Sign in

Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me

@allshire-lab.bsky.social
1.3K followers 476 following 66 posts

Professor, University of Edinburgh. Science: epigenetics, variegation, heterochromatin, heteroresistance, resistance, bet hedging, fungal biology & pathogens. Pets: Airedale Terriers. Duolingo: 🇫🇷 level 61. Opinions here are my own

PostsRepliesMedia
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 12/06/2026
In our latest collaborative work we identify a novel form of reversible fluconazole heteroresistance that is associated with variable islands of heterochromatin in clinical isolates of Cryptococcus neoformans. Thanks to all @ Allshire, Heitman Bicanic labs especially 1st author @ybecky.bsky.social
eur02.safelinks.protection.outlook.com
Variable ectopic heterochromatin islands provide an alternative route to antifungal heteroresistance in Cryptococcus neoformans
The fungal pathogen Cryptococcus neoformans is estimated to cause approximately 180,000 deaths annually, primarily among immunocompromised HIV patients in resource-limited countries in central and sou...
3155
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 09/04/2026
Very upsetting to hear the sad news of Greg Hannon’s passing. I always enjoyed our far too few conversations we had over the years. He had an interesting and insightful perspective on any science being discussed. He will be missed. www.cruk.cam.ac.uk/news/in-memo...
cruk.cam.ac.uk
In Memoriam: Professor Greg Hannon (1964–2026) - Cancer Research UK Cambridge Institute
Greg was already a world-renowned scientist when appointed Director, and for the community, he was a visionary leader, a cherished mentor, and a singular force of nature whose influence shaped the research landscape.
14121
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Hetan Shah @hetanshah.bsky.social · 01/02/2026
Hot off the press - a letter from the Exec Chair of @ukri.org explaining his plans and in particular the financial position of STFC. It notes curiosity driven research is protected and will make up around half of UKRI spend over the coming period www.ukri.org/news/open-le...
ukri.org
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
74644
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 01/02/2026
www.ukri.org/news/open-le... So let’s fiddle while researchers, whose funding is paused, get burned because their current funding is in its last 12 months. Lack of clarity & transparency creates uncertainty. Researchers need to plan ahead, they can’t without application deadlines to work towards
ukri.org
Open letter from Ian Chapman to research and innovation community
UKRI Chief Executive outlines changes to UKRI investment approach, addressing concerns about research funding and the financial position of STFC.
140
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 15/12/2025
Thanks to all involved in both labs for making this happen - well done!
010
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 01/12/2025
www.embopress.org/doi/full/10.... Our latest now online at EMBO Journal. Read if you are interested in how epimutations mediate antifungal resistance & how this might result in heteroresistance in human & cereal crop fungal pathogens. Big Thx & congrats to Andreas Fellas, Pin Tong & Alison Pidoux
embopress.org
Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance | The EMBO Journal
imageimageHeterochromatin-island epimutations can provide resistance to caffeine and antifungal drugs in the fission yeast Schizosaccharomyces pombe. This study reveals that some epimutations cause re...
0125
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 24/11/2025
AI is good at needling people, had me in stitches following this thread!
021
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 11/11/2025
A lot of interest in QED Science as an automated review system linked to preprint servers. All we need now is funding level for authors to be somehow linked to the overall score provided by the AI and we can do away with grant writing and grant reviewing and panels. Cut the bureaucracy in science!
130
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 08/09/2025
A big car park where the Darwin Building at King’s Building, University of Edinburgh used to be
020
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 24/07/2025
The Darwin Building @edinburghup.bsky.social which housed the UK’s first Dept of Molecular Biology is no more! Many notable scientists worked their & passed through: 1968-2018. We look forward to a suitable replacement that promotes excellent biological research allowing many more key discoveries.
1101
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 28/06/2025
@edinburghairport.bsky.social What are you playing at? Delta 122 flight from Boston lands 06:30 Passengers have to wait on plane cos Customs hall does not open until 07:00 - Ridiculous get your act together FFS!!
