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Doug Dyer

@douglaspdyer.bsky.social
1.2K followers 560 following 106 posts

Immune cell recruitment, glycocalyx, chemokines and extracellular matrix at the Manchester Centre for Cell Matrix research and Lydia Becker Institute for Immunology he/him www.wellcome-matrix.org/people/doug… #glycotime

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Reposted by Doug Dyer
Lydia Becker Institute @lydiabeckeriii.bsky.social · 17/08/2026
📣 We are delighted to announce world-leading immunologist Prof Sarah Gaffen as the incoming Director of the Lydia Becker Institute. Prof Gaffen succeeds founding Director @tracyh9494.bsky.social on Jan 1, 2027, as Tracy steps down after 8 years to focus on mentoring talent. 👉 tinyurl.com/3n4x5ave
Professor Sarah Gaffen Quote - "I am delighted to take on the role of 
Director of the Lydia Becker Institute. 
The ecosystem in Manchester provides opportunities to bridge immunology across disciplines. I'm eager to work across partner centres in fields like cancer immunology, neuroimmunology, and women’s health."Professor Duncan Ivison Quote - "Sarah is an outstanding choice to lead the Lydia Becker Institute. Her vision and leadership will build on existing strengths, helping to drive innovation, deliver real-world impact, and further enhance our world-leading immunology research."Professor Tracy Hussell Quote - “Every institute benefits from a fresh perspective. Sarah shares the same energy and enthusiasm I have for thinking beyond traditional research silos and nurturing people at all stages of their career.”
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Lydia Becker Institute @lydiabeckeriii.bsky.social · 10/07/2026
How do our lungs heal after viral infections like flu or COVID-19? New research from @douglaspdyer.bsky.social @tracyh9494.bsky.social and Ziyun Zhang shows how the glycocalyx—a sugar layer on lung immune cells—adapts to inflammation to coordinate tissue repair. #ImmunoSky tinyurl.com/39eatz9r
tinyurl.com
How lung immune cells repair after viral infection
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Doug Dyer @douglaspdyer.bsky.social · 02/07/2026
We can now share the peer reviewed version of our story exploring the effect of location specific queues in regulating the lung macrophage glycocalyx www.sciencedirect.com/science/arti...
sciencedirect.com
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Lorna Milne @lornamilne.bsky.social · 08/05/2026
New pre-print *finally* out! We've developed ToF-SIMS for in-situ glycosaminoglycan (GAG) analysis. Here's why that matters 👇📄 (1/9) www.biorxiv.org/content/10.6...
biorxiv.org
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Anna Mazzola @annamazz.bsky.social · 01/05/2026
Some useful public speaking tips from Freud here.
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Doug Dyer @douglaspdyer.bsky.social · 01/05/2026
delighted to share our new pre-print developing label-free glycosaminoglycan analysis of diverse complex biological samples, led by @h-davies-s.bsky.social working closely with David Knight and Rebecca Miller alongisde our recent recruit Samie Dalgarno www.biorxiv.org/content/10.6...
biorxiv.org
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Waggoner Lab @labwaggoner.bsky.social · 23/04/2026
Long-lived CD163+ and Tim4+ gut macrophages in the lamina propria are spatially restricted by TGF-β rupress.org/jem/article/... @jem.org @tovah-shaw-lab.bsky.social @edinburghuni.bsky.social @manchesterup.bsky.social
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Chris Ashwood @cashwood.proteaglyco.com · 01/04/2026
We are proud to announce the discovery of Glyco-Carbohydrates, a paradigm shift in glycobiology! Traditional glycoconjugates (proteins, lipids & RNA) max out at 50% carbohydrate. Ours are 100% carbohydrate AND glycans, unlocking truly homogenous properties. TBA April 1st, 2027! 🍬 #glycotime
An April Fools joke about a "discovery" of fully glycosylated molecules.
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Waggoner Lab @labwaggoner.bsky.social · 30/03/2026
Defective HLA-G1 glycosylation disrupts Siglec-7–mediated NK cell tolerance at the maternal–fetal interface in recurrent pregnancy loss link.springer.com/article/10.1...
