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Tolga Bozkurt

@tolgaboz.bsky.social
530 followers 415 following 15 posts

Scientist @Imperial College, host-pathogen interactions, plant immunity, cell biology, autophagy, proteolysis, immune receptors. bozkurtlab.co.uk Co-founder @ResurrectBio.bsky.social

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Reposted by Tolga Bozkurt
Danve Castroverde @danvec.bsky.social · 03/07/2026
Surface immune signaling unlocks NLR activation through mRNA alternative splicing www.science.org/doi/10.1126/...
science.org
Surface immune signaling unlocks NLR activation through mRNA alternative splicing
Plants activate pattern-triggered immunity (PTI) and effector-triggered immunity (ETI) to combat pathogens. However, how these systems coordinate immune activation while preventing autoimmunity remain...
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Reposted by Tolga Bozkurt
Mauricio Contreras @mpcontreras.bsky.social · 20/05/2026
Check out our latest work! AlphaFold 3 revealed a transient immune receptor complex that eluded biochemical studies for almost a decade 🤯 We describe a conserved structural logic underlying sensor–helper communication in an NLR immune receptor network 🧵👇
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Reposted by Tolga Bozkurt
Mauricio Contreras @mpcontreras.bsky.social · 20/05/2026
Check out our updated activation-and-release model. This one image condenses over 10 years of work from many legendary @kamounlab.bsky.social members 🤯 Big shoutout to Chih-Hang, @tolgaboz.bsky.social, Lida, Aki, Selvaraj, @jmadhuprakash.bsky.social, @hsuanpai.bsky.social, Ben and many more!
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Reposted by Tolga Bozkurt
Ignacio_Rubio-Somoza @ignaciorubiosomoza.bsky.social · 03/05/2026
Congrats!, nice paper!. It would be interesting to know how transient are the resistosomes regulating ion transfer during real infection and check their putative autonomous and non-autonomous signaling roles as sensing molecular engines to coordinate defense responses :)
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Reposted by Tolga Bozkurt
Mariana Schuster @marischuster.bsky.social · 03/05/2026
For the textbooks 🤩. Many congratulations to the authors!
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Reposted by Tolga Bozkurt
Imperial Life Sciences @imperiallifesci.bsky.social · 02/05/2026
Imperial scientists led by @tolgaboz.bsky.social have uncovered a hidden plant defence system using internal calcium signals. The discovery could help create more resilient crops, reduce pesticide use, and support sustainable food systems. www.imperial.ac.uk/news/article...
imperial.ac.uk
Scientists uncover hidden plant defence system that could inform next-generation resilient crops and production
A newly discovered immune mechanism shows how plants use internal calcium signals to fight disease, potentially opening new pathways for stronger, mo...
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Reposted by Tolga Bozkurt
Danve Castroverde @danvec.bsky.social · 01/05/2026
A helper NLR channels organellar calcium to trigger plant immunity www.science.org/doi/10.1126/...
science.org
A helper NLR channels organellar calcium to trigger plant immunity
Upon activation, plant nucleotide-binding leucine-rich repeat (NLR) immune receptors are known to assemble into oligomeric resistosomes that insert into the plasma membrane, forming calcium (Ca2+)–per...
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Reposted by Tolga Bozkurt
Team Thomma @teamthomma.bsky.social · 30/04/2026
Delighted to see this work out in #ScienceAdvancesResearch @science.org where we uncover a surprising evolutionary origin of fungal effector proteins as ancient antimicrobials. Led by the super-star @mesny.bsky.social in the frame of @ceplas.bsky.social @mibinet.bsky.social & @madfungi.bsky.social
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Reposted by Tolga Bozkurt
Freddie King @freddie-king.bsky.social · 01/05/2026
Very excited to see our recent work on NRG1 organellar targeting now published! It has been a pleasure working with Tarhan on this, combining synthetic biology/genetics with some incredible microscopy 🤝 www.science.org/doi/10.1126/...
science.org
A helper NLR channels organellar calcium to trigger plant immunity
Upon activation, plant nucleotide-binding leucine-rich repeat (NLR) immune receptors are known to assemble into oligomeric resistosomes that insert into the plasma membrane, forming calcium (Ca2+)–per...
