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Jiorgos Kourelis

@jiorgoskourelis.bsky.social
990 followers 308 following 3 posts

Imperial College London. Exploring plant-microbe interactions & receptor-dependent immunity. Bioinformatics, evolution, synthetic biology. #PlantScience #Bioengineering kourelislab.com

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Jiorgos Kourelis @jiorgoskourelis.bsky.social · 04/06/2026
📢 PDRA Position - Plant Immune Receptor Bioengineering at Imperial College London 🌱 Start: Aug 2026 (flexible) 🧪 Wet lab + bioinformatics 📅 Up to 3 years (ERC-funded) 📍 South Kensington, on site ℹ️ shorturl.at/VIITk 🔗 kourelislab.com #PlantImmunity #PlantPathology 🙏 Share with interested candidates!
shorturl.at
Description
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Rita Maravilha Marques @ritamaravilha.bsky.social · 29/01/2026
1/12 I'm ecstatic to share my preprint on legume NLR tissue expression! We investigated the NLRomes of 28 legumes + 4 outgroups, examining tissue expression across 7 legume species. Paper thread below 🧵👇 @thesainsburylab.bsky.social @itqbnova.bsky.social 🔗https://doi.org/10.64898/2026.01.25.701577
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Jiorgos Kourelis @jiorgoskourelis.bsky.social · 23/01/2026
📢 2 PhD Positions Available in Plant Immune Receptor Bioengineering at Imperial College London 🌱 Start: Oct 2026 📅 Deadline: 10 Feb 2026 🇬🇧 UK/settled status only 💰 Fully funded (48 months) ℹ️ Info: shorturl.at/po61I #PlantImmunity #PlantPathology #SyntheticBiology 🙏 Share with interested candidates!
imperial.ac.uk
PhD Opportunities | Faculty of Natural Sciences | Imperial College London
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Clémence Marchal @clemmar.bsky.social · 03/12/2025
Excited to share our latest work on plant immune receptor biochemistry! @kamounlab.bsky.social @hsuanpai.bsky.social @mpcontreras.bsky.social Jose Salguero Linares @danielluedke.bsky.social @adnroide.bsky.social @jiorgoskourelis.bsky.social www.biorxiv.org/content/10.6...
CC-NLRs exhibit diverse conformations in the resting state.
Figure depicts different NLR resting and activated states. While ZAR1 exists as a monomer bound to its guardees in its resting state, several forms have been observed for the NRC2 helper, including dimers, tetramers, and filaments. While filament-like structures were observed via confocal microscopy for NRC2 upon overexpression in planta, these structures were not detected for its paralog NRC4, suggesting a potentially different resting state configuration for NRC4. Our work suggests that the Pik CC-NLR pair forms a hetero-complex bound to the plasma membrane in its resting state. How effector binding to the integrated domain (ID) of the Pik-1 sensor leads to the activation of the complex remains to be determined.
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Mariana Schuster @marischuster.bsky.social · 16/07/2025
#PlantChemetics #2025ISMPMI
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Sam Mugford @samtmugford.bsky.social · 14/07/2025
Chewing the fat with old colleagues @jiorgoskourelis.bsky.social #ismpmi2025
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Tolga Bozkurt @tolgaboz.bsky.social · 07/07/2025
Plz RT. We are looking for a postdoc to join our collborative project on AI-guided bioengineering of plant immune receptors @tolgaboz.bsky.social and @jiorgoskourelis.bsky.social labs: www.jobs.ac.uk/job/DNV032/r...
jobs.ac.uk
Research Associate in Programmable Plant Immunity at Imperial College London
Apply for the Research Associate in Programmable Plant Immunity role on jobs.ac.uk, the top job board for academic positions in higher education. View details and apply now.
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Alexander Förderer @alexanderforderer.bsky.social · 03/06/2025
Excited to share the first preprint from my lab @mpi-mp-potsdam.bsky.social in Potsdam! Huge thanks to @o-sulkowski.bsky.social and the whole team for their hard work and dedication. 📄 www.biorxiv.org/content/10.1...
biorxiv.org
Diversification of the "EDVID" packing motif underpins structural and functional variation in plant NLR coiled-coil domains
· Nucleotide-binding leucine-rich repeat receptors (NLRs) are critical in plant immunity and display remarkable allelic diversity. Coiled-coiled NLRs (CC-NLRs) are the most widespread group of these r...
