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The American Society for Clinical Investigation @the-asci.org · 22/09/2026

📣 Call for posters: The ASCI is now accepting abstract submissions for the 2027 AAP/ASCI/APSA Joint Meeting Deadline: October 12, 2026 More info: buff.ly/Iq6VZFY

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Home - The American Society for Clinical Investigation

This is the home page for The American Society for Clinical Investigation website.

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The American Society for Clinical Investigation @the-asci.org · 18/09/2026

ASCI member Chirag R. Parikh & team recently published in JCI Insight! In this peek Behind the Paper, authors Serena D. Souza and Wassim Obeid work on the new urine test that may help with earlier diagnosis for the rare kidney disease cystinosis in children 📎: doi.org/10.1172/jci....

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The American Society for Clinical Investigation @the-asci.org · 15/09/2026

📣 Nominations are OPEN for the 2027-2029 ASCI Postbaccalaureate Program!! 🔹 2 Postbacs Awarded 🔹 2 year laboratory research experience 🔹 ASCI-member lab 🔹 Immersive and mentored 🔹 MCAT and Med School Application Prep Learn more: buff.ly/uF7BsNQ

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The ASCI Postbaccalaureate Program - The American Society for Clinical Investigation

The ASCI Postbaccalaureate Program page on The American Society for Clinical Investigation website.

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JCI insight @insight.jci.org · 14/09/2026

Suggesting a novel therapy for systemic sclerosis: doi.org/10.1172/jci.... @eduardomarban.bsky.social & team report that an orally delivered noncoding RNA (TY1) reduces inflammation and organ fibrosis in models of systemic sclerosis through inhibition of the cGAS/STING axis. @the-asci.org

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The American Society for Clinical Investigation @the-asci.org · 14/09/2026

📣 Nominations are OPEN for the 2027-2028 ASCI PSSF Fellowship Program!! 🔸 5 Fellowships Awarded 🔸 MD-or DO-only medical students 🔸 Med school research gap year (12 months) 🔸 Physician-scientist track 🔸 Immersive and mentored Learn More: buff.ly/0bsi5B8

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ASCI PSSF Fellowship - The American Society for Clinical Investigation

ASCI PSSF Fellowship page on The American Society for Clinical Investigation website.

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Journal of Clinical Investigation @jci.org · 10/09/2026

Proposing a combination treatment for reducing death from cerebral malaria: doi.org/10.1172/JCI2... Alvin H. Schmaier & team report on a role for bradykinin in cerebral malaria and find plasma kallkrein inhibitors target host-mediated vascular dysfunction. @the-asci.org

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JCI insight @insight.jci.org · 10/09/2026

Changing the paradigm for loss of the Y chromosome: doi.org/10.1172/jci.... Dan Theodorescu & team report Y chromosome loss increases progressively from healthy tissues to cancer, suggesting it is an early and previously unrecognized driver of cancer development. @the-asci.org

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The American Society for Clinical Investigation @the-asci.org · 09/09/2026

Congratulations to ASCI member Masashi Yanagisawa for the Lasker prize @laskerfdn.bsky.social! Mignot and Yanagisawa are recognized for their discovery of the role of orexins/hypocretins in wake, sleep, and narcolepsy. Yanagisawa previously presented at the ASCI scientific session: buff.ly/kJKbBLY

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Masashi Yanagisawa, MD, PhD - The American Society for Clinical Investigation

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The American Society for Clinical Investigation @the-asci.org · 09/09/2026

Mignot and Yanagisawa win the Lasker prize from from @laskerfdn.bsky.social for discovery of the role of orexins/hypocretins in wake, sleep, and narcolepsy: doi.org/10.1172/JCI2... In this Viewpoint, Clifford B. Saper places Mignot’s and Yanagisawa’s discoveries in a historical context.

