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Li-Kun Phng

@phnglab.bsky.social
410 followers 149 following 29 posts

Cell, Developmental and Vascular Biologist. Laboratory for Vascular Morphogenesis. RIKEN Center for Biosystems Dynamics Research.

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Li-Kun Phng @phnglab.bsky.social · 15/06/2026
Yes, do attend #Angioscience26 and hear me talk about how #actin and cellular hydraulics control endothelial #mechanobiology during #angiogenesis and #EHT! #zebrafish
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Li-Kun Phng @phnglab.bsky.social · 29/05/2026
Looking forward to participating in this top-notch meeting!
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Li-Kun Phng @phnglab.bsky.social · 29/05/2026
Thank you @navbo.bsky.social for featuring @phnglab.bsky.social as Lab of the Month in May! www.navbo.org/members-labs/
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Vermot Lab @vermotlab.bsky.social · 27/04/2026
🚨 How do mechanical forces shape a developing organ? Our new #ScienceAdvances @science.org study, led by the amazing @cvagenapantoula.bsky.social, reveals a Piezo1-driven hydraulic mechanism, where mechanical cues control cell volume to guide cardiac formation ❤️🐟 🔗 www.science.org/doi/10.1126/...
science.org
Piezo1-mediated mechanohydraulic control of cell volume drives cardiac morphogenesis
Mechanical forces shape the developing heart by controlling cell volume through a Piezo1-driven hydraulic mechanism.
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Li-Kun Phng @phnglab.bsky.social · 14/04/2026
Latest preprint from @phnglab.bsky.social @riken-bdr.bsky.social ! We show cellular hydraulics as a determinant of hemogenic endothelial cell (HEC) survival during endothelial-to-hematopoietic (EHT) transition. www.biorxiv.org/cgi/content/... #mechanobiology #zebrafish #endothelialcells
biorxiv.org
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Li-Kun Phng @phnglab.bsky.social · 26/02/2026
Happy to share a write-up of our recent publication @natcomms.nature.com demonstrating how circumferential actomyosin-driven endothelial cell contractions constrict vessel diameter, providing insights into mechanisms of normal vessel remodelling and CCM. www.bdr.riken.jp/en/news/rese...
bdr.riken.jp
When vessel constriction fails: Cellular mechanics linking developmental remodeling to vascular malformations
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Li-Kun Phng @phnglab.bsky.social · 11/02/2026
Feb 11 is International Day of Women and Girls in Science and at RIKEN BDR, we celebrate the achievements of #womeninscience by holding an IDWGIS Symposium. We also recently launched Mirai Alliance, a mentorship network for women researchers in life sciences. www.bdr.riken.jp/en/news/bdr-...
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Ondine Cleaver @ondinecleaver.bsky.social · 10/02/2026
🚨 SAVE-THE-DATE 🚨 SEEON ANGIOSCIENCE! Fantastic, long-running meeting on Development & Maintenance of the Vasculature. 🗓️ Sept 2026 🌍 Bavaria, Germany Registration open! Join us! vwfb.de/start/regist...
Information on the conference on vascular development and maintenance held in Bavaria, Germany in September 2026. Conference is held in a historical monastery on a lake in beautiful Bavaria. Registration is now open! Lots of great speakers that are leaders in the field. We will pick a large number of talks from abstracts to elevate early career investigators. Join us!
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Li-Kun Phng @phnglab.bsky.social · 30/12/2025
Simply delighted to end the year with the acceptance of Yan’s paper www.nature.com/articles/s41.... It was a heroic effort on her part, and many thanks to all our collaborators for their help! @vizcie.bsky.social @juliaeckert.bsky.social
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RIKEN Center for Biosystems Dynamics Research (BDR) @riken-bdr.bsky.social · 18/09/2025
🪰Yu-Chiun Wang’s team & Univ. of Hohenheim group discovered how fly embryos solve the “tissue tectonic collision” that occurs in morphogenetic movements between tissues and why the #cephalicfurrow evolved, a longstanding mystery to developmental biologists. In @nature.com doi.org/10.1038/s415...
doi.org
Divergent evolutionary strategies pre-empt tissue collision in gastrulation - Nature
Flies have evolved two distinct strategies for managing mechanical stresses during embryogenesis: out-of-plane cell division in midges and transient out-of-plane tissue folding in fruit flies.
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Yu-Chiun Wang @yuchiunwang.bsky.social · 15/09/2025
Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.
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Li-Kun Phng @phnglab.bsky.social · 09/09/2025
Another successful #leducq #ReVAMP meeting held at Orford, Canada! Great science, food and friendship... Thanks @ondinecleaver.bsky.social for hosting us and showing us the way up the mountain! A la prochaine!
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eLife @elife.bsky.social · 09/09/2025
Tiny molecular spirals in cells can scale up to control the twist and turn of entire tissues, an important step towards understanding left-right symmetry in tissues and organs. buff.ly/2pSf3xS
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Julia Eckert @juliaeckert.bsky.social · 15/08/2025
Now published in @natcomms.nature.com! 🥳 👉 rdcu.be/eATn3 We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
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Julia Eckert @juliaeckert.bsky.social · 11/07/2025
A fantastic week at the Mechanobiology Conference in Vietnam, filled with fascinating talks, fruitful discussions, and amazing people. Huge thanks to the organizers and ICISE for making it all possible!
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Li-Kun Phng @phnglab.bsky.social · 02/06/2025