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AmirAli Toghani @amiralito.bsky.social · 26/02/2025
🧵 🥬 Lettuce begin! Super excited to share our new manuscript on contrasting patterns of evolution in sensor and helper NLRs in the NRC network! Tune in for some plant immunology and molecular evolution… 🌱🧬💻 (1/14) www.biorxiv.org/content/10.1...
biorxiv.org
A hierarchical immune receptor network in lettuce reveals contrasting patterns of evolution in sensor and helper NLRs
Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) are known for their rapid evolution, even at the intraspecific level, yet the rates of evolution differ significantly across v...
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Baptiste Castel @baptistebio.bsky.social · 10/02/2025
www.freepatentsonline.com/y2025/003458... Pikobodies can directly target effectors, not only GFP or mCherry. An impressive technology from @jiorgoskourelis.bsky.social @clemmar.bsky.social @kamounlab.bsky.social
freepatentsonline.com
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mjbanfield.bsky.social @mjbanfield.bsky.social · 27/01/2025
Abstract submission is now open for the IS-MPMI meeting in Cologne, Germany in July. You could consider submitting to the “Structure Informed Synthetic Biology: From Design to Function” session co-chaired by myself and @jiorgoskourelis.bsky.social 😁. Submission deadline 11 March.
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Jake Wintermute @synbio1.bsky.social · 15/01/2025
This pretty much settles it: we're entering the era of low-cost, on-demand binders for everything Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech www.nature.com/articles/s41...
nature.com
De novo designed proteins neutralize lethal snake venom toxins - Nature
Deep learning methods have been used to design proteins that can neutralize the effects of three-finger toxins found in snake venom, which could lead to the development of safer and more accessible an...
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Tolga Bozkurt @tolgaboz.bsky.social · 10/12/2024
Our first annual lab Christmas/New Year dinner together with @jiorgoskourelis.bsky.social lab. Amazing food, fantastic company, and a wonderful team. Excited for another year of great discoveries ahead!
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Jiorgos Kourelis @jiorgoskourelis.bsky.social · 04/12/2024
📢 PhD Opportunity in my lab on Plant Immune Receptor Bioengineering at @imperiallifesci.bsky.social 🌱 Start: October 2025 📅 Deadline: 12th January 2025 🇬🇧 Open to UK students 💰 Fully funded ℹ️ More info: tinyurl.com/w6ap9v9f ❗ #PlantImmunity #PlantPathology 🙏 Please share with interested candidates!
findaphd.com
Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London on FindAPhD.com
PhD Project - Bioengineering of plant NLR (nucleotide-binding leucine-rich repeat) immune receptors to enhance disease resistance at Imperial College London, listed on FindAPhD.com
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Pierre Buscaill @pierrebuscaill.bsky.social · 02/12/2024
🌿 Excited to share our latest research on how host proteases regulate immune activation! Read more about how SBT5.2 releases and inactivates flg22: www.nature.com/articles/s41... rdcu.be/d1UsT Congratulations to all involved! #PlantImmunity #PlantPathology #PlantChemeticsLab
nature.com
Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast - Nature Communications
Plants recognize bacteria by perceiving a 22-residue epitope in flagellin. Plant-secreted SBT5.2 subtilases are found to inactivate this epitope, leading to elicitor removal and reducing costly immuni...
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Sophien Kamoun @kamounlab.bsky.social · 27/11/2024
New!!!👇 #NLRbiology Kudos @amiralito_ @ryoheiterauchi @YuSugiharaY
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Adam Bentham @adamrbentham.bsky.social · 27/11/2024
Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors? biorxiv.org/cgi/content/...
biorxiv.org
Can AI modelling of protein structures distinguish between sensor and helper NLR immune receptors?
NLR immune receptors can be functionally organized in genetically linked sensor-helper pairs. However, methods to categorize paired NLRs remain limited, primarily relying on the presence of non-canoni...
