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Stephen V Mahler

@svmahler.bsky.social
1.5K followers 672 following 51 posts

Behavioral Neuroscientist, Prof, ICAN co-Director, Ivan Pavlov fan. Interested in rats, drugs, motivation circuits, orexin, VP, DREADDs, psychedelics, neurodevelopment, etc faculty.sites.uci.edu/mahlerlab www.youtube.com/@stephenvmahler56

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Reposted by Stephen V Mahler
Matt Hill @cannabrain.bsky.social · 16h
**Recruitment** We are looking to hire a psychiatrist/scientist (MD or MD/PhD) who focuses on neuromodulation, particularly rTMS in the Department of Psychiatry at the University of Calgary. Come join myself, @mayoonthebrain.bsky.social and more. Details 👇 careers.ucalgary.ca/jobs/1829278...
careers.ucalgary.ca
Academic Position in Neuromodulation Research, Department of Psychiatry, Cumming School of Medicine in Calgary, ...
Academic Position in Neuromodulation Research, Department of Psychiatry, Cumming School of Medicine in Calgary, ...
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Stephen V Mahler @svmahler.bsky.social · 28/09/2026
Important paper, and excellent title!
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Zoe McElligott @nanopharmnc.bsky.social · 26/09/2026
Our new investigation examining how #SBI-553 a biased modulator of NTSR1 alters motivated feeding and NST potentiation of inhibitory transmission in the extended amygdala is now online! www.sciencedirect.com/science/arti...
sciencedirect.com
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Jeremy Berg @jeremymberg.bsky.social · 23/09/2026
This was posted on Monday www.nih.gov/news-events/... 1/2
nih.gov
NIH makes major investments to advance human-based research infrastructure and technologies
Projects spanning the nation will accelerate scientific discovery, reduce reliance on animals.
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Stephen V Mahler @svmahler.bsky.social · 21/09/2026
New paper showing a biological component of the so-called "gateway effect" of early-life cannabis on later-life opioid addiction. Following footsteps of @neurovoice.bsky.social, we show AdolTHC 🔼 opioid reward behaviors, and alters neural network responses to heroin doi.org/10.1016/j.ad...
doi.org
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Jeremiah Cohen @jeremiahycohen.bsky.social · 16/09/2026
Happy to share the version of record of our locus coeruleus paper here: www.nature.com/articles/s41... Prior thread on some of our discoveries in this study: bsky.app/profile/jere...
nature.com
Topographic structure and function of locus coeruleus noradrenaline neurons - Nature
Dorsal and ventral noradrenergic neurons in the locus coeruleus form topographic subpopulations whose projection patterns and activity encode choice switching, reward-prediction errors and disregard o...
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Ryan J Hollister @phaneritic.bsky.social · 09/09/2026
Fair warning! The listings for my latest batch of 3D-Printed scale model volcano tissue box covers will go live tomorrow morning (Thursday) around 8am PDT. I think I counted 27 are available this time. A decent variety from which to choose! Will pack this weekend and ship Mon. phaneritic.etsy.com
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David Moorman @davidmoorman.bsky.social · 31/08/2026
Our 🧠lab is hiring a new RA to help study neural changes associated with chronic alcohol, start date ASAP. Ideal for recent college graduates looking for research experience. Please send me any recommendations or have them reach out to me, and please forward/share with your colleagues – thanks!
Aerial view of the University of Massachusetts Amherst campus, May 2018. Credit: Greg Saulmon / The Republican file
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aaron bornstein @aaronbornstein.bsky.social · 03/09/2026
UC Irvine Cognitive Sciences is hiring! Focus on social cognition, broadly construed. Come be my colleague :) I am not on the search committee but happy to talk about the campus, environment, careers, etc any time. recruit.ap.uci.edu/JPF10411
recruit.ap.uci.edu
Assistant Professor - Cognitive Sciences
University of California, Irvine is hiring. Apply now!