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Journal of Clinical Investigation @jci.org · 04/09/2026

Alpha-Gal syndrome is a tick bite-associated allergy characterized by reactions to alpha-Gal found in red meat doi.org/10.1172/JCI1... Peter D. Crompton & team show the potential of alpha-Gal-specific mAbs to prevent the allergy by blocking IgE binding to alpha-Gal. @the-asci.org

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JCI insight @insight.jci.org · 03/09/2026

Welcome to the kidney! R Ariel Gomez & team examine the role of renin cells in renal neurovascular morphogenesis & remodeling. The video: mouse kidney cortex with renin cells (magenta), the renal arterial tree (green), nerve fibers (yellow): doi.org/10.1172/jci.... @the-asci.org

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Journal of Clinical Investigation @jci.org · 03/09/2026

Early signals shape cardiac macrophage phenotypes & repair outcomes: doi.org/10.1172/JCI1... Kory J Lavine & team traced monocyte differentiation trajectories after injury & identified an MHCIIhi population with an early IFN response signature associated with enhanced cardioprotection @the-asci.org

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JCI insight @insight.jci.org · 01/09/2026

This proteomic score outperforms widely used clinical risk models: doi.org/10.1172/jci.... Corey et al. report on blood proteins that help predict heart disease risk in diabetes and are modified by GLP-1 therapy, improving risk assessment beyond traditional clinical factors. @the-asci.org

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JCI insight @insight.jci.org · 28/08/2026

A new approach for kicking osteoarthritis: doi.org/10.1172/jci.... Wen Jiang @wenjiang-nano.bsky.social @mdanderson.bsky.social & team find blocking a key immune sensor, NOD2, in cartilage cells reduces joint damage in osteoarthritis mouse models. @the-asci.org

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Journal of Clinical Investigation @jci.org · 26/08/2026

Reproductive life after In vitro fertilization: doi.org/10.1172/JCI2... JCI Editor Serdar E. Bulun discusses what the observations in mouse models from Rhon-Calderon et al. (doi.org/10.1172/JCI2...) might mean for human offspring born with IVF assistance @the-asci.org

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The American Society for Clinical Investigation @the-asci.org · 25/08/2026

Nominations are now open for ASCI’s 2027 Early-Career Awards (E-Gen & YPSA): buff.ly/Yv9Cmbb For early-career physician-scientists who have made notable achievements in their research, these awards encourage and inspire through broad participation in the ASCI physician-scientist community.

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Journal of Clinical Investigation @jci.org · 21/08/2026

Anti-malaria mAb demonstrates durable protection in African adults doi.org/10.1172/JCI2... Peter D. Crompton & team assessed the phase II trial of CIS43LS, revealing that the long-acting mAb maintained over 80% protection through a single malaria season. @mmv.org @the-asci.org

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JCI insight @insight.jci.org · 21/08/2026

A differential diagnosis for acute kidney injury: doi.org/10.1172/jci.... Chirag R. Parikh & team @kpmproject.bsky.social reveal that acute interstitial nephritis is a potentially common cause of acute kidney injury and sometimes not suspected by physicians. @the-asci.org

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JCI insight @insight.jci.org · 15/08/2026

Saturday Spotlight💫 : When muscle membranes leak: doi.org/10.1172/jci.... Elizabeth M. McNally & team discover (mouse) muscle lacking two proteins critical for resealing damaged sarcolemma (dysferlin & annexin A6) cause leaky membranes and invite macrophages to come take a bite. @the-asci.org

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Journal of Clinical Investigation @jci.org · 15/08/2026

Targeting GLP1R and IL17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation-driven model: doi.org/10.1172/JCI2... @the-asci.org

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JCI - Targeting GLP-1R and IL-17A suppresses obesity-induced leukemia in an oncogenic PTPN11 mutation–driven model

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Journal of Clinical Investigation @jci.org · 16/08/2026

Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1: doi.org/10.1172/JCI1... By Aaron D. Schimmer & team @pmresearch-uhn.bsky.social @the-asci.org

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JCI - Elevated mitochondrial protein import in acute myeloid leukemia increases reliance on mitochondrial protease LONP1

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The American Society for Clinical Investigation @the-asci.org · 11/08/2026

Meet our 2026 ASCI Postbaccalaureate (Postbac) Scholars. Congratulations Madelyn Blake and Luisa Morgan!