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David Posner, PhD @davidposner.bsky.social · 30/03/2026
@hepworth-lab.bsky.social new paper alert. Matt and I wrote a research highlight about recent papers that describe mechanisms of ILC2-neuron crosstalk. If you're interested in reading it, check it out! onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
<em>Immunology & Cell Biology</em> | ASI Journal | Wiley Online Library
Emerging roles of ILC2 in neuronal crosstalk across organs. In a series of studies published in 2025, ILC2 were shown to regulate nervous system function across a range of organs across the body. Wit...
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ASMB @amsocmatbio.bsky.social · 26/03/2026
Our #JuniorPI feature for #ASMB2025 spotlights @tranejoan.bsky.social from @officialuom.bsky.social, whose work explores collagen homeostasis in fibrosis and repair🔬 She is also co‑chair of ASMB Outreach, strengthening community engagement.🎥-https://youtu.be/abjDOI39WJY @themeshwork.bsky.social
youtu.be
Dr. Joan Chang, Junior PI
YouTube video by ASMB - American Society for Matrix Biology
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Journal of Clinical Investigation @jci.org · 13/03/2026
Organized immunity in the CNS: What stroke reveals about neuroinflammation and lymphoid niches: doi.org/10.1172/JCI2... Catalina Lee-Chang comments on Yang et al.: doi.org/10.1172/JCI1...
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Dr Laura McCulloch @dr-l-mcculloch.bsky.social · 09/03/2026
Interested in how age related immune dysfunction might impact stroke risk and outcomes? Check out our systematic review led by Vanda Wen Teng Ho at the National University of Singapore www.frontiersin.org/journals/agi...
frontiersin.org
Frontiers | Immunosenescence and its impact on ischemic stroke risk and outcomes in older adults: a systematic review
BackgroundAge is a major risk factor for ischemic stroke (IS), with immunosenescence–age-related immune system dysfunction - contributing to worse outcomes. ...
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Waggoner Lab @labwaggoner.bsky.social · 10/03/2026
Long-lived resident tissue macrophages govern intraocular pressure homeostasis by regulating extracellular matrix turnover, contributing to resistance-generating tissues that are dysfunctional in glaucoma @cp-immunity.bsky.social www.cell.com/immunity/ful... @dukeeyecenter.bsky.social
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Chris Ashwood @cashwood.proteaglyco.com · 09/03/2026
Pleased to share our native glycomics workflow preserving O-acetylation, detecting this labile modification in rat (53%) and mouse (9%) serum N-glycans. Integrally, O-acetyls are invisible under standard reductive conditions. Now published at Molecular Omics. Link: academic.oup.com/molecular-om...
academic.oup.com
Native PGC-LC–MS profiling reveals distinct O-acetylation patterns of Sialylated N-glycans across mammalian sera
Abstract. O-acetylation of sialic acids represents an additional layer of structural diversity and biological complexity, occurring at various hydroxyl pos
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Casanova Lab @casanovalab.bsky.social · 02/03/2026
1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...
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Waggoner Lab @labwaggoner.bsky.social · 26/02/2026
Review @annualreviews.bsky.social @gabyrabi.bsky.social Glycan-Binding Proteins in Immunity www.annualreviews.org/content/jour...
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Naba Lab UIC @nabalabuic.bsky.social · 25/02/2026
Registration for #MBE2026 is now open! Join us in Oulu 🇫🇮 for the flagship European meeting dedicated to fundamental #ECM research. ECRs and trainees, this is a unique chance to connect with leaders in the field, present your work, gain visibility, and build your network! More at www.mbe2026.org
Flyer of the Matrix Biology Europe conference listing invited speakers
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Guillaume Jacquemet @guijacquemet.bsky.social · 20/02/2026
You still have 3 days to apply to the postdoc positions available in my lab 😀 🔬Come and work with us 🔬
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Fiona J Whelan @whelanfj.bsky.social · 17/02/2026
📣 2026 PhD studentship 📣 Via @manchester.ac.uk 's President's Doctoral Scholar Awards, we are encouraging applications for a PhD on the effect of pollutant exposure on microbe-immune cross talk. This project will incorporate microbiology, immunology, & bioinformatics. Deadline: 16 March 2026!
findaphd.com
(President's Doctoral Scholar Award) A mechanistic understanding of microbe-immune cross talk in the face of pollutant challenge at The University of Manchester on FindAPhD.com
PhD Project - (President&#39;s Doctoral Scholar Award) A mechanistic understanding of microbe-immune cross talk in the face of pollutant challenge at The University of Manchester, listed on FindAPhD.c...
