What I told early-career researchers about prediction, rigour, failure, priors — and the tyranny of bar graphs.

To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...

To cause rice blast disease, the filamentous fungus Magnaporthe oryzae develops a specialised infection cell called an appressorium, which generates enormous turgor to breach the rice leaf cuticle. Al...

Andy Posbe turned our ten lessons on AI structure prediction into a thread. Here it is, one lesson at a time.

Angiosperm seed formation requires the coordinated development of the products of double fertilization—the embryo and the endosperm. The endosperm mediates efficient nutrient transfer from surrounding...

Plants perceive external and internal signals via receptors to modulate their growth, development, and defenses. Leucine-rich-repeat receptor-like-kinase (RLKs) and receptor-like-proteins (RLPs) are t...

Engineering the barley NLR RGH2 enhances recognition of blast pathogen effectors from rice and wheat, leading to improved disease resistance.

A plant pathogen effector suppresses an activated helper NLR via a host ENTH domain–containing protein, NbTOL9a.

A plant pathogen effector suppresses an activated helper NLR via a host ENTH domain–containing protein, NbTOL9a.

RNA viruses co-opt host endomembranes to form replication complexes, often triggering cellular stress and immune responses. Here, we show that Arabidopsis thaliana activates selective autophagy to res...

Abstract. IQ-TREE (https://iqtree.github.io/) is a widely used open-source software tool for efficiently inferring phylogenetic trees under maximum likelih

Artificial intelligence (AI) systems such as AlphaFold have transformed structural biology by enabling accurate prediction of protein structures. However, their capacity to uncover new classes of…

The AI system AlphaFold has transformed how we predict protein structures. But sometimes the most interesting discoveries come from asking…

PUBLISHED: 30.04.26 | THE SAINSBURY LABORATORY

Fungal effectors may have evolved from ancient antimicrobials, shaping plant microbiota and immunity during infection.

Plant intracellular immune receptors are widely deployed in breeding to protect crops from disease. In addition to nucleotide-binding leucine-rich repeat receptors (NLRs), tandem kinase proteins (TKPs...