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Tolga Bozkurt @tolgaboz.bsky.social · 01/05/2026
Final version of our NRG1 MS is out! We uncover a surprising mechanism: the helper NLR NRG1 targets organellar membranes to trigger immunity Great collaborations with @KamounLab, @JiorgosKourelis, @jonathandgjones, @AdamWu9527, and the @Phil_Carella labs! science.org/doi/10.1126/sc…
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Reposted by Tolga Bozkurt
Sophien Kamoun @kamounlab.bsky.social · 01/05/2026
Just published: A helper NLR challenges the membrane localisation dogma "Plant NLR immune receptors are astonishingly diverse - functionally and structurally. We have only scratched the surface, and there are many more surprises in store." medium.com/p/a-helper-n...
medium.com
A helper NLR challenges the membrane localisation dogma
PUBLISHED: 30.04.26 | THE SAINSBURY LABORATORY
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Reposted by Tolga Bozkurt
Şuayb Üstün @suaybuestuen.bsky.social · 30/04/2026
Thrilled to introduce our next act 🎭 in @cp-molcell.bsky.social sciencedirect.com/science/arti... led by @glangin.bsky.social We uncover how proteotoxic stress is integrated across compartments, controlling proteasome activation ⚖️ vs photosynthesis repression 🌱 🧵(1/6) #proteostasis
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Şuayb Üstün @suaybuestuen.bsky.social · 24/04/2026
🚨 Paper out now in #ScienceAdvances @science.org 🌱🦠 Pathogens don’t just target protein degradation—they also hijack host translation. "Bacteria use P-body condensates to attenuate host translation during infection" ⚖️♻️ led by @manuelgonzalezfuen.bsky.social www.science.org/doi/10.1126/...
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Tolga Bozkurt @tolgaboz.bsky.social · 23/04/2026
Proud to share this preprint from Freddie_King and Juan Carlos @AdamWu9527 & @lderevnina labs! AS109-mediated agroinfiltration enables transient expression across non-model plants and positions faba bean as a tractable system for studying disease-resistance
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Reposted by Tolga Bozkurt
Juan (胡安) @angiopteris.bsky.social · 23/04/2026
Finally out! A follow-up to our Rhizobium rhizogenes story with @tolgaboz.bsky.social and Lida. We hope this work will make it easier to study many other plant species. www.biorxiv.org/content/10.6...
biorxiv.org
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Reposted by Tolga Bozkurt
Gitta Coaker @gittacoaker.bsky.social · 23/01/2026
I'm excited to see this out after hearing Matt give a nice seminar a few months ago. Ralstonia is such an interesting pathogen! www.pnas.org/doi/10.1073/...
pnas.org
The EPS-I exopolysaccharide transforms Ralstonia wilt pathogen biofilms into viscoelastic fluids for rapid dissemination in planta | PNAS
Ralstonia solanacearum species complex (RSSC) pathogens cause destructive plant wilt diseases of a wide variety of crops, leading to significant ag...
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Tolga Bozkurt @tolgaboz.bsky.social · 23/01/2026
Exciting PhD positions on plant immunity and engineering plant disease resistance with an excellent supervisor @jiorgoskourelis.bsky.social. Strongly recommend.👇
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The Plant Cell @theplantcell.bsky.social · 16/10/2025
Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses (Enoch Lok Him Yuen, Zachary Savage, Vojtěch Pražák, et al) doi.org/10.1093/plce... #PlantScience
doi.org
Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses
Chloroplast tethering to the pathogen interface via membrane contact sites promotes focal callose deposition and strengthens plant immunity.
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Reposted by Tolga Bozkurt
David Gaboriau @dgaboriau.bsky.social · 16/10/2025
Recent paper from @tolgaboz.bsky.social’s group at @imperiallifesci.bsky.social focuses on membrane contact sites between chloroplasts and the pathogen interface and their role in immunity 🎉 Delighted to have helped 🔬
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Tolga Bozkurt @tolgaboz.bsky.social · 17/10/2025
Let's keep in touch: How membrane contact sites drive immune responses url: academic.oup.com/plcell/artic...
academic.oup.com
Let's keep in touch: How membrane contact sites drive immune responses
Inside every cell, a pulsating network of molecular messengers orchestrates life's most critical conversations. While vesicular trafficking facilitates lon
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Tolga Bozkurt @tolgaboz.bsky.social · 25/09/2025
Huge congratulations to Nick Eilmann, our undergrad intern and tutee, for winning two BSPP awards — the Undergraduate Exam Award 2025 and the Undergraduate Project Prize 2025!