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Marc Somssich @somssich.bsky.social · 27/11/2024
📜 A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization 🧑‍🔬 Nick Dunken, @algazuccaro.bsky.social, et al. 📔 Cell Host & Microbe 🔗 www.sciencedirect.com/science/arti... #️⃣ #PlantScience #PlantImmunity
sciencedirect.com
A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization
The intracellular colonization of plant roots by the beneficial fungal endophyte Serendipita indica follows a biphasic strategy, including a host cell…
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Parvinder Kahlon @parvinderkahlon.bsky.social · 22/11/2024
New Preprint! Excited to share our method for profiling light elements in plant tissues using XRF. Fast, cost-effective, and no extraction needed—perfect for stress-related studies in plants. Read more: www.biorxiv.org/content/10.1... #PlantScience #XRF #Innovation
biorxiv.org
Quantitative light element (sodium and potassium) profiling in plant tissues using monochromatic X-ray fluorescence analysis
Accurately determining the elemental composition of plant tissues is essential for physiological studies on plant stress, including salinity tolerance. However, high-throughput routine analysis of lig...
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Sophien Kamoun @kamounlab.bsky.social · 18/11/2024
Thank you Simon @SimonStael for hosting me today in Uppsala to talk to the Swedish University of Agricultural Sciences @_SLU students about GOHREP and how to science in general. Great discussions! kamounlab.medium.com/gohrep-and-p...
kamounlab.medium.com
GOHREP and PLESI: guides to navigate through your research projects
Students can struggle to articulate the goals and rationale behind their research projects and navigate through the day to day challenges of laboratory research. GOHREP and PLESI can be helpful…
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Adam Steinbrenner @adsteinbrenner.bsky.social · 18/11/2024
Reintroducing myself on Bluesky @adsteinbrenner.bsky.social -- I'm a plant biologist at UW Seattle (just recently made Associate Professor!) We study the plant immune system with a special interest in recognition of chewing herbivores and host-pest molecular evolution.
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Nick Talbot @talbotlabtsl.bsky.social · 19/11/2024
Last few days to apply for a PhD studentship in my group @thesainsburylab.bsky.social biodtp.norwichresearchpark.ac.uk/projects/ide...
biodtp.norwichresearchpark.ac.uk
Identification of novel virulence determinants in the rice blast fungus Magnaporthe oryzae | Doctoral Training Partnership
TALBOT_S25DTP
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Frank Menke @frankmenke.bsky.social · 18/11/2024
📣 PhD opportunity at @thesainsburylab.bsky.social Norwich, UK. "Investigating host penetration by the rice blast fungus" with Dr Frank Menke and Nick Talbot @FrankMenke.bsky.social @talbotlabtsl.bsky.social Apply before 25 Nov 2024! ⬇️ biodtp.norwichresearchpark.ac.uk/projects/inv...
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The Sainsbury Laboratory @thesainsburylab.bsky.social · 19/11/2024
📄 NEW PUBLICATION: Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome @amiralito.bsky.social @mpcontreras.bsky.social @kamounlab.bsky.social @m_selvaraj @mhz1989 @HsuanPai1 www.tsl.ac.uk/publications... journals.plos.org/plosbiology/...
journals.plos.org
Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome
Plants use NLR immune receptors, which often require downstream "helper" NLRs, for pathogen defense. This study identifies and structurally characterizes the mechanisms of NLR activation, showing that...
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Tatsuya Nobori @tatsuyanobori.bsky.social · 18/11/2024
Had a fantastic visit to Tübingen! Enjoyed discussions with the wonderful people at MPI @galofir.bsky.social @plantevolution.bsky.social (anyone else on this platform 🤔?). A big thank you to Shanshan Wang for nominating me for a prestigious seminar series. Special thanks to Honour for the tour!
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Christine Faulkner @pdchristine.bsky.social · 01/10/2024
We're looking for a postdoc to join our team. If you are fascinated by mechanisms of cell-to-cell communication in plants, get in touch to find out more. #PlantScience www.jic.ac.uk/vacancies/po...
jic.ac.uk
Postdoctoral Researcher (Faulkner Group) | John Innes Centre
An exciting opportunity has arisen for a Postdoctoral Researcher to join the Faulkner Group at the John Innes Centre, working on cutting-edge science in the field of Cell and Developmental Biology.
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Nature Plants @natplants.nature.com · 15/11/2024
New Article: "The complete genome assembly of Nicotiana benthamiana reveals the genetic and epigenetic landscape of centromeres" rdcu.be/d0h6Q ...revealing the structure, epigenetic landscape and evolutionary dynamics of its centromeres following allotetraploidization. #PlantScience
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Mauricio Contreras @mpcontreras.bsky.social · 14/11/2024
One bacterial NLR recognizing three different phage proteins vis direct interaction! How cool is that? www.nature.com/articles/s41...
nature.com
Diversification of molecular pattern recognition in bacterial NLR-like proteins - Nature Communications
Avs proteins are bacterial anti-phage pattern recognition receptors evolutionarily related to eukaryotic NLRs. Here, Béchon et al show that a single bacterial Avs can recognize different phage protein...