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Samantha Butler @samanthabutler.bsky.social · 02/09/2026
Please spread the news - the Department of Neurobiology at UCLA is hiring. This is an open rank search for all and any amazing neuroscientists! Please apply here by Nov 15th, first review end of October : recruit.apo.ucla.edu/JPF11296
recruit.apo.ucla.edu
Open-rank tenure-track faculty position
University of California, Los Angeles is hiring. Apply now!
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Brian Wiltgen @wiltgenlab.bsky.social · 21/08/2026
Come work with the fantastic faculty at UC Davis! Great place to live and do science 🧪 recruit.ucdavis.edu/JPF07812
recruit.ucdavis.edu
Assistant Professor of Psychology - Biological Bases of Behavior
University of California, Davis is hiring. Apply now!
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Stephen V Mahler @svmahler.bsky.social · 31/08/2026
New paper in @sfnjournals.bsky.social JNeurosci from Butcher, Ramirez, and Ruiz etal! We show that #addiction is not a unitary entity in the brain, and that even different opioid drugs recruit diff brain mechs. Highlighted in "this week in the Journal!" www.jneurosci.org/content/46/3...
jneurosci.org
This Week in The Journal
How Early-Life Stress Sensitizes Young Mice to Stressors Rebekah L. Rashford, Lisa Z. Fang, Michael DeBerardine, Hye Ji J. Kim, Laura W. Hirschfield, et al. (see article [e2217252026][1]) Adverse ...
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IYKYK 🌮 @nisslbody.blacksky.app · 16/08/2026
Without basic research, translational and applied research grind to a halt. We don't know what any given discoveries might be useful for in the future, but that doesn't mean we should limit research to studies that have a clear pathway to applicability.
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CosmicRami 🏳️‍🌈🏳️‍⚧️ @rami.spaceaustralia.com · 07/08/2026
This is fun. On the top left type in your suburb. Then ues the back and forth arrows to see where your home was over the last 750 million years. My suburb spent a good time of that underwater! Try yours here: dinosaurpictures.org/ancient-eart... HT @iflscience.com
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Ben Saunders @bensaunders.bsky.social · 03/08/2026
The final version of our amygdala dopamine paper is out! BLA dopamine dynamically tracks emotional salience and not value or reward prediction error. Congrats to Dr. Megan Brickner!! www.nature.com/articles/s41...
nature.com
Basolateral amygdala dopamine transmits emotional salience - Nature Communications
The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...
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Dr. Cate Peña @cate-cholamine.bsky.social · 29/07/2026
Excited to share this paper led by two undergrads in the lab, out now in Neurobiology of Stress! Temporal reorganization of maternal care during early life stress in mice doi.org/10.1016/j.yn...
doi.org
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Daniel Castro @flanbrain.bsky.social · 21/07/2026
Fresh from the Castro Lab! We characterize how mu opioid receptors on pancreatic alpha cells regulate ingestive phenotypes. Surprise! Mu can act both inside and outside the brain😱 Congrats to our technician Diego De Gregorio! @ssibsociety.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Pancreatic mu opioid receptors regulate metabolism and ingestive behaviors
The mu opioid receptor system has long been recognized for its role in regulating ingestive behaviors and food palatability. However, beyond their rob…
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Stephen V Mahler @svmahler.bsky.social · 14/07/2026
Are ultrasonic vocalizations a window into the subjective effects of drugs of abuse, and VTA dopamine neuron manipulations, in rats? 🤔 New answers to these questions, & intriguing new questions raised! urldefense.com/v3/__https:/...
urldefense.com
Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs
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Vikaas Sohal @vikaassohal.bsky.social · 10/07/2026
New preprint led by @christineliu.art! How do psychedelics improve cognitive flexibility? Psilocybin prevents inflexibility caused by aberrant mesocortical error signaling (but not inflexibility due to other mechanisms); this is tied to plasticity of PFC-MD neurons: www.biorxiv.org/content/10.6...
biorxiv.org
Psilocybin selectively rescues cognitive flexibility impairments caused by aberrant prefrontal error signaling
Psychedelic drugs show remarkable potential for treating psychiatric disorders, but the mechanisms underlying their therapeutic effects remain relatively unknown. Here, we demonstrate that psilocybin ...
