Many computational problems possess the following three features: (1) the problem could be solved efficiently if a linear operator could be diagonalized, (2) direct diagonalization is infeasible due t...

Two-Dimensional Template Matching implemented in Python - Lucaslab-Berkeley/Leopard-EM

Many computational problems possess the following three features: (1) the problem could be solved efficiently if a linear operator could be diagonalized, (2) direct diagonalization is infeasible due t...

Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron microscopy. However, only a few large and abundant c...

Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron microscopy. However, only a few large and abundant c...

Flatiron Institute researcher Pilar Cossio builds tools to analyze experimental measurements and reveal how environmental changes alter the behavior of RNA molecules.

Visualizing Structure, Dynamics and Interactions Using Cryo-EM on Simons Foundation

In situ cryo-EM coupled with 2D template matching (2DTM) holds the potential to visualize the cellular structureome in context, but further developments are required to make this a reality. We describe Leopard-EM (Location and orientation of particles found using two-dimensional tEmplate Matching), an extensible Python package for 2DTM to accelerate in situ structural biology.

Explore the interior of an algal cell on your four paws. Built with experimental data and populated with actual protein structures, Meowtabolism offers a glimpse of the vast world inside the basic fun...

The European Commission and the Australian Government have begun discussing their scientific cooperation through Australia’s association with Horizon Europe

Modular Python packages the cryo-ET community can depend on.

Overview of the Leopard-EM package for 2DTM in Python

The ability to generate high-resolution views of cells with cryogenic electron microscopy (cryo-EM) can reveal the molecular mechanisms of biological processes in their native cellular context. The re...

Recent breakthroughs in single-particle cryogenic electron microscopy (cryo-EM) and protein structure prediction have transformed our ability to resol…

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University of California, Berkeley is hiring. Apply now!

New techniques allow scientists to see protein structures in their native environments