Reposted by @leosong.bsky.socialRubin Lab @therubinlab.bsky.social · 12/02/2026Check out our latest preprint from @jnvmartinson.bsky.social and @leosong.bsky.social! 🌟🦠 We found that conjugative plasmids can actively eliminate recipient bacteria that resist plasmid acquisition. 🧵 35936
Reposted by @leosong.bsky.socialbioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11/02/2026Plasmids weaponize conjugation to eliminate non-permissive recipients www.biorxiv.org/content/10.64898/20… 02910
Reposted by @leosong.bsky.socialAmanda Alker @atp-alker.bsky.social · 05/01/2026During my postdoc in @therubinlab.bsky.social, @leosong.bsky.social and I aimed to make CRISPR-associated transposons more efficient for editing bacteria. Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social 12511
Reposted by @leosong.bsky.socialRubin Lab @therubinlab.bsky.social · 05/01/2026Our identification of homologous recombination effectors RecD and RecA guided coupling λ-Red recombineering with CAST, boosting editing efficiency in model (E. coli) and non-model (P. putida, K. michiganesis) Gammaprotebacteria, expanding CAST’s utility as a precise bacterial genome editor. (2/2) 032
Reposted by @leosong.bsky.socialInnovative Genomics Institute @innovativegenomics.bsky.social · 05/01/2026New in Science Magazine Science Advances from the Doudna Lab, Rubin Lab and Cress Lab —Identification of proteins influencing #CRISPR-associated #transposases for enhanced #GenomeEditing. Read here: ow.ly/U0s450XS82n 0137
Reposted by @leosong.bsky.socialRubin Lab @therubinlab.bsky.social · 05/01/2026Happy New Year from the Rubin Lab! 🎇 We're excited to start 2026 off with a fresh publication at @science.org Advances. Here, we identified a cast (😉) of host factors affecting VchCAST using genome-wide screens and validated their improvement or inhibition of CAST activity. (1/2)science.orgIdentification of proteins influencing CRISPR-associated transposases for enhanced genome editingWhole-genome screening reveals strategies to boost CRISPR-associated transposase genome editing efficiency. 1217
Reposted by @leosong.bsky.socialAnna Vardapetyan @annavardapetyan.bsky.social · 07/12/2024Grad school panel event for the @innovativegenomics.bsky.social undergrad and tech journal club! 012
