Inside cells, DNA is intimately associated with proteins, forming chromatin. The protein constituents of chromatin vary across the tree of life: histones are the principal building blocks of chromatin...

Unbelievably, it's the 15th year of this thing. What is it? Improbably, the nig… Rhodri Marsden needs your support for Duvet Know It's Christmas, 2025

Histone H3 lysine 4 trimethylation (H3K4me3) at gene promoters is thought to play a central role in gene transcription. H3K4 methylation is deposited by the SET1 (A/B) and MLL (1-4) multi-protein comp...

Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining functional centromeres.

A new work from the Klose lab published in the journal Molecular Cell

Unbelievably, it's the 14th year of this thing. What is it? Improbably, the nig… Rhodri Marsden needs your support for Duvet Know It's Christmas, 2024

Kelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog...