Mothers of the most solitary great ape plan and structure playdates, even when it comes at a cost

Liu et al. identify a population of Lef1+ hypothalamic neurons that coordinates feeding and thermogenic adaptations to cold. Cold suppresses Kcnk2/TREK-1 function to enhance neuronal activity, revealing a molecular mechanism linking environmental temperature to neural and metabolic responses.

UConn researchers found that brief and sustained activation of an arousal-related brain region had markedly different effects on how the mouse brain encoded ...

YouTube video by Max Planck Institute of Animal Behavior

Nature Neuroscience - Related memories are sometimes encoded in overlapping neurons. The authors show that the prefrontal cortex controls this type of memory organization in the hippocampus through...

The website of the 52nd EBBS Meeting :: EBBS 2027

Neuropsychopharmacology - Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption

Learn about neuroscientists who have started new labs or independent lines of research in Latin America over the past five years.

A key role for retrograde neuromodulatory signalling in motivated behaviour is shown through dynamic endocannabinoid release within a thalamostriatal circuit that regulates behavioural engagement during reward seeking.

Genetics profoundly influences aggression by shaping neural circuits, but the underlying mechanisms remain unclear. Here, authors show that strain differences in male mouse aggression are linked to di...

Jarvie et al. identify two populations of parabrachial CGRP neurons, one that responds rapidly to appetitive signals during ingestion and the other that responds slowly to aversive visceral cues. The rapid CGRP neuron activation during ingestion is shown to be required for post-ingestive learning but not, as previously believed, satiety.

Understanding how early life stress becomes biologically embedded remains a major challenge in neuroscience. In this Review, Maze and colleagues discuss recent advances in cell-type-specific epigeneti...

Mice spontaneously form leader and follower roles during cooperation, and the medial prefrontal cortex encodes these role dynamics and an egocentric social value map of the partner’s position.

Parental care is a conserved and robust feature of mammalian reproductive behaviour, but is highly variable, even within individuals. Jamieson and Kohl describe the neural circuits that drive parental...

DeepOF: An open-source Python library for mouse behavioral analysis.

Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of cal...

A specific pathway reassigns emotional valence to a known mouse, while the hippocampus’s own representation of that animal’s identity remains stable.

Central glucose-dependent insulinotropic polypeptide receptor (GIPR) signalling is required for the efficacy of GIP-based obesity therapeutics, yet how distinct subpopulations of GIPR neurons shape ap...

Escape from threat is one of the most ancient and conserved sensorimotor transformations and must satisfy two competing demands. It must be fast and reliable, because failing to escape genuine threats...

In a mouse model of Huntington’s disease, targeted modulation of neuronal activity restores network function and improves motor deficits.

The populations of CRHR2-expressing neurons in the lateral septum of mice involved in threat-related behaviour in response to environmental challenges are defined.

Walker, Lowenstein, et al. demonstrate that hunger neurons in the mouse hypothalamus are rapidly activated not only by actual energy deficit but also by environmental cues predicting future fasting. This predictive hunger signal is conveyed by upstream Sim2-expressing neurons, revealing that the brain proactively anticipates energy shortfalls before they occur.

Nature Metabolism - Semaglutide-induced weight loss is shown to depend on Gs-coupled signalling in GLP1R-expressing hindbrain neurons, with a critical role for cAMP in mediating neuronal activation...

Nature Reviews Neuroscience - Structured social hierarchies, in which individuals differ in their access to resources and influence over other group members, are a characteristic of many social...

Rodent behavior; Biological sciences; Zoology

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implicati...

Piantadosi et al. show mice flexibly adjust choices between reward options based on the punishment potential in a BLA-dependent manner. They find that BLA neuronal representation of punishment reactiv...

In mice, female aggression is governed by an amygdala–to–medial hypothalamus circuit that is strengthened during pregnancy and is dynamically amplified by oxytocin during lactation.

Raam, Li, Gu and colleagues identify neural mechanisms underlying group huddling in mice during cold exposure. They find that the prefrontal cortex encodes decisions to huddle and that silencing neura...

The 2026 Gordon Research Conference on Hypothalamus will be held in Newry, Maine. Apply today to reserve your spot.

The authors present the GrimACE, an automated cage-side system that uses computer vision to score mouse pain and behavior. The tool, which detects postsurgery pain and analgesic effects, enables repea...