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Journal of Clinical Investigation @jci.org · 11/08/2026

What role does obesity play in promoting leukemia? doi.org/10.1172/JCI2... Kapur et al. uncover IL-17A driven, metabolism-coupled immunosuppression as a mechanistic link between obesity and SHP2-mutant leukemias & highlight a therapeutic strategy for patients with obesity.

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Journal of Clinical Investigation @jci.org · 10/08/2026

Behind the scenes (Image 1/2): Sharing a glimpse of life in the Schimmer lab at Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. (Photography by Nathan Duong) Dr. Aaron D. Schimmer featured in image 2/2

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The American Society for Clinical Investigation @the-asci.org · 07/08/2026

Meet the 2026-2027 ASCI PSSF Fellows! Our 5 Fellows were drawn from an exceedingly talented group of candidates nominated by their medical school dean.

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Journal of Clinical Investigation @jci.org · 05/08/2026

John K. Lee & team @fredhutch.org present a framework for combinations of Ab-drug conjugate targets & payloads that may be applied to improve metastatic, castration-resistant prostate cancer: doi.org/10.1172/JCI2... @the-asci.org

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Journal of Clinical Investigation @jci.org · 04/08/2026

Behind the scenes: Celebrating with Team Menon lab: From right to left, Dr Madhav C Menon (corresponding author), Gabriel C Barsotti, John F Pell (First author), EM Tanvir (co-first author) and Anand C Reghuvaran. And first author John Pell in the Lab.

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Journal of Clinical Investigation @jci.org · 04/08/2026

How do high-risk APOL1 variants lead to kidney transplant rejection? doi.org/10.1172/JCI1... Madhav C Menon & team @yaleschoolofmed.bsky.social discover that APOL1 variants promote CD8 T-cell activation via Ca2+ signaling, causally explaining their link to kidney rejection. @the-asci.org

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JCI insight @insight.jci.org · 31/07/2026

Perm1 has many cytoprotective and organ protective functions: doi.org/10.1172/jci.... Here, Sadoshima & team discover Perm1 reduces harmful stress and limits cardiac damage in mouse models of heart attack by enhancing Nrf2-driven antioxidant defense. @the-asci.org #Cardioprotection

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Journal of Clinical Investigation @jci.org · 30/07/2026

The gut-joint axis & the effects of antibiotics: doi.org/10.1172/JCI2... @msdiamondlab.bsky.social & team @washumedicine.bsky.social find antibiotics-triggered changes in the microbiome worsen alphavirus-induced arthritis in mice by modulating infiltrating & resident immune cells in joint tissues

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JCI insight @insight.jci.org · 27/07/2026

Proposing a diagnostic shift for the monogenic autoimmune disorder APECED: doi.org/10.1172/jci.... Lionakis & team find APECED is recognized earlier by expanding the diagnostic criteria to include 3 early manifestations—APECED rash, autoimmune enteritis & enamel hypoplasia.

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Journal of Clinical Investigation @jci.org · 24/07/2026

SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver: doi.org/10.1172/JCI2... Hossein Ardehali @hosseinardehali.bsky.social provides a commentary on Lu et al. doi.org/10.1172/JCI2... @the-asci.org

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Journal of Clinical Investigation @jci.org · 23/07/2026

Providing valuable resources for the study of gastric cancer: doi.org/10.1172/JCI1... Yu Chen & team modeled gastric cancer progression with KO mice, finding deficiency of Kmt2c & Kmt2d led to dysplasia and loss of both genes with Pten resulted in invasive adenocarcinoma. @the-asci.org

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JCI insight @insight.jci.org · 23/07/2026

This aging-related communication axis helps explain why older age increases MASLD incidence: doi.org/10.1172/jci.... Diehl & team @dukemedschool.bsky.social describe an inter-organ aging axis in which hepatocytes determine the rate of organ aging during metabolic stress in mice.