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Lex Kravitz @kravitzlab.com · 09/07/2026
I am happy to share our latest manuscript, led by newly-minted PhD Justin Wang, identifying a neural population that selectively controls hedonic, but not homeostatic, feeding. www.biorxiv.org/content/10.6...
biorxiv.org
Ventral pallidal GABAergic neurons control hedonic feeding and obesity
Food intake is governed by two interacting drives. The homeostatic hunger drive regulates food intake to fulfill caloric needs while the hedonic drive promotes intake of palatable foods outside of cal...
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Christine Rabinak, PhD, MBA @brainsbeesbikes.bsky.social · 06/07/2026
Our paper was accepted in Biological Psychology, and it's the first first-author publication for Christopher Thomas. Chris led the innovative modeling work behind this study, and I couldn't be prouder of what he accomplished. #Psychophysiology #BiologicalPsychology doi.org/10.1016/j.bi...
doi.org
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Admirable Women @admirablewomen.bsky.social · 26/06/2026
#OTD in 1903, Marie Curie--the legendary Polish-French physicist & chemist--defended her doctoral thesis on radioactive substances at the U. de la Sorbonnes becoming the first woman in France to earn a doctorate in #physics. She won Nobel Prize in Physics (1903) & in Chemistry (1911). #WomenInSTEM
A black-and-white photograph of Polish-French physicist and chemist Marie Skłodowska-Curie (1867–1934), the first person to win two Nobel Prizes. She sits sideways on a simple wooden chair, leaning her left elbow juust off the backrest with her hand supporting her chin. Her expression is intense, serious, and deeply contemplative, with dark hair loosely swept up. She wears a dark, long-sleeved dress with voluminous fabric gathering at the shoulders, typical of the late 19th or early 20th century. To her right, a long wooden worktable stretches across the room, cluttered with laboratory apparatus, including a vertical brass instrument, glass bottles, and jars. The background reveals a room with large paneled windows and a door, suggesting a makeshift or academic laboratory setting. The composition focuses heavily on Curie's powerful gaze, evoking an introspective, solemn mood that speaks to her monumental sacrifices and historic dedication to the study of radioactivity.
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UCI Center for the Study of Cannabis @ucicannabis.bsky.social · 22/06/2026
🧠 Turns out microglia—the brain's immune cells—are key partners in memory. In this UC Irvine ICAL study, depleting them disrupted endocannabinoid-dependent plasticity and episodic memory; boosting 2-AG signaling rescued both. 🔗 www.jneurosci.org/content/45/2... #Neuroscience #Microglia
jneurosci.org
Microglia Support Both the Singular Form of LTP Expressed by the Lateral Perforant Path and Episodic Memory
We report here that microglia exert a surprisingly discrete but functionally critical influence on synaptic plasticity in the mouse hippocampus. Treatment of adult male mice with colony-stimulating…
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Kurt Fraser @kurtfraser.bsky.social · 18/06/2026
I'm looking to hire a research technician/lab manager. This role is ideal for someone looking to gain experience and independence after undergraduate research on their way to graduate school. Please encourage anyone interested to apply: hr.myu.umn.edu/jobs/ext/374... (job code 374183)
hr.myu.umn.edu
Careers
The Fraser Lab at the University of Minnesota (https://fraserlab.psych.umn.edu/) is recruiting a full-time research technician to support the lab. As a part of the Department of Psychology we are involved in the greater neuroscience research community at the University of Minnesota which provides excellent access to training and professional development. The Fraser Lab is interested in the neurobiological basis of motivated behavior and investigates how defined brain circuits contribute to behavioral regulation. We make use of modern neuroscience approaches to record and manipulate neural activity in real-time as rodents perform complex behavioral tasks to relate precise aspects of neural activity to well-defined psychological processes. To do so, we regularly use optogenetics, chemogenetics, calcium imaging, biosensors, pharmacology, and immunohistochemistry. Our ultimate goal is to decipher the neural mechanisms regulating behavior and to characterize how these are altered in psychiatric illness, such as addiction, or by differences in lived experience, such as after early life adversity, to potentially identify novel therapeutics. We seek a team member who can play a lead role in lab operations, collaborate closely with the PI, and engage in team-building and growth.Duties:Laboratory logistics, maintenance and operations (30%):
