NASA’s first chief astronomer.
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Reposted by Kris Willis
Picard Tips @picardtips.bsky.social · 08/09/2026
Picard programming tip: A computer is like a mischievous genie. It will give you exactly what you ask for, but not always what you want.
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Terry McGlynn @hormiga.bsky.social · 03/09/2026
I'm only a few days into being an AAAS Policy Fellow, but if any of tweeps here are interested in applying, I'm glad to share about my application experience and what it's been like so far. Only 2% if my cohort are "senior" (>15 years post-PhD), but it's a great opportunity for experienced faculty!
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amanda @mndymn.bsky.social · 02/09/2026
AORs/signing officials (SO) still have access, but administrative officials (AO) no longer do, meaning they cannot upload JIT docs on behalf of PI. Potentially quite disruptive, depending on institutional workflow for submissions.
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Susan Ferrari @srferrar.bsky.social · 02/09/2026
Striking and worrisome data from NSF: compared to all institutions, emerging research institutions showed bigger drops in funding rate and # of new proposals funded over the past few years. Really curious what’s going on here.
Line chart data on NSF funding, comparing all institutions with a subset of emerging research institutions. ERIs show bigger recent drops than all institutions in funding rate and # of institutions funded.
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C&EN (Chemical & Engineering News) @cenmag.bsky.social · 02/09/2026
Ada Yonath, a structural biologist and Nobel laureate who pioneered the technique of cryo bio-crystallography, died Aug. 31, at the age of 87, according to a release from the Weizmann Institute of Science. #chemsky 🧪
cen.acs.org
Ada Yonath, Nobel laureate and crystallographer, dies at 87
She was awarded the 2009 Nobel Prize in Chemistry for her contributions to mapping the structure of the ribosome
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Jeremy Berg @jeremymberg.bsky.social · 02/09/2026
Many problems go away when you intentionally don’t collect the data.
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Drug Monkey @drugmonkey.bsky.social · 28/08/2026
Some stats on the % of MPI proposals here. Somewhat interesting. As is the claim NIH expected MPI to be unpopular- it’s 30%. grants.nih.gov/news-events/...
grants.nih.gov
When Are Two Heads Better Than One? Considerations When Using the NIH Multiple Principal Investigator Model | Grants & Funding
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Picard Tips @picardtips.bsky.social · 26/08/2026
Picard management tip: Don't scoff at unfamiliar suggestions. You don't know as much as you think.
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Chemjobber @chemjobber.bsky.social · 26/08/2026
apparently a speaker said "Watson, Crick and Franklin" and the AI-driven transcription edited the "Franklin" out; iirc President Hernandez confirmed this happened from the podium #chemchat
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Amadi Lovelace @amaditalks.bsky.social · 25/08/2026
Remember that if you got the Moderna Covid vaccine, you have Dolly Parton to thank, she gave the largest individual contribution toward their research to make it possible.
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Kris Willis @kawillis.bsky.social · 25/08/2026
One more time for the people in the back: peer review should be scrutinized just the same as any other part of the scientific process! Otherwise it’s just another argument from authority.
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Kris Willis @kawillis.bsky.social · 25/08/2026
Kudos to @samzhang.bsky.social @nicklaberge.bsky.social, Quinten, @aaronclauset.bsky.social and @danlarremore.bsky.social for this important work bringing more transparency to the peer review process 🧪 #metascience
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Karolina Heyduk @kheyduk.bsky.social · 24/08/2026
New NSF BIO solicitation says expected number of awards is 250-300. Historically, the number of awards is closer to 800-1000 for the Directorate of Bio Sciences: grantwitness.org/nsf/analyses... Unless I'm missing large, non-core programs, this seems really not good?
grantwitness.org
Agency Pulse: Grantmaking at NSF
An independent, up-to-date, grant-level record of federal science funding disruptions in the United States.
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Nature Cell Biology @natcellbio.nature.com · 24/08/2026
☕Li et al. report that FLT3 inhibition impairs selenoprotein translation and induces #ferroptosis to suppress FLT3-mutant #leukemia. This can be counteracted by dietary vitamin E, which may disrupt the efficacy of tyrosine kinase inhibitors in AML treatment. www.nature.com/articles/s41...
nature.com
Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia - Nature Cell Biology
Li et al. report that FLT3 inhibition impairs selenoprotein translation and induces ferroptosis to suppress FLT3-mutant leukaemia. This can be counteracted by dietary vitamin E, which may disrupt the ...
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Saganism @sagan.bsky.social · 23/08/2026
“Before you become too entranced with gorgeous gadgets, remember that the goal is not to have more information, but to have more understanding.” — Arthur C. Clarke
A black and white portrait of Arthur C. Clarke wearing glasses and a suit, standing in front of a futuristic set with large white mechanical arms and curved structures.
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Drug Monkey @drugmonkey.bsky.social · 21/08/2026
To their credit, NIH has posted a CSV file of the ~3,300 responses received. New ground in RFI transparency to my recollection. grants.nih.gov/sites/defaul...
grants.nih.gov
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Simon Fisher @profsimonfisher.bsky.social · 21/08/2026
Hello, human geneticist here. There is no scientific basis for attempts to define people in terms of “good” or “bad” genes - these are discredited views in service of racist ideologies. For consensus & concerns of experts in our field, see e.g. this 2020 statement from @geneticssociety.bsky.social:
Statement from the American Society of Human Genetics in 2020, countering the myth of "good genes". It reads as follows:
"Genetics demonstrates that humans cannot be divided into biologically distinct subcategories or races, and any efforts to claim the superiority of humans based on any genetic ancestry have no scientific evidence. Moreover, it is inaccurate to claim genetics as the determinative factor in human strengths or outcomes when education, environment, wealth, and health care access are often more potent factors. There is no factual basis for attempts to define communities or regions of people with "good" or "bad" genes and a century of science has debunked such claims, which can feed discredited views and racist ideologies. Unchecked, unethical application of false genetic "theories" have resulted in past atrocities from forced sterilizations to the Holocaust and can still fuel unethical social policies worldwide today. Over the decades, our field also has reflected on its own role in such now-condemned ideas, and we speak out vocally as a community and as individuals to combat their resurgence.
We must protect and advance the ethical use of genetics and genomics knowledge for the profound good it can realize, including better, more precise healthcare that leverages what we are discovering about human genetic commonality and diversity. The human genetics community dedicates itself to this goal each day, and today we are improving and saving hundreds of thousands of lives. As the ASHG community focuses on realizing the benefits of human genetics and genomics research for people everywhere, we also urge societal attention to address profound educational, economic and health inequalities that fuel differences in human experience and well-being. By pursuing all of these activities, humans can celebrate our common heritage as one people, embrace and fully tap our valued diversity, and help achieve optimal life outcomes for all."
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