Nature Metabolism - Semaglutide-induced weight loss is shown to depend on Gs-coupled signalling in GLP1R-expressing hindbrain neurons, with a critical role for cAMP in mediating neuronal activation...

This study by de Araujo Salgado and Krashes reveals how high-fat diets suppress defensive neural circuits, driving riskier foraging in the presence of predation. The findings highlight how high-fat fo...

In 2025, the words we use to describe emotions matter, but their definitions are controversial. Here, I unpack the different positions in this space and the rationales behind them—and I invite 13…

The findings, gleaned from the most comprehensive map yet of brain activity during decision-making in mice, show that the process is even more distributed than previously thought.

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A. James Hudspeth, a Rockefeller neuroscientist who discovered how sound waves are converted into electrical signals in the ear's cochlea, died Saturday at his home in Manhattan. A pioneering scientist and dedicated mentor, he was the university's F.M. ...

Glucagon-like peptide 1 receptor (GLP1R) agonists like semaglutide drive weight loss through the brain, but insights into their intracellular signaling mechanisms are lacking. Although canonically GLP...

It is difficult to fathom why anyone intelligent enough to be a scientist would actually choose to be one. Doing good science requires the utmost exertion of body, mind and spirit, yet is consistently...

Fear learning is a critical adaptive mechanism that enables the association of an environmental cue (the conditioned stimulus, CS) with a potential threat (the unconditioned stimulus, US), even when t...

American University is a student-centered research institution located in Washington, DC, with highly-ranked schools and colleges, internationally-renowned faculty, and a reputation for creating meani...

The rise and fall of motivational states may take place over timescales as long as many days. We used mouse mating behavior to model how the brain orchestrates slow-timescale changes in motivation. Ma...

Studies of body-to-brain communication often examine one stimulus or organ at a time, yet the brain must integrate many body signals during behavior. For example, food consumption generates diverse or...

ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

High sugar–containing foods are readily consumed, even after meals and beyond fullness sensation (e.g., as desserts). Although reward-driven processing of palatable foods can promote overeating, the n...

YouTube video by Kempner Institute at Harvard University

Douglass et al. employ long-term, continuous fiber photometry to uncover new modes of agouti-related peptide (AgRP) neuron regulation in ad libitum, fasted, and circadian conditions. AgRP neuron activity exhibits a circadian rhythm, which controls daily feeding patterns through a neural circuit from the suprachiasmatic nucleus via the dorsomedial hypothalamus.

A drug with a novel mechanism protects people against the AIDS virus for 6 months. It could speed the end of the epidemic—if those who need it most get access

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Carter was president from 1977 to 1981, but he was perhaps more famous for the life he led after he left office. He was one of the biggest advocates for peace, democracy and human rights.