120
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Jeremy Berg @jeremymberg.bsky.social · 04/06/2025
New powerful article up in the New York Times on cancelled and delayed grants www.nytimes.com/interactive/...
nytimes.com
Here Are the Nearly 2,500 Medical Research Grants Canceled or Delayed by Trump (Gift Article)
Some cuts have been starkly visible, but the country’s medical grant-making machinery has also radically transformed outside the public eye.
11302207
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 30/05/2025
Looking forward to my visit to ibfg.usal-csic.es in Salamanca today. Thanks to Alfonso Fernandez Alvarez for inviting me.
060
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 20/05/2025
NB: the UK - including Scotland - is an ERC partner, English speaking and has an exceptionally strong discovery research base.
030
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 20/05/2025
Congratulations to our colleague Prof Donal O’Carroll FRS, School of Biological Sciences, University of Edinburgh, on his election as a fellow of the Royal Society of London (the UK nation academy of sciences) - very well deserved.
030
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 20/05/2025
And now for something completely different: my nephew Arthur Allshire (1st yr PhD student @bair.berkeley.edu) and co just released his first paper: Videomimic - Visual imitation enables contextual humanoid control. He is now working on sobering up the robot! www.videomimic.net
videomimic.net
VideoMimic
120
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 13/05/2025
Gov.UK now needs to be proactive in making it attractive for disaffected scientists to move to the UK. Advantages: English speaking & exceptionally strong research base. An opportunity to drive future economic growth - act now or miss out! arstechnica.com/science/2025...
arstechnica.com
Europe launches program to lure scientists away from the US
EU will spend over $500 million to recruit researchers and scientists.
010
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 13/05/2025
Pros: English speaking, strong research base. Cons: visa/health costs & broke universities. If, like EU, UK is to benefit by attracting disaffected talented scientists from other countries Gov.UK will need to make moving here attractive & affordable! Many non-OxBridge Universities can’t recruit.
031
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 10/05/2025
Happy 65th to Paul Hewson (aka Bono @U2) as usual mine follows soon after yours - funny that. ‘It’s a beautiful day’ enjoy!
media.tenor.com
a man wearing sunglasses with his mouth open and the words it 's a beautiful day below him
ALT: a man wearing sunglasses with his mouth open and the words it 's a beautiful day below him
010
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 05/05/2025
Looks like a fantastic AI tool for predicting protein sequences that will aggregate/form prions. Key was testing >100,000 in vivo using a neat assay in yeast/S. cerevisiae
040
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 30/04/2025
Register for the excellent Epigenetics Gordon Research Conference Barcelona 10-15 Aug25. Theme: Epigenetic Variation: Mechanisms & Impact Across Systems. **FUNDING AVAILABLE to support attendance** ~15 talks to be chosen from submitted abstracts, so upload yours ASAP: www.grc.org/epigenetics-...
051
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 30/04/2025
Congratulations to Wendy Bickmore on her election as an International Member of the US National Academy of Sciences www.nasonline.org
nasonline.org
National Academy of Sciences
The National Academy of Sciences (NAS) is a private, nonprofit organization of the country’s leading researchers, recognizing and promoting outstanding science.
0393
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 30/04/2025
Congratulations to Bill Earnshaw, my colleague and lab next door, on his election as a Member of the US National Academy of Sciences www.nasonline.org
nasonline.org
National Academy of Sciences
The National Academy of Sciences (NAS) is a private, nonprofit organization of the country’s leading researchers, recognizing and promoting outstanding science.
