Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 29/09/2026🔬 Two PhD positions in Biophysics/Structural Biology at FMP Berlin! The Research Unit Molecular Biophysics at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), led by Adam Lange, is looking for two PhD students. Applications are open until November, 30. 033
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 29/09/2026Christian Hackenberger vom Leibniz-FMP gehört zu den „100 wichtigsten Köpfen der Wissenschaft“ des Tagesspiegels. Mit seiner Forschung zur Chemischen Biologie arbeitet er an Ansätzen für die Krebstherapie und hat das Unternehmen Tubulis mitgegründet. Zum Artikel: www.tagesspiegel.de/wissen/sie-h... 050
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Einstein Foundation Berlin @einsteinberlin.bsky.social · 21/09/2026Mit der P5-Konjugation entwickelten Christian Hackenberger + Team / @fmpberlin.bsky.social stabile, wirksame Antikörper-Wirkstoff-Konjugate (ADCs), die Chemotherapeutika gezielt zu Tumorzellen transportieren. 📗 Aus der Reihe „Durchbruchspotenzial“ im #ALBERTJournal Nr. 11 „Gesundheitsforschung“. 032
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Leibniz-Gemeinschaft @leibniz-gemeinschaft.de · 16/09/2026🧠 KI-Anwendungen Hoffnungsträger in der Medizin: Von der Wirkstoffentwicklung bis zum Frühwarnsystem für epileptische Anfälle. Forschende erzählen von ihrer Arbeit an KI-Werkzeugen für die Medizin 👉️ www.leibniz-magazin.de/alle-artikel... @fmp-berlin.de @iwmtue.bsky.social @leibnizipht.bsky.social 022
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 20/08/2026New paper from the Lange group – together with colleagues from the groups Sun, Roderer, and Schmieder: Integrated structural biology reveals binding mode of scorpion toxin to Ca²⁺-gated K⁺ channel. Out now in Nature Communications: www.nature.com/articles/s41... 042
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 12/08/2026August’s Scientific Picture of the Month is a joint effort from the Schmieder, Milles and broichhagenj.bsky.social labs: May the fluorescence be with you, young scientist ⚔️ Fluoride substitution enables fluorescence, while ¹⁹F NMR provides kinetic insights. 032
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/07/2026Our scientific image of the month: Follow your heart - said no neuron ever 🫶 Thank you for providing this beautiful picture, Pia Venneker from the lab of @noalipstein.bsky.social 030
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 10/04/2026Snowflakes in a flask: Jamie Isern (Fiedler lab) shows us crystals of a protected myp-inositol derivative that bloom in a glass flask after purification. This molecule is a key building block in the synthesis of inositol polyphosphate probes, used to study cellular signaling pathways. 010
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/03/2026Aluminium - a study in structure. Enjoy this month's scientific picture from Stephanie Wendt (Technical Services). 010
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/03/2026Congrats to Milena Roth on receiving the Master’s Prize of the German Society for Biochemistry and Molecular Biology! 🎉 Her outstanding thesis in @agatawitkowska.bsky.social group at FMP uncovered new insights into neuronal protein–membrane interactions. 061
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/02/2026Scientific picture of the month by Pia Venneker (Lipstein lab): An elegant mix of stardust, nervous breakdown, and fluorescent spaghetti – hippocampal neurons with astrocytes, glowing nuclei, neuron markers and dendrites. 💥 000
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 30/01/2026Exciting discovery! AG Lange and the FMP Chemical Biology Section at FMP identified selective inhibitors of intramembrane rhomboid proteases and revealed their modes of action.Full paper: onlinelibrary.wiley.com/doi/10.1002/... Picture: Created in BioRender. Bohg, C. (2026) biorender.com/vi9hi4f 021
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 13/01/2026Cold Snow, warm sun and bright ideas: The first scientific picture of the New Year, captured by Franziska Ringleb (FMP Directorate). 020
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/12/2025New in PNAS: Tight junctions tune kidney Ca2+ flow. Using high‑res imaging, CLDN14 swaps in for CLDN16, breaks the CLDN16/19 pore, and lowers Ca2+ reabsorption. Read: www.pnas.org/doi/10.1073/... 020
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Agata Witkowska @agatawitkowska.bsky.social · 21/11/2025A fascinating seminar today with Prof. Bettina Winckler (UVA) at @fmp-berlin.de! She shared incredible insights into endosome trafficking in neurons. Thanks to ECN Berlin for funding our "Molecular Mechanisms of Neuronal Connectivity" series. @neurocure.bsky.social @einsteinberlin.bsky.social 051