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DGMB @matrixbiologie.bsky.social · 17/02/2026
One week left to submit your abstract for this fantastic meeting 👇 It’s gonna be a great year for matrix meetings! 😎 Fancy a full week of matrix biology? Catch a direct flight from Manchester to Frankfurt after #BSMB and join us in Heidelberg for #DGMB2026 😉
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Doug Dyer @douglaspdyer.bsky.social · 17/02/2026
Reposting as one week left for early bird registration and to get your abstract in!!
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Waggoner Lab @labwaggoner.bsky.social · 12/02/2026
Vaccine-induced immune thrombocytopenia and thrombosis occurs in persons with Ig light-chain allele IGLV3-21*02 or *03 that recognizes a specific epitope on the adenoviral core protein pVII, resulting in misdirection of antibody targeting PF4 @nejm.org www.nejm.org/doi/full/10....
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Lydia Becker Institute @lydiabeckeriii.bsky.social · 10/02/2026
Prof Sheena Cruickshank @sheencr.bsky.social offers insight in The Guardian @theguardian.com on the science behind sneezing and what it reveals about our health #ImmunoSky www.theguardian.com/society/2026...
theguardian.com
The sneeze secret: how much should you worry about this explosive reflex?
It is one of the most powerful involuntary actions the human body can perform. But is a big sneeze a sign of illness, pollution or something else entirely?
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Guillaume Jacquemet @guijacquemet.bsky.social · 06/02/2026
You still have time to apply if you are interested in joining my lab!!
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Dave Baltrus 🦦 @surtlab.bsky.social · 05/02/2026
Been on multiple search committees For me (personally so YMMV)…I basically dismiss everything that’s labeled *submitted* unless there’s a preprint I can read
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Doug Dyer @douglaspdyer.bsky.social · 05/02/2026
Very excited to announce that registration is open for the BSMB Spring 2026 meeting in Manchester, April 13-14th. Already an amazing lineup and lots of opportunities to speak! Register, bsmb.ac.uk/meetings/ecm... @mcrcellmatrix.bsky.social
bsmb.ac.uk
ECM biology across tissue sites. Location, location, location
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Gill Wilson @gillwilson00.bsky.social · 04/02/2026
Introducing the amazing Dr Lily Koumbas Foley 🥰📚👩‍🎓 @crgglasgow.bsky.social @uofgsii.bsky.social
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Lydia Becker Institute @lydiabeckeriii.bsky.social · 04/02/2026
Dr Alexander Clarke @ajclarke.bsky.social joins us from @ox.ac.uk tomorrow to give a talk entitled: “Powering the germinal centre reaction" 📆 Thursday 5th Feb 🕛 12:00 PM 📍 Michael Smith Lecture Theatre @britsocimm.bsky.social MIG Seminar #ImmunoSky
British Society for Immunology MIG seminar, Dr Alex Clarke, University of Oxford:

“Powering the germinal centre reaction"

Thursday 5th February
12 pm
Michael Smith Lecture Theatre
Lydia Becker Institute of Immunology and Inflammation
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mcb-sheffield.bsky.social @mcb-sheffield.bsky.social · 30/01/2026
Join us in Sheffield! We are keen to support early career researchers in applying for independent research fellowships to join our friendly & collaborative environment, in areas related to gene expression, mechanistic cell biology & cancer biology. For more info 👇 sheffield.ac.uk/biosciences/...
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Ryan Flynn @raflynn5.bsky.social · 28/01/2026
Science update from my postdoc Peiyuan Chai - his work “glycoRNA complexed with heparan sulfate regulates VEGF-A signaling” is now published @nature.com uncovering a new layer or glycoRNA-regulation of growth factor mediated control physiological processes rdcu.be/e1bBX
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Waggoner Lab @labwaggoner.bsky.social · 21/01/2026
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social www.nature.com/articles/s41...
