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Tom Van Agtmael

@tomvanagtmael.bsky.social
362 followers 105 following 74 posts

Professor of matrix biology, University of Glasgow. Interests: extracellular matrix biology/disease, collagen, cerebrovascular disease, small vessel disease, stroke. Views are my own.

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Tom Van Agtmael @tomvanagtmael.bsky.social · 20/08/2026
Happy to report our new publication by Gaia Brezzo in @matrix biology from collaboration with Karen Horsburgh. Col4a1 mutation in mouse model of cerebral #small_vessel_disease causes white matter defects that can be modulated by targeting protein folding www.sciencedirect.com/science/arti...
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Julie S. Di Martino, PhD. @juliesdimartino.bsky.social · 04/08/2026
Official link to apply to join my team as a lab assistant: lnkd.in/gpQgnVzX
lnkd.in
LinkedIn
This link will take you to a page that’s not on LinkedIn
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EMBL Events @events.embl.org · 31/07/2026
Get your calendars, because the new 2027 EMBL Annual Poster has arrived: s.embl.org/2027-poster Whether you'd like to enhance your skills in a practical course or engage with the latest research at one of our conferences, we've got you covered. See you at EMBL in 2027! 🙌 #LifeSciences #EMBL
The image depicts the 2027 EMBL Annual Poster featuring the new events programme for 2027. On the left side is a colorful banner, on the right is the list of events sorted by month
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Yanlan Mao @yanlanmao.bsky.social · 30/07/2026
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
cell.com
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 29/07/2026
Always enjoy grabbing lunch with the team. Getting away from the lab gets people to know each other, discuss ideas, and create a team bond..all while enjoying nice food
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Hao Yin @haoyin.bsky.social · 23/07/2026
Induced Lox KO in Myh11+ Smooth Muscle Cell, but not PDGFRα+ fibroblast, ⏬Angiotensin II-induced 🐭Cardiac Fibrosis Cardiac hypertrophy remain unaltered in both Lox KO models A possible SMC-to-Fibroblast matrix/mechano-transducive cascade in fibrosis bioRxiv 2026 www.biorxiv.org/content/10.6...
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Eric Topol @erictopol.bsky.social · 16/07/2026
The aortic dissection that led to Senator Graham's sudden death. Could it have been prevented? What is being done to reduce the toll of aortic dissection with so many people having a dilated proximal aorta and so few progressing to a catastrophic event? www.statnews.com/2026/07/15/l...
statnews.com
Graham’s death from aortic dissection raises questions about preventing the rare disorder
When the body’s most important blood vessel tears from the inside, it’s a medical emergency that can be years in the making.
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Eric Topol @erictopol.bsky.social · 16/07/2026
This is big. The first vaccine tested to PREVENT pancreatic cancer in high-risk individuals aacrjournals.org/cancerdiscov...
aacrjournals.org
First-in-human testing of a mutant KRAS vaccine for pancreatic cancer interception in high-risk cohorts
Abstract. Pancreatic ductal adenocarcinoma (PDAC) arises from precursor lesions over a decade-plus, offering a window for interception in high-risk individuals, but current surveillance detects a mino...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 18/07/2026
New paper from Alex Naba and her lab on a very poorly understood extracellular matrix protein. SNED1 modulates ECM architecture and cell proliferation via its LDV integrin-binding motif journals.biologists.com/jcs/article-...
journals.biologists.com
SNED1 modulates ECM architecture and cell proliferation via its LDV integrin-binding motif
The extracellular matrix (ECM) is a complex scaffold of proteins that supports multicellular structures. Interactions between cells and the ECM via receptors, like integrins, govern cellular phenotype...
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JCI insight @insight.jci.org · 12/07/2026
Spotlight: 📗From our Special Issue on Fibrosis Benjamin D. Humphreys @humphreyslab.bsky.social provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org
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Daniel Gorelick @danielgorelick.bsky.social · 01/07/2026
Paying peer reviewers works. Benefits authors, editors & reviewers. Hopefully other journals will try this.
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Naba Lab UIC @nabalabuic.bsky.social · 03/07/2026
Highlights from Matrix Biology Europe 2026 #MBE2026, including the now traditional pics of past and present Rupert Timpl awardees and of the Dick Heinegård jury that I was honored to participate in this year again!