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/11/2025May the (icy) force be with you ⚔️: This month's scientific picture comes from Abhirup Majumdar (Fiedler lab). This ice sculpture was formed at the base of a flask during an exothermic reaction at low temperatures 🧊. Great contribution! 020
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 22/10/2025New study by @noalipstein.bsky.social and Nils Brose, @mpi-nat.bsky.social links UNC13A gene variants to a new developmental disorder — offering insights into ALS and potential therapies. 👏 Read the full paper: www.nature.com/articles/s41...nature.comPathogenic UNC13A variants cause a neurodevelopmental syndrome by impairing synaptic function - Nature GeneticsPathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and... 081
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 14/10/2025Congrats to Sigrid Milles, junior group leader at @fmp-berlin.de on receiving a Boehringer Ingelheim Stiftung Exploration Grant! 🎉 Her team studies how flexible, intrinsically disordered proteins form condensates to control clathrin-mediated endocytosis — combining NMR, smFRET & live-cell work. 🧫🫧 072
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)rupi42ai @rupi42ai.bsky.social · 13/10/2025Neue Episode im Wirkstoffradio! WSR088 LNDW 2025: Depression & intrinsisch unstrukturierte Proteine mit Gästen aus dem @fmp-berlin.de www.wirkstoffradio.de/2025/10/12/w... #LNDW #Wissenschaftspodcast #Medizin #Podcast #Leibniz #Berlin #Depression #IDPwirkstoffradio.deWSR088 LNDW 2025: Depression & intrinsisch unstrukturierte ProteineDiese Episode wurde bei der LNDW 2025 aufgezeichnet. Darin sprechen Bernd Rupp und Ralf Schülein über Depressionen sowie Therapien mit Antidepressiva. Anschließend erläutert Sigrid Milles die Rolle in... 022
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 10/10/2025Our scientific picture of the month sets a spooky vibe 👻🎃 Thanks to the @broichhagenj.bsky.social lab for providing us with Chem o'lanterns 031
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 07/10/2025Congratulations to @volkerhaucke-lab.bsky.social for receiving the prestigious Reinhart Koselleck Grant by the @dfg.de (German Research Foundation) once again! 🎉 www.linkedin.com/feed/update/...linkedin.comAnother award for Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Professor at Freie Universität Berlin: The Deutsche Forschungsgemeinschaft (DFG) -… ...Another award for Volker Haucke, Director at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Professor at Freie Universität Berlin: The Deutsche Forschungsgemeinschaft (DFG) - G... 051
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 23/09/2025Congrats to Volker Haucke, Director at the Leibniz-FMP on being awarded the Ernst Schering Prize 2025 for his pioneering work on the function of signaling lipids that control how cells respond to hormones, nutrients and messengers. 3174
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Vince Arafiles @vincearafiles.bsky.social · 17/09/2025🔥After years of hard work, it's finally out in @natchem.nature.com🔥 The Hackenberger group @fmp-berlin.de developed #🎯DarT-labeling, a #photocatalyticproximitylabeling method using deazaflavin - a ✅ biocompatible ✅ easily synthesized ✅ chemically benign #photocatalyst www.nature.com/articles/s41...nature.comEnergy-transfer photoproximity labelling in live cells using an organic cofactor - Nature ChemistryCurrent photoproximity labelling methods often require metal-based catalysts to map protein interactomes but, owing to their toxicity, they have limited intracellular applicability. A deazaflavin cofa... 2113
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 01/09/2025Daniel Roderer and his group revealed the first high-res structure of Fap2 from Fusobacterium nucleatum (cryo-EM/ET). Fap2 binds immune cells (TIGIT) and colorectal cancer cells (Gal-GalNAc), showing how Fusobacteria colonize tumors and escape the immune system. www.nature.com/articles/s41... 020
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Max Ruwolt @mruwolt.bsky.social · 20/08/2025Brace yourselves! Arif from the Fiedler lab discovered+characterized in collaboration with us & other groups within the @fmp-berlin.de a novel PTM: autocatalytic oligophosphorylation (up to 6 Phosphates 😲). Still mysterious in origin, function & regulation. www.nature.com/articles/s41...nature.comNucleoside diphosphate kinase A (NME1) catalyses its own oligophosphorylation - Nature ChemistryOur understanding of how post-translational modification—protein phosphorylation—impacts the complexity of eukaryotic signalling pathways is continuously expanding. Now, protein oligophosphorylation h... 092