0113
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 26/04/2025
movie u have watched more than six times using gifs (hard mode no star wars star trek or LOTR) “I never had any friends later on like the ones I had when I was twelve. Jesus, does anyone?”
media.tenor.com
a movie poster for stand by me shows a group of young men walking down train tracks
ALT: a movie poster for stand by me shows a group of young men walking down train tracks
100
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Ashani Weeraratna @ashi-w.bsky.social · 24/04/2025
The power of NIH funded research. @deniswirtz.bsky.social hub.jhu.edu/2025/04/22/n...
hub.jhu.edu
Johns Hopkins researchers decipher complex behaviors behind deadly cancers
Engineer Denis Wirtz and colleagues are using artificial intelligence and multiscale imaging to reveal how tumors grow, spread, and vary across populations
06327
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 24/04/2025
Our latest collaborative work with Keith Matthews’ lab using synthetic DNA binding proteins to explore the chromatin protein contexts of repetitive sequences in Trypanosoma brucei in now on bioRxiv - thanks to all involved! 2025.04.22.649942; doi: doi.org/10.1101/2025...
doi.org
Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins
Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...
0113
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 18/04/2025
Almost there! 6 more points to seal it.
000
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Edinburgh Infectious Diseases @uoe-eid.bsky.social · 02/04/2025
Very pleased to see @who.int publishing its very first reports on tests and treatments for #fungal #infections - and the contributions made by @bachmanntill.bsky.social, EID AMR Strategy lead. edinburgh-infectious-diseases.ed.ac.uk/news-and-eve... @allshire-lab.bsky.social @bethmills.bsky.social
edinburgh-infectious-diseases.ed.ac.uk
Edinburgh contributes to major WHO reports on fungal infections
April 2025: The World Health Organisation has issued its first-ever reports on tests and treatments for fungal infections.
074
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 06/04/2025
How chromatin is replicated - key to understanding epigenetic memory mechanisms underlying epimutations
093
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 22/03/2025
Register for the renowned Epigenetics Gordon Research Conference Barcelona 10-15 August 2025. A great line up of speakers on the theme: Epigenetic Variation: Mechanisms & Impact Across Systems. ~15 talks to be chosen from submitted abstracts, so upload yours ASAP: www.grc.org/epigenetics-...
grc.org
064
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 11/03/2025
20’ until the News Agents but the world to rights - or lefts or mid-road really- in the Usher Hall, Edinburgh
000
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Keith Edwards @keithedwards.bsky.social · 07/03/2025
BREAKING: Elon Musk's rocket explosion nearly hit a commercial flight. This kind of content is being downranked on X. Please share it here. This is so dangerous.
502157428794
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 06/03/2025
Register interest in THE EPIGENETICS Gordon Research Conference Barcelona 10-15 August 2025. A great line up of speakers on the theme: Epigenetic Variation: Mechanisms & Impact Across Systems. ~15 talks to be chosen from submitted abstracts, so upload yours ASAP: www.grc.org/epigenetics-...
grc.org
2025 Epigenetics Conference GRC
The 2025 Gordon Research Conference on Epigenetics will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
1207
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 04/03/2025
Alessia Buscaino at #ECFG17 gives a wonderful talk on her discovery that Candida albicans has active RNAi afterall and how she is unraveling its biological role in regulating TLO genes encoding a diverse array of Mediator Med2 proteins and in pathogenesis. See DOI: 10.1073/pnas.2315926121
070
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 04/03/2025
Great talk from Aaron Vogan #ECFG17 on giant Starship transposable elements that move gene cargoes within and between fungal species to confer novel phenotypes. All regulated by the Captain Tyrosine recombinase. Very enterprising! Beam me up Scottie!
0163
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 04/03/2025
Post-doc in fungal molecular cell biology. Seeking person with an understanding of gene expression and phenotypic analysis, who is interested in epigenetic regulation in fungi, to explore mechanisms of antifungal resistance in Zymoseptoria tritici and Schizosaccharomyces pombe. Email me! #ECFG17
13635
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 03/03/2025
www.theguardian.com/technology/2...
theguardian.com
Elon Musk survives as fellow of Royal Society despite anger among scientists
Questions remain over whether further action will be taken after resignations and calls for the Tesla CEO to be expelled
113
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 03/03/2025
Great to be back in my home city Dublin for #ECFG17 Fungi are amazing, the things they do to survive …like paralyse passing nematodes as detailed in fantastic talk by Yen-Ping Hsueh doi: 10.1126/sciadv.ade4809 ‘Resistance is fungile’ Folks below are not infected, it was an oomycete in the potatoes!
