William Garland @willgarland.bsky.social · 06/10/2026mbg.au.dk/en/news-and-...mbg.au.dkA decades-old mystery in RNA processing solvedResearchers at the Department of Molecular Biology and Genetics (MBG) together with collaborators in Denmark, France, and Germany, have uncovered the molecular explanation for an observation that has ... 0123
William Garland @willgarland.bsky.social · 29/09/2026New from the lab! We uncover how the cap-binding complex promotes first-intron splicing: ZC3H18 recruits splicing factors while competing with the RNA-decay machinery, linking two alternative fates for newly made RNA. doi.org/10.1016/j.mo... 02913
Reposted by William GarlandCedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/nscience.orgEscape of the BC200 gene to a human poxvirus reveals its persistent transposition in primatesTransposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta... 217086
Reposted by William GarlandPeter Andersen @germline.bsky.social · 08/09/2026We are recruiting a PhD student 🥼🙋 Topic: how germ cells bend gene expression dogmas Fly genetics + proteomics + genomics. Fully funded. Aarhus University 🇩🇰 info on the project and how to apply👇 mbg.au.dk/en/peter-and... I'd really appreciate it if you'd help spread the word. Thanks 03446
Reposted by William GarlandVirginia Busetto @virginiabusetto.bsky.social · 08/09/2026Very excited to share our new preprint: “A pseudohelicase-centered complex couples assembly-dependent RNA cleavage to poly(UG)ylation”! 🎉 Want to know more? 🧵👇 www.biorxiv.org/content/10.6... 33211
William Garland @willgarland.bsky.social · 14/08/2026Postdoc in Nuclear RNA Biology at Aarhus University! Interested in mammalian nuclear RNA production and turnover? Come join Torben Heick Jensen’s team in Aarhus 🇩🇰 www.au.dk/om/stillinge...au.dkPostdoc position in Nuclear RNA Biology - Ledig stilling på Aarhus UniversitetLedig stilling ved RNA-biologi og -innovation, Aarhus Universitet 01111
Reposted by William GarlandAndrii Bugai @abugai.bsky.social · 17/06/2026Check out our latest research, just published in Nature @nature.com @molbiolau.bsky.social @au.dk Molecular basis of polyadenylated RNA fate determination in the nucleus www.nature.com/articles/s41...nature.comMolecular basis of polyadenylated RNA fate determination in the nucleus - NatureBiochemical, structural and cell biological analyses reveal that UAP56 (DDX39B) assembles with a TREX-2–like module that redirects non-functional polyadenylated RNAs from export to degradati... 16027
Reposted by William GarlandAna Gázquez-Gutiérrez @anagazquezg.bsky.social · 05/03/2026I'm so happy to share our latest paper! Now out in @narjournal.bsky.social 🥳 Did you know that transposable elements embedded in mRNAs can form dsRNA and activate innate immunity? 🧬🦠 Have a look! academic.oup.com/nar/article/... #TEsky #RNAsky #RNAbiology #immunity #NARacademic.oup.comControl of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8Abstract. The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prev 24718
William Garland @willgarland.bsky.social · 06/02/2026academic.oup.com/nar/article/...academic.oup.comDirect coupling of the human nuclear exosome adaptors NEXT and PAXT with transcription termination and processing machineriesAbstract. In human cells, the Nuclear EXosome Targeting (NEXT) and Poly(A) tail eXosome Targeting (PAXT) adaptors direct the nuclear exosome to degrade pre 000
William Garland @willgarland.bsky.social · 06/02/2026Pleased to be a small part of this collaboration with the @labconti.bsky.social now published at @narjournal.bsky.social. Here we combine structure prediction, biochem, cryo-EM, and IP-based approaches to explore connections between RNA quality control to transcription termination complexes. 171
Reposted by William GarlandPlaschka lab @plaschkalab.bsky.social · 21/11/2025Messenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4) 25925
Reposted by William GarlandUlrich Hohmann @hohmannulrich.bsky.social · 12/10/2025Thrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available! 68331
William Garland @willgarland.bsky.social · 17/09/2025How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens. www.biorxiv.org/content/10.1...biorxiv.orgMolecular basis of polyadenylated RNA fate determination in the nucleusEukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs, that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, including prote... 02813
William Garland @willgarland.bsky.social · 10/09/2025Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus! Deadline is October 1st danish-rna-society.nemtilmeld.dk/8/ 053
William Garland @willgarland.bsky.social · 22/07/2025Postdoc positions available in the THJ group in Aarhus, Denmark 🇩🇰 Please share around 🤝 048
William Garland @willgarland.bsky.social · 03/07/2025Happy to share our latest collaboration with the Cusack and Kadlec groups—now published in @natsmb.nature.com Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex Article: rdcu.be/euC4U News & Views: rdcu.be/euC5l 040
Reposted by William GarlandTorben Heick Jensen @heick.bsky.social · 27/06/2025Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...mbg.au.dkA postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus UniversityVacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University 0136
William Garland @willgarland.bsky.social · 19/06/2025Spotlight: shorturl.at/E6je8 Article: shorturl.at/cJsDGshorturl.at 010
William Garland @willgarland.bsky.social · 19/06/2025We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social. Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell. 1162
William Garland @willgarland.bsky.social · 17/06/2025mbg.au.dk/en/news-and-...mbg.au.dkInternational recognition for Aarhus researchers: RNA science takes offRNA research in Aarhus is taking a significant leap forward. Two researchers from the same department and research environment have both just been awarded one of Europe’s most prestigious research gra... 031
William Garland @willgarland.bsky.social · 02/06/2025Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social www.biorxiv.org/content/10.1...biorxiv.orgControl of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8The type I interferon (IFN) response is the main innate immune pathway against viruses in mammals. This pathway must be tightly regulated to prevent viral spread while avoiding excessive immune respon... 0103
William Garland @willgarland.bsky.social · 28/04/2025I've been wanting to try something like this. Awesome to see that it works 👍 110
Reposted by William Garlandalbinsan.bsky.social @albinsan.bsky.social · 07/04/2025Very proud to share this work just out in NAR: spearheaded by @jamieauxillos.bsky.social and Arnauld Stigliani: TLDR-seq, a method for 5’ to 3’ end long-read sequencing of capped RNAs regardless of 3’ end polyadenylation, based on the @nanoporetech.com platform. (1/4) tinyurl.com/3c2ksdmr 12811
Reposted by William GarlandTorben Heick Jensen @heick.bsky.social · 20/02/2025PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk 0812
Reposted by William GarlandAlphaFold Unofficial @alphafold.bsky.social · 20/02/2025“Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. AI co-scientist is a collaborative tool to help experts gather research and refine their work” blog.google/feed/google-...blog.googleWe’re launching a new AI system for scientists.Today Google is launching an AI co-scientist, a new AI system built on Gemini 2.0 designed to aid scientists in creating novel hypotheses and research plans. Researchers… 0226
Reposted by William GarlandLeopold Parts @leopoldparts.bsky.social · 31/01/2025We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church. www.science.org/doi/10.1126/...science.orgRandomizing the human genome by engineering recombination between repeat elementsWe lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re... 213861
William Garland @willgarland.bsky.social · 07/02/2025New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology @molbiolau.bsky.social mbg.au.dk/en/news-and-...mbg.au.dkPostdoc positions in Nuclear RNA Biology - Vacancy at Aarhus UniversityVacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University 099
Reposted by William GarlandRNA Society @rnasociety.bsky.social · 04/02/2025We are pleased to announce registration for RNA 2025 - the 30th Annual Meeting of the RNA Society - is now open! www2.rnasociety.org This year’s meeting will be held at the beautiful Town and Country Resort & Convention Center in sunny San Diego, California, USA from May 27th - June 1st, 2025. 14124
Reposted by William GarlandCell Press @cellpress.bsky.social · 31/01/2025Hello BlueSky! Follow us to stay up to date on the inspiring science published in our journals and more. To get started, check out our #starterpack to meet all the Cell Press journals currently on the platform, with more to come🧪🔬🤖🧬🌳🪲 go.bsky.app/TdKYuS7 06523
William Garland @willgarland.bsky.social · 21/01/2025Resident colour blind member of the lab here 🙋♂️ Please make your figures friendly to us. 050
Reposted by William GarlandbioRxiv Genomics @biorxiv-genomic.bsky.social · 10/01/2025Restrictor slows early transcription elongation to render RNA polymerase II susceptible to termination at non-coding RNA loci www.biorxiv.org/content/10.1101/202… 044
William Garland @willgarland.bsky.social · 07/01/2025Is there a common contaminant database for proximity labelling-MS data? I see that the CRAPome has a section for proximity-dependent biotinylation but it is limited to human cells. I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap. 000
Reposted by William GarlandMRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 29/12/202440 years ago all of Genbank was published in print form by NAR. The same format today would require over 4 light seconds of shelf space. To a year of progress in 2025. 15559215
William Garland @willgarland.bsky.social · 21/12/2024Cell lines are frozen, chrome tabs, spreadsheets and documents have been closed. All done for this year ✌️ Back in Derbyshire and busy making sausage rolls. It's been a productive year, but i'm in dire need of a break. 000
William Garland @willgarland.bsky.social · 13/12/2024This project was speaheaded by Guifen Wu and is now available online at @naturecomms.bsky.social doi.org/10.1038/s414...doi.orgRNA 3′end tailing safeguards cells against products of pervasive transcription termination - Nature CommunicationsPervasive transcription generates numerous unadenylated RNAs, usually degraded by the NEXT/nuclear exosome pathway. Here, the authors show that, upon NEXT inactivation, these RNAs are removed by compe... 000
William Garland @willgarland.bsky.social · 13/12/2024📢 Latest publication from the lab! We explore how cells manage the excess pA− RNAs generated by pervasive transcription. While the NEXT complex usually takes charge, in its absence, a network of tailing enzymes, export factors, and exonucleases steps in to modify and degrade these RNAs. 194
Reposted by William GarlandGav Armstrong @nchemgav.bsky.social · 10/12/2024Don't use red and green data lines/surfaces in the same panel please #chemsky. It can be difficult for some colorblind readers to differentiate them. I've accepted (in principle) 2 papers today, and both sets of authors were asked to remove red/green colour contrasts www.nature.com/articles/d41...nature.comColour me better: fixing figures for colour blindnessImages can be made more accessible by choosing hues, shapes and textures carefully. 411347
William Garland @willgarland.bsky.social · 29/11/2024New preprint! Great to be a part of this collaboration with the Cusack and Kadlec groups. Here we have uncovered the cryo-EM structure of the snRNA export complex, revealing how PHAX bridges CBC-bound RNA to CRM1-RanGTP, committing it to export. www.biorxiv.org/content/10.1...biorxiv.orgStructural basis for the synergistic assembly of the snRNA export complexThe nuclear cap-binding complex (CBC) and its partner ARS2 play crucial roles in regulating Pol II transcript fate through mutually exclusive interactions with RNA effectors. One such effector, PHAX, ... 031
Reposted by William GarlandAnita Corbett @acorbe2.bsky.social · 19/11/2024 Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025 18346
Reposted by William GarlandJess Kelley @jesskelley.bsky.social · 26/11/2024Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)cell.comThe PNUTS phosphatase complex controls transcription pause releaseKelley et al. discover that the PNUTS phosphatase complex plays an essential role in gene transcription by controlling RNA polymerase II pause release. PNUTS achieves this through its TND, which recog... 26628
Reposted by William GarlandJohn F. Cryan @jfcryan.bsky.social · 20/11/2024Like ‘old Twitter’: The scientific community finds a new home on Bluesky www.science.org/content/arti...science.orgLike ‘old Twitter’: The scientific community finds a new home on BlueskyAfter recent changes to Elon Musk’s X, a gradual migration turns into a stampede 07327
William Garland @willgarland.bsky.social · 08/11/2024Latest from the lab, finally out in Molecular Cell. Here we show a physical and functional link between the Microprocessor and a variant NEXT complex. Together, these complexes degrade the 5' flanks of pre-miRNAs and other stem-loop-containing RNAs. doi.org/10.1016/j.mo... 073
William Garland @willgarland.bsky.social · 08/11/2024This is more of a reminder to myself to keep checking this. 020
William Garland @willgarland.bsky.social · 12/07/2024We put together a Molecular Cell preview for the latest papers from Wojtek Galej and Stefanie Jonas uncovering fascinating new details about the Integrator complex. Preview here: t.co/XGMwJwBOZa Articles here: t.co/9lx1z3bvE6 t.co/k0EqO54gXB 022
William Garland @willgarland.bsky.social · 02/06/2024Representing MBG🇩🇰 at #RNA24 We actually got some sun out of Edinburgh 010
William Garland @willgarland.bsky.social · 02/06/2024Lovely bonus from #RNA24 was winning a (very generous) poster prize ✌️ 000
Reposted by William GarlandbioRxiv Molecular Biology @biorxiv-molbio.bsky.social · 02/06/2024DNA-directed termination of mammalian RNA polymerase II www.biorxiv.org/content/10.1101/202… biorxiv.orgDNA-directed termination of mammalian RNA polymerase II https://www.biorxiv.org/content/10.1101/2024.06.01.596947v1 The best-studied mechanism of eukaryotic RNA polymerase II (RNAPII) transcriptional termination invo 022