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Sigrid Milles @millessigrid.bsky.social · 21/08/2025I am happy to share our new article on dynamic Eps15 and Dab2 networks in endocytosis studied by #NMR, and forming #LLPS. Research was done at @fmp-berlin.de and at the Institut de Biologie Structurale (IBS). www.nature.com/articles/s41...nature.comPromiscuous and multivalent interactions between Eps15 and partner protein Dab2 generate a complex interaction network - Nature CommunicationsEps15, a protein involved in endocytosis initiation, uses small folded EH domains to bind disordered partner proteins and its own disordered tail, thus forming a dynamic network via phase separation t... 0114
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 19/08/2025Great work by @broichhagenj.bsky.social at Leibniz-FMP, David Hodson at @rdm.ox.ac.uk and the whole team! 030
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 14/08/2025⏰Join us for the NMR Symposium, Nov 26–27, 2025, celebrating our new 1.2 GHz NMR spectrometer. To present a poster, send your abstract to NMR2025@fmp-berlin.de. Registrations are open until September 15th! 032
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 13/08/2025Great cover art by @barthvanrossum.bsky.social for @jacs.acspublications.org: Influenza lifecycle showing M2’s roles, from activation in the low-pH endosome to viral uncoating, RNA release, and budding of new particles. View the article from the Lange lab here: pubs.acs.org/doi/10.1021/... 041
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 12/08/2025Thanks to Yanwei Su from @volkerhaucke-lab.bsky.social, we have a new scientific image of the month: When morphology gets romantic 🫶- this is a U2OS cell overexpressing Sec61b (ER), stained with LAMP1 (lysosome) and DAPI (nuclei), to test lysosome–ER membrane contact sites. 093
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Magnetic Resonance News @nmr900.bsky.social · 11/08/2025PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET, Dr. Sigrid Milles, The Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmp-berlin.de Berlin, Germany leibniz-fmp.softgarden.io/job/58144047... #NMRjobs #NMRchat #NMR 🧲leibniz-fmp.softgarden.ioPhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) at Leibniz-Forschungsinstitut für Molekulare PharmakologieWe're looking for: PhD position on studying intrinsically disordered proteins by NMR and single molecule FRET (f/m/d) (Part Time) • Berlin, Deutschland 023
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/07/2025Our scientific image of the month July comes from Kati Fischermanns, @broichhagenj.bsky.social lab and is titled: "96 wells celebrate diversity" 🌈 It was created by scaling up tunable photocontrol over cells. 010
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/07/2025With his exceptional work, Prof. Dr. Volker Haucke @volkerhaucke-lab.bsky.social has made it onto the #FallingWallsFoundation shortlist for the #ScienceBreakthrough of the Year 2025 in the #LifeSciences category. Congratulations! 010
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 02/07/2025The #LongNightoftheSciences at @fmp-berlin.de was a great success: Many visitors took a look behind the scenes during the lab tours and were inspired by research. Thanks to everyone who came and see you around next year! 010
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Leibniz-Gemeinschaft @leibniz-gemeinschaft.de · 24/06/2025Kampf dem Kunststoff! In der Forschung fallen Unmengen #Plastikmüll an. Lässt sich das ändern? www.leibniz-magazin.de/alle-artikel... #LeibnizMagazin #Müll #Nachhaltigkeit #Forschung @fmp-berlin.de 051
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 23/06/2025New in @jacs.acspublications.org: New insights into the flu virus: The Lange lab used proton-detected solid-state NMR combined with the Sun lab's expertise in QM/MM+MD simulations to reveal how pH changes drive conformational shifts in the influenza A M2 channel. pubs.acs.org/doi/10.1021/... 031
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)chrischmied.bsky.social @chrischmied.bsky.social · 06/06/2025Wonderful to present my work leading a large European consortium around @fmp-berlin.de and @eu-openscreen.bsky.social at #ELMI2025. We produce large-scale #open-source high quality Cell Painting data for drug discovery 💊. First dataset published: doi.org/10.1016/j.is... Stay tuned for more! 062
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 28/05/2025Get ready for this upcoming event: Lecture series on Allostery in Drug Discovery 💊 www.linkedin.com/feed/update/...linkedin.comGet ready for this upcoming event, a lecture series on Allostery in Drug… | Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Get ready for this upcoming event, a lecture series on Allostery in Drug Discovery (ALLODD) - hosted by Prof. Dr. Marc Nazaré from Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and Dr.... 000
