In our latest collaborative work we identify a novel form of reversible fluconazole heteroresistance that is associated with variable islands of heterochromatin in clinical isolates of Cryptococcus neoformans. Thanks to all @ Allshire, Heitman Bicanic labs especially 1st author @ybecky.bsky.social
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Variable ectopic heterochromatin islands provide an alternative route to antifungal heteroresistance in Cryptococcus neoformans
The fungal pathogen Cryptococcus neoformans is estimated to cause approximately 180,000 deaths annually, primarily among immunocompromised HIV patients in resource-limited countries in central and sou...