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Melanie Jackson @mjjaxn.bsky.social · 19/06/2026
The Seven Social Sins are: Wealth without work. Pleasure without conscience. Knowledge without character. Commerce without morality. Science without humanity. Worship without sacrifice. Politics without principle. -Frederick Lewis Donaldson in Westminster Abbey, London, on March 20, 1925
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Cajal Club @cajalclub.bsky.social · 11/06/2026
Congratulations to Oswald Steward of UC Irvine, recipient of the 2026 Kavli Prize in Neuroscience for discoveries revealing how local protein synthesis in neurons shapes brain development, plasticity, learning, and recovery from injury. #Neuroscience @kavliprize.bsky.social @ucicncm.bsky.social
This is a portrait of neuroscientist Oswald Steward.
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aaron bornstein @aaronbornstein.bsky.social · 28/05/2026
New lab preprint! Dr. (x2) @biancaleonard.bsky.social leads a multidisciplinary team investigating the opposing effects of early-life unpredictability and anhedonia on foraging under threat of predation. Her results suggest that anhedonia may sometimes be an adaptive response to experience. 🧵 below!
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Stories of WiN @storiesofwin.bsky.social · 27/05/2026
Check out our latest profile! Dr. Megan Peters (@meganakpeters.bsky.social) studies how the brain represents & uses uncertainty and she also co-founded the online summer school, Neuromatch Academy. Learn more at the link below! #WomenInNeuroscience #StoriesOfWiN www.storiesofwin.org/profiles/202...
storiesofwin.org
Dr. Megan Peters — Stories of WiN
studies how the brain represents and uses uncertainty and she also co-founded the online summer school, Neuromatch Academy
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Prof Amy Milton @profamymilton.bsky.social · 22/05/2026
Proud to see some of Luise Pickenhan’s (not yet on BlueSky) PhD work published in @psychopharmacology.bsky.social
link.springer.com
Probing the habitual and compulsive-like basis of (dys)functional checking in the Observing Response Task, a rodent analogue relevant to obsessive-compulsive disorder
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aaron bornstein @aaronbornstein.bsky.social · 11/09/2025
Come work with us! UC Irvine Cognitive Sciences is looking for a new Assistant Professor to join our team: recruit.ap.uci.edu/JPF09896 I'm not on the committee, but happy to talk if you're interested.
recruit.ap.uci.edu
Assistant Professor - Cognitive Sciences
University of California, Irvine is hiring. Apply now!
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Stephen V Mahler @svmahler.bsky.social · 21/05/2026
Brimming with pride for my lab, and especially Bri Morales, Selen Dirik, and Erica Ramirez, who won grad student awards from the @ucirvine.bsky.social CNLM today, along with lab alum Jorge Mendoza. What an honor to work with them, and everyone else who makes our lab work! @ucicannabis.bsky.social
Briana MoralesSelen DirikErica RamirezJorge Mendoza
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Andrew Hardaway @andrewhardaway.bsky.social · 08/05/2026
Psilocybin in the Treatment of Cocaine Use Disorder jamanetwork.com/journals/jam... Some really cool findings from Peter Hendricks of UAB Psychiatry!
jamanetwork.com
Psilocybin in the Treatment of Cocaine Use Disorder
This randomized clinical trial evaluates whether, compared with placebo, the use of psilocybin in the treatment of cocaine use disorder yields a higher percentage of cocaine abstinent days, a greater ...
