Nuclei within the limbic system like the central amygdala (CeA) play a critical role in mediating fear, motivation, reward, and appetitive behavior. A…

The opinions expressed in this editorial are the personal views of the authors (S.E. Kahn, C.A.M. Anderson, J.B. Buse, and E. Selvin) and do not represent

Nature Metabolism, Published online: 22 May 2026; doi:10.1038/s42255-026-01534-8Semaglutide-induced weight loss is shown to depend on Gs-coupled signalling in GLP1R-expressing hindbrain neurons, with a critical role for cAMP in mediating neuronal activation and downstream effects.

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implicati...

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implicati...

Glucagon-like peptide 1 receptors (GLP-1Rs) are highly expressed in the brain and are responsible for mediating the acute anorexigenic actions of widely prescribed GLP-1R agonists. Neurobiological efforts to localize the hypophagic effects of GLP-1R agonists in the brain have mainly focused on the h …

The New Jersey pharma giant will acquire a suite of cancer molecules

Researchers at Washington University in St. Louis find the timing of biopsy can affect how doctors diagnose tumors and when those cancers may be more sensitive to chemotherapy.

Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...

The company said it planned to seek Food and Drug Administration approval for the drug, orforglipron, before the end of the year.

Researchers say scientific community is in state of whiplash and accuse president of trying to ‘destroy’ vital work

Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

'The fault, Dear Reader, lies not in the mice but in our targets'

United States Senate Committee on Appropriations

Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.