081
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 25/02/2025
Epigenetics Gordon Research Conference. Consider joining us for what will be an excellent, exciting meeting and will be held in Europe for the first time: 10-15 Aug25 Barcelona, Spain. Please repost and apply early - this meeting is popular! www.grc.org/epigenetics-...
grc.org
2025 Epigenetics Conference GRC
The 2025 Gordon Research Conference on Epigenetics will be held in Castelldefels, Barcelona Spain. Apply today to reserve your spot.
13619
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 31/12/2024
Just managed to squeeze in a final 5.5k before the looming storm to take my total to 750k for 2024. Best wishes to all for 2025 - it seemed so far in the future when I was a 60s kid!
040
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 28/12/2024
Great collaboration with Claudia, Nicolai et al. Congratulations to all!
020
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 28/12/2024
Flowering time mutant or climate change (it has been very mild): Crocuses on the Leith Links Edinburgh at Christmas- 🤔 confused 💐 will probably snow soon - that will teach it!
010
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 21/12/2024
Double whammy: Wellcome Centres are no more & MRC Units are on their last funding cycle. Huge blow to science in cities other than Cambridge-Oxford-London which continue to have well-funded institutes with excellent infrastructure (Crick, LMB etc). The rest of us…? www.science.org/content/arti...
science.org
Funding overhaul threatens historic U.K. research units
Scientists protest new “challenge-led” grants replacing funding that supported long-term basic research
153
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 29/11/2024
In case you did not see it the first time posted. If you are interested in how chromatin-based epimutations mediate resistance in fungi …… read our latest preprint…….
0149
Reposted by Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me
Altmetric @altmetric.com · 25/11/2024
Tell me you aren’t reading our brilliantly hilarious and informative timeline… …without telling me you aren’t reading our brilliantly hilarious and informative timeline.
4395
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 25/11/2024
A very considered and well argued piece by Dorothy Bishop. Those of us who remain can hopefully get this overturned: eur02.safelinks.protection.outlook.com?url=http%3A%...
eur02.safelinks.protection.outlook.com
Why I have resigned from the Royal Society
The Royal Society is a venerable institution founded in 1660, whose original members included such eminent men as Christopher Wren, Robert H...
081
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 16/11/2024
2 protocols here from the team - special thanks to Manu Shukla for organising it: ChIPmentation for Epigenomic Analysis in Fission Yeast doi: 10.1007/978-1-0716-4168-2_18 Genome-Wide Profiling of Histone Modifications in Fission Yeast Using CUT&Tag doi: 10.1007/978-1-0716-4168-2_22
0183
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 16/11/2024
As a Fellow of this august society I wonder what happed about this 🤔: www.theguardian.com/technology/a...
theguardian.com
Royal Society facing calls to expel Elon Musk amid concerns about conduct
Exclusive: Some fellows fear tech billionaire could bring institution into disrepute with incendiary comments
120
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 16/11/2024
This succinctly sums up why many of us have switched from the other place: The exodus from X to Bluesky has happened – the era of mass social media platforms is over | Gaby Hinsliff www.theguardian.com/commentisfre...
theguardian.com
The exodus from X to Bluesky has happened – the era of mass social media platforms is over | Gaby Hinsliff
There’s comfort in being surrounded by like-minded people, but challenge is important, and we may have to look for it elsewhere, says Guardian columnist Gaby Hinsliff
031
Robin Allshire 🇮🇪 🇪🇺✊🏿 ⬆️ Zak’s favourite nucleosome: K9me @allshire-lab.bsky.social · 15/11/2024
I originally posted this 24Aug: “IMO: all scientific researchers, their institutes/universities, funding agencies, academic societies, & research publishers/journals should stop using Xitter. @Musk has made it toxic we should not support it” 3 mths on its even more urgent for scientists to act!
120