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Here, the authors show that protein design is a generalizable strategy to generate new antimicrobials by neutralizing the function of bacterial adhesins to combat two causative agents of urinary tract infections, E. coli and A. baumannii.

Background Testing microbial interaction hypotheses, including metabolite cross-feeding, remains a major challenge in microbiome research. Phages have the potential to probe organism-organism interact...

Professor Tung Le, John Innes Centre – contact me Professor Jonathan Todd, Quadram Institute & UEA Dr Ngat Tran, John Innes Centre Horizontal gene transfer (HGT) is a major driver of bacterial…

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Abstract. Broad-host-range IncA and IncC (A/C) conjugative plasmids propagate multidrug resistance in bacteria and mobilize chromosomal resistance islands,

Plasmids drive bacterial adaptation, but how their diversity arises has remained unclear. Here, they show that in Staphylococcus aureus, mobile genetic elements repeatedly fuse and delete plasmids, re...

Resource supply is generally considered a dominant driver of microbial diversity. Here, using a four-species bacterial consortium, we asked whether...

CRISPR-Cas provides RNA-mediated adaptive immunity, but how its first RNA-guided effector arose is unclear. In this study, we report the discovery of Viral Interference Programmable Repeat (VIPR) syst...

The Institute for Systems Biology (ISB) seeks a highly motivated andtalented Assistant, Associate, or Full Professor to join our faculty and leadtransformative efforts in AI, machine learning, and com...

Corals harbor intracellular algal symbionts in specialized organelles that enable them to build diverse reef ecosystems. Corals and other cnidarians have repeatedly evolved this symbiosis through the ...

The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.

funny table-of-contents images from scientific journal articles. inspired by crazy TOC images and...

by Christoph — Besides a resurrection tale that I'll re­late to in the se­cond part, this post will be about an­ti-de­fense sys­tems of plas­mids as an in­trin­sic part of the seem­ing­ly end­less…

The Great Barrier Reef Microbial Genomes Database compiles prokaryotic, viral and eukaryotic genomes from seawater collected from the Great Barrier Reef, providing a rich resource for the study of mar...

The crucial role of the gut microbiome in human health has driven a need to understand bacterial function within their complex native ecosystem. Howev…

H-NS is an abundant nucleoid-associated protein found in Enterobacterales species. Some conjugative plasmids encode H-NS homologues, which are thought to facilitate plasmid maintenance and reduce the ...

Join Vibrio2026: The International Meeting on the Biology of Vibrios, September 13-16, 2026. Learn more on Fourwaves.

Genome-wide selective sweeps commonly occur in the human gut microbiome and can spread across the world within decades to produce epidemic-like population structures.

Understanding carbon cycling requires simplifying bacterial diversity into functional groups defined by genetic signatures.

Published in The ISME journal

The Freeman Hrabowski Scholars Program offers comprehensive support to outstanding early career faculty committed to scientific excellence in their own research, and to fostering labs that expand the ...

Great science deserves to be read — not buried under unclear writing. This is the updated 2026 edition of your favorite guide to writing…

Scientists have developed a new method to measure ocean surface currents over large areas in greater detail than ever before.