iiinova — where your digital self keeps evolving

Sara R Heras @herassr.bsky.social · 28/04/2026

Felices por haber organizado y compartido las Primeras Jornadas Andaluzas sobre el Síndrome 22q11.2. Gracias a todos los que lo hicieron posible! www.genyo.es/investigador...

genyo.es

Investigadores de la UGR y GENyO, clínicos y la Asociación Síndrome 22q11.2 Andalucía estrechan lazos para impulsar el abordaje integral del Síndrome 22q11.2 - GENyO

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Joanna W Jachowicz @jjachowicz.bsky.social · 02/03/2026

If you want to explore ncRNA dynamics during mammalian development, love microscopy, and are not afaraid of transposons biology, apply‼️ We are looking for a postdoc to join our team at @imbavienna.bsky.social More details 👇🏻

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Torben Heick Jensen @heick.bsky.social · 06/03/2026

Postdoc positions available in my lab in Aarhus, Denmark on 'Mammalian Nuclear RNA Production and Turnover Systems'. Please get in touch for further information or simply apply here: mbg.au.dk/en/news-and-...

mbg.au.dk

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University

Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

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Sara R Heras @herassr.bsky.social · 05/03/2026

Graphical abstract from our new paper in Nucleic Acids Research with @saramaciasrna.bsky.social 🧬 DGCR8 prevents accumulation of endogenous dsRNA derived from Alu elements within mRNAs, avoiding aberrant activation of the interferon response. academic.oup.com/nar/article/...

academic.oup.com

Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8

Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev

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Sara MaciasRNA @saramaciasrna.bsky.social · 05/03/2026

A great collaboration of my group with @herassr.bsky.social and @heick.bsky.social groups searching for mammalian dsRNAs and their importance to human disease 🧬

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Sara R Heras @herassr.bsky.social · 05/03/2026

Our New paper in Nucleic Acids Research, in collaboration with @saramaciasrna.bdky.social! A new link between TEs, RNA regulation, innate immunity and 22qDS. Congrats to the authors,specially @anagazquezg.bsky.social academic.oup.com/nar/article/...

academic.oup.com

Validate User

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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 13/01/2026

Avanzamos en nuestras investigaciones sobre el síndrome #22q11. @herassr.bsky.social presentará los nuevos resultados publicados por nuestro grupo de investigación en la próxima conferencia internacional 22q11 que se celebrará en Creta en julio. Gracias a la asociación 22q Andalucía por su apoyo. 💪🏻

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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 21/11/2025

Mañana 22 de Noviembre es el Día Internacional del Síndrome 22q #22q11. En el grupo de @herassr.bsky.social en Genyo nos hemos sumado a su visibilización. #hazvisible22q

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Sara R Heras @herassr.bsky.social · 20/11/2025

Deeply greatful to the 22q11.2 Andalucia Association and to all the artists and attendencees who filled the theater yesterday in Granada!! Your support helps us to move forward in understanding 22q11 Deletion Syndrome. #22q #22q11 #GENYO#UGR

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Cedric Feschotte @cedricfeschotte.bsky.social · 18/11/2025

TE x ZFP = Evolution! Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.

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Raquel Fueyo @fueyoraquel.bsky.social · 01/10/2025

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

rdcu.be

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

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Addgene @addgene.bsky.social · 20/05/2025

Exciting work! Plasmids are available at Addgene: www.addgene.org/browse/artic...

addgene.org

Addgene: Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase

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Michelle Percharde @mpercharde.bsky.social · 14/05/2025

The nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more. journals.biologists.com/dev/article/...

nucleoli are dynamically reprogrammed in early mammalian development

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Raquel Fueyo @fueyoraquel.bsky.social · 12/05/2025

I am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...

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Marco Trizzino @marcotrizzino.bsky.social · 07/04/2025

New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n www.biorxiv.org/content/10.1...

biorxiv.org

Human-specific transposable elements shaped the evolution of craniofacial development through regulation of neural crest migration

Craniofacial development and neural crest specification are evolutionarily conserved processes, yet subtle modifications to their gene regulatory networks drive species-specific craniofacial diversity...

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Ursula von der Leyen @vonderleyen.ec.europa.eu · 05/05/2025

We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers. As well as ambitious proposals for R&I in the next EU budget. We will also offer the best and brightest the right incentives to come to Europe ↓

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Cedric Feschotte @cedricfeschotte.bsky.social · 30/04/2025

💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n

pnas.org

Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS

Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound of TE-derived sequences repurposed for organismal function. ...

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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 27/03/2025

Esta pérdida de un alelo de DGCR8 ocurre en el síndrome 22q11 y señala que no siempre los modelos de ratón reflejan la complejidad en humana. Gracias a los coautores y las IPs @herassr.bsky.social y @saramaciasrna.bsky.social, así como a @uji.es Artículo aquí ➡️ academic.oup.com/nar/article/...

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Guillermo Peris 🧬💻 @waltzingpiglet.bsky.social · 27/03/2025

🔴 NUEVO ARTÍCULO DE NUESTRO GRUPO en @narjournal.bsky.social!!! 🧬 #TEsky La pérdida de un alelo del gen DGCR8 en células madre embrionarias humanas afecta a su pluripotencia interfiriendo en una red de elementos transponibles y microARNs que es específica de primates. (1/2)

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Sara R Heras @herassr.bsky.social · 27/03/2025

Our latest paper is out in NAR! 🥳 In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates. Read: academic.oup.com/nar/article-...

academic.oup.com

DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects

Abstract. The 22q11.2 deletion syndrome (22qDS) is a human disorder where the majority of clinical manifestations originate during embryonic development. 2

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Sara MaciasRNA @saramaciasrna.bsky.social · 27/03/2025

Our last paper in collaboration with Sara RHeras is finally out 🥳we modelled Dgcr8 haploinsufficiency in hESCs and exciting differences between 🧘🏽‍♂️and 🐭 at the transposon and miRNA content -HERVH & C19MC Thanks to all the coauthors and funders academic.oup.com/nar/article/...

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Hablando de Ciencia @hablandodeciencia.com · 20/01/2025

No os perdáis este artículo sobre la relación entre los microARN y el cáncer. Por @herassr.bsky.social y nuestro socio Pablo Tristán

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