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Tom Van Agtmael @tomvanagtmael.bsky.social · 14/11/2025
PhD project alert: if interested in learning more about stroke, vascular dementia and mitochondria (yes there is some matrix there as well!) Come and join us! collaboration with Kostas Tokatlidis Email me if interested. Application deadline: 12 January 2026 www.gla.ac.uk/colleges/mvl...
gla.ac.uk
University of Glasgow - Colleges - College of Medical, Veterinary & Life Sciences - MVLS Graduate School - PhD Research Opportunities - College Futures Themes PhD Programme - Projects - Fundamentals of Life Projects
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sher12.bsky.social @sher12.bsky.social · 27/09/2025
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Tom Van Agtmael @tomvanagtmael.bsky.social · 18/09/2025
New paper out from Markus Ruegg lab on gene therapy for muscular dystrophy due to laminin mutations: Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy. www.biorxiv.org/content/10.1...
biorxiv.org
Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy
Adeno-associated virus (AAV)-mediated gene replacement holds promise for treating genetic diseases but faces challenges due to AAV's limited packaging capacity and potential immune responses to transg...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 16/09/2025
Really excited to tell you about our paper just out in the journal Matrix Biology. @erinboland.bsky.social set out to investigate what the impact of basement membrane defects are on adult heart function/biology. www.sciencedirect.com/science/arti...
sciencedirect.com
Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function
Collagen IV is a major constituent of basement membranes and mutations in the genes COL4A1 and COL4A2 present clinically as a variable, multi-system d…
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Yoshi Ishikawa @collagenyoshi.bsky.social · 10/07/2025
"My" latest review is online now. We need your creativity! 😎 👇👇👇 Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored | Biochemistry pubs.acs.org/doi/10.1021/...
pubs.acs.org
Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored
Collagen embodies an intriguing paradox in protein biology. Despite being one of the most abundant protein superfamilies in vertebrates and having a seemingly simple structural organization, its biosy...
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Eric Topol @erictopol.bsky.social · 12/07/2025
Here's what it gets you
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Valerio Val Izzi @valerioizzi.bsky.social · 12/07/2025
Am I back from the best conference ever? Yes! But do I also see a crucial tool for the analysis of the #ECMatrix in scRNAseq? Also yes!! Another fantastic tool in collaboration with @nabalabuic.bsky.social 🔥🔥🔥
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Naba Lab UIC @nabalabuic.bsky.social · 11/07/2025
Perfect timing on the last day of the 2025 #Collagen Gordon Research Conference! Our paper, in collaboration with @valerioizzi.bsky.social describing #MatriCom, a tool to infer ECM communication systems from scRNA-Seq datasets, is now published in @jcellsci.bsky.social! doi.org/10.1242/jcs....
doi.org
MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–extracellular matrix interactions
Highlighted Article: MatriCom is a web application devised to mine single-cell RNA-sequencing datasets to infer extracellular matrix (ECM)–ECM and cell–ECM communication systems across cell population...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 13/06/2025
New data from the Deltas lab on targeting ER stress in Alport Syndrome. Chemical chaperone 4-phenylbutyrate treatment alleviates the kidney phenotype in a mouse model of Alport syndrome with a pathogenic variant in Col4a3 www.sciencedirect.com/science/arti...
sciencedirect.com
Chemical chaperone 4-phenylbutyrate treatment alleviates the kidney phenotype in a mouse model of Alport syndrome with a pathogenic variant in Col4a3
Alport Syndrome is a severe inherited glomerulopathy caused by pathogenic variants in genes encoding collagen-IV, the most abundant component of the g…
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Tom Van Agtmael @tomvanagtmael.bsky.social · 30/05/2025
New paper in Nature Cell Biol from @johannaivaska.bsky.social and @ivaskalab.bsky.social Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells rdcu.be/eoAUD
rdcu.be
Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells
Nature Cell Biology - Conway et al. show that integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 26/05/2025
Really excited to work with the Ruggiero lab over the summer as visiting professor at the Institute Genomics Functional De Lyon, ENS de Lyon. #Collagen. #Matrix and #disease treatments. @uofgmvls.bsky.social @uofgscmh.bsky.social
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Tom Van Agtmael @tomvanagtmael.bsky.social · 18/05/2025
And how are you meant to drive away from here? Parking in Barcelona
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Melanie Simms @melaniesimms.bsky.social · 28/04/2025
And we recreated it 150 years later. www.gla.ac.uk/news/archive...
gla.ac.uk
UofG recreates 150-year-old professors' photo for International Women's Day
Some of the University of Glasgow’s senior women leaders assembled to give their own historic take on a 150-year-old, all-male professors’ photo ahead of celebrations for International Women’s Day.
