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This review is included in the review collection "Metabolic Reprogramming in Cancer: Mechanisms and Therapeutic Opportunities", edited by Shensi Shen (@seansi.bsky.social) and Jean Ehrland Ricci (@jer-06.bsky.social). 🔗 Discover the Review Collection: www.nature.com/collections/...

Reposted by Jean-Ehrland RICCI

and 3) how metabolic interventions can suppress tumor-derived immunosuppressive signals, enhancing the efficacy of immune checkpoint inhibitors (ICIs), and improving the persistence and cytotoxicity of adoptive T cell therapies.

Reposted by Jean-Ehrland RICCI

Check how this review provides an overview of 1) how metabolism regulates the development and function of T cells, NK cells, and macrophages, 2) how tumors exploit these metabolic vulnerabilities to create an immune-hostile microenvironment that compromises immune cell activity,

Reposted by Jean-Ehrland RICCI

“Metabolic modulation of immune cell function: mechanisms and therapeutic implications in cancer immunotherapy” 🔵 Pleased to share the latest review from Alexandre Puissant, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 29/09/2026

Reposted by Jean-Ehrland RICCI

Check how the authors demonstrated that tumor-derived CD52 orchestrates a multi-layered immunosuppressive network that attenuates CD8+ T cell cytotoxicity, facilitating early immune evasion, and highlighted its value as a prognostic biomarker and therapeutic target.

Oncogenesis @oncogenesisnature.bsky.social · 29/09/2026

Reposted by Jean-Ehrland RICCI

“Integrated scRNA-Seq and functional profiling reveal CD52 as a driver of pancreatic ductal adenocarcinoma metastasis and immunosuppression” 🔵 Taiping Zhang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 25/09/2026

Reposted by Jean-Ehrland RICCI

Oncogenesis @oncogenesisnature.bsky.social · 25/09/2026

Reposted by Jean-Ehrland RICCI

Check how the authors synthesize recent advances in the understanding of lipid metabolism reprogramming across pediatric cancers and how they conclude that effective lipid-targeting therapies will require a precision-medicine framework that defines metabolic dependencies in patients.

Oncogenesis @oncogenesisnature.bsky.social · 25/09/2026

Reposted by Jean-Ehrland RICCI

“Reprogramming lipid metabolism in pediatric cancers” 🔵 Excited to share the latest review from Raphael J. Morscher, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 22/09/2026

Reposted by Jean-Ehrland RICCI

Check how the authors revealed that the transcriptional state of melanoma cells is the main determinant of their mechanosensitivity and that targeting mechanical stimuli from the ECM holds significant potential for enhancing the efficacy of therapies in melanoma.

Oncogenesis @oncogenesisnature.bsky.social · 22/09/2026

Reposted by Jean-Ehrland RICCI

“Extracellular matrix stiffness determines the phenotypic behavior of dedifferentiated melanoma cells through a DDR1/2-dependent YAP mechanotransduction pathway” 🔵 Sophie Tartare-Deckert‘s latest research is now available in #Oncogenesis. ▶️ Read the full article: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 17/09/2026

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Oncogenesis @oncogenesisnature.bsky.social · 17/09/2026

Reposted by Jean-Ehrland RICCI

Check how whether using modulators targeting NRF2-regulated pathways to induce ferroptosis in cancer cells, or by leveraging NRF2 activity as a biomarker to identify ferroptosis-susceptible tumors, NRF2 may ultimately serve as a critical bridge to translate ferroptosis into clinical application.

Oncogenesis @oncogenesisnature.bsky.social · 17/09/2026

Reposted by Jean-Ehrland RICCI

“Tipping the balance: NRF2’s dual role in ferroptotic fate” 🔵 Excited to share the latest review from Clarissa Rocha, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 15/09/2026

Check how their findings establish a novel Testican-1/Wnt/β-catenin axis driving CRC tumorigenesis and progression, positioning it as a promising therapeutic target to overcome Wnt-mediated progression and resistance.

Oncogenesis @oncogenesisnature.bsky.social · 15/09/2026

Reposted by Jean-Ehrland RICCI

“Testican-1 activates Wnt/β-Catenin signaling to drive colorectal cancer progression” 🔵 Nathaniel Weygant‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Jean-Ehrland RICCI @jer-06.bsky.social · 11/09/2026

Many thanks, @bensahralab.bsky.social , for this excellent review in Oncogenesis. An insightful synthesis of how oncogenic signalling rewires nucleotide metabolism & how these pathways can be therapeutically exploited. A highly recommended read from a leading expert in the field!

