Reposted by Arsen PetrovicCathy Spangler @cathyspangler.bsky.social · 22/09/2026I'm excited to share our new preprint, where we show that fine-tuning gold nanoparticle conjugation to different Fab structural elements can produce powerful, rigidly coupled, labeling tools for in-situ cryo-ET. Take a look if you want to see an AuNP in an EM map!🔬🧠 www.biorxiv.org/content/10.6... 15528 0
Reposted by Arsen PetrovicKranzusch Lab @kranzuschlab.bsky.social · 10/09/2026Stunning cryo-ET analysis from the Harrison Lab capturing every stage of how non-membrane viruses infect animal cells www.science.org/doi/10.1126/... 08326 0
Reposted by Arsen PetrovicBen Engel @cellarchlab.com · 08/09/2026MemBrain v2 is on @natmethods.nature.com now? I never had a @biorxivpreprint.bsky.social with 164 citations before😅 ...Which is also to say: Thank you to the amazing #TeamTomo community, many of whom not only beta tested, but also contributed diverse training data. This one belongs to all of us! 🤗🔬🧪 011027 0
Reposted by Arsen PetrovicMax Renner @maxrenner.bsky.social · 04/05/2026📢 We are now recruiting a PhD student in Structural and Molecular Virology in Sweden 🇸🇪 Work on RNA viruses using cryo-EM and in situ cryo-ET, with access to world-class microscopy infrastructure Perfect for candidates with backgrounds in biochem, structural bio, and virology More info ⬇️ 12829 0
Reposted by Arsen PetrovicCarter Lab @carter-lab.bsky.social · 24/03/2026Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6... 620684 0
Reposted by Arsen PetrovicFlorian Schur @schurlab.bsky.social · 13/02/2026Open Postdoc position in our lab! #actin #Huntingtin #cryoET #cellbio If you enjoy working at the interface of cell biology, structural biology, and quantitative imaging, this could be an excellent fit. ista.ac.at/en/job/postd... Please share and feel free to reach out if there are questions!ista.ac.atPostdoc Research Group SchurThe Schur lab at the Institute of Science and Technology Austria (ISTA) has an open postdoc position for a highly motivated candidate to be part of our ERC-funded project ActinID. Our Group ... 13219 0
Reposted by Arsen PetrovicThe EMBO Journal @embojournal.org · 28/01/2026Arianna Esposito Verza, @andrea-musacchio.bsky.social et al describe the long-sought-after mechanism of Bora dependency of PLK1 activation by Aurora A kinase during mitotic entry Another #RefereedPreprint ℅ @reviewcommons.org link.springer.com/article/10.1...link.springer.comMolecular requirements for PLK1 activation by T-loop phosphorylation - The EMBO JournalActivation of PLK1, a master mitotic kinase, requires phosphorylation of its activation segment on Thr210, within a basic consensus sequence for Aurora kinases. Aurora B-dependent phosphorylation of T... 1199 0
Reposted by Arsen PetrovicWilfling Lab @wilflinglab.bsky.social · 13/01/2026We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉 212139 0
Reposted by Arsen PetrovicMax Renner @maxrenner.bsky.social · 02/11/2025www.nature.com/articles/d41...nature.comThe EU’s Horizon research fund needs to stay a defence-free zoneIt is time to sound the alarm as the EU’s research priorities face an unprecedented degree of political interference. 052 0
Reposted by Arsen PetrovicWout Oosterheert @woutoosterheert.bsky.social · 28/10/2025Are you excited to uncover the molecular mechanisms of actin filament assemblies that drive cell migration using cryo-EM? Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...werkenbijavl.nlPhD Student – Structural Biology of Actin Filament Assemblies | Werken bij AVL 067 0
Reposted by Arsen PetrovicRicardo D. Righetto @lifeonthewedge.bsky.social · 23/10/2025Our colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧biorxiv.orgIcecream: High-Fidelity Equivariant Cryo-Electron TomographyCryo-electron tomography (cryo-ET) visualizes 3D cellular architecture in near-native states. Recent deep-learning methods (CryoCARE, IsoNet, DeepDeWedge, CryoLithe) improve denoising and artifact cor... 45620 0
Reposted by Arsen PetrovicBen Engel @cellarchlab.com · 23/10/2025Hey #TeamTomo …would you like to try some 🍦ICECREAM!? Our @unibas.ch colleagues over at the @ivandokmanic.bsky.social lab have developed a stunningly effective tool to de-noise and de-wedge your tomograms. The contrast and details will give you brain freeze! 🍨❄️🤯 Please try, we need feedback 🧪🧶🧬🔬 14416 0
Reposted by Arsen PetrovicKenneth Ehses @denkenny.bsky.social · 08/10/2025✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo 🔗 www.biorxiv.org/content/10.1... 28322 0