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Guillaume Jacquemet @guijacquemet.bsky.social · 21/01/2026
🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs). Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬 Details in thread 🧵👇 #ScienceSky #Postdoc #AcademicJobs Please RT🫶
cellmig.org
CELL MIGRATION LAB
We study cell migration in health and disease
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Ben Schumann @drglycoben.bsky.social · 20/01/2026
Out now in @natchembio.nature.com: Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells 🎉 www.nature.com/articles/s41... check out the press release below! #glycotime
nature.com
Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells - Nature Chemical Biology
The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and ...
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The NCFG @thencfg.bsky.social · 15/01/2026
Have you ever wondered how many N-Glycans or #glycoproteins there are on cells? The numbers are massive: calculations suggest about 20 to 200 million N-glycans per human cell! Read the full blog post: research.bidmc.org/ncfg/blog/24... #glycobiology #glycotime #cells #biology
An AI generated image showing a dense forest of glycans on the surface of the cell.
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Akul Mehta @akulmehta.bsky.social · 15/01/2026
#Glycans probably have more "copies/cell" than #proteins and changes in #glycosylation could potentially be remarkable biomarkers for diseases as well as targets for therapeutics. This post explores the abundance of glycans on the cell surface and it is worth a read to recognize these #biomolecules.
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Chris Wincup @chriswincup.bsky.social · 14/01/2026
Really looking forward to speaking (for the 3rd year!) at the British Society for Immunology (@britsocimm.bsky.social) Foundations of Immunology course on 18 March 🧬 A brilliant one-day online course covering core immunology for all backgrounds 🧪 Register 👉 www.immunology.org/training/Fou...
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Guillaume Jacquemet @guijacquemet.bsky.social · 15/01/2026
🚨 Job Alert! 🚨 We have an opening at our Microscopy Core Facility in Turku 🇫🇮. If you love imaging 🔬 and helping scientists succeed, we want you! 👇 abo.rekrytointi.com/paikat/index... #Microscopy #ScienceJobs #CoreFacility #Imaging @turkubioscience.bsky.social
abo.rekrytointi.com
Laboratory Engineer (Senior), in Advanced Imaging, 1.5.2026-31.12.2028
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Olivier Neyrolles @oneyrolles.bsky.social · 13/01/2026
🥳 𝐄𝐱𝐜𝐢𝐭𝐞𝐝 𝐭𝐨 𝐬𝐡𝐚𝐫𝐞 𝐨𝐮𝐫 𝐥𝐚𝐭𝐞𝐬𝐭 𝐰𝐨𝐫𝐤 𝐬𝐡𝐨𝐰𝐢𝐧𝐠 𝐡𝐨𝐰 𝐩𝐨𝐥𝐲𝐬𝐢𝐚𝐥𝐲𝐥𝐚𝐭𝐢𝐨𝐧, 𝐚 𝐫𝐚𝐫𝐞 𝐩𝐫𝐨𝐭𝐞𝐢𝐧 𝐦𝐨𝐝𝐢𝐟𝐢𝐜𝐚𝐭𝐢𝐨𝐧, 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐞𝐬 𝐢𝐧𝐟𝐥𝐚𝐦𝐦𝐚𝐭𝐨𝐫𝐲 𝐦𝐨𝐧𝐨𝐜𝐲𝐭𝐞 𝐦𝐨𝐛𝐢𝐥𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐟𝐫𝐨𝐦 𝐭𝐡𝐞 𝐛𝐨𝐧𝐞 𝐦𝐚𝐫𝐫𝐨𝐰. ✍️ Aurélien Boyancé, Nelly Gilles, @yoannrombouts.bsky.social & coll. @ipbstoulouse.bsky.social 📖 shorturl.at/IDwza 👇 A short thread...