Oncogenesis @oncogenesisnature.bsky.social · 11/09/2026

Reposted by Jean-Ehrland RICCI

“The oncogenic control of nucleotide synthesis” 🔵 Excited to share the latest review from Issam Ben-Sahra (@bensahralab.bsky.social) , now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 08/09/2026

Check how their findings reveal a novel CAFs/PTGDS-PAQR9-MAPK signaling axis that promotes neuroendocrine differentiation and drives pancreatic ductal adenocarcinoma progression, offering new therapeutic opportunities to overcome stromal-mediated chemoresistance.

Oncogenesis @oncogenesisnature.bsky.social · 08/09/2026

Reposted by Jean-Ehrland RICCI

“CAF-derived PTGDS drives pancreatic cancer neuroendocrine differentiation and chemoresistance via PAQR9-MAPK” 🔵 Yuchong Zhao‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 04/09/2026

Oncogenesis @oncogenesisnature.bsky.social · 04/09/2026

Reposted by Jean-Ehrland RICCI

This review examines how excessive mitochondrial fission and fusion both play critical and contradictory roles in tumorigenesis, and while targeting mitochondrial dynamics shows therapeutic promise, drawbacks such as toxicity and tumor heterogeneity require further investigation.

Oncogenesis @oncogenesisnature.bsky.social · 04/09/2026

Reposted by Jean-Ehrland RICCI

“Imbalances of mitochondrial dynamics in solid tumors” 🔵 Excited to share the latest review from Maarten F. Bijlsma, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 01/09/2026

Reposted by Jean-Ehrland RICCI

Check how their data demonstrates that MKRN3 is a bona fide tumor suppressor gene in ovarian cancer as MKRN3 suppresses cancer cells’ proliferation largely through CSDE1 ubiquitination.

Oncogenesis @oncogenesisnature.bsky.social · 01/09/2026

Reposted by Jean-Ehrland RICCI

“The central precocious puberty-associated gene MKRN3 is a tumor suppressor regulating CSDE1 ubiquitination in ovarian cancer” 🔵 Yuan Lu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 27/08/2026

Reposted by Jean-Ehrland RICCI

Check how their findings establish catestatin as a novel regulator of melanoma growth and therapeutic resistance and provide a mechanistic rationale for the development of CST-based peptide therapeutics targeting both treatment-naive and drug-resistant melanoma.

Oncogenesis @oncogenesisnature.bsky.social · 27/08/2026

Reposted by Jean-Ehrland RICCI

“Catestatin peptide impedes melanoma progression and drug resistance by reprogramming oncogenic signaling pathways” 🔵 Sushil K. Mahata‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 24/08/2026

Reposted by Jean-Ehrland RICCI

“Multi-omics analysis reveals LARP1 as a key integrator of translation and metabolism in AML” 🔵 Leonidas C. Platanias'(@leonidasplatan1.bsky.social) latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 24/08/2026

Reposted by Jean-Ehrland RICCI

Check how by linking mRNA stability, selective translation, and protein regulation, LARP1 supports leukemic cell survival and promotes drug resistance, which postulates LARP1 as a promising novel target to enhance sensitivity to these drugs in AML.

Oncogenesis @oncogenesisnature.bsky.social · 14/07/2026

Reposted by Jean-Ehrland RICCI

Check how their research identifies SHP1 as a critical intracellular checkpoint that promotes tumor immune evasion by concurrently suppressing DC antigen presentation and the formation of central memory CD8+ T cells, nominating it as a promising therapeutic target for immunotherapy-resistant cancers

Oncogenesis @oncogenesisnature.bsky.social · 14/07/2026

Reposted by Jean-Ehrland RICCI

“SHP1 expression in tumor-associated dendritic cells drives immunoevasion via impairing CD8+ memory T cell responses” 🔵 Yuan Zhang‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 10/07/2026

Oncogenesis @oncogenesisnature.bsky.social · 10/07/2026

Reposted by Jean-Ehrland RICCI

and (3) explores the therapeutic potential of targeting iron-dependent processes beyond the scope of ferroptosis.