Reposted by Arsen PetrovicMolecular Cell @cp-molcell.bsky.social · 02/10/2025Biochemical reconstitution of sister chromatid cohesion establishment during DNA replicationdlvr.itBiochemical reconstitution of sister chromatid cohesion establishment during DNA replicationGenome inheritance during cell divisions relies on replicated sister DNAs being connected by cohesin rings. Minamino et al. reconstitute sister chromatid cohesion establishment during DNA replication using purified budding yeast proteins. The experiments yield molecular insight into more than one way in which sister chromatid cohesion can be built. 053 0
Reposted by Arsen PetrovicAndré Nadler @nadlerlab.bsky.social · 21/08/2025Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41... 31346130 0
Reposted by Arsen PetrovicBronwyn Lucas @bronwynalucas.bsky.social · 30/08/2025First pre-print from the Lucas Lab led by Matthew Giammar and @joshdcryoem.bsky.social online today! We develop a new, extensible Python implementation of 2DTM and apply it to build pixel size optimization, constrained search and characterize molecular motions in situ www.biorxiv.org/content/10.1...biorxiv.orgLeopard-EM: An extensible 2DTM package to accelerate in situ structural biologyThe ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re... 88431 0
Reposted by Arsen PetrovicEugene Valkov @eugenevalkov.bsky.social · 06/05/2025A tribute to George Sheldrick and SHELX and the impact on macromolecular and small-molecule crystallography journals.iucr.org/a/issues/202...journals.iucr.orgGeorge M. Sheldrick (1942–2025)In memory of George Sheldrick. 14014 0
Reposted by Arsen PetrovicJournal of Cell Biology @jcb.org · 24/03/2025Interactions with multiple inner #kinetochore proteins determine mitotic localization of FACT, say Julia Schweighofer, Bhagyashree Mulay, Andrea Musacchio (@andrea-musacchio.bsky.social) and colleagues: rupress.org/jcb/article/... #Mitosis 0143 0
Arsen Petrovic @arsenpet.bsky.social · 26/03/2025Congrats Ben and colleagues!!Fantastic work 👏 🙌 020 0
Reposted by Arsen PetrovicDanielle Grotjahn @nanigrotjahn.bsky.social · 07/03/2025For #teamtomo, context is everything. We highlight the power of #surfacemorphometrics in guiding STA and quantitatively assessing the impact of these structures on the local environment. 1st collab paper w/ @zidlab.bsky.social (hopefully many more to come!) @tomo.science @hamid13r.bsky.social 03713 0
Reposted by Arsen PetrovicBen Barad @baradlab.com · 07/03/2025Happy to share that the final version of record for our ( @nanigrotjahn.bsky.social) #teamtomo mitochondrial cotranslation story is online at @jcb.org! We combined STA with surface morphometrics to learn how ribosomes bind to and alter mitochondrial membranes in yeast. rupress.org/jcb/article/... 110827 0
Reposted by Arsen PetrovicMPI for Multidisciplinary Sciences @mpi-nat.bsky.social · 27/02/2025Optical #nanoscopy without “ON/OFF” – Stefan Hell, @thomas-hensel.bsky.social, and co-workers have increased the resolution in fluorescence #microscopy 🔬 by a factor of 30 without having to sequentially switch fluorescent molecules between light & dark states. ⬇️ www.mpinat.mpg.de/4938925/pr_2... 1136 0
Reposted by Arsen PetrovicAlexis Barr @alexisbarr.bsky.social · 25/02/2025Still hard to believe but Béla Novák died suddenly on Saturday. We've lost a fantastic colleague, mentor & great friend to many. There was really no-one else like him. Working with him was so much fun & I owe him a lot. All my thoughts are with his family. www.merton.ox.ac.uk/news/remembe...merton.ox.ac.ukRemembering Professor Béla Novák 1956 - 2025With great sadness, we announce the loss of Professor Béla Novák. 84017 0
Reposted by Arsen PetrovicTitia Sixma @titiasixma.bsky.social · 20/02/2025Today Jan Drenth would have been 100 years, but sadly he passed away last week. He was the founding father of structural biology in the Netherlands and his modesty, his gentle humor and his generosity set the spirit for the amazing environment in Groningen where i did my PhD. 0308 0
Reposted by Arsen PetrovicConstantin Pape @cppape.bsky.social · 12/02/2025After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool. www.nature.com/articles/s41... 11351119 0
Reposted by Arsen PetrovicElisabeth Bik @elisabethbik.bsky.social · 11/02/2025Retraction of a paper from the lab of a Stanford Nobel Prize winner. The PI dismissed our combined concerns as 'micro-duplications that are typical image processing artifacts'. But after consulting with an 'image analysis expert', the authors retracted the paper. pubpeer.com/publications... 914023 0
Arsen Petrovic @arsenpet.bsky.social · 05/02/2025Fantastic news Sven!Wishing you a success in your new journey 👏 110 0