Thanks to the generosity of #FujiharaFoundation and the excellent organization of Fumio Motegi and his team, the ' #Mechanics of Life Across Scales' symposium was held successfully at beautiful Awaji. We had 3 days of fantastic #mechanobiology talks with speakers from Japan, India, Europe and US.
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Li-Kun Phng @phnglab.bsky.social · 22/04/2025
Had the absolute pleasure of hosting the Leducq ReVAMP biannual meeting @riken-bdr.bsky.social in Kobe this spring! #endothelial #mechanobiology #vascularmalformations See you all again in Fall @ondinecleaver.bsky.social @mvikkula.bsky.social
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Li-Kun Phng @phnglab.bsky.social · 15/04/2025
Check us out @the-node.bsky.social !
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Institut Jacques Monod @ijmonod.bsky.social · 21/01/2025
📢 Mechanobiology Conference III: From Fundamental Research to Applications 📅 July 06-12 📍 ICISE Quy Nhon, central Vietnam The registration and abstract submission is now open! 🔗 icisequynhon.com/conferences/...
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Li-Kun Phng @phnglab.bsky.social · 02/04/2025
Thank you @the-node.bsky.social‬ for inviting me to write a 'Behind the Story' piece on our recent study! Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis thenode.biologists.com/exploring-th...
thenode.biologists.com
Exploring the Uncharted Waters of Endothelial Tip Cell Migration: A Story of Aquaporins, Hydrostatic Pressure, and Angiogenesis - the Node
Behind the Paper Story of “Combined forces of hydrostatic pressure and actin polymerisation drive endothelial tip cell migration and sprouting angiogenesis”.
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Rashmi Priya @rashmi-priya.bsky.social · 10/03/2025
Stoked to present our latest, superbly led by Chris et al & @torres-sanchez.bsky.social We tackled a fundamental problem – how tissues are patterned during development – found that geometry-constrained ECM fractures pattern the myocardium in the vertebrate heart 1/n www.biorxiv.org/content/10.1...
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Li-Kun Phng @phnglab.bsky.social · 10/03/2025
At #RIKEN BDR, women represent 10% of PIs, 31% of researchers, 38% of students and 74% of technical staff. On #IDWGIS last month, we celebrated their achievements and contributions to research at BDR. www.bdr.riken.jp/en/news/bdr-... #internationalwomensday
bdr.riken.jp
Careers in Science—Perspectives of Women Researchers and Technical Staff
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Biomedical Picture of the Day BPoD @bpodaily.bsky.social · 06/03/2025
Zebrafish study reveals that, along with actin polymerisation, hydrostatic pressure underlies the push of endothelial tip cells into new territory 📹: Igor Kondrychyn et al RIKEN Center for Biosystems Dynamics Research, Kobe, Japan in @elife.bsky.social ➡️: bpod.org.uk/archive/2025...
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Li-Kun Phng @phnglab.bsky.social · 05/03/2025
Chuffed to find out that our work was featured as an Insight article in @elife.bsky.social elifesciences.org/articles/106.... Thank you Sean Sun and colleague for highlighting our work!
elifesciences.org
Morphogenesis: Fluid transport comes to the fore
Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
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eLife @elife.bsky.social · 03/03/2025
Proteins that allow water to move in and out of cells help shape the development of new blood vessels. buff.ly/41n6ii0
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sameerthukral.bsky.social @sameerthukral.bsky.social · 22/02/2025
What an honor to host @itaiyanai.bsky.social at RIKEN-BDR, Kobe! From learning Night Science creativity, to see them come alive with Day Science rigor, Itai truly demonstrated the "yes, and" attitude in person! Thank you for your great energy, passion and generosity! Can't wait to have you back!
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Li-Kun Phng @phnglab.bsky.social · 21/02/2025
Read the Research Highlight here! www.riken.jp/en/news_pubs... @RIKEN BDR
riken.jp
Water gives cells a push in blood vessel formation
RIKEN researchers have shown that that hydrostatic pressure is one of two mechanisms that control endothelial cell migration during angiogenic sprouting in zebrafish
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Li-Kun Phng @phnglab.bsky.social · 21/02/2025
Happy to announce that the final version of our paper on #endothelial cell #migration #mechanobiology, #angiogenesis, #hydrostaticpressure is out on @elife.bsky.social doi.org/10.7554/eLif... !! In our revised paper, we show that disrupted osmotic gradient and water inflow impair tip cell migration!
doi.org
Combined forces of hydrostatic pressure and actin polymerization drive endothelial tip cell migration and sprouting angiogenesis
Investigation of Aquaporin water channels unveils water inflow and build-up of hydrostatic pressure in endothelial tip cells as a novel mechanism of endothelial cell migration and blood vessel formati...
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sameerthukral.bsky.social @sameerthukral.bsky.social · 18/02/2025
Excited to host @itaiyanai.bsky.social at RIKEN BDR, Kobe over the next few days! Looking forward to learning about "Tails" and how to use Night Science "Tales" to supercharge creativity in science! Thank you Itai for accepting our invitation!
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Li-Kun Phng @phnglab.bsky.social · 21/01/2025
Excited to announce that we will be holding another #mechanobiology across scales symposium this year in beautiful Awaji Island #Japan! We have a star-studded lineup of speakers and it's free participation (free accommodation and food!)! Register here: www.igm.hokudai.ac.jp/85th-fujihar...
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