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Tom Van Agtmael @tomvanagtmael.bsky.social · 29/04/2025
20 degrees in Edinburgh. those of you who know Scottish tenement flats built in early 1900s (in which I live) know this means opening the windows to warm the house 😂
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Tom Van Agtmael @tomvanagtmael.bsky.social · 28/04/2025
Another collagen IV paper on the "to read" list... new review just out in the journal #matrix_biology "The life cycle of type IV collagen" by David Sherwood www.sciencedirect.com/science/arti...
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Doug Dyer @douglaspdyer.bsky.social · 28/04/2025
So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...
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Rachel Lennon @rachellennon.bsky.social · 28/04/2025
Curious about collagen?? There is an amazing program for the Collagen Gordon in New Hampshire this year. We have ample speaker slots reserved for abstract submissions. Come and join us! www.grc.org/collagen-con... July 6 - 11, 2025 www.grc.org/collagen-grs... July 5 - 6, 2025 Doug,Rachel,Alex
grc.org
2025 Collagen Conference GRC
The 2025 Gordon Research Conference on Collagen will be held in New London, New Hampshire. Apply today to reserve your spot.
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Tom Van Agtmael @tomvanagtmael.bsky.social · 28/04/2025
To all our undergraduate student's at @uofglasgow.bsky.social ..good luck with your exams!
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Steve Wang @stevewang251.bsky.social · 26/04/2025
Heard from a former (undergrad) student who just defended her PhD. Students: tell your old profs about your successes and achievements. It's not bragging, and we love to hear about it. It's one of the best parts of being an educator. #academicsky
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Jon Humphries @jdhl18.bsky.social · 25/04/2025
Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution and adaptation www.sciencedirect.com/science/arti...
sciencedirect.com
Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution and adaptation
Collagen IV is a major component of basement membranes, a specialized form of extracellular matrix that enabled the assembly of multicellular epitheli…
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Jon Humphries @jdhl18.bsky.social · 25/04/2025
Protocol for extraction and characterization of mouse brain-derived extracellular matrix for neuronal cell culture www.sciencedirect.com/science/arti...
sciencedirect.com
Protocol for extraction and characterization of mouse brain-derived extracellular matrix for neuronal cell culture
Neuronal cell cultures are highly sensitive to their microenvironment, particularly the choice of coating substrate. Here, we present a protocol to is…
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Tom Van Agtmael @tomvanagtmael.bsky.social · 25/04/2025
Delighted our first adventure into #collagen III mutations in #vascular Ehlers Danlos Syndrome is out. In patient cells, ER stress is part of mechanism; targeting via clinically approved chemical chaperones rescued intracellular - and #matrix defects. rdcu.be/ejhSR
rdcu.be
The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome
Cell Death Discovery - The chemical chaperone 4-phenylbutyric acid rescues molecular cell defects of COL3A1 mutations that cause vascular Ehlers Danlos Syndrome
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Kit Yates @kityates.bsky.social · 04/03/2025
🚨I promised I'd say more on the Royal Society and Elon Musk, so here it is. 🚨 I've resigned my position as Associate Editor at Royal Society's journal Open Science in protest at their lack of action over Elon Musk. My op-ed in @theguardian.com www.theguardian.com/commentisfre...
theguardian.com
Elon Musk is a proven danger to good science, but the Royal Society won’t say so. That’s why I resigned | Kit Yates
It is vital to act, and I urge colleagues to do so. How can we stand by and laud this man while he undermines scientific integrity? asks academic and author Kit Yates
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Tom Van Agtmael @tomvanagtmael.bsky.social · 04/03/2025
Around campus at @uofglasgow.bsky.social this morning.
