ISB identifies B cells that drive harmful autoantibody production after COVID-19, revealing links between viral infection and autoimmunity.

These 50 STEM standouts on this list are actively advancing the world’s understanding of medicine, meteorology and large language models.

Throughout the 2025-26 academic school year, the ISB Education team provides quarterly updates on curriculum, programs, interns, and more.

Dfam and Repbase are joining under a fully open framework, making decades of transposable element data freely available to accelerate genome annotation and genomics research.

Lost Women of Science co-founder Katie Hafner joined Nobel laureate Mary Brunkow to talk overlooked women scientists, mentorship, and more.

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Nobel laureate Mary Brunkow will be the featured speaker at Saturday's 151st commencement. She's a scientist, not a tech executive — and unlike other graduation speakers this season, she's not plannin...

Emerging evidence links the gut microbiome to sleep quality, yet measuring sleep at scale remains challenging. Commercial wearables, such as Fitbit, capture objective sleep and activity data in natura...

A multiomics study published in Cell reveals how ethnicity and geography shape metabolism, immunity, the microbiome, and biological aging.

A new high-throughput platform profiles antigen-specific CD4+ T cells at single-cell resolution for vaccine and cancer research.

Laasya's STiSA research paper examines the neurological and psychological effects of adolescent nicotine use.

New research shows oxidative stress can prime tuberculosis bacteria to rapidly evolve antibiotic resistance, reshaping how resistance begins.

Scientists identify 1,700+ new protein-like molecules in the human genome, revealing a hidden layer with implications for cancer and disease.

BackgroundThe microbiome-gut-brain axis is a mediator of stress-related disorders. The number of preclinical studies exploring the potential causal mechanism...

Alice Kane on aging, frailty, and healthspan, highlighting new biomarkers, sex differences, and insights into menopause and women’s health.

ISB research shows how targeted therapy can trigger a stress-driven escape program, allowing cancer cells to adapt early and evade treatment.

Combined small-cell lung cancer can change identity, forming hybrid cells and distinct tumor environments that may drive aggressive disease.

Throughout the 2025-26 academic school year, the ISB Education team provides quarterly updates on curriculum, programs, interns, and more.

Institute for Systems Biology (ISB) is a nonprofit scientific research organization in Seattle. Learn how our science is transforming health.

A Long COVID patient shares her journey with brain fog, fatigue, and recovery as researchers discuss new insights from the RECOVER study.

Phage-bacteria interactions are typically studied in bulk culture, which obscures cell-cell differences. Here the authors study phage-bacteria interactions using single-cell transcriptomics, identifyi...

ISB researchers use single-cell sequencing to reveal hidden defenses against bacteriophages and uncover how some cells escape infection.

2026 bracket Welcome to STAT Madness, a bracket-style contest to find the best innovation in science and medicine. Explore groundbreaking innovations from

A “digital gut” predicted which probiotics and high‑fiber diets would take hold in people's guts and produce healthier outcomes.