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Stephen V Mahler @svmahler.bsky.social · 08/05/2026
A true legend of behavioral neuroscience, and exceptionally kind man. His generous mentorship touched many of us who never even worked with him. The field he helped shape mourns him today.
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This skeet will self destruct @pardoguerra.bsky.social · 07/05/2026
Quite amazing that the @uofcalifornia.bsky.social forced faculty and staff to install super-invasive cybersecurity software as a preventive measure but has had zero interest in dealing with the massive risks that they assumed with, for example, Canvas. Bravo... www.dailycal.org/news/campus/...
dailycal.org
Cybercrime group ShinyHunters seizes UC Berkeley Canvas in nationwide attack, 600K student, staff records at risk
UC Berkeley’s learning management platform bCourses, the software that all 43,000 students use to access their class materials, has been seized by hackers. When students attempt to log in, they
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Stephen V Mahler @svmahler.bsky.social · 07/05/2026
Canvas is down just ahead of finals at @ucirvine.bsky.social. This makes at least 3 occasions where my data have been stolen via companies hired by my employer. This time the students are affected too, cool!
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Dr. Julia Lemos @sciencejuls.bsky.social · 07/05/2026
Happy 100th Birthday to global treasure David Attenborough ❤️
static.klipy.com
David Attenborough's Bird Encounter
ALT: David Attenborough's Bird Encounter
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Stephen V Mahler @svmahler.bsky.social · 07/05/2026
Check out this very cool new paper on rat ultrasonic vocalizations emitted in a naturalistic habitat--some surprising findings, and cool quantitative analyses done by Jordan Saltzman in the Ron Frostig Lab in Neurobiology & Behavior @ucirvine.bsky.social www.cell.com/iscience/ful...
cell.com
Correlating ultrasonic communication with behavior in a small-scale rat colony living in a naturalistic habitat
Rodent behavior; Biological sciences; Zoology
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Tallie Z Baram @talliezee.bsky.social · 29/04/2026
Stunning, enduring effects of early-life oxytocin- from neuronal firing to behavior! by Gall & Lynch 🧪🧠 www.nature.com/articles/s41.... @npp-journal.bsky.social @oyiz.bsky.social @julielauterborn.bsky.social @dulaclab.bsky.social @flaviodonato82.bsky.social @svmahler.bsky.social
nature.com
Lasting effects of early-life oxytocin treatment on LTP and episodic memory in a mouse model of Fragile X syndrome - Neuropsychopharmacology
Neuropsychopharmacology - Lasting effects of early-life oxytocin treatment on LTP and episodic memory in a mouse model of Fragile X syndrome
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Patrick Piantadosi @ppiantad.bsky.social · 16/04/2026
Officially out today! Long-running project, many thanks to give - in particular to my mentors & collaborators, the postbacs who worked so hard on each experiment, and the reviewers. If you love the amygdala, give it a read. www.sciencedirect.com/science/arti...
sciencedirect.com
Risk reshapes amygdala representation of choice
Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is evident when animals curtail the …
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Dr. Diana Li @dianateuthis.bsky.social · 15/04/2026
Join me online today at 1pm ET to hear how the @zuckermanbrain.bsky.social Public Programs team built our Teacher Institute for Neuroscience and Society program for NYC middle school teachers: cnlm.uci.edu/connect Thank you to @danafoundation.bsky.social for making this program possible! 🧪🧠
cnlm.uci.edu
CONNECT Initiative - Center for the Neurobiology of Learning and Memory | UCI CNLM
CONNECT SEMINAR SERIES 2025-26 CONNECT is an initiative supported by UC Irvine’s Center for the Neurobiology of Learning and Memory to build networks and share resources and expertise in the…
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Ileana Morales @reallyile.bsky.social · 31/03/2026
Happy to report mine and Kent’s paper exploring cortical hedonic hotspots is officially out! 🐀🐀🐀
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Drug Monkey @drugmonkey.bsky.social · 31/03/2026
Notification of the end of continuous submission and updating the late submission policy. grants.nih.gov/grants/guide...