Oncogenesis @oncogenesisnature.bsky.social · 10/07/2026

Reposted by Jean-Ehrland RICCI

This review (1) discusses how iron-dependent pathways contribute to tumor development, (2) describes the relevance of iron crosstalk within the tumor microenvironment in promoting tumor growth, metabolic reprogramming and immune evasion...

Oncogenesis @oncogenesisnature.bsky.social · 10/07/2026

Reposted by Jean-Ehrland RICCI

“Iron and metabolic rewiring in cancer” 🔵 Excited to share the latest review from Naiara Santana-Codina, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 07/07/2026

Reposted by Jean-Ehrland RICCI

“Ubiquitin-specific protease 11 suppresses cuproptosis in colorectal cancer by regulating the ubiquitination and stability of ISCU” 🔵 Songling Yan‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 07/07/2026

Reposted by Jean-Ehrland RICCI

Check how this study reveals a novel regulatory pathway wherein USP11 promotes CRC progression by stabilizing ISCU and suppressing cuproptosis, contributing to tumor resistance against cuproptotic stress and highlights a potential therapeutic target for sensitizing CRC to copper-induced cell death.

Oncogenesis @oncogenesisnature.bsky.social · 02/07/2026

Reposted by Jean-Ehrland RICCI

It also describes approaches to target this signalling pathway, where aberrant, with the goal of eradicating the CSC population responsible for cancer initiation and progression, and importantly, patient relapse to many clinical therapeutics.

Oncogenesis @oncogenesisnature.bsky.social · 02/07/2026

Reposted by Jean-Ehrland RICCI

This review provides an overview of the role of Sphingosine 1-phosphate in stem cell biology in both normal physiology and disease.

Oncogenesis @oncogenesisnature.bsky.social · 02/07/2026

Reposted by Jean-Ehrland RICCI

“Sphingosine 1-phosphate signalling in cancer stem cells” 🔵 We're pleased to share the latest review by Jason A. Powell, and Stuart M. Pitson, now available in #Oncogenesis. ▶️ Read the full review here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 30/06/2026

Check how their findings support a model whereby HPCAL1 promotes CRC aggressiveness by sustaining canonical Wnt signaling, thereby functioning as a critical facilitator of the cellular plasticity required for metastatic progression.

Oncogenesis @oncogenesisnature.bsky.social · 30/06/2026

Reposted by Jean-Ehrland RICCI

“HPCAL1 promotes colorectal cancer progression via TCF7/p65-mediated Wnt ligand upregulation and Wnt/β-catenin pathway activation” 🔵 Zunmin Zhu‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 26/06/2026

Reposted by Jean-Ehrland RICCI

Check how their data strongly indicates that treatment with gemcitabine is well tolerated by FA/BRCA deficient mice and may provide an alternative treatment modality for chemoradiotherapy of HNSCC in Fanconi patients.

Oncogenesis @oncogenesisnature.bsky.social · 26/06/2026

Reposted by Jean-Ehrland RICCI

“Gemcitabine as chemotherapy of head and neck cancer in Fanconi anemia patients” 🔵 Interesting research led by Ruud H. Brakenhoff was featured in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

Oncogenesis @oncogenesisnature.bsky.social · 23/06/2026

Reposted by Jean-Ehrland RICCI

“Inhibition of LIMK by Cofilin-1 peptidomimetics enhances actin depolymerization and reduces metastasis of non-small cell lung cancer” 🔵 Yi-Jang Lee‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...

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Oncogenesis @oncogenesisnature.bsky.social · 19/06/2026

Check how their findings reveal the underlying mechanism of PLEKHA4 in regulating glioblastoma cell glycolysis and indicate a potential new target for GBM treatment.

Oncogenesis @oncogenesisnature.bsky.social · 17/06/2026

Reposted by Jean-Ehrland RICCI

Check how this work identifies the enhanced vulnerability of cyclin E-overexpressing TNBC cells to CDC7 kinase inhibition and substantial synergy when combined with CDK8 inhibition.

Oncogenesis @oncogenesisnature.bsky.social · 17/06/2026

Reposted by Jean-Ehrland RICCI

“Cyclin E modulates vulnerability to CDC7 kinase inhibition” 🔵 Agnieszka K. Witkiewicz‘s latest research is now available to read in #Oncogenesis. ▶️ Read the full open access article here: www.nature.com/articles/s41...