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Reposted by Tolga Bozkurt
Yasin Dagdas @plantophagy.bsky.social · 11/09/2025
Just planted in @jcellsci.bsky.social 🌳 😍 An A. thaliana mutant lacking all nine #ATG8 isoforms provides genetic evidence for functional specialization of #ATG8 in plants forest.biologists.com/landscape/?i...
forest.biologists.com
Landscape - The Forest of Biologists
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Reposted by Tolga Bozkurt
David Gaboriau @dgaboriau.bsky.social · 07/09/2025
Congratulations to all involved 🎉 Delighted to have helped a bit with some FLIM-FRET, and amazed at how much chloroplasts do.
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Reposted by Tolga Bozkurt
New Phytologist @newphyt.bsky.social · 05/09/2025
'I feel privileged to do science every day – it is wonderful to be able to follow a passion and be paid for it! It is flexible and absorbing. I would recommend it to everyone.' In Profile: Caroline Dean 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... #LatestIssue #PlantScience
Caroline Dean.
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Tolga Bozkurt @tolgaboz.bsky.social · 06/09/2025
Our latest work on how chloroplasts contribute to immunity: Membrane contact sites between chloroplasts and the pathogen interface underpin plant focal immune responses url: academic.oup.com/plcell/artic...
academic.oup.com
Validate User
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Reposted by Tolga Bozkurt
parkergroup.bsky.social @parkergroup.bsky.social · 29/08/2025
Many thanks to Dr. Dmitry Lapin for writing a highlight of our collaborative study and sharing it on his lab’s website. Learn more about coordinated Ca²⁺ influx cascades for quantitative control of plant immunity here: phoenix-plant.com/highlights-o...
phoenix-plant.com
News in plant immunology
Contents Coordinated Ca2+ influx cascades for quantitative control of plant immunity Coordinated Ca2+ influx cascades for quantitative control of plant immunity Written by Dmitry Lapin, J…
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Tolga Bozkurt @tolgaboz.bsky.social · 23/08/2025
Big cheers to Edward on his last day with us . Thanks for being an awesome BSPP summer intern — we’ll miss having you around! #BSPP #PlantScience
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Reposted by Tolga Bozkurt
Tatsuya Nobori @tatsuyanobori.bsky.social · 27/07/2025
Loved Naomi Nakayama’s talk-truly original research! #PlantBio2025
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Reposted by Tolga Bozkurt
Insta Science @instascience.bsky.social · 27/07/2025
A mesmerizing time-lapse of the Sun in ultraviolet light, captured by the Solar Dynamics Observatory spacecraft over a month. -Credits: NASA
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Reposted by Tolga Bozkurt
Aude Bernheim @audeber.bsky.social · 24/07/2025
🦠🧍‍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...
science.org
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Phil Carella @philcarella.bsky.social · 23/07/2025
I’m very grateful and excited to start our ARIA-funded project on redesigning plant immunity!
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Tolga Bozkurt @tolgaboz.bsky.social · 07/07/2025
Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors @tolgaboz.bsky.social and @jiorgoskourelis.bsky.social labs: www.jobs.ac.uk/job/DNV032/r...
jobs.ac.uk
Research Associate in Programmable Plant Immunity at Imperial College London
Apply for the Research Associate in Programmable Plant Immunity role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
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Reposted by Tolga Bozkurt
Yu Sugihara @yusugihara.bsky.social · 16/07/2025
Thank you to AmirAli Toghani @amiralito.bsky.social, Raoul Frijters, Tolga Bozkurt @tolgaboz.bsky.social, Ryohei Terauchi, and Sophien Kamoun @kamounlab.bsky.social for the wonderful supports!