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Sorek Lab @soreklab.bsky.social · 14/11/2024
Happy to see our paper out @ Nat Comm We discovered a bacterial NLR-like pattern recognition receptor that can sense 3 different viral proteins as a signature for infection. This explains its broad defense against different phage families Congrats Nathalie Béchon! www.nature.com/articles/s41...
nature.com
Diversification of molecular pattern recognition in bacterial NLR-like proteins - Nature Communications
Avs proteins are bacterial anti-phage pattern recognition receptors evolutionarily related to eukaryotic NLRs. Here, Béchon et al show that a single bacterial Avs can recognize different phage protein...
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Corné Pieterse @cornepieterse.bsky.social · 13/11/2024
First steps on Bluesky.... Let's test how it works by re-sharing Klokhuis Dutch national kids TV broadcast on our Netherlands Plant Ecophenotyping Centre: hetklokhuis.nl/tv-uitzendin... #PlantScience
hetklokhuis.nl
Uitzending - Plantenlaboratorium
Om ervoor te zorgen dat iedereen op de aardbol genoeg te eten heeft zullen we heel slim met ons voedsel om moeten gaan. Tirsa gaat naar een hightech plantenlaboratorium in Utrecht. Daar wordt uitvoeri...
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Marc Somssich @somssich.bsky.social · 11/11/2024
New paper from Simon Snoeck, Oliver Johanndrees, Thorsten Nürnberger & Cyril Zipfel. "Plant pattern recognition receptors: from evolutionary insight to engineering" #PlantScience #PlantImmunity
nature.com
Plant pattern recognition receptors: from evolutionary insight to engineering - Nature Reviews Genetics
Genomic and pangenomic data are yielding insights into the evolution of plant pattern recognition receptors (PRRs) and their molecular triggers. Recent advances in in silico and in vivo methods, along...
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Doryen Bubeck @doryenbubeck.bsky.social · 12/11/2024
Looking forward to a new platform for science! Help me build my #cryoEM #STEM network after jumping ship.
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Gitta Coaker @gittacoaker.bsky.social · 13/11/2024
www.biorxiv.org/content/10.1...
biorxiv.org
Comprehensive Evaluation of AlphaFold-Multimer, AlphaFold3 and ColabFold, and Scoring Functions in Predicting Protein-Peptide Complex Structures
Determining the three-dimensional structures of protein-peptide complexes is crucial for elucidating biological processes and designing peptide-based drugs. Protein-peptide docking has become essentia...
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Marc Somssich @somssich.bsky.social · 11/11/2024
There are even more here, btw: go.bsky.app/H3986W6
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Marc Somssich @somssich.bsky.social · 28/09/2024
I have updated the #PlantScience #StarterPack. You can now include 150 accounts, instead of the initial 50. I have tried to focus on active accounts. go.bsky.app/8Zfmwf7
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Kay Schneitz @kschneitz.bsky.social · 08/03/2024
Very nice work by Liam Elliott et.al. from the Kirchhelle lab on the role of cell edges in the control of plant growth and morphogenesis. www.nature.com/articles/s41... #plantscience #plantdevelopment #plantbiology 🌾🧪
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Jack Rhodes @jackrhodes.bsky.social · 16/02/2024
Bioengineering secreted proteases converts divergent Rcr3 orthologs and paralogs into extracellular immune co-receptors
biorxiv.org
Bioengineering secreted proteases converts divergent Rcr3 orthologs and paralogs into extracellular immune co-receptors
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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The Sainsbury Laboratory @thesainsburylab.bsky.social · 20/12/2023
📄 New Preprint: Functional divergence shaped the network architecture of plant immune receptors. @jiorgoskourelis.bsky.social @amiralito.bsky.social @biorxiv-plants.bsky.social www.biorxiv.org/content/10.1... www.tsl.ac.uk/publications...
