MEMORANDUM OF DECISION PURSUANT TO FED. R. CIV. P. 52(A)(1) signed by Judge Noël Wise on 8/28/2026. (akw, COURT STAFF) (Filed on 8/28/2026)

Pericytes regulate cerebrovascular development, while vascular smooth muscle cells prevent hemorrhage and blood–brain barrier breakdown at vascular hotspots in juvenile and adult zebrafish.

Join one of the 24 Institutes and Centers within the NIH that awards extramural grants! Extramural grants account for approximately 80 percent of NIH's budget and are awarded to investigators at more ...

Recombinant adeno-associated viruses (rAAVs) have shown promise for orthopedic diseases. However, conventional AAV vectors face major challenges, where immune responses reduce transgene efficacy and inadequate vector potency requires higher doses, leading to increased costs and safety concerns. Here, we show that Pluronic F-127 (PF127) micelles encapsulating rapamycin (PF127-RAPA), co-administered with AAV vectors, significantly enhanced AAV transduction efficiency and reduce its immunogenicity. Mechanistically, PF127-RAPA modulates the morphology and mechanical properties of the nuclear membrane, which is associated with enhanced passive transport mediated by nuclear pore complexes (NPCs) and thereby increased AAV nuclear entry. Concurrently, PF127-RAPA reduced AAV particle accumulation in the cytoplasm, minimizing MHC class I presentation of capsid proteins and attenuating the cellular immune response. Notably, in postmenopausal osteoporosis and rheumatoid arthritis mouse models, PF1

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The NIH Data Book page reporting Research Project Grants (RPG) and Fellowship awards by race has been updated for FY2025. Completely unsurprisingly, despite the impression that may have been convey…

The mitochondrial dye MitoTracker is commonly used to investigate intercellular mitochondrial transfer (IMT), particularly between astrocytes and neurons. Hole et al. compare MitoTracker with a geneti...

According to the Urban Indian Health Institute, the first recorded case of a missing and murdered Indigenous woman or girl was in 1943. Two-thirds of all the cases they gathered for a 2025 study were ...

Bioinformatics, 2026, 0–0 doi: 10.1093/bioinformatics/xxxxx Advance Access Publication Date: DD Month YYYY Genome Analysis Genome Analysis bedder: flexible genome interval intersection with user-defi...

Alt: a group of characters from the Simpsons cartoon show with one of the kids crying and saying “stop, stop! he 's already dead.”

View Sophia Elaine Burdine Schwartz's obituary, contribute to their memorial, see their funeral service details, and more.

The FY2025 funding picture was disrupted significantly by the mandate for Multi-Year Funding of about half of the budget for extramural awards. This produced a mid-year declaration by NCI that thei…

Inspired by the loss of their mother, they have poured millions into studying a key protein behind frontotemporal dementia. But all has not gone according to plan

The Department of Biology at California State University, Northridge (CSUN) is seeking a tenure-track faculty member in Vertebrate Functional Morphology.