Tissue morphogenesis integrates developmental programs with cell mechanics, yet the mechanisms coupling these processes remain poorly understood. We investigated this link during neuroepithelial morph...

Lab-grown organoids wire into mice missing a key part of their brain, offering a new way to test drugs for developmental conditions.

The differentiation variability of human pluripotent stem cell lines is diagnosed and corrected.

The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...

Steady-state RNA abundance measurements mask the synthesis and decay rates that shape gene expression. Analog intrinsic recoding sequencing (AIR-seq) repurposes the base-pairing properties of N4-hydro...

Experimentally replaying tumour evolution in divergent mouse strains reveals the importance of interactions between genetic ancestry and acquired cancer-driving mutations in shaping the earliest stages of cancer development.

The highly dynamic mechanical environment of the developing cerebral cortex has the potential to encode information vital for neuronal differentiation. Changes in local biophysical properties have bee...

Summary: A reaction-diffusion mechanism recapitulates pattern emergence in an in vitro model of neuromesodermal progenitors under a variety of boundary and geometrical perturbations.

Gibbons et al. present a human corticospinal organoid slice-based connectoid model, with physically separate but functionally coupled cortical and spinal regions. Allowing cell-type-specific observations, the platform uncovers a developmental maturation-dependent decline in human axon regeneration and a transcriptional program intrinsic to cortical projection neurons that, when targeted, promotes repair post-injury.

Quantitative comparison of morphogenesis across individuals remains a fundamental challenge, as developing embryos vary in shape, orientation and developmental tempo. Moreover, real-time three-dimensi...

Garge et al. use experimentally matched mass spectrometry and RNA-sequencing to quantify proteins, phosphosites and transcripts across four key stages of human and mouse gastruloid development.

Red blood cells have been modified to form strong clots that halt any bleeding almost instantly and then promote tissue regeneration.

Frenster et al. utilize mosaic mouse gastruloids as a model of cell fitness and competition, identifying a temporal window between primed pluripotency and early gastrulation during which cell competit...

A new peptide sequencing approach converts amino acids into DNA sequences, which are easily read.