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Frank Menke @frankmenke.bsky.social · 14/07/2025
Poster at #ISMPMI2025 from collaborations with @sainburylab.bsky.social #Proteomics group: P011 ( @isabelmonte.bsky.social ), P073 ( @HeeKungAng group), P086 & P034 (Zipfel group) P101 ( @tolgaboz.bsky.social ) and P130 ( @jonathandgjones.bsky.social and XiaoLin)
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Reposted by Tolga Bozkurt
Morgan Carter @morgancarterphd.bsky.social · 15/07/2025
Use of mutants to shut down NLR activity but not localization and structure formation so it can be observed. www.pnas.org/doi/10.1073/... Dynamic localization of a helper NLR at the plant–pathogen interface underpins pathogen recognition | PNAS
pnas.org
Dynamic localization of a helper NLR at the plant–pathogen interface underpins pathogen recognition | PNAS
Plants employ sensor–helper pairs of NLR immune receptors to recognize pathogen effectors and activate immune responses. Yet, the subcellular local...
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Reposted by Tolga Bozkurt
Morgan Carter @morgancarterphd.bsky.social · 15/07/2025
Unsurprisingly beautiful microscope images from @tolgaboz.bsky.social, which you can browse in this preprint #2025ISMPMI Tldr; NLRs can target different membrane interfaces, not just the plasma membrane. www.biorxiv.org/content/10.1... A helper NLR targets organellar membranes to trigger immunity
A person giving a scientific talk at a pit lectern with conference logo. A fluorescent microscope image of plant cell is shown on a slide
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Reposted by Tolga Bozkurt
Thomas Ott @ottlab.bsky.social · 07/07/2025
Happy to share our newest paper fresh from the press. Have a look, how cells prepare to host symbiotic infections. We really appreciate the reviewers comments. Enjoy the microscopy and other experiments by the lead PostDoc Morgane Batzenschlager & collaborators. elifesciences.org/articles/88588
elifesciences.org
Competence for transcellular infection in the root cortex involves a post-replicative, cell-cycle exit decision in Medicago truncatula
Imaging deep root tissues with a combination of cell-cycle reporters reveals that a cortical cell file traversed by symbiotic bacteria exhibits reduced proliferative potential and enters a prolonged G...
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Reposted by Tolga Bozkurt
Yuli Ding @yuliding.bsky.social · 23/06/2025
I'm very pleased to present the @cp-devcell.bsky.social Voices on plant model organism: www.sciencedirect.com/science/arti.... While we appreciate the diversity of plant models, one often questions which model is the "best"?
sciencedirect.com
Exploring the diversity of plant model organisms
Increasing plant genome research, together with advanced transformation technology, enables researchers to address their research questions more effec…
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Reposted by Tolga Bozkurt
Yuli Ding @yuliding.bsky.social · 23/06/2025
It's been a really fun ride to put this Voices together, and huge thanks to all authors contributed: @seedrevolutionlab.bsky.social John Bowman @michaelraissig.bsky.social @philippaborrill.bsky.social Sabeeha Merchant; Feng Qin; Enoch Lok Him Yuen; @tolgaboz.bsky.social; Fang Xie
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Tolga Bozkurt @tolgaboz.bsky.social · 07/07/2025
Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors @tolgaboz.bsky.social and @jiorgoskourelis.bsky.social labs: www.jobs.ac.uk/job/DNV032/r...
jobs.ac.uk
Research Associate in Programmable Plant Immunity at Imperial College London
Apply for the Research Associate in Programmable Plant Immunity role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
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Reposted by Tolga Bozkurt
Yasin Dagdas @plantophagy.bsky.social · 11/04/2025
Nice paper though it fails to mention very relevant articles on plant #autophagy from @tolgaboz.bsky.social lab. Here's one of them: europepmc.org/article/MED/... #plantblindness
europepmc.org
Europe PMCEurope PMC
Europe PMC is an archive of life sciences journal literature.
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Reposted by Tolga Bozkurt
Phil Carella @philcarella.bsky.social · 19/12/2024
Very happy to share the final version of our work on the evolution of broad host virulence in Pseudomonas out now @cellhostmicrobe It’s just in time for the holidays 🎄🦠 www.cell.com/cell-host-mi...
cell.com
A necrotizing toxin enables Pseudomonas syringae infection across evolutionarily divergent plants
Grenz et al. interrogate the Pseudomonas syringae species complex for its capacity to infect evolutionarily divergent host plants. Their results demonstrate that broad host isolates from phylogroup 2 rely on the lipopeptide toxin syringomycin to promote host necrosis and enhance bacterial growth in plants.