tsl.ac.uk
The Sainsbury Laboratory | Functional divergence shaped the network…
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Marc Somssich @somssich.bsky.social · 19/12/2023
📜 Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome 🧑‍🔬 Muniyandi Selvaraj, @kamounlab.bsky.social, @nlrpapi.bsky.social, et al. 📔 @biorxiv-plants.bsky.social 🔗 www.biorxiv.org/content/10.1... #️⃣ (Feeds) #PlantScience #PlantImmunity #PlantEffectors
biorxiv.org
Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Mark A. Hanson @hansonmark.bsky.social · 17/12/2023
US NIH recommends $14k boost to postdoc salary to keep positions competitive. That's a ~25% increase. Sorely needed if academia wants to retain the talent needed to remain at the leading edge of the pursuit of knowledge. #AcademicSky www.science.org/content/arti...
science.org
NIH advisory group recommends $14,000 boost in postdoc pay
Researchers shouldn’t be in postdoc positions for more than 5 years, the group also suggests
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Marc Somssich @somssich.bsky.social · 18/12/2023
📜 A decaploid pitcher plant genome reveals a novel role for recessive subgenomes 🧑‍🔬 Kenji Fukushima 📔 @natureplants.bsky.social 🔗 www.nature.com/articles/s41... #️⃣ (Feeds) #PlantScience #PlantGenomics #CarnivorousPlants #PlantShape #NepenthesGracilis #PitcherPlant
nature.com
A decaploid pitcher plant genome reveals a novel role for recessive subgenomes - Nature Plants
Genomic polyploidy is prevalent in the plant kingdom, giving rise to dominant and recessive subgenomes. We show that the recessive subgenomes of the pitcher plant Nepenthes gracilis had a crucial role...
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Sophien Kamoun @kamounlab.bsky.social · 18/12/2023
Just published: CryoEM structure of a helper NLR!
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Sophien Kamoun @kamounlab.bsky.social · 15/12/2023
To what extent is plant immunity organ-specific? Find out in this paper by Daniel @daniel_luedke et al. www.biorxiv.org/content/10.1...
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bioRxiv Plant Bio @biorxiv-plants.bsky.social · 14/12/2023
A root-specific NLR network confers resistance to plant parasitic nematodes www.biorxiv.org/content/10.1101/202…
biorxiv.org
A root-specific NLR network confers resistance to plant parasitic nematodes https://www.biorxiv.org/content/10.1101/2023.12.14.571630v1
Nucleotide-binding domain and leucine-rich repeat immune receptors (NLRs) confer disease resistance
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Yori Dola @gene-boy.bsky.social · 25/11/2023
It seems we can now gene edit important plant pathogens like Xanthomonas and P. syringae! Yan et al. (2023) used FnCas12a and exogenous NHEJ proteins to allow the bacteria to repair the DSBs. Check it out: journals.plos.org/plospathogen... #plantimmunity
journals.plos.org
CRISPR/FnCas12a-mediated efficient multiplex and iterative genome editing in bacterial plant pathoge...
Author summary Genetic manipulation of bacterial genomes has greatly advanced our understanding of bacterial physiology and pathogenesis, which further helps us build up cell factories for the product...
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The Tattooed Professor @schwessinger.bsky.social · 26/11/2023
Updated version: We now show the suitability of our wheat protoplast assay for 7 avriulence effectors from 3 different wheat pathogens some not inducing HR. Our assay also works for extracellular recognition as shown by AvrStb6. Enjoy. www.biorxiv.org/content/10.1...
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Alain Tissier @atissier.bsky.social · 26/11/2023
Here is our latest preprint. Fusions of Cas9 to specific viral 5' exonucleases increase homology directed repair 30-fold in transient and 10-fold in stable transformations. Making non-selectable knock-ins and gene replacements possible. Congrats to the whole team! www.biorxiv.org/content/10.1...
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Michelle Hulin @michhulin.bsky.social · 25/11/2023
Yesterday was my last day at @thesainsburylab.bsky.social! Had a wonderful 3 years in the Ma lab 💚. Looking forward to the next adventure at Michigan State University #newPI #womaninSTEM
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Ronald Pierik @ronaldpierik.bsky.social · 10/11/2023
Are you excited about molecular biology of plant-light interactions? We have good news! We have extended the deadline for application to our tenure track position @WUR to 27 November. #plantscijobs
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Chenxin Li, PhD @chenxinli2.bsky.social · 08/11/2023
Not enough people know about bioicons.com Open source vector graphics. Free alternatives to BioRender.
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