grants.nih.gov
NOT-OD-26-064: Update of NIH Late Application Submission Policy and End of Continuous Submission
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Update of NIH Late Application Submission Policy and End of Continuous Submission NOT-OD-26-064. NIH
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Bryan Roth @zenbrainest.bsky.social · 27/03/2026
Mechanistic insights into the therapeutic properties of delta opioid receptor | Science Advances www.science.org/doi/10.1126/...
science.org
Mechanistic insights into the therapeutic properties of delta opioid receptor
Integrated structural and dynamic analyses uncover strategies to target the δ-opioid receptor for improved analgesic efficacy.
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Drug Monkey @drugmonkey.bsky.social · 03/03/2026
Yes! We literally cannot shut up about our work.
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Stephen V Mahler @svmahler.bsky.social · 04/03/2026
Interested in addiction and cormorbid disorders? Join us for our ICAN symposium on Mar. 18 in @ucirvine.bsky.social, featuring Josh Gordon, @neurovoice.bsky.social, Tony George, @nanopharmnc.bsky.social, Khaled Moussawi, Meg Fox, Firoza Mamdani, & more! All welcome! www.bio.uci.edu/event/ican-s...
bio.uci.edu
UC Irvine Center for Addiction Neuroscience (ICAN) Symposium - Charlie Dunlop School of Biological Sciences
Bridging the Lab and the Clinic to Address Addiction and Comorbid Affective and Psychosis Disorders Please register below for the UC Irvine Center for Addiction Neuroscience (ICAN) Symposium on Wednes...
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Steve W. C. Chang @stevewcchang.bsky.social · 25/02/2026
Very excited to share a Special Collection at the Journal of Neuroscience (@sfnjournals.bsky.social) - Central Questions for Social Neuroscience Research. This issue includes some of the latest perspectives on social neuroscience research. Please check it out!👇 www.jneurosci.org/content/46/8
jneurosci.org
The Journal of Neuroscience: 46 (8)
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Kate Wassum @katewassum.bsky.social · 25/02/2026
🚨📃New Wassum Lab Paper 📃🚨 Out today, Melissa Malvaez, Nick Griffin, Andrea Suarez & team discovered that dopamine can enable reward predictions to shape how we pursue reward. Surprisingly, we find that dopamine can constrain instrumental reward seeking. www.jneurosci.org/content/46/8... 🧵👇🏻
jneurosci.org
Dopamine Supports Reward Prediction to Shape Reward-Pursuit Strategy
Reward predictions not only promote reward pursuit, they also shape how reward is pursed. Such predictions are supported by environmental cues that signal reward availability and probability. Such cue...
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Serge Ahmed @sergeahmed.bsky.social · 19/02/2026
A simple voluntary action reduces high-fat diet intake and obesity in mice This is a very elegant multi-continental study 👏 www.cell.com/current-biol...
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Dr. Cate Peña @cate-cholamine.bsky.social · 18/02/2026
I am so proud to share @forrestdrogers.bsky.social’s postdoctoral magnum opus, now out in @nature.com! Forrest discovered a novel role for Agouti in the MPOA of the hypothalamus to integrate socio-environmental information to flexibly tune paternal behavior www.nature.com/articles/s41... Thread! 👇🏻
nature.com
Agouti integrates environmental cues to regulate paternal behaviour - Nature
Expression of agouti signalling protein in neurons in the medial preoptic area is increased by group housing and negatively associated with care, and overexpression of Agouti reduces care and enhances...
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davidweinshenker.bsky.social @davidweinshenker.bsky.social · 19/02/2026
New Special Issue out in #AddictionNeuroscience edited by @talialerner.bsky.social on dopamine circuitry and heterogeneity in addiction with articles by @daylab.bsky.social, Tom Hnasko, @mtorregrossa1.bsky.social, and Awatramani Rajeshwar check it out! www.sciencedirect.com/special-issu...
sciencedirect.com
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