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Niko Mouchtouris, MD @nikomouchtouris.bsky.social · 27/11/2024
Mechanical thrombectomy for ischemic stroke improves blood-brain barrier permeability and minimizes secondary injury! Our latest study used DP-pcASL to measure BBBP www.sciencedirect.com/science/arti...
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Jon Humphries @jdhl18.bsky.social · 23/02/2025
Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition academic.oup.com/cardiovascre...
academic.oup.com
Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition
AbstractAims. In this study, we aimed to uncover genes associated with stressed cardiomyocytes by combining single-cell transcriptomic datasets from failin
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Tom Van Agtmael @tomvanagtmael.bsky.social · 24/02/2025
@ccstorytime.bsky.social one for you?
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Tom Van Agtmael @tomvanagtmael.bsky.social · 23/02/2025
New review on small vessel disease, a major but poorly understood cause of vascular dementia and stroke, by Hugh Markus and Anne Joutel. journals.physiology.org/doi/abs/10.1...
journals.physiology.org
The pathogenesis of cerebral small vessel diseases and vascular cognitive impairment | Physiological Reviews | American Physiological Society
Cerebral small vessel disease (cSVD) is the broadly accepted term nowadays to designate a heterogeneous group of diseases caused by in situ damages of small brain vessels commonly related to aging, hy...
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Shireen Lamande @mamareen8.bsky.social · 21/02/2025
Labor hasn’t delivered on more effective nature laws. It’s not just embarrassing, it’s calamitous
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Eric Topol @erictopol.bsky.social · 22/02/2025
Update on the Measles outbreak in Texas and New Mexico www.nytimes.com/2025/02/22/u... There likely hundreds of cases, so many not being diagnosed. And many more to come. All preventable.
nytimes.com
Measles Outbreak in Texas and New Mexico Sickens Nearly 100 People
Texas reported 90 cases this week, while New Mexico reported nine. A majority of the cases have been in a Texas county where vaccination rates have lagged behind the rest of the state.
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Joan Chang @tranejoan.bsky.social · 18/02/2025
#ECMatrix guides #CellFate and patterning www.nature.com/articles/s41...
nature.com
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology
Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 18/02/2025
Luminescent sensing of conformational integrin activation in living cells www.cell.com/cell-reports...
cell.com
Luminescent sensing of conformational integrin activation in living cells
Villari et al. present the generation of a luminescent reporter for a β1 integrin activation sensor (β1IAS). A siRNA HTS on β1IAS KI endothelial cells revealed previously uncharacterized regulators of...
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Carmelo Ferrai @carmeloferrai.bsky.social · 17/02/2025
www.nature.com/articles/s41...
nature.com
Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis - Nature Communications
Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell in...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 18/02/2025
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke www.nature.com/articles/s41...
nature.com
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke - Nature Neuroscience
Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function ...
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Baptiste Lacoste @blacoste.bsky.social · 18/02/2025
Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes
doi.org
Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke - Nature Neuroscience
Bernier, Hefendehl et al. describe a stromal progenitor cell population consisting of pericytes, venular smooth muscle cells and perivascular fibroblasts in the adult brain that modify their function ...
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🦋 Gourdon Lab 🦠🔬 @delphe.bsky.social · 17/02/2025
🧪This is just a teaser. Stay tuned for more information coming soon! #6thISMB
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Centre for the Cellular Microenvironment @theglasgowcemi.bsky.social · 17/02/2025
Check out this paper in Advanced Science, great collaboration between UMONS Research, Innovation & Entrepreneurship @sgabriele.bsky.social & @giusciccone.bsky.social, @manuelsalmeron.bsky.social, both @ibecbarcelona.eu & @theglasgowcemi.bsky.social @uofglasgow.bsky.social: 👉 doi.org/10.1002/advs...
doi.org
Epithelial Cell Mechanoresponse to Matrix Viscoelasticity and Confinement Within Micropatterned Viscoelastic Hydrogels
Extracellular matrix (ECM) viscoelasticity and spatial confinement regulate cellular processes such as cancer progression, yet their interplay remains poorly understood. By developing fibronectin (FN...
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Tom Van Agtmael @tomvanagtmael.bsky.social · 18/02/2025
And with the anti-vaccine sentiment coming from government this will unfortunately only get worse
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