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Marília Horta Jung 🇵🇹🇪🇺🇨🇿🇺🇦 @phytophthorarc.bsky.social · 12/03/2025
Just out, First Look version: Preserving the Biologically Coherent Generic Concept of #Phytophthora, ‘Plant Destroyer’ | #PhytoPathology apsjournals.apsnet.org/doi/10.1094/... #Oomycetes #Taxonomy #Phylogeny #Cladistics #Paraphyly #PlantBiosecurity #ScientificCommunication #PlantDiseaseManagement
apsjournals.apsnet.org
Preserving the Biologically Coherent Generic Concept of Phytophthora, ‘Plant Destroyer’ | Phytopathology®
Phytophthora is a long-established, well known and globally important genus of plant pathogens. Phylogenetic evidence has shown that the biologically distinct, obligate biotrophic downy mildews evolve...
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Niklaus Grunwald @grunwald.bsky.social · 12/03/2025
Our community consensus position on conserving the genus #Phytophthora: Preserving the Biologically Coherent Generic Concept of Phytophthora, ‘Plant Destroyer’ | Phytopathology® apsjournals.apsnet.org/doi/10.1094/...
apsjournals.apsnet.org
Preserving the Biologically Coherent Generic Concept of Phytophthora, ‘Plant Destroyer’ | Phytopathology®
Phytophthora is a long-established, well known and globally important genus of plant pathogens. Phylogenetic evidence has shown that the biologically distinct, obligate biotrophic downy mildews evolve...
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Reposted by Tolga Bozkurt
Team_Zuccaro @algazuccaro.bsky.social · 07/03/2025
Latest story from Pia Saake: Plant Lipids Mediate Immune Responses to Fungal Lipids in Barley! nph.onlinelibrary.wiley.com/doi/full/10....
nph.onlinelibrary.wiley.com
Ergosterol‐induced immune response in barley involves phosphorylation of phosphatidylinositol phosphate metabolic enzymes and activation of diterpene biosynthesis
Lipids play crucial roles in plant–microbe interactions, functioning as structural components, signaling molecules, and microbe-associated molecular patterns (MAMPs). However, the mechanisms underly...
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Tolga Bozkurt @tolgaboz.bsky.social · 07/03/2025
Join us at the inaugural FEBS EMBO Cell Biology of Host-Pathogen Meeting! Explore how microbes reshape host cell architecture & metabolism. Abstract deadline: 1st of April . meetings.embo.org/event/24-hos.... #EMBOcellBioHostPath
meetings.embo.org
Cell biology of host-pathogen interactions
Microbial infections lead to drastic changes in the architecture and metabolism of the host cell. The inaugural FEBS EMBO Cell Biology of Host-Pathogen Interaction Advanced Course explores the mechan…
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TheUstunLab @theustunlab.bsky.social · 06/03/2025
Next up in the last session of our #plantscience retreat is Shanshuo Zhu who is talking about her exciting data on cell-type specific autophagy and its role in bacterial infection #proteostasis
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New Phytologist @newphyt.bsky.social · 06/03/2025
Ralstonia wilt #pathogens consume an in planta diet of amino acids with a dash of sugar 📖 nph.onlinelibrary.wiley.com/doi/10.1111/... 👆 A #Commentary by Hamilton & Lowe-Power on this article by Baroukh et al. 👇 📖 nph.onlinelibrary.wiley.com/doi/10.1111/...
Figure 1: Baroukh et al. at the Laboratoire des Interactions Plantes Microorganismes, part of the National Research Institute for Agriculture, Food and the Environment, Toulouse, France, have shed light on xylem infection physiology by combining experimentation and mathematical modeling.
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Michael Hothorn @structplantbio.bsky.social · 19/02/2025
Structure, enzyme mechanism and regulation of the PPIP5K inositol pyrophosphate phosphatase out in @naturecomms.bsky.social. Great work by Pierre Raia, Kitaik Lee, @fxrico.bsky.social, with Dorothea Fiedler @fmp-berlin.de & Vikram Panse @ethzurich.bsky.social/UZH. Funded by @snf-fns-ch.bsky.social
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Tolga Bozkurt @tolgaboz.bsky.social · 05/03/2025
Excited to host @geminiteamlab.bsky.social for our departmental seminars @imperiallifesci.bsky.social. Thrilling work on molecular plant-virus interactions!
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