ALT: a cartoon of squidward from spongebob squarepants says you 're not doing the technique

This Review examines recently gained insights into the roles of ESCRT complexes in viral infection, immunity, cancer and neurological disease.

Ham et al. identify fumarate as an endogenous inhibitor of PINK1-Parkin-mediated mitophagy through succination of specific cysteine residues in Parkin. This metabolite-induced modification disrupts Pa...

EIF2AK1/HRI kinase negatively regulates PINK1 mitophagy.

Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...

Nature Structural & Molecular Biology, Published online: 29 May 2025; doi:10.1038/s41594-025-01557-xAutophagy is initiated by the Unc-51-like kinase protein kinase complex (ULK1C) and class III phosphatidylinositol 3-OH kinase complex I (PI3KC3-C1). Here, the authors reveal the structure of the 2:1:1 core of ULK1C and its complex with PI3KC3-C1. ULK1C transitions to a 2:2:2 complex in the presence of PI3KC3-C1, suggesting a mechanism for autophagy induction.

Cell Death & Disease - NDP52 and its emerging role in pathogenesis

ALT: a man says go check it out in front of a shelf

Our cells are smart – they’re able to get rid of damaged parts and recycle useful parts to keep us healthy. This process seems to break down in conditions like Parkinson’s and Alzheimer’s disease, an...

Nature - Structures and mechanism of human mitochondrial pyruvate carrier

ALT: a penguin wearing a bear hat and a blue sweater is jumping in the air

Autophagosomes form from seed membranes that expand through bulk-lipid transport via the bridge-like lipid transporter ATG2. The origins of the seed membranes and their relationship to the lipid trans...

Nuclear-encoded mitochondrial proteins rely on N-terminal targeting sequences (N-MTS) for their import. These N-MTSs interact with the translocation machinery and are cleaved in the matrix by the mito...

Mitochondrial quality control is critical in muscle to ensure contractile and metabolic function. BNIP3L/Nix is a BCL2 member, a mitophagy receptor, and has been implicated in muscle atrophy. Human...

Selective macroautophagy/autophagy relies on newly formed double-membrane compartments, known as phagophores, to sequester and recycle diverse cellular components, including organelles, biomolecula...