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Journal of Clinical Investigation @jci.org · 20/07/2026

Can we reverse immunosuppression in glioblastoma? doi.org/10.1172/JCI1... Daniel J. Brat & team discover a pathway that glioblastoma cells use to activate macrophages and suppress anti-tumor immunity, revealing the PDPN-CLEC5A-Syk pathway as a potential therapeutic target. @the-asci.org

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The American Society for Clinical Investigation @the-asci.org · 17/07/2026

📣Now open: ASCI nominations for active and international membership for 2027 may be submitted Deadline: September 10, 2026, 11:59 pm EST. buff.ly/wmMYast

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The American Society for Clinical Investigation @the-asci.org · 15/07/2026

📣📣Announcing 🎉🎉 Kevin N. Sheth, MD, receives the 2026 Bruce F. Scharschmidt and Peggy S. Crawford Translational Medicine Award. In this highlight, Dr. Kevin Navin Sheth offers some words for the aspiring physician scientist. For the full interview with Dr. Anna Greka: youtu.be/lcaHk_Y9VKM

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JCI insight @insight.jci.org · 13/07/2026

📗From our Special Issue on Fibrosis Robert Schwabe & colleagues provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org

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Journal of Clinical Investigation @jci.org · 13/07/2026

New information on how estrogen impacts the heart: doi.org/10.1172/JCI2... Using iPCs and two rodent models, Kurt W. Prins @kurtprins.bsky.social @the-asci.org & team find estrogen exerts cardioprotective effects by regulating microtubules.

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JCI insight @insight.jci.org · 09/07/2026

📗From our Special Issue on Fibrosis Benjamin D. Humphreys @humphreyslab.bsky.social provide a Review on the shared mechanisms of organ #fibrosis: doi.org/10.1172/jci.... @the-asci.org

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Journal of Clinical Investigation @jci.org · 08/07/2026

Targeting gut microbiota offers a strategy for MASH doi.org/10.1172/JCI2... Y. Eugene Chen @the_asci.org & team show an ammonia-producing bacterium weakens the gut barrier & over activates liver immune cells in MASH models. And DT-109 lowered ammonia & improved disease

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Journal of Clinical Investigation @jci.org · 08/07/2026

The 1st cellular and molecular analysis of the liver in pulmonary arterial hypertension (human tissue): doi.org/10.1172/JCI2... @kurtprins.bsky.social & team find PAH reshapes liver metabolism, inflammation & fibrosis in a manner distinct from NASH & Fontan-associated liver disease. @the-asci.org

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Journal of Clinical Investigation @jci.org · 03/07/2026

Cellular plasticity as a therapeutic vulnerability: HNF4α is a key target in lung adenocarcinoma: doi.org/10.1172/JCI2... Raymond Ho and Jason C. Mills @the-asci.org provide a Commentary on Dadzie et al. doi.org/10.1172/JCI1...

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JCI insight @insight.jci.org · 01/07/2026

Wearables support safer outpatient care for detection of cytokine release syndrome in patients with myeloma: doi.org/10.1172/jci.... Samir Parekh & team show wearable temperature sensors detected early signs of CAR-T treatment toxicity hours before standard hospital monitoring.

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The American Society for Clinical Investigation @the-asci.org · 01/07/2026

📣📣Announcing 🎉🎉 Julie Zikherman receives the ASCI/Marian W. Ropes, MD, Award In this video highlight, Dr. Zikherman discusses important factors during her training time. The full interview with ASCI President-Elect Dr. Julie A. Bastarache: youtu.be/TwsTQ8O4XZw

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Journal of Clinical Investigation @jci.org · 30/06/2026

Beyond neuronal degeneration: oligodendroglial dysfunction as a driver of spinocerebellar ataxia type 1 pathogenesis Associate Editor Puneet Opal discusses compelling evidence from Lee et al. that substantially expands current models of SCA1 pathogenesis: doi.org/10.1172/JCI2...

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JCI insight @insight.jci.org · 30/06/2026

Asparaginase is essential for acute lymphoblastic leukemia, but it is limited by drug-induced pancreatitis doi.org/10.1172/jci.... Sohail Z. Husain & team find early omics patterns in children with ALL & asparaginase-induced pancreatitis feature disrupted lipid–immune responses

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JCI insight @insight.jci.org · 29/06/2026

The largest genomic study of young women with BRCA1 and BRCA2-associated #BreastCancer: doi.org/10.1172/jci.... Katherine L. Nathanson & team perform a comparative analysis of distinct genomic landscapes in young-onset gBRCA1/2 breast cancer.

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