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 26/05/2025The lab of noalipstein.bsky.social introduced a new mouse line to label presynaptic terminals with chemical dyes, enabling imaging of fixed & live neurons at confocal & super-res. They synthesized & validated a cell-impermeable dye, BG-SiR-d12, improving image quality! pubs.acs.org/doi/10.1021/...pubs.acs.orgEndogenous SNAP-Tagging of Munc13-1 for Monitoring Synapse NanoarchitectureSynaptic function is governed by highly regulated protein machineries, whose abundance and spatial localization change continually. Studies to determine dynamic changes in synaptic protein nanoarchit... 010
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)chrischmied.bsky.social @chrischmied.bsky.social · 14/05/2025Big step for open science! 🎉 Our @eu-openscreen.bsky.social consortium drops their first open Cell Painting dataset. Wolff et al. 2025: doi.org/10.1016/j.is... FAIR, high-quality & ready to power AI in drug discovery. 100K+ compounds coming in 2025! #OpenData #CellPainting #DrugDiscovery 012
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 29/04/2025FMP-Director Volker Haucke in @tagesspiegel.de: Why we should not accept the US government's attack on science. www.tagesspiegel.de/wissen/gleic... (article behind paywall)tagesspiegel.deGleichschaltung in den USA : Solidarität mit US-Forschenden!Die US-Regierung will Wissenschaft ideologisch kontrollieren. Das gefährdet die Grundprinzipien freier Forschung, die am besten in internationaler Kooperation gedeiht. Der Zellbiologe und Leibniz-Prei... 020
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)chrischmied.bsky.social @chrischmied.bsky.social · 14/04/2025Join us for the CytoData Symposium and Hackathon: cytodata25.eu-openscreen.eu Registration open now! Symposium November 20–21, 2025 Hackathon November 17–19, 2025 @eu-openscreen.bsky.social @mdc-berlin.bsky.social @fmp-berlin.de @cytodata.bsky.social 011
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 03/04/2025Today was #GirlsDay 2025: An opportunity to show girls at @fmp-berlin.de what science has in store for them: www.linkedin.com/feed/update/...linkedin.com#girlsday #naturalsciences #lightandelectronmicroscopy #nmrspectroscopy… | Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Today was #GirlsDay 2025: An opportunity to show girls about professions or study subjects in which the proportion of women is below 40 percent, e.g. in the fields of #naturalsciences. 🔬👩🔬 12 school... 010
Reposted by Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)Leibniz-Gemeinschaft @leibniz-gemeinschaft.de · 31/03/2025🎉 Freie Wissenschaft. Starke Forschung. 30 Jahre Leibniz-Gemeinschaft. 🎉 Am 31.3.1995 wurden wir unter dem Namen „Wissenschaftsgemeinschaft Blaue Liste“ gegründet – ein Ergebnis der deutschen Wiedervereinigung & ein erfolgreicher Beitrag zum Zusammenwachsen der Wissenschaft in Ost und West. (1/4) 77021
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 25/03/2025Congratulations to @volkerhaucke-lab.bsky.social for receiving the Gottfried Wilhelm Leibniz Prize 2025 by @dfg.de The award recognises Haucke's research on lipid signaling and synaptic transmission in the nervous system. Insights into his work can be found here: www.youtube.com/watch?v=rl8m...youtube.comVolker Haucke - Gottfried Wilhelm Leibniz-Preisträger 2025 im PortraitYouTube video by DFG bewegt 030
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 19/03/2025Read the latest article with Prof. @volkerhaucke-lab.bsky.social in @tagesspiegel.de www.tagesspiegel.de/wissen/wisse...tagesspiegel.de„Wissenschaft wird hier fast unmöglich gemacht“: Berliner Leibniz-Preisträger prangert Forschungshürden anWie entstehen lebende Zellstrukturen aus dem Nichts? Diese Frage treibt den Molekularbiologen Volker Haucke an. Den Forschungsstandort Deutschland sieht er allerdings in ernster Gefahr. 000
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 18/03/2025Congratulations to Dr. Christopher Schmied from @fmp-berlin.de for winning the #EinsteinFoundationAward. Together with Helena Jambor, the scientists were recognized for their project "PixelQuality," improving scientific image publication practices. 030
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 04/03/2025This month's scientific image runs under the motto: "Can't see the forest for the trees". It's an overloaded negative stain EM of DIBMA-nanodiscs that didn't break and caused this crystalline aggregates 💠Thanks to @hsawczyc.bsky.social (Lange lab) for providing us with this gem! 000
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 11/02/2025The scientific image of the month February shows two clawed frogs (Xenopus laevis) in their colorful underwater world 🐸 Big thanks to Martina Lauersdorf! 010
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) @fmpberlin.bsky.social · 07/01/2025Mariposa Microscopy 🦋First Scientific Image of 2025 from Maria Kowald (@LipsteinNoa Lab) and @TolgaSoykan (Lehmann Lab) shows a cerebellum slice from a mutant mouse that was stained with a SNAP-tag ligand, producing a beautiful butterfly-shaped signal. #Microscopy #Neuroscience 000