iiinova — where your digital self keeps evolving

Reposted by Wout Oosterheert

Ryan Hylton @rkhylton.bsky.social · 27/07/2026

One cell, one tomogram! Our montage tomography workflow, MOSAIC, is out in Structure, and MontageMaker is on GitHub! MOSAIC: www.cell.com/structure/fu... MontageMaker: github.com/MPI-Dortmund... Big thanks to @maikaboiero.bsky.social, Adriana Prajica, Gavin Rice, and @raunser-lab.bsky.social!

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Reposted by Wout Oosterheert

Netherlands Cancer Institute @nkinl.bsky.social · 13/07/2026

Will you be our next junior group leader? Check out how Natalie Scholes, Gordie Watt and @woutoosterheert.bsky.social experience starting their groups at the Netherlands Cancer Institute. Apply before August: www.nki.nl/news-events/... #Vacancy #JuniorPI #ResearchOpportunity #NKI #EarlyDetection

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Reposted by Wout Oosterheert

Alushin Lab @alushinlab.bsky.social · 22/04/2026

Very pleased that after a rigorous (and lengthy) review process, our paper visualizing how myosin generated forces modulate actin filament structure for mechanosensitive recogntion by α-catenin has appeared in @nature.com : www.nature.com/articles/s41...

nature.com

Myosin forces remodel F-actin for mechanosensitive protein recognition - Nature

Structural studies demonstrate that myosin generates forces that cause structural changes in actin, modulating cooperative binding by α-catenin and thus signal transduction and intercellular communica...

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Reposted by Wout Oosterheert

Thorsten Wagner @thorstenwagner.bsky.social · 19/02/2026

In September 2024, I was diagnosed with ALS. Today, I can no longer speak, I am confined to a wheelchair, and I can no longer move my arms. It's really shitty. I will write here soon about how I am coping with this and how I am trying to stay cheerful. #ALS

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Reposted by Wout Oosterheert

Netherlands Cancer Institute @nkinl.bsky.social · 20/02/2026

We;re hiring Junior Group Leaders! 🔬✨ We’re looking for researchers in immunology, chemical biology, AI in biology, or protein design to launch their own independent groups in our collaborative, international environment. www.nki.nl/news-events/...

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Reposted by Wout Oosterheert

Friedrich Förster @fridof.bsky.social · 04/11/2025

Very happy that NWO supports this major upgrade of our national EM infrastructure. It is great that this initiative got broad support all over NL, and it will EMPower fantastic science - looking forward to that! www.uu.nl/en/news/33-m...

uu.nl

33 million euro investment for national electron microscope facility EMPower

A major new national facility for electron microscopy, called EMPower, has been awarded to a consortium of Dutch universities and medical centers. EMPower aims to pave the way for major discoveries im...

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Wout Oosterheert @woutoosterheert.bsky.social · 28/10/2025

Are you excited to uncover the molecular mechanisms of actin filament assemblies that drive cell migration using cryo-EM? Only 1.5 week to apply for this exciting PhD position in my newly established lab at the Netherlands Cancer Institute in Amsterdam: www.werkenbijavl.nl/vacatures/ph...

werkenbijavl.nl

PhD Student – Structural Biology of Actin Filament Assemblies | Werken bij AVL

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Wout Oosterheert @woutoosterheert.bsky.social · 13/10/2025

Very excited that my final postdoctoral work is now online in Cell @cellpress.bsky.social. www.sciencedirect.com/science/arti... Using 16 (!) cryo-EM structures, we uncovered how the three proteins coronin, cofilin and AIP1 work together to rapidly disassemble actin filaments.

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Reposted by Wout Oosterheert

cryoEM papers @cryoempapers.bsky.social · 12/10/2025

Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1 pubmed.ncbi.nlm.nih.gov/41075793/ #cryoEM

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Reposted by Wout Oosterheert

Tobias Raisch @traisch.bsky.social · 18/09/2025

We just published this paper of which I am immensely proud: www.nature.com/articles/s41... In the study, we uncover how the enzyme MPO disassembles #nucleosomes in a process called NETosis, a funky mechanism of #neutrophils to kill #pathogens that you might have never heard of. Let's dive in... 🧵

nature.com

Myeloperoxidase transforms chromatin into neutrophil extracellular traps - Nature

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

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Wout Oosterheert @woutoosterheert.bsky.social · 30/09/2025

Thrilled to announce that from tomorrow (October 1st), I'll start as a junior group leader at the Netherlands Cancer Institute (NKI) @nkinl.bsky.social in Amsterdam 😄. www.nki.nl/news-events/... 1/3

nki.nl

New group leader Wout Oosterheert: the devil is in the details | Netherlands Cancer Institute

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Reposted by Wout Oosterheert

Tassos Perrakis @tassosperrakis.bsky.social · 13/09/2025

Featuring #AlphaBridge features from @alvarezsalmoral.bsky.social, with @jonasteuwen.bsky.social and team, our new work from @nkinl.bsky.social nl.bsky.social @oncodeinstitute.bsky.social . Have a look at ahmpc.eu for more!

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Wout Oosterheert @woutoosterheert.bsky.social · 25/08/2025

Happy to have made a tiny contribution to this work (including the shown movie 😄). Amazing work by Fakler lab @uni-freiburg.de and @raunser-lab.bsky.social @mpi-dortmund.bsky.social about Ca-ion transport by PMCA2-NPTN complexes, now out in @nature.com www.nature.com/articles/s41...

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Reposted by Wout Oosterheert

Carter Lab @carter-lab.bsky.social · 05/08/2025

Excited to share our latest work with @simonbullock11.bsky.social! We looked at how diverse mRNAs get selected for subcellular localization and it turns out that a single protein can recognize different RNA elements using shared features that weren’t apparent before. www.biorxiv.org/content/10.1...

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Reposted by Wout Oosterheert

Alushin Lab @alushinlab.bsky.social · 18/02/2025

Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances: bit.ly/3EFpD6h

bit.ly

Afadin mediates cadherin-catenin complex clustering on F-actin linked to cooperative binding and filament curvature

Afadin strengthens adherens junctions by stabilizing cadherin-catenin complex clusters on curved F-actin.

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Reposted by Wout Oosterheert

Tianyang Liu @tianyang22.bsky.social · 31/01/2025

Working on actin cytoskeleton and Arp2/3 complex? Check out our latest work～https://www.biorxiv.org/content/10.1101/2025.01.31.635869v1 In this work, we found SPIN90 forms a dimer, facilitating bidirectional actin filament nucleation by activating two Arp2/3 complex #Cryo-EM #Actin #Arp2/3

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Wout Oosterheert @woutoosterheert.bsky.social · 23/01/2025

My first post on this forum! 😄 I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... Big thanks to my amazing colleagues in Dortmund

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