Reposted by Arsen PetrovicIMP @impvienna.bsky.social · 04/02/2025We will soon welcome @svenklumpe.bsky.social to the Vienna BioCenter, where he will use cryo-Electron Tomography to study - among other things - how #transposons shape #germlines. Sven's lab will be @imbavienna.bsky.social *AND* the IMP. Full story: www.viennabiocenter.org/about/news/s...viennabiocenter.orgSven Klumpe to start cryo-Electron Tomography lab at IMP and IMBAThe Vienna BioCenter institutes IMP and IMBA will soon host a joint research group headed by Sven Klumpe. The structural biologist will join the two institutes with an innovative double-affiliation to... 3577 0
Reposted by Arsen PetrovicBeck Laboratory @becklab.bsky.social · 17/01/2025In a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below: 7428136 0
Reposted by Arsen PetrovicRobin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 21/12/2024Double whammy: Wellcome Centres are no more & MRC Units are on their last funding cycle. Huge blow to science in cities other than Cambridge-Oxford-London which continue to have well-funded institutes with excellent infrastructure (Crick, LMB etc). The rest of us…? www.science.org/content/arti...science.orgFunding overhaul threatens historic U.K. research unitsScientists protest new “challenge-led” grants replacing funding that supported long-term basic research 153 0
Reposted by Arsen PetrovicFabian Eisenstein @eisfabian.bsky.social · 17/12/2024SPACEtomo v1.2 is online! github.com/eisfabian/SP... - Improved GUIs for lamella detection, target selection and CLEM registration make it the best target selection workflow for PACEtomo on any kind of lamella sample. - Easier installation and configuration Any feedback is much appreciated! :) 04316 0
Reposted by Arsen PetrovicRichard Lenski @relenski.bsky.social · 12/12/2024Shareable link to @carlzimmer.bsky.social article in NYTimes on serious concerns over mirror bacteria, published in Science today. www.nytimes.com/2024/12/12/s...nytimes.comA ‘Second Tree of Life’ Could Wreak Havoc, Scientists Warn (Gift Article)Research on so-called mirror cells, which defy fundamental properties of living organisms, should be prohibited as too dangerous, biologists said. 812073 0
Reposted by Arsen Petrovicdfachinetti.bsky.social @dfachinetti.bsky.social · 12/12/2024It is time to ask for a Xmas present to your PI! Register to this amazing EMBO aneuploidy meeting that will be held on a beautiful lake close to Milan, Italy on the 27 of April! Registration deadline is approaching! 082 0
Arsen Petrovic @arsenpet.bsky.social · 12/12/2024Glad that we could contribute a bit from the cryo end!😀 Thanks Constantin and Sarah!! 010 0
Arsen Petrovic @arsenpet.bsky.social · 12/12/2024An insightful in situ study on the catalytic cycle and the spatial organization of the TriC chaperonin by Frydman and Beck labs.Congrats! @becklab.bsky.social #TeamTomodoi.orgIn situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor - NatureTRiC functions at near full occupancy to fold newly synthesized proteins inside cells. 040 0
Reposted by Arsen PetroviccryoEM papers @cryoempapers.bsky.social · 10/12/2024Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex pubmed.ncbi.nlm.nih.gov/39651296/ 001 0
Arsen Petrovic @arsenpet.bsky.social · 10/12/2024What an unexpected finding!Congratulation to all the authors.👏 doi.org/10.1083/jcb....doi.orgThe kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching | Journal of Cell Biology | Rockefeller University PressAlves Domingos et al. uncover a non-cell-division-related function for the kinetochore protein KNL-1 in dendrite arborization. They show that KNL-1 regulat 010 0
Reposted by Arsen PetrovicAndrea Musacchio @andrea-musacchio.bsky.social · 17/11/2024I gladly bring this meeting to your attention so that you can mark dates in your calendar in case your are interest. Additional information will follow. Please circulate if possible. 17747 0
Reposted by Arsen PetrovicBen Engel @cellarchlab.com · 29/11/2024Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍 Shimakawa et al: www.cell.com/cell/fulltex... Nam et al: www.cell.com/cell/fulltex... @biozentrum.bsky.social press release: www.biozentrum.unibas.ch/news/detail/... Read on for more... 1/🧵 723965 0
Reposted by Arsen PetrovicConstantin Pape @cppape.bsky.social · 26/11/2024We are looking for a Data Scientist at the MBExC Excellence Cluster in Göttngen: shorturl.at/Jln3V . Please RT! Read on for more details.shorturl.atInstitut für Medizinische Informatik -- Data Scientist (f/m/d)Data Scientist (f/m/d) 11713 0
Reposted by Arsen PetrovicChristophe 🔬 Leterrier @christlet.bsky.social · 19/11/2024Best thing you could watch in 2016 and best thing you can watch today. RIP Thomas Reese 23510 0
Arsen Petrovic @arsenpet.bsky.social · 18/11/2024Thanks Rémi for doing this! Can you add me please? 100 0