In a mouse model of Huntington’s disease, targeted modulation of neuronal activity restores network function and improves motor deficits.

During learning, neural circuits reorganize to encode new information and adapt behavioral responses. Ca2+/calmodulin-dependent protein kinase II (CaM…

Zhang et al. show that mice flexibly adjust how past experiences guide choices in fast- and slow-changing environments. Retrosplenial cortex neurons display a wide range of history-integration timesca...

Cell type–specific striatal activity during movement is shaped by cortical and thalamic inputs with complementary roles.

How a Tiny Brain Region Helps You Learn Complex Movements, One Neuron at a Time on Simons Foundation

The brain’s ability to prioritize sensory information is crucial for adaptive behavior, yet its mechanisms remain unclear. We investigated basal forebrain cholinergic neurons modulating olfactory bulb...

Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in the executi...

Synapses on different dendritic domains store distinct types of information

Synaptic plasticity underlies learning by modifying specific synaptic inputs to reshape neural activity and behavior. However, the rules governing which synapses will undergo different forms of plasti...

Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...

Huntington′s disease (HD) is a devastating movement disorder without a current cure. Although the monogenic basis of HD is well-defined, the complex downstream effects that underlie behavioral symptom...

During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated whe...

By recording large populations of neurons in behaving monkeys using newly developed silicon probes, we show that intermittent periods of memorandum-specific spiking coexist with synaptic mechanis...

The authors show that neural activity and synaptic plasticity in the orbitofrontal cortex mediate multiple timescales of reinforcement learning (RL) for meta-RL, which parallels a form of meta-RL in a...

The brain’s functional connectome continually rewires throughout an organism’s life. In this study, we sought to elucidate the operational principles of such rewiring in mouse primary motor cortex...