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Rémi Hatinguais @remicillin.bsky.social · 06/01/2026
Our lab is hiring a PhD student to investigate how glycans affect antitumor immune responses in metastases and how this can be modulated to improve immunotherapy! More info here 👇 #glycotime werkenbij.amsterdamumc.org/en/vacatures...
werkenbij.amsterdamumc.org
Vacatures - PhD tumor immunology of peritoneal metastasis - Amsterdam UMC
Colorectal cancer with peritoneal metastases has a particularly poor prognosis. In this KWF-funded project, you will investigate how glycan structures affect immune responses in peritoneal metastasis and whether glycan inhibition can restore anti-tumor immunity.
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Guillaume Jacquemet @guijacquemet.bsky.social · 06/01/2026
Delighted to share the latest paper from the lab "Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers" Amazing work driven by @follainga.bsky.social with contributions from many. link.springer.com/article/10.1...
link.springer.com
Fast label-free live imaging with FlowVision reveals key principles of cancer cell arrest on endothelial monolayers - The EMBO Journal
The rapid, transient, and unpredictable nature of interactions between circulating cells and the endothelium challenges the investigation of these events under flow conditions. Here, we developed an i...
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Pallett Lab UCL @pallettlab.bsky.social · 06/01/2026
Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026" Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science 📆16-17th April www.immunology.org/events/fuell...
immunology.org
Fuelling the immune response IV: UK immunometabolism meeting 2026 | British Society for Immunology
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Anne Imberty @anneimb.bsky.social · 18/12/2025
Major update for unilectin.unige.ch with now more than 2800 3D-structures with annotation, literature and details of interaction!! HumanLectome also up to date. Thanks to Boris Schnider at @sib.swiss and @glycoexpasy.bsky.social for super work. More exciting news soon with LectomeXplore upgrade
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Jessica Stark @jcstark.bsky.social · 16/12/2025
Out now: We present antibody-lectin chimeras (AbLecs) as a molecular platform to target sugars, or glycans, for cancer immunotherapy. www.nature.com/articles/s41... www.nature.com/articles/s41... @mitkochinstitute.bsky.social @mitdeptofbe.bsky.social @mitcheme.bsky.social @stanford-chemh.bsky.social
nature.com
Antibody-lectin chimeras for glyco-immune checkpoint blockade - Nature Biotechnology
Cancer immunotherapy benefits from antibody-lectin chimeras that block glyco-immune checkpoints.
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Lydia Becker Institute @lydiabeckeriii.bsky.social · 10/12/2025
🏆 Huge congratulations to our Director Professor Tracy Hussell @tracyh9494.bsky.social who has been awarded the Nature 2025 Lifetime Achievement Award for Mentoring in Science for her exceptional support of emerging scientists. #ImmunoSky @nature.com sites.manchester.ac.uk/lydia-becker...
sites.manchester.ac.uk
Professor Tracy Hussell Receives Nature Lifetime Achievement Award for Mentoring in Science
Professor Tracy Hussell receives the 2025 Nature Lifetime Achievement Award for Mentoring in Science, recognising her outstanding support of early-career researchers.
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Judi Allen @profjudiallen.bsky.social · 04/12/2025
Beautiful talk by Matt Hepworth, so many exciting things happening at barrier surfaces. @hepworth-lab.bsky.social #BSI2025 @britsocimm.bsky.social @lydiabeckeriii.bsky.social
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Judi Allen @profjudiallen.bsky.social · 01/12/2025
www.theguardian.com/science/2025...
theguardian.com
Why we have to continue with animal testing for medical research | Letters
Letters: Dr Robin Lovell-Badge and Prof Emma Robinson respond to an editorial on using new technologies to reduce the reliance on animal experiments
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Megan Priestley @megtriesscience.bsky.social · 27/11/2025
Really looking forward to speaking about my PhD work at this webinar with @merrylabnotts.bsky.social @themeshwork.bsky.social ! 🦠🎄
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Calum Bain @bainlab.bsky.social · 27/11/2025
Thanks for sharing @mucosalimmunol.bsky.social. This work was led by @lizihegarty.bsky.social during her PhD @edinuni-irr.bsky.social funded by @wellcometrust.bsky.social. Now being continued after our relocation to @uofgsii.bsky.social. Might be of interest to